Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses

Anyeseu Park; Jeong Yoon Lee

doi:10.1007/s12275-024-00159-4

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Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses: Anyeseu Park, Jeong Yoon Lee; Journal of Microbiology 2024;62(7):491-509.
DOI: https://doi.org/10.1007/s12275-024-00159-4
Published online: July 22, 2024

The Laboratory of Viromics and Evolution, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, 54531, Republic of Korea

Corresponding author: Jeong Yoon Lee,
Email: jeongyoon.lee@jbnu.ac.kr

Received: 15 May 2024 • Revised: 26 June 2024 • Accepted: 4 July 2024

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Abstract

Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors with limited capacity have evolved to third-generation vectors flacking viral coding sequences, balancing safety and gene-carrying capacity. The applications of adenoviral vectors for gene therapy and anti-viral treatments have expanded through the use of in vitro ligation and homologous recombination, along with gene editing advancements such as CRISPR-Cas9. Current research aims to maintain the efficacy and safety of adenoviral vectors by addressing challenges such as pre-existing immunity against adenoviral vectors and developing new adenoviral vectors from rare adenovirus types and non-human species. In summary, adenoviral vectors have great potential in gene therapy and vaccine development. Through continuous research and technological advancements, these vectors are expected to lead to the development of safer and more effective treatments.

Keywords: HtpsC;Adenoviral vector;Adenovirus;Streptococcus suis serotype 2;adhesion;Cancer therapy;Gene therapy;epithelial cells;invasion;Vaccine

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Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses

J. Microbiol. 2024;62(7):491-509. Published online July 22, 2024

DOI: https://doi.org/10.1007/s12275-024-00159-4

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