Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium

Nakyeong Ha; Eun-Jin Lee

doi:10.1007/s12275-023-00027-7

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Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium: Nakyeong Ha ¹, Eun-Jin Lee ²; Journal of Microbiology 2023;61(3):289-296.
DOI: https://doi.org/10.1007/s12275-023-00027-7
Published online: March 2, 2023

¹Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea, ²Lee¹Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea, ²Lee

Corresponding author: Eun-Jin Lee , Tel: ,

Received: 4 January 2023 • Revised: 8 February 2023 • Accepted: 8 February 2023

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Abstract

The metal cofactors are essential for the function of many enzymes. The host restricts the metal acquisition of pathogens for their immunity and the pathogens have evolved many ways to obtain metal ions for their survival and growth. Salmonella enterica serovar Typhimurium also needs several metal cofactors for its survival, and manganese has been found to contribute to Salmonella pathogenesis. Manganese helps Salmonella withstand oxidative and nitrosative stresses. In addition, manganese affects glycolysis and the reductive TCA, which leads to the inhibition of energetic and biosynthetic metabolism. Therefore, manganese homeostasis is crucial for full virulence of Salmonella. Here, we summarize the current information about three importers and two exporters of manganese that have been identified in Salmonella. MntH, SitABCD, and ZupT have been shown to participate in manganese uptake. mntH and sitABCD are upregulated by low manganese concentration, oxidative stress, and host NRAMP1 level. mntH also contains a Mn2+- dependent riboswitch in its 5′ UTR. Regulation of zupT expression requires further investigation. MntP and YiiP have been identified as manganese efflux proteins. mntP is transcr!ptionally activated by MntR at high manganese levels and repressed its activity by MntS at low manganese levels. Regulation of yiiP requires further analysis, but it has been shown that yiiP expression is not dependent on MntS. Besides these five transporters, there might be additional transporters that need to be identified.

Keywords: OTU diversity;bacterial community structure;basal attine ants;next generation sequencing

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Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium

J. Microbiol. 2023;61(3):289-296. Published online March 2, 2023

DOI: https://doi.org/10.1007/s12275-023-00027-7

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