Timing and Evolution of the Most Recent Common Ancestor of the Korean Clade HIV Subtype B Based on Nef and Vif Sequences

Mi-Suk Kim; So-Young Jang; Chan-Seung Park; Keon-Myung Lee; Dong-Hun Lee; Chan-Hee Lee

doi:10.1007/s12275-008-0240-x

Articles

Page Path: HOME > J. Microbiol > Volume 47(1); 2009 > Article

Research Support, Non-U.S. Gov't
Timing and Evolution of the Most Recent Common Ancestor of the Korean Clade HIV Subtype B Based on Nef and Vif Sequences: Mi-Suk Kim ¹, So-Young Jang ¹, Chan-Seung Park ¹, Keon-Myung Lee ², Dong-Hun Lee ¹, Chan-Hee Lee ¹; Journal of Microbiology 2009;47(1):85-90.
DOI: https://doi.org/10.1007/s12275-008-0240-x
Published online: February 20, 2009

¹School of Life Sciences, Chungbuk National University, Chungbuk 361-763, Republic of Korea, ²School of Electrical and Computer Engineering, Chungbuk National University, Chungbuk 361-763, Republic of Korea¹School of Life Sciences, Chungbuk National University, Chungbuk 361-763, Republic of Korea, ²School of Electrical and Computer Engineering, Chungbuk National University, Chungbuk 361-763, Republic of Korea

Corresponding author: Chan-Hee Lee , Tel: 82-43-261-2304,

Received: 25 September 2008 • Accepted: 5 December 2008

prev next

67 Views
0 Download
5 Crossref
5 Scopus

Full Article

Abstract

Molecular phylogenetic studies of the HIV-1 isolated from Koreans have suggested the presence of the so- called “Korean clade”, which can be defined as a cluster free of foreign isolates. The Korean clade accounts for more than 60% of Korean isolates and exerts characteristic amino acid sequences. Thus, it is merited to estimate when this Korean clade first emerged in order to understand the evolutionary pattern of the Korean clade. We analyzed and reconstructed the most recent common ancestor (MRCA) sequences from nef (n=229) and vif (n=179) Korean clade sequences. Linear regression analyses of sequence divergence estimates were plotted against sampling years to infer the year in which there was zero divergence from the MRCA sequences. MRCA sequences suggested the Korean clade was first emerged around 1984, before the first detection of HIV-1 in Korea in 1985. Further studies on synonymous and nonsynonymous substitution rates suggested positive selection event for the Korean clade, while other subtype B had undergone negative to neutral evolution.

Keywords: HIV-1;Korean clade;common ancestor

Figure & Data

References

Citations

Citations to this article as recorded by

Sequence Length of HIV-1 Subtype B Increases over Time: Analysis of a Cohort of Patients with Hemophilia over 30 Years
Young-Keol Cho, Jung-Eun Kim, Brian T. Foley
Viruses.2021; 13(5): 806. CrossRef
Genetic Analysis of the Full-Length gag Gene from the Earliest Korean Subclade B of HIV-1: An Outbreak among Korean Hemophiliacs
Young-Keol Cho, Jung-Eun Kim, Brian T. Foley
Viruses.2019; 11(6): 545. CrossRef
Phylogenetic and Temporal Dynamics of Human Immunodeficiency Virus Type 1B in China: Four Types of B Strains Circulate in China
Jingrong Ye, Hongyan Lu, Xueli Su, Ruolei Xin, Lishi Bai, Ke Xu, Shuangqing Yu, Xia Feng, Hong Yan, Xiong He, Yi Zeng
AIDS Research and Human Retroviruses.2014; 30(9): 920. CrossRef
The origin and diversity of the HIV-1 pandemic
Joris Hemelaar
Trends in Molecular Medicine.2012; 18(3): 182. CrossRef
Full Genome Analysis of an Emerging Cluster of Human Immunodeficiency Virus Type 1 Subtype B Infection in Hong Kong
Stephen K.W. Tsui, Nga-Yin Fong, Sai-Kam Li, Ka-Kit Leung, Denise P.C. Chan, Paul K.S. Chan, Ka-Hing Wong, Shui-Shan Lee
AIDS Research and Human Retroviruses.2010; 26(1): 117. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Timing and Evolution of the Most Recent Common Ancestor of the Korean Clade HIV Subtype B Based on Nef and Vif Sequences

J. Microbiol. 2009;47(1):85-90. Published online February 20, 2009

DOI: https://doi.org/10.1007/s12275-008-0240-x

Related articles