Carbon Source Dependent Dynamics of the Ccr4-Not Complex in Saccharomyces cerevisiae

Joakim Norbeck

doi:10.1007/s12275-008-0122-2

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Carbon Source Dependent Dynamics of the Ccr4-Not Complex in Saccharomyces cerevisiae: Joakim Norbeck; Journal of Microbiology 2008;46(6):692-696.
DOI: https://doi.org/10.1007/s12275-008-0122-2
Published online: December 24, 2008

Department of Chemical and Biological Engineering/Molecular Biotechnology, Chalmers University of Technology, SE-41296 Goteborg, SwedenDepartment of Chemical and Biological Engineering/Molecular Biotechnology, Chalmers University of Technology, SE-41296 Goteborg, Sweden

Received: 20 May 2008 • Accepted: 18 September 2008

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Abstract

We have investigated the composition of the conserved Ccr4-Not complex during different physiological states of Saccharomyces cerevisiae. Major changes were found, most notably in the expression of the central scaffold protein Not1p, which was strongly reduced in the absence of glucose. The low expression of Not1p was also evident from the inability of Pop2p to co-purify Not1p in cells from cultures lacking glucose. However, Not1p was still essential under conditions of low expression. The downregulation of Not1p indicates that many of the Ccr4-Not complex components are likely to have roles outside of the complex. We suggest that the use of different carbon sources will be a good starting point to unravel these functions.

Keywords: protein interactions;TAP-tag;NOT1

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HIPK family kinases bind and regulate the function of the CCR4-NOT complex
Alfonso Rodriguez-Gil, Olesja Ritter, Juliane Hornung, Hilda Stekman, Marcus Krüger, Thomas Braun, Elisabeth Kremmer, Michael Kracht, M. Lienhard Schmitz, Anne Spang
Molecular Biology of the Cell.2016; 27(12): 1969. CrossRef
Ccr4-Not complex: the control freak of eukaryotic cells
Jason E. Miller, Joseph C. Reese
Critical Reviews in Biochemistry and Molecular Biology.2012; 47(4): 315. CrossRef
The Ccr4–Not complex
Martine A. Collart, Olesya O. Panasenko
Gene.2012; 492(1): 42. CrossRef

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Carbon Source Dependent Dynamics of the Ccr4-Not Complex in Saccharomyces cerevisiae

J. Microbiol. 2008;46(6):692-696. Published online December 24, 2008

DOI: https://doi.org/10.1007/s12275-008-0122-2

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