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Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale.
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Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale.
Allan de Carvalho1, Marcia Giambiagi-deMarval2, Ciro César Rossi1
Journal of Microbiology 2024;62(9):775-784
DOI: https://doi.org/10.1007/s12275-024-00156-7
Published online: July 22, 2024
1Department of Biochemistry and Molecular Biology, Federal University of Vicosa, Minas Gerais, 36570-000, Brazil.
2Paulo de Góes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Corresponding author:  Ciro César Rossi,
Email: ciro.rossi@ufv.br
Received: 14 May 2024   • Revised: 12 June 2024   • Accepted: 21 June 2024
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Recently emancipated from the Staphylococcus genus due to genomic differences, Mammaliicoccus sciuri, previously classified as an occasional pathogen, emerges as a significant player in the landscape of resistance gene dissemination among Staphylococcaceae. Despite its classification, its role remained enigmatic. In this study, we delved into the genomic repertoire of M. sciuri to unravel its contribution to resistance and virulence gene transfer in the context of One Health. Through comprehensive analysis of publicly available genomes, we unveiled a diverse pan-immune system adept at defending against exogenous genetic elements, yet concurrently fostering horizontal gene transfer (HGT). Specifically, exploration of CRISPR-Cas systems, with spacer sequences as molecular signatures, elucidated a global dissemination pattern spanning environmental, animal, and human hosts. Notably, we identified the integration of CRISPR-Cas systems within SCCmecs (Staphylococcal Cassette Chromosome mec), harboring key genes associated with pathogenicity and resistance, especially the methicillin resistance gene mecA, suggesting a strategic adaptation to outcompete other mobile genetic elements. Our findings underscored M. sciuri's active engagement in HGT dynamics and evolutionary trajectories within Staphylococcaceae, emphasizing its central role in shaping microbial communities and highlighting the significance of understanding its implications in the One Health framework, an interdisciplinary approach that recognizes the interconnectedness of human, animal, and environmental health to address global health challenges.

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    Mammaliicoccus sciuri's Pan-Immune System and the Dynamics of Horizontal Gene Transfer Among Staphylococcaceae: a One-Health CRISPR Tale.
    J. Microbiol. 2024;62(9):775-784.   Published online July 22, 2024
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