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The Fission Yeast Homologue of Gle1 is Essential for Growth and Involved in mRNA Export
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HOME > J. Microbiol > Volume 46(4); 2008 > Article
Research Support, Non-U.S. Gov't
The Fission Yeast Homologue of Gle1 is Essential for Growth and Involved in mRNA Export
DongGeRaMi Moon 1, Jin-Ah Bae 2, Hyun Jin Cho 1, Jin Ho Yoon 1
Journal of Microbiology 2008;46(4):422-428
DOI: https://doi.org/10.1007/s12275-008-0177-0
Published online: August 31, 2008
1Department of Biology, Institute of Basic Sciences, Sungshin Women's University, Seoul 136-742, Republic of Korea , 2Department of Education, Sungshin Women's University, Seoul 136-742, Republic of Korea1Department of Biology, Institute of Basic Sciences, Sungshin Women's University, Seoul 136-742, Republic of Korea , 2Department of Education, Sungshin Women's University, Seoul 136-742, Republic of Korea
Corresponding author:  Jin Ho Yoon , Tel: 82-2-920-7675, 
Received: 14 July 2008   • Accepted: 22 July 2008
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Abstract

We have isolated Gle1 homologue (named as spgle1) as a partial multicopy suppressor of the synthetic lethality of rae1-167 elf1-21 in fission yeast Schizosaccharomyces pombe. The spgle1 is also able to complement partially temperature-sensitive phenotype of rae1-167 only at a lower restrictive temperature. The spgle1 gene contains one intron and encodes a 480 amino-acid protein with predicted molecular weight of 56.2 kDa. We showed that spgle1 gene is essential for vegetative growth and functional Gle1-GFP protein is localized mainly in NPC. The accumulation of poly(A)+ RNA in the nucleus is exhibited when expression of spgle1 is repressed or over-expressed. These results suggest that the spGle1 protein is also involved in mRNA export in fission yeast.

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    The Fission Yeast Homologue of Gle1 is Essential for Growth and Involved in mRNA Export
    J. Microbiol. 2008;46(4):422-428.   Published online August 31, 2008
    DOI: https://doi.org/10.1007/s12275-008-0177-0
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