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Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells.
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Review
Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells.
Huiling Xu1, Shengnan Wang1,2, Xiaozhou Wang1, Pu Zhang3, Qi Zheng1, ChangXi Qi4, Xiaoting Liu4, Muzi Li1, Yongxia Liu1, Jianzhu Liu1,4
Journal of Microbiology 2024;62(8):581-590
DOI: https://doi.org/10.1007/s12275-024-00162-9
Published online: August 30, 2024
1College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China.
2The ShangHai Hanvet Bio-Pharm Co. Ltd., Shanghai, 200135, People's Republic of China.
3The Affiliated Taian City Central Hospital of Qingdao University, Tai`an, 271000, Shandong, People's Republic of China.
4Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
Corresponding author:  Yongxia Liu,
Email: liuyongxia@sdau.edu.cn
Jianzhu Liu,
Email: liujz@sdau.edu.cn
Received: 25 May 2024   • Revised: 3 July 2024   • Accepted: 25 July 2024
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Abstract

Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins. The bacteria manipulate some Rab GTPases, escape the cell, and get to survive. In this review, we will focus on summarizing the many processes of how bacteria manipulate Rab GTPases to control their escape.

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    Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells.
    J. Microbiol. 2024;62(8):581-590.   Published online August 30, 2024
    DOI: https://doi.org/10.1007/s12275-024-00162-9
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