Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

Huiling Xu; Shengnan Wang; Xiaozhou Wang; Pu Zhang; Qi Zheng; ChangXi Qi; Xiaoting Liu; Muzi Li; Yongxia Liu; Jianzhu Liu

doi:10.1007/s12275-024-00162-9

Review
Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells: Huiling Xu¹, Shengnan Wang^1,2, Xiaozhou Wang¹, Pu Zhang³, Qi Zheng¹, ChangXi Qi⁴, Xiaoting Liu⁴, Muzi Li¹, Yongxia Liu¹, Jianzhu Liu^1,4; Journal of Microbiology 2024;62(8):581-590.
DOI: https://doi.org/10.1007/s12275-024-00162-9
Published online: August 30, 2024

¹College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China
²The ShangHai Hanvet Bio-Pharm Co. Ltd., Shanghai, 200135, People's Republic of China
³The Affiliated Taian City Central Hospital of Qingdao University, Tai`an, 271000, Shandong, People's Republic of China
⁴Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China

Corresponding author: Yongxia Liu,
Email: liuyongxia@sdau.edu.cn
Jianzhu Liu,
Email: liujz@sdau.edu.cn

Huiling Xu and Shengnan Wang contributed equally to this study as co-first authors.

Received: 25 May 2024 • Revised: 3 July 2024 • Accepted: 25 July 2024

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Abstract

Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins. The bacteria manipulate some Rab GTPases, escape the cell, and get to survive. In this review, we will focus on summarizing the many processes of how bacteria manipulate Rab GTPases to control their escape.

Keywords: Bacteria;Escape;Host;Rab GTPases;Toxins;Vesicle trafficking

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Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

J. Microbiol. 2024;62(8):581-590. Published online August 30, 2024

DOI: https://doi.org/10.1007/s12275-024-00162-9

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