The “Cins” of Our Fathers: Rejuvenated Interest in Colicins to Combat Drug Resistance

Sumudu Upatissa; Robert J. Mitchell

doi:10.1007/s12275-023-00023-x

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The “Cins” of Our Fathers: Rejuvenated Interest in Colicins to Combat Drug Resistance: Sumudu Upatissa , Robert J. Mitchell; Journal of Microbiology 2023;61(2):145-158.
DOI: https://doi.org/10.1007/s12275-023-00023-x
Published online: February 8, 2023

Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of KoreaDepartment of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea

Corresponding author: Robert J. Mitchell ,

Received: 5 December 2022 • Revised: 17 January 2023 • Accepted: 27 January 2023

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Abstract

With the growing threat of antibiotic resistance, researchers around the globe are seeking alternatives to stem bacterial pathogenesis. One such alternative is bacteriocins, proteins produced by bacterial species to inhibit the growth and viability of related bacterial species. With their diverse mechanisms, which include pore formation and nuclease activities, and narrow spectrum of activities, which limit their impact to only certain bacterial species, unlike many chemical antibiotics, bacteriocins offer intriguing possibilities to selectively control individual bacterial populations. Within this review, therefore, we highlight current research exploring the application of colicins and microcins, a subset of bacteriocins, with an emphasis on their activities against drug-resistant pathogens, both in in vitro and in vivo settings.

Keywords: Bacteriocins · Colicins · Multidrug-resistant pathogens · In vivo applications

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International Journal of Molecular Sciences.2023; 24(16): 12636. CrossRef

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The “Cins” of Our Fathers: Rejuvenated Interest in Colicins to Combat Drug Resistance

J. Microbiol. 2023;61(2):145-158. Published online February 8, 2023

DOI: https://doi.org/10.1007/s12275-023-00023-x

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