Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis

Ruonan Wang; Rongyu Li; Peng Zheng; Zicheng Yang; Cheng Qian; Zhou Wang; Senhe Qian

doi:10.1007/s12275-023-00042-8

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Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis: Ruonan Wang ¹, Rongyu Li ², Peng Zheng ¹, Zicheng Yang ¹, Cheng Qian ¹, Zhou Wang ¹, Senhe Qian ¹; Journal of Microbiology 2023;61(5):543-558.
DOI: https://doi.org/10.1007/s12275-023-00042-8
Published online: April 13, 2023

¹College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, People’s Republic of China, ²School of Basic Medical Sciences, Wannan Medical College, Wuhu 241002, People’s Republic of China¹College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, People’s Republic of China, ²School of Basic Medical Sciences, Wannan Medical College, Wuhu 241002, People’s Republic of China

Corresponding author: Senhe Qian ,

Received: 30 January 2023 • Revised: 13 March 2023 • Accepted: 14 March 2023

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Abstract

Silver nanoparticles (AgNPs) exhibit strong antibacterial activity and do not easily induce drug resistance; however, the poor stability and biocompatibility in solution limit their widespread application. In this study, AgNPs were modified with Polygonatum sibiricum Polysaccharide (PSP) to synthesize PSP@AgNPs with good stability, biocompatibility, and antibacterial activity. When PSP@AgNP synthesis was performed under a reaction time of 70 min, a reaction temperature of 35 °C, and an AgNO3- to-PSP volume ratio of 1:1, the synthesized PSP@AgNPs were more regular and uniform than AgNPs, and their particle size was around 10 nm. PSP@AgNPs exhibited lower cytotoxicity and hemolysis, and stronger bacteriostatic activity. PSP@AgNPs damage the integrity and internal structure of cells, resulting in the leakage of intracellular nucleic acids and proteins. The rate of cell membrane damage in Escherichia coli and Staphylococcus aureus treated with PSP@ AgNPs increased by 38.52% and 43.75%, respectively, compared with that of AgNPs. PSP@AgNPs inhibit the activities of key enzymes related to antioxidant, energy and substance metabolism in cells. The inhibitory effects on the activities of superoxide dismutase (SOD), catalase (CAT), adenosine triphosphate enzyme (ATPase), malate dehydrogenase (MDH), and succinate dehydrogenase (SDH) in E. coli and S. aureus cells were significantly higher than those of AgNPs. In addition, compared with AgNPs, PSP@AgNPs promote faster healing of infected wounds. Therefore, PSP@AgNPs represent potential antibacterial agents against wound infections.

Keywords: Pseudomonas;aggregation;hydrolysed fats;membrane fluidity;sodium dodecyl sulphate

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Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis

J. Microbiol. 2023;61(5):543-558. Published online April 13, 2023

DOI: https://doi.org/10.1007/s12275-023-00042-8

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