- Volume 54(3); March 2016
-
Research Support, Non-U.S. Gov't
- EDITORIAL] Human fungal pathogens: Why should we learn?
-
Jeong-Yoon Kim
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J. Microbiol. 2016;54(3):145-148.
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DOI: https://doi.org/10.1007/s12275-016-0647-8
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Abstract
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Human fungal pathogens that cause invasive infections are
hidden killers, taking lives of one and a half million people
every year. However, research progress in this field has not
been rapid enough to effectively prevent or treat life-threatening
fungal diseases. To update recent research progress
and promote more active research in the field of human fungal
pathogens, eleven review articles concerning the virulence
mechanisms and host interactions of four major human fungal
pathogens–Candida albicans, Cryptococcus neoformans,
Aspergillus fumigatus, and Histoplasma capsulatum–are
presented in this special issue.
-
Citations
Citations to this article as recorded by

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Memórias do Instituto Oswaldo Cruz.2023;[Epub] CrossRef - A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic
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Microorganisms.2023; 11(6): 1384. CrossRef - Clinical infections in neurosurgical oncology: An overview
Tomaz Velnar, Nina Kocivnik, Roman Bosnjak
World Journal of Clinical Cases.2023; 11(15): 3418. CrossRef - The effect of herbal medicine in innate immunity to Candida albicans
Meng-Yuan Bao, Ming Li, Qing-Ru Bu, Yue Yang, Hang Song, Chang-Zhong Wang, Tian-Ming Wang, Ning Li
Frontiers in Immunology.2023;[Epub] CrossRef - Betulinic acid and Drummondin E: Potential inhibitors of Unfolded Protein Response Pathway of Candida auris
Nahid Akhtar, Amit Joshi, Vikas Kaushik, Sangeetha Mohan, M. Amin-ul Mannan
Research Journal of Pharmacy and Technology.2023; : 2867. CrossRef - Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants
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Ali Jangjou, Zahra Zareshahrabadi, Milad Abbasi, Amirreza Talaiekhozani, Hesam Kamyab, Shreeshivadasan Chelliapan, Ahmad Vaez, Ali Golchin, Lobat Tayebi, Ehsan Vafa, Ali Mohammad Amani, Hossein Faramarzi
Sustainability.2022; 14(19): 12942. CrossRef - Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?
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International Journal of Molecular Sciences.2022; 23(11): 6345. CrossRef - WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
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Proceedings of the National Academy of Sciences.2021;[Epub] CrossRef - Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system
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Kritika Bajaj, Robert M. Buchanan, Craig A. Grapperhaus
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Fungal Genetics and Biology.2021; 157: 103623. CrossRef - Membrane-Interacting Antifungal Peptides
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Pathogens.2021; 10(10): 1303. CrossRef - Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds
Martin van Eijk, Stephanie Boerefijn, Lida Cen, Marisela Rosa, Marnix J H Morren, Cornelis K van der Ent, Bart Kraak, Jan Dijksterhuis, Ivan D Valdes, Henk P Haagsman, Hans de Cock
Medical Mycology.2020; 58(8): 1073. CrossRef - Broad-Spectrum Antimicrobial and Antibiofilm Activity of a Natural Clay Mineral from British Columbia, Canada
Shekooh Behroozian, Sarah L. Svensson, Loretta Y. Li, Julian E. Davies, Pascale F. Cossart
mBio.2020;[Epub] CrossRef - Antimicrobial host defence peptides: functions and clinical potential
Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson
Nature Reviews Drug Discovery.2020; 19(5): 311. CrossRef - Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence
Sharel P. Díaz-Pérez, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Adolfo López-Torres, Irvin E. Jácome-Galarza, Verónica Anaya-Martínez, Verónica Gómez-Ruiz, Jesús Campos-García, Rosa E. Nuñez-Anita, Rafael Ortiz-Alvarado, Martha I. Ramírez-Díaz,
Infection and Immunity.2020;[Epub] CrossRef - Fungal evolution: major ecological adaptations and evolutionary transitions
Miguel A. Naranjo‐Ortiz, Toni Gabaldón
Biological Reviews.2019; 94(4): 1443. CrossRef -
Acute Lung Injury and Repair Induced by Single Exposure of
Aspergillus Fumigatus
in Immunocompetent Mice
Nathália L S O Malacco, Jéssica A M Souza, Aline C Mendes, Milene A Rachid, Lucas R Kraemer, Matheus S Mattos, Graziele N Lima, Lirlândia P Sousa, Daniele G Souza, Vanessa Pinho, Mauro M Teixeira, Remo C Russo, Frederico M Soriani
Future Microbiology.2019; 14(17): 1511. CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Characterization of fungal biodiversity and communities associated with the reef macroalga Sargassum ilicifolium reveals fungal community differentiation according to geographic locality and algal structure
Benjamin J. Wainwright, Andrew G. Bauman, Geoffrey L. Zahn, Peter A. Todd, Danwei Huang
Marine Biodiversity.2019; 49(6): 2601. CrossRef - Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development
Danielle J. Lee, Holly O’Donnell, Françoise H. Routier, Joe Tiralongo, Thomas Haselhorst
Cells.2019; 8(11): 1348. CrossRef - Fungal dissemination is limited by liver macrophage filtration of the blood
Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang, Meiqing Shi
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BIO-PROTOCOL.2019;[Epub] CrossRef - Linolenic Acid-Modified MPEG-PEI Micelles for Encapsulation of Amphotericin B
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Future Medicinal Chemistry.2019; 11(20): 2647. CrossRef - Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens
Daiane Flores Dalla Lana, Bruna Gerardon Batista, Gabriella da Rosa Machado, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, William Lopes, Marilene Henning Vainstein, Alejandro Peixoto de Abreu L
Saudi Pharmaceutical Journal.2019; 27(8): 1064. CrossRef - Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy
Shivani Verma, Puneet Utreja
Asian Journal of Pharmaceutical Sciences.2019; 14(2): 117. CrossRef - Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients
Patricia Postina, Julian Skladny, Tobias Boch, Oliver A. Cornely, Axel Hamprecht, Peter-Michael Rath, Jörg Steinmann, Oliver Bader, Thomas Miethke, Anne Dietz, Natalia Merker, Wolf-Karsten Hofmann, Dieter Buchheidt, Birgit Spiess
Frontiers in Microbiology.2018;[Epub] CrossRef - Cryptic Aspergillus from clinical samples in the USA and description of a new species in section Flavipedes
João P. Z. Siqueira, Nathan Wiederhold, Josepa Gené, Dania García, Margarete T. G. Almeida, Josep Guarro
Mycoses.2018; 61(11): 814. CrossRef - Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
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Nature Communications.2018;[Epub] CrossRef - Fungi-Induced Upper and Lower Respiratory Tract Allergic Diseases: One Entity
Aleksandra Barac, David S. Y. Ong, Ljiljana Jovancevic, Aleksandar Peric, Pavol Surda, Vesna Tomic Spiric, Salvatore Rubino
Frontiers in Microbiology.2018;[Epub] CrossRef - Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity
Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos del Fresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, M
EMBO Molecular Medicine.2018;[Epub] CrossRef - The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors
Surabhi Goyal, Juan Camilo Castrillón-Betancur, Esther Klaile, Hortense Slevogt
Frontiers in Immunology.2018;[Epub] CrossRef - JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression
Xueqiang Zhao, Yahui Guo, Changying Jiang, Qing Chang, Shilei Zhang, Tianming Luo, Bin Zhang, Xinming Jia, Mien-Chie Hung, Chen Dong, Xin Lin
Nature Medicine.2017; 23(3): 337. CrossRef - Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing
Ruth Alonso, Diana Pisa, Begoña Aguado, Luis Carrasco
Journal of Alzheimer's Disease.2017; 58(1): 55. CrossRef - Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges
Ghareb M. Soliman
International Journal of Pharmaceutics.2017; 523(1): 15. CrossRef - Conclusion and future perspectives on antifungal stewardship
Jose María Aguado, Jose Tiago Silva, Emilio Bouza
Journal of Antimicrobial Chemotherapy.2016; 71(suppl 2): ii43. CrossRef
Reviews
- REVIEW] Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota
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Sarah Höfs , Selene Mogavero , Bernhard Hube
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J. Microbiol. 2016;54(3):149-169. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5514-0
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Abstract
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The interaction between Candida albicans and its host cells is
characterized by a complex interplay between the expression
of fungal virulence factors, which results in adherence, invasion
and cell damage, and the host immune system, which
responds by secreting proinflammatory cytokines, activating
antimicrobial activities and killing the fungal pathogen. In
this review we describe this interplay by taking a closer look
at how C. albicans pathogenicity is induced and executed,
how the host responds in order to prevent and clear an infection,
and which mechanisms C. albicans has evolved to
bypass these immune responses to avoid clearance. Furthermore,
we review studies that show how the presence of other
microorganisms affects this interplay.
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Citations
Citations to this article as recorded by

- REVIEW] Hgc1-Cdc28–how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?
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Yue Wang
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J. Microbiol. 2016;54(3):170-177. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5550-9
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Abstract
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The fungal human pathogen Candida albicans can cause invasive
infection with high mortality rates. A key virulence
factor is its ability to switch between three morphologies:
yeast, pseudohyphae and hyphae. In contrast to the ovalshaped
unicellular yeast cells, hyphae are highly elongated,
tube-like, and multicellular. A long-standing question is what
coordinates all the cellular machines to construct cells with
distinct shapes. Hyphal-specific genes (HSGs) are thought
to hold the answer. Among the numerous HSGs found, only
UME6 and HGC1 are required for hyphal development.
UME6 encodes a transcription factor that regulates many
HSGs including HGC1. HGC1 encodes a G1 cyclin which
partners with the Cdc28 cyclin-dependent kinase. Hgc1-
Cdc28 simultaneously phosphorylates and regulates multiple
substrates, thus controlling multiple cellular apparatuses for
morphogenesis. This review is focused on major progresses
made in the past decade on Hgc1’s roles and regulation in
C. albicans hyphal development and other traits important
for infection.
-
Citations
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-
Systematic analysis of the
Candida albicans
kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation
in vitro
and
in vivo
Juraj Kramara, Min-Ju Kim, Tomye L. Ollinger, Laura C. Ristow, Rohan S. Wakade, Robert Zarnowski, Melanie Wellington, David R. Andes, Aaron G. Mitchell, Damian J. Krysan, Judith Berman
mBio.2024;[Epub] CrossRef - Hgc1 Independence of Biofilm Hyphae in Candida albicans
Anupam Sharma, Norma V. Solis, Manning Y. Huang, Frederick Lanni, Scott G. Filler, Aaron P. Mitchell, Yong-Sun Bahn
mBio.2023;[Epub] CrossRef - Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans
Anupam Sharma, Aaron P Mitchell, J Berman
G3: Genes, Genomes, Genetics.2023;[Epub] CrossRef -
Use of the Iron-Responsive
RBT5
Promoter for Regulated Expression in Candida albicans
Yinhe Mao, Norma V. Solis, Anupam Sharma, Max V. Cravener, Scott G. Filler, Aaron P. Mitchell, Michael Lorenz
mSphere.2022;[Epub] CrossRef -
Systematic Metabolic Profiling Identifies
De Novo
Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation
Enrico Garbe, Franziska Gerwien, Dominik Driesch, Tina Müller, Bettina Böttcher, Markus Gräler, Slavena Vylkova, Manuel Liebeke
mSystems.2022;[Epub] CrossRef - The Antimicrobial Peptide AMP-17 Derived from Musca domestica Inhibits Biofilm Formation and Eradicates Mature Biofilm in Candida albicans
Chaoqin Sun, Xinyu Zhao, Zhenglong Jiao, Jian Peng, Luoxiong Zhou, Longbing Yang, Mingjiao Huang, Chunren Tian, Guo Guo
Antibiotics.2022; 11(11): 1474. CrossRef - Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans
Kyunghun Min, Thomas F. Jannace, Haoyu Si, Krishna R. Veeramah, John D. Haley, James B. Konopka, Joachim Morschhäuser
PLOS Pathogens.2021; 17(8): e1009861. CrossRef - The Ndr/LATS Kinase Cbk1 Regulates a Specific Subset of Ace2 Functions and Suppresses the Hypha-to-Yeast Transition in Candida albicans
Rohan S. Wakade, Laura C. Ristow, Mark A. Stamnes, Anuj Kumar, Damian J. Krysan, James W. Kronstad
mBio.2020;[Epub] CrossRef - The regulation of hyphae growth in Candida albicans
Hui Chen, Xuedong Zhou, Biao Ren, Lei Cheng
Virulence.2020; 11(1): 337. CrossRef - Phosphatidate phosphatase Pah1 has a role in the hyphal growth and virulence of Candida albicans
Chunhua Mu, Chaoying Pan, Qi Han, Qizheng Liu, Yue Wang, Jianli Sang
Fungal Genetics and Biology.2019; 124: 47. CrossRef - Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound
Fatmah M. Alqahtani, Brock A. Arivett, Zachary E. Taylor, Scott T. Handy, Anthony L. Farone, Mary B. Farone, Shankar Thangamani
PLOS ONE.2019; 14(12): e0226068. CrossRef - N-Acetylglucosamine Regulates Morphogenesis and Virulence Pathways in Fungi
Kyunghun Min, Shamoon Naseem, James B. Konopka
Journal of Fungi.2019; 6(1): 8. CrossRef - Fungal microsclerotia development: essential prerequisites, influencing factors, and molecular mechanism
Zhangyong Song
Applied Microbiology and Biotechnology.2018; 102(23): 9873. CrossRef - A comprehensive analysis of Candida albicans phosphoproteome reveals dynamic changes in phosphoprotein abundance during hyphal morphogenesis
Priyanka Ghorai, Mohammad Irfan, Alka Narula, Asis Datta
Applied Microbiology and Biotechnology.2018; 102(22): 9731. CrossRef - A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion
Carlos Garcia, Anaïs Burgain, Julien Chaillot, Émilie Pic, Inès Khemiri, Adnane Sellam
Scientific Reports.2018;[Epub] CrossRef - Candida albicans morphology: still in focus
Ilse D. Jacobsen, Bernhard Hube
Expert Review of Anti-infective Therapy.2017; 15(4): 327. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - CDK phosphorylates the polarisome scaffold Spa2 to maintain its localization at the site of cell growth
Haitao Wang, Zhen‐Xing Huang, Jie Ying Au Yong, Hao Zou, Guisheng Zeng, Jiaxin Gao, Yanming Wang, Ada Hang‐Heng Wong, Yue Wang
Molecular Microbiology.2016; 101(2): 250. CrossRef
- REVIEW] Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans
-
Lois M. Douglas , James B. Konopka
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J. Microbiol. 2016;54(3):178-191. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5621-y
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44
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34
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Abstract
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Candida albicans is a human fungal pathogen capable of causing
lethal systemic infections. The plasma membrane plays key
roles in virulence because it not only functions as a protective
barrier, it also mediates dynamic functions including secretion
of virulence factors, cell wall synthesis, invasive hyphal
morphogenesis, endocytosis, and nutrient uptake. Consistent
with this functional complexity, the plasma membrane is
composed of a wide array of lipids and proteins. These components
are organized into distinct domains that will be the
topic of this review. Some of the plasma membrane domains
that will be described are known to act as scaffolds or barriers
to diffusion, such as MCC/eisosomes, septins, and sites
of contact with the endoplasmic reticulum. Other zones mediate
dynamic processes, including secretion, endocytosis, and
a special region at hyphal tips that facilitates rapid growth.
The highly organized architecture of the plasma membrane
facilitates the coordination of diverse functions and promotes
the pathogenesis of C. albicans.
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Citations to this article as recorded by

- Zingerone effect against Candida albicans growth and biofilm production.
Sayali Chougule, Sargun Basrani, Tanjila Gavandi, Shivani Patil, Shivanand Yankanchi, Ashwini Jadhav, Sankunny Mohan Karuppayil
Journal of Medical Mycology.2024; : 101527. CrossRef - Regulation of yeast polarized exocytosis by phosphoinositide lipids
Matthew W. Volpiana, Aleksa Nenadic, Christopher T. Beh
Cellular and Molecular Life Sciences.2024;[Epub] CrossRef - Sur7 mediates a novel pathway for PI4,5P2 regulation in C. albicans that promotes stress resistance and cell wall morphogenesis
Carla E. Lanze, James B. Konopka, Amy Susanne Gladfelter
Molecular Biology of the Cell.2024;[Epub] CrossRef - Anti-Candida activity of flavonoids - an overview
Savu Mihaela, Marius Stefan
Journal of Experimental and Molecular Biology.2024; 25(1): 67. CrossRef - Emerging Roles of Exocyst Complex in Fungi: A Review
Qussai Zuriegat, Yakubu Saddeeq Abubakar, Zonghua Wang, Meilian Chen, Jun Zhang
Journal of Fungi.2024; 10(9): 614. CrossRef - Candida albicans pathways that protect against organic peroxides and lipid peroxidation
Kara A. Swenson, Kyunghun Min, James B. Konopka, Aaron P. Mitchell
PLOS Genetics.2024; 20(10): e1011455. CrossRef - A Comparative Review of Eugenol and Citral Anticandidal Mechanisms: Partners in Crimes Against Fungi
Zinnat Shahina, Tanya E. S. Dahms
Molecules.2024; 29(23): 5536. CrossRef - Hinokitiol inhibits Aspergillus fumigatus by interfering with the cell membrane and cell wall
Fanyue Meng, Xing Liu, Cui Li, Xudong Peng, Qian Wang, Qiang Xu, Jialin Sui, Guiqiu Zhao, Jing Lin
Frontiers in Microbiology.2023;[Epub] CrossRef -
Candida albicans
resistance to hypochlorous acid
Lois M. Douglas, Kyunghun Min, James B. Konopka, J. Andrew Alspaugh
mBio.2023;[Epub] CrossRef - Inhibition of cell cycle-dependent hyphal and biofilm formation by a novel cytochalasin 19,20‑epoxycytochalasin Q in Candida albicans
Kwanrutai Watchaputi, L. A. Channa Bhathiya Jayasekara, Khanok Ratanakhanokchai, Nitnipa Soontorngun
Scientific Reports.2023;[Epub] CrossRef - Unique roles of aminophospholipid translocase Drs2p in governing efflux pump activity, ergosterol level, virulence traits, and host–pathogen interaction in Candida albicans
Shweta Singh, Sandeep Hans, Aijaz Ahmad, Zeeshan Fatima, Saif Hameed
International Microbiology.2022; 25(4): 769. CrossRef - Rosemary essential oil and its components 1,8-cineole and α-pinene induce ROS-dependent lethality and ROS-independent virulence inhibition in Candida albicans
Zinnat Shahina, Raymond Al Homsi, Jared D. W. Price, Malcolm Whiteway, Taranum Sultana, Tanya E. S. Dahms, Roy Aziz Khalaf
PLOS ONE.2022; 17(11): e0277097. CrossRef - Cinnamon Leaf and Clove Essential Oils Are Potent Inhibitors of Candida albicans Virulence Traits
Zinnat Shahina, Ali Molaeitabari, Taranum Sultana, Tanya Elizabeth Susan Dahms
Microorganisms.2022; 10(10): 1989. CrossRef -
Candida albicans
Reactive Oxygen Species (ROS)-Dependent Lethality and ROS-Independent Hyphal and Biofilm Inhibition by Eugenol and Citral
Zinnat Shahina, Easter Ndlovu, Omkaar Persaud, Taranum Sultana, Tanya E. S. Dahms, Damian J. Krysan
Microbiology Spectrum.2022;[Epub] CrossRef - In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans
Arumugam Ganeshkumar, Suvaiyarasan Suvaithenamudhan, Rajendran Rajaram
Current Microbiology.2021; 78(1): 292. CrossRef - The Antibacterial Synthetic Flavonoid BrCl-Flav Exhibits Important Anti-Candida Activity by Damaging Cell Membrane Integrity
Cornelia Babii, Mihaela Savu, Iuliana Motrescu, Lucian Mihail Birsa, Laura Gabriela Sarbu, Marius Stefan
Pharmaceuticals.2021; 14(11): 1130. CrossRef - The Sur7 cytoplasmic C terminus regulates morphogenesis and stress responses in Candida albicans
Carla E. Lanze, Sai Zhou, James B. Konopka
Molecular Microbiology.2021; 116(4): 1201. CrossRef - Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans
Jenna E. Foderaro, James B. Konopka, Mairi C. Noverr
Infection and Immunity.2021;[Epub] CrossRef - Modulation of Immune Responses by Particle Size and Shape
Maksim V. Baranov, Manoj Kumar, Stefano Sacanna, Shashi Thutupalli, Geert van den Bogaart
Frontiers in Immunology.2021;[Epub] CrossRef - derived 5,6,8-trihydroxy-7,4′ dimethoxy flavone inhibits ergosterol synthesis and the production of hyphae and biofilm in
Mrudula Patel, Vartika Srivastava, Aijaz Ahmad
Journal of Ethnopharmacology.2020; 259: 112965. CrossRef - The Role of Secretory Pathways in Candida albicans Pathogenesis
Christiane Rollenhagen, Sahil Mamtani, Dakota Ma, Reva Dixit, Susan Eszterhas, Samuel A. Lee
Journal of Fungi.2020; 6(1): 26. CrossRef - Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits
Cristina Nicoleta Ciurea, Irina-Bianca Kosovski, Anca Delia Mare, Felicia Toma, Ionela Anca Pintea-Simon, Adrian Man
Microorganisms.2020; 8(6): 857. CrossRef - Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi
Carla E. Lanze, Rafael M. Gandra, Jenna E. Foderaro, Kara A. Swenson, Lois M. Douglas, James B. Konopka
Microbiology and Molecular Biology Reviews.2020;[Epub] CrossRef - Si vis pacem para bellum: A prospective in silico analysis of miRNA-based plant defenses against fungal infections
André F. Gabriel, Marina C. Costa, Francisco J. Enguita, Ana Lúcia Leitão
Plant Science.2019; 288: 110241. CrossRef - Advances in understanding of the oxysterol-binding protein homologous in yeast and filamentous fungi
Shangkun Qiu, Bin Zeng
International Microbiology.2019; 22(2): 169. CrossRef - The Yin and Yang of Current Antifungal Therapeutic Strategies: How Can We Harness Our Natural Defenses?
Tomas Di Mambro, Ilaria Guerriero, Luigi Aurisicchio, Mauro Magnani, Emanuele Marra
Frontiers in Pharmacology.2019;[Epub] CrossRef - Plasma membrane architecture protects Candida albicans from killing by copper
Lois M. Douglas, James B. Konopka, Valeria C. Culotta
PLOS Genetics.2019; 15(1): e1007911. CrossRef - Boric Acid and Commercial Organoboron Products as Inhibitors of Drug-Resistant Candida albicans
Bryan Larsen, Marija Petrovic, Francesco De Seta
Mycopathologia.2018; 183(2): 349. CrossRef - Helminth eggs as parasitic indicators of fecal contamination in agricultural irrigation water, biosolids, soils and pastures
María Claudia Campos, Milena Beltrán, Nancy Fuentes, Gerardo Moreno
Biomédica.2018; 38(1): 42. CrossRef - Selective BET bromodomain inhibition as an antifungal therapeutic strategy
Flore Mietton, Elena Ferri, Morgane Champleboux, Ninon Zala, Danièle Maubon, Yingsheng Zhou, Mike Harbut, Didier Spittler, Cécile Garnaud, Marie Courçon, Murielle Chauvel, Christophe d’Enfert, Boris A. Kashemirov, Mitchell Hull, Muriel Cornet, Charles E.
Nature Communications.2017;[Epub] CrossRef - Calcium Enhances Bile Salt-Dependent Virulence Activation in Vibrio cholerae
Amanda J. Hay, Menghua Yang, Xiaoyun Xia, Zhi Liu, Justin Hammons, William Fenical, Jun Zhu, Nancy E. Freitag
Infection and Immunity.2017;[Epub] CrossRef - MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi
Jenna Foderaro, Lois Douglas, James Konopka
Journal of Fungi.2017; 3(4): 61. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Fungal cell membrane-promising drug target for antifungal therapy
D.G. Sant, S.G. Tupe, C.V. Ramana, M.V. Deshpande
Journal of Applied Microbiology.2016; 121(6): 1498. CrossRef
- REVIEW] The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogen
-
Joachim Morschhäuser
-
J. Microbiol. 2016;54(3):192-201. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5628-4
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Abstract
-
The yeast Candida albicans is a member of the microbiota
in the gastrointestinal and urogenital tracts of most healthy
persons, but it can also cause symptomatic infections, especially
in immunocompromised patients. During the life-long
association with its human host, C. albicans generates genetically
altered variants that are better adapted to changes in
their environment. A prime example of this microevolution
is the development of resistance to the commonly used drug
fluconazole, which inhibits ergosterol biosynthesis, during
antimycotic therapy. Fluconazole resistance can be caused by
mutations in the drug target, by changes in the sterol biosynthesis
pathway, and by gain-of-function mutations in transcription
factors that result in the constitutive upregulation
of ergosterol biosynthesis genes and multidrug efflux pumps.
Fluconazole also induces genomic rearrangements that result
in gene amplification and loss of heterozygosity for resistance
mutations, which further increases drug resistance.
These genome alterations may affect extended chromosomal
regions and have additional phenotypic consequences. A
striking case is the loss of heterozygosity for the mating type
locus MTL in many fluconazole-resistant clinical isolates,
which allows the cells to switch to the mating-competent opaque
phenotype. This, in turn, raises the possibility that sexual
recombination between different variants of an originally clonal,
drug-susceptible population may contribute to the generation
of highly fluconazole-resistant strains with multiple
resistance mechanisms. The gain-of-function mutations in
transcription factors, which result in deregulated gene expression,
also cause reduced fitness. In spite of this, many clinical
isolates that contain such mutations do not exhibit fitness defects,
indicating that they have overcome the costs of drug
resistance with further evolution by still unknown mechanisms.
-
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- Structural, physicochemical characterization and antimicrobial activities of a new tris(8-quinolinolato-κ2N,O)cobalt(III) ethanol solvate [Co(C9H6NO)3].(C2H6O)
Salsabil Idoudi, Badiaa Essghaier, Mohamed Faouzi Zid, Saoussen Namouchi Cherni
Journal of Molecular Structure.2024; 1296: 136848. CrossRef - Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors
Joachim Morschhäuser, Aaron P. Mitchell
PLOS Pathogens.2024; 20(11): e1012643. CrossRef -
The
Neosartorya (Aspergillus) fischeri
antifungal protein NFAP2 has low potential to trigger resistance development in
Candida albicans in vitro
Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy, Gustavo H. Goldman, Norman van Rhijn
Microbiology Spectrum.2024;[Epub] CrossRef - Tackling multi-drug resistant fungi by efflux pump inhibitors
Kritika Engle, Gautam Kumar
Biochemical Pharmacology.2024; 226: 116400. CrossRef - The TAC1 Gene in Candida albicans: Structure, Function, and Role in Azole Resistance: A Mini-Review
Amir Hossein Mahdizade, Akbar Hoseinnejad, Mona Ghazanfari, Mohammad Javad Boozhmehrani, Seyed Sobhan Bahreiny, Mahdi Abastabar, Roberta Galbo, Letterio Giuffrè, Iman Haghani, Orazio Romeo
Microbial Drug Resistance.2024; 30(7): 288. CrossRef - Boric Acid for the Treatment of Vaginitis: New Possibilities Using an Old Anti‐Infective Agent: A Systematic Review
Matilde Lærkeholm Müller, Christina Damsted Petersen, Ditte Marie L. Saunte, Althea East-Innis
Dermatologic Therapy.2024;[Epub] CrossRef - Anti-fungal peptides: an emerging category with enthralling therapeutic prospects in the treatment of candidiasis
Jyoti Sankar Prusty, Ashwini Kumar, Awanish Kumar
Critical Reviews in Microbiology.2024; : 1. CrossRef - Microevolution during Chronic Infection May Lead T. asahii to Coexist with the Host
Gen Ba, Xuelian Lv, Xin Yang, Wenling Wang, Junhong Ao, Rongya Yang, Ioannis D. Bassukas
Dermatology Research and Practice.2024;[Epub] CrossRef - Cluster analysis allowed to identify antifungal drugs that retain efficacy against Candida albicans isolated from patients with inflammatory diseases of the soft tissues of the maxillofacial area
Mariia Faustova, Volodymyr Dobrovolskyi, Galina Loban’, Yevhenii Bereza, Aleksandra Kotelnikova, Oleksandr Dobrovolskyi
Frontiers in Oral Health.2024;[Epub] CrossRef -
Two different types of tandem sequences mediate the overexpression of
TinCYP51B
in azole-resistant
Trichophyton indotineae
Tsuyoshi Yamada, Mari Maeda, Hiroaki Nagai, Karine Salamin, Yun-Tsan Chang, Emmanuella Guenova, Marc Feuermann, Michel Monod, Andreas H. Groll
Antimicrobial Agents and Chemotherapy.2023;[Epub] CrossRef - Anticandidal activity of nanocomposite based on nanochitosan, nanostarch and mycosynthesized copper oxide nanoparticles against multidrug-resistant Candida
Mohamed Saied, Mohamed Hasanin, Tarek M. Abdelghany, Basma H. Amin, Amr H. Hashem
International Journal of Biological Macromolecules.2023; 242: 124709. CrossRef - Assessing the In Vitro Potential of Glatiramer Acetate (Copaxone®) as a Chemotherapeutic Candidate for the Treatment of Cryptococcus neoformans Infection
Vinicius Alves, Pedro Henrique Martins, Bruna Miranda, Iara Bastos de Andrade, Luiza Pereira, Christina Takiya Maeda, Glauber Ribeiro de Sousa Araújo, Susana Frases
Journal of Fungi.2023; 9(8): 783. CrossRef - Detrimental consequences of tebuconazole on redox homeostasis and fatty acid profile of honeybee brain
Máté Mackei, Csilla Sebők, Júlia Vöröházi, Patrik Tráj, Fruzsina Mackei, Barnabás Oláh, Hedvig Fébel, Zsuzsanna Neogrády, Gábor Mátis
Insect Biochemistry and Molecular Biology.2023; 159: 103990. CrossRef - Benzamidine Conjugation Converts Expelled Potential Active Agents into Antifungals against Drug-Resistant Fungi
Xue Wang, Xueyang Jin, Zhiyu Xie, Hongyang Zhang, Tiantian Liu, Hongbo Zheng, Xiaoyi Luan, Yan Sun, Wenjie Fang, Wenqiang Chang, Hongxiang Lou
Journal of Medicinal Chemistry.2023; 66(19): 13684. CrossRef - Advances in efficacy enhancement of photosensitizer-mediated photodynamic antimicrobial chemotherapy
Benard M. Isaiah, Edith K. Amuhaya, Clare I. Muhanji
Journal of Porphyrins and Phthalocyanines.2023; 27(06): 819. CrossRef - Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Martina Raschig, Bernardo Ramírez‐Zavala, Johannes Wiest, Marco Saedtler, Marcus Gutmann, Ulrike Holzgrabe, Joachim Morschhäuser, Lorenz Meinel
Archiv der Pharmazie.2023;[Epub] CrossRef - A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans
Arome Solomon Odiba, Olanrewaju Ayodeji Durojaye, Ifeoma Maureen Ezeonu, Anthony Christian Mgbeahuruike, Bennett Chima Nwanguma
Infection and Drug Resistance.2022; Volume 15: 3111. CrossRef - Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata
Benjamin Kingsley Harley, Anthony Martin Quagraine, David Neglo, Mike Okweesi Aggrey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Cedric Dzidzor Amengor, Jonathan Jato, Yussif Saaka, Theophilus Christian Fleischer, Umakanta Sarker
PLOS ONE.2022; 17(11): e0278096. CrossRef - Antifungal Exposure and Resistance Development: Defining Minimal Selective Antifungal Concentrations and Testing Methodologies
Emily M. Stevenson, William H. Gaze, Neil A. R. Gow, Alwyn Hart, Wiebke Schmidt, Jane Usher, Adilia Warris, Helen Wilkinson, Aimee K. Murray
Frontiers in Fungal Biology.2022;[Epub] CrossRef - The Risk Factors and Mechanisms of Azole Resistance of Candida tropicalis Blood Isolates in Thailand: A Retrospective Cohort Study
Teera Leepattarakit, Orawan Tulyaprawat, Popchai Ngamskulrungroj
Journal of Fungi.2022; 8(10): 983. CrossRef - Genomic Variation-Mediating Fluconazole Resistance in Yeast
Wen-Yao Wang, Hong-Qing Cai, Si-Yuan Qu, Wei-Hao Lin, Cheng-Cheng Liang, Hao Liu, Ze-Xiong Xie, Ying-Jin Yuan
Biomolecules.2022; 12(6): 845. CrossRef - Antifungals and Drug Resistance
Chowdhury Mobaswar Hossain, Lisa Kathleen Ryan, Meeta Gera, Sabyasachi Choudhuri, Nazmun Lyle, Kazi Asraf Ali, Gill Diamond
Encyclopedia.2022; 2(4): 1722. CrossRef -
Synergistic Effect of the Combination of Deferoxamine and Fluconazole
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and
In Vivo
against Fluconazole-Resistant
Candida
Spp.
Lulu An, Jingwen Tan, Yuanyuan Wang, Siyu Liu, Yongyong Li, Lianjuan Yang
Antimicrobial Agents and Chemotherapy.2022;[Epub] CrossRef - Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis
Wuqiang Wen, Hongxuan Cao, Yunyuan Huang, Jie Tu, Chen Wan, Jian Wan, Xinya Han, Han Chen, Jiaqi Liu, Li Rao, Chen Su, Chao Peng, Chunquan Sheng, Yanliang Ren
Journal of Medicinal Chemistry.2022; 65(3): 2656. CrossRef - Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival
Ifeanyi Elibe Mba, Emeka Innocent Nweze, Emmanuel Aniebonam Eze, Zikora Kizito Glory Anyaegbunam
Infection, Genetics and Evolution.2022; 99: 105256. CrossRef - Activity of poly(methacrylic acid)-silver nanoparticles on fluconazole-resistant Candida albicans strains: Synergistic and cytotoxic effects
Cecília Maria Cruz Falcão, Audrey Andrade, Vanderlan Nogueira Holanda, Regina Celia Bressan Queiroz de Figueiredo, Eulália Azevedo Ximenes, Anderson Stevens Leonidas Gomes
Journal of Applied Microbiology.2022; 132(6): 4300. CrossRef - Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies
Raphaëlle Youf, Max Müller, Ali Balasini, Franck Thétiot, Mareike Müller, Alizé Hascoët, Ulrich Jonas, Holger Schönherr, Gilles Lemercier, Tristan Montier, Tony Le Gall
Pharmaceutics.2021; 13(12): 1995. CrossRef - Etoposide and Camptothecin Reduce Growth, Viability, the Generation of Petite Mutants, and Recognize the Active Site of DNA Topoisomerase I and II Enzymes in Candida glabrata
Dulce Andrade-Pavón, Omar Gómez-García
Indian Journal of Microbiology.2021; 61(3): 306. CrossRef - 8-hydroxyquinoline-5-(N-4-chlorophenyl) sulfonamide and fluconazole combination as a preventive strategy for Candida biofilm in haemodialysis devices
Letícia Fernandes da Rocha, Bruna Pippi, Angélica Rocha Joaquim, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefria
Journal of Medical Microbiology
.2021;[Epub] CrossRef - Genetic diversity and molecular epidemiology of Candida albicans from vulvovaginal candidiasis patients
Ji-yun Tian, Yong-gang Yang, Shi Chen, Yong Teng, Xin-zheng Li
Infection, Genetics and Evolution.2021; 92: 104893. CrossRef - Chronic recurrent vulvovaginitis is not only due to Candida
Alicia Arechavala, Ricardo Negroni, Gabriela Santiso, Roxana Depardo, Pablo Bonvehí
Revista Iberoamericana de Micología.2021; 38(3): 132. CrossRef - Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans
Wasim Uddin, Darshan Dhabalia, S.M. Udaya Prakash, M. Anaul Kabir
Journal of Genetic Engineering and Biotechnology.2021; 19(1): 92. CrossRef - Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration
Xueyang Jin, Ming Zhang, Jinghui Lu, Ximeng Duan, Jinyao Chen, Yue Liu, Wenqiang Chang, Hongxiang Lou
Journal of Advanced Research.2021; 34: 65. CrossRef - Lysinibacillus Isolate MK212927: A Natural Producer of Allylamine Antifungal ‘Terbinafine’
Sayed E. El-Sayed, Neveen A. Abdelaziz, Hosam-Eldin Hussein Osman, Ghadir S. El-Housseiny, Ahmed E. Aleissawy, Khaled M. Aboshanab
Molecules.2021; 27(1): 201. CrossRef - New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation
Justyna Rewak-Soroczynska, Paulina Sobierajska, Sara Targonska, Agata Piecuch, Lukasz Grosman, Jaroslaw Rachuna, Slawomir Wasik, Michal Arabski, Rafal Ogorek, Rafal J. Wiglusz
International Journal of Molecular Sciences.2021; 22(6): 3112. CrossRef - The phosphatome of opportunistic pathogen Candida species
Krisztina Szabó, Márton Miskei, Ilona Farkas, Viktor Dombrádi
Fungal Biology Reviews.2021; 35: 40. CrossRef - Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance
Xin Wang, Jun Liu, Jinyao Chen, Ming Zhang, Chuan Tian, Xiaoping Peng, Gang Li, Wenqiang Chang, Hongxiang Lou
Bioorganic Chemistry.2021; 110: 104771. CrossRef - Activity of Compound Agrimony Enteritis Capsules against invasive candidiasis: Exploring the differences between traditional Chinese medicine prescriptions and its main components in the treatment of diseases
Jun Li, Ze-Hua Jin, Jia-Sheng Li, Liu-Yan Su, Ying-Xian Wang, Yi Zhang, Ding-Mei Qin, Gao-Xiong Rao, Rui-Rui Wang
Journal of Ethnopharmacology.2021; 277: 114201. CrossRef - Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
Eric Delarze, Ludivine Brandt, Emilie Trachsel, Marion Patxot, Claire Pralong, Fabio Maranzano, Murielle Chauvel, Mélanie Legrand, Sadri Znaidi, Marie-Elisabeth Bougnoux, Christophe d’Enfert, Dominique Sanglard
Frontiers in Microbiology.2020;[Epub] CrossRef - A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris
Eva-Maria Mayr, Bernardo Ramírez-Zavala, Ines Krüger, Joachim Morschhäuser, Aaron P. Mitchell
mSphere.2020;[Epub] CrossRef - Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design
Brian C. Monk, Alia A. Sagatova, Parham Hosseini, Yasmeen N. Ruma, Rajni K. Wilson, Mikhail V. Keniya
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.2020; 1868(3): 140206. CrossRef - Dispiropyrrolidine tethered piperidone heterocyclic hybrids with broad-spectrum antifungal activity against Candida albicans and Cryptococcus neoformans
Sarah Lawson, Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Shankar Thangamani
Bioorganic Chemistry.2020; 100: 103865. CrossRef - Lipid composition and cell surface hydrophobicity of Candida albicans influence the efficacy of fluconazole–gentamicin treatment
Jakub Suchodolski, Jakub Muraszko, Aleksandra Korba, Przemysław Bernat, Anna Krasowska
Yeast.2020; 37(1): 117. CrossRef - Adaptive Laboratory Evolution of Native Torulaspora delbrueckii YCPUC10 With Enhanced Ethanol Resistance and Evaluation in Co-inoculated Fermentation
Daniela Catrileo, Andrea Acuña-Fontecilla, Liliana Godoy
Frontiers in Microbiology.2020;[Epub] CrossRef - Genotype, biofilm formation ability and specific gene transcripts characteristics of endodontic Enterococcus faecalis under glucose deprivation condition
Yawen Liu, Yifan Ping, Yuhua Xiong, Ruyu Zhou, Fulu Xu, Juan Wang, Jin Li
Archives of Oral Biology.2020; 118: 104877. CrossRef - Improved Methods of Extraction and In Vitro Evaluation of Antimicrobial Potential of Stem Bark of Terminalia arjuna
Sarita Khatkar, Arun Nanda, Shahid Husain Ansari
Current Biochemical Engineering.2019; 5(1): 50. CrossRef - The small GTPase Rhb1 is involved in the cell response to fluconazole inCandida albicans
Yu-Wen Chen, Ying-Chieh Yeh, Hsueh-Fen Chen, Ruei-Ching Chen, Guan-Yu Lin, Yu-Ting Chen, Chung-Yu Lan
FEMS Yeast Research.2019;[Epub] CrossRef - The Magnitude ofCandida albicansStress-Induced Genome Instability Results from an Interaction Between Ploidy and Antifungal Drugs
Ognenka Avramovska, Meleah A Hickman
G3 Genes|Genomes|Genetics.2019; 9(12): 4019. CrossRef - Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
Wen-Xuan Wang, Xinxiang Lei, Hong-Lian Ai, Xue Bai, Jing Li, Juan He, Zheng-Hui Li, Yong-Sheng Zheng, Tao Feng, Ji-Kai Liu
Organic Letters.2019; 21(4): 1108. CrossRef - Antifungal Activity of a Hydroethanolic Extract From Astronium urundeuva Leaves Against Candida albicans and Candida glabrata
Bruna Vidal Bonifácio, Taissa Vieira Machado Vila, Isadora Fantacini Masiero, Patrícia Bento da Silva, Isabel Cristiane da Silva, Érica de Oliveira Lopes, Matheus Aparecido dos Santos Ramos, Leonardo Perez de Souza, Wagner Vilegas, Fernando Rogério Pavan,
Frontiers in Microbiology.2019;[Epub] CrossRef - Dissection of the regulatory role for the N-terminal domain in Candida albicans protein phosphatase Z1
Krisztina Szabó, Zoltán Kónya, Ferenc Erdődi, Ilona Farkas, Viktor Dombrádi, Joy Sturtevant
PLOS ONE.2019; 14(2): e0211426. CrossRef - The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicans
Shen-Huan Liang, Richard J. Bennett
Journal of Fungi.2019; 6(1): 10. CrossRef - Evolution of Fluconazole-Resistant Candida albicans Strains by Drug-Induced Mating Competence and Parasexual Recombination
Christina Popp, Bernardo Ramírez-Zavala, Sonja Schwanfelder, Ines Krüger, Joachim Morschhäuser, Judith Berman
mBio.2019;[Epub] CrossRef - Accelerated evolution at chaperone promoters among Antarctic notothenioid fishes
Samuel N. Bogan, Sean P. Place
BMC Evolutionary Biology.2019;[Epub] CrossRef - Elevation of cell wall chitin via Ca2+–calcineurin‐mediated PKC signaling pathway maintains the viability of Candida albicans in the absence of β‐1,6‐glucan synthesis
Qi Han, Na Wang, Chaoying Pan, Yue Wang, Jianli Sang
Molecular Microbiology.2019; 112(3): 960. CrossRef - Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
Brian C. Monk, Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, Danyon O. Graham, Harith F. Hassan, Danni Chen, Joel D. A. Tyndall
Antimicrobial Agents and Chemotherapy.2019;[Epub] CrossRef - The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
Jingxiang Zhang, Liping Li, Quanzhen Lv, Lan Yan, Yan Wang, Yuanying Jiang
Frontiers in Microbiology.2019;[Epub] CrossRef - Two New 1,3,4-Oxadiazoles With Effective Antifungal Activity Against Candida albicans
Isis Regina Grenier Capoci, Karina Mayumi Sakita, Daniella Renata Faria, Franciele Abigail Vilugron Rodrigues-Vendramini, Glaucia Sayuri Arita, Admilton Gonçalves de Oliveira, Maria Sueli Felipe, Bernard Maigret, Patricia de Souza Bonfim-Mendonça, Erika S
Frontiers in Microbiology.2019;[Epub] CrossRef - Anti-candidal activity of selected analgesic drugs used alone and in combination with fluconazole, itraconazole, voriconazole, posaconazole and isavuconazole
J. Król, U. Nawrot, M. Bartoszewicz
Journal de Mycologie Médicale.2018; 28(2): 327. CrossRef - Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor
Alexandra Carreira, João Boavida Ferreira, Iliana Pereira, João Ferreira, Paulo Filipe, Ricardo Boavida Ferreira, Sara Monteiro
Journal of Medical Microbiology.2018; 67(2): 198. CrossRef - Varying susceptibility of clinical and environmental Scedosporium isolates to chemical oxidative stress in conidial germination
Cindy Staerck, Charlotte Godon, Jean-Philippe Bouchara, Maxime J. J. Fleury
Archives of Microbiology.2018; 200(3): 517. CrossRef - Rice Defensin OsAFP1 is a New Drug Candidate against Human Pathogenic Fungi
Akihito Ochiai, Kodai Ogawa, Minami Fukuda, Masahiro Ohori, Takumi Kanaoka, Takaaki Tanaka, Masayuki Taniguchi, Yoshiyuki Sagehashi
Scientific Reports.2018;[Epub] CrossRef - Thiobarbiturates as potential antifungal agents to control human infections caused by Candida and Cryptococcus species
Muhammad Shabeer, Luiz C. A. Barbosa, Milandip Karak, Amanda C. S. Coelho, Jacqueline A. Takahashi
Medicinal Chemistry Research.2018; 27(4): 1043. CrossRef - A Case for Antifungal Stewardship
Rachel A. Miller
Current Fungal Infection Reports.2018; 12(1): 33. CrossRef -
A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes
YOR1
Overexpression and Beauvericin Resistance in Candida albicans
Bernardo Ramírez-Zavala, Hannah Manz, Frank Englert, P. David Rogers, Joachim Morschhäuser
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef - Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species
J. D. Sobel, R. Sobel
Expert Opinion on Pharmacotherapy.2018; 19(9): 971. CrossRef - CYP51 as drug targets for fungi and protozoan parasites: past, present and future
Galina I. Lepesheva, Laura Friggeri, Michael R. Waterman
Parasitology.2018; 145(14): 1820. CrossRef - TLS dependent and independent functions of DNA polymerase eta (Polη/Rad30) from Pathogenic Yeast Candida albicans
Kodavati Manohar, Doureradjou Peroumal, Narottam Acharya
Molecular Microbiology.2018; 110(5): 707. CrossRef - Potential effect of 2-isopropyl-5-methylphenol (thymol) alone and in combination with fluconazole against clinical isolates of Candida albicans, C. glabrata and C. krusei
A. Sharifzadeh, A.R. Khosravi, H. Shokri, H. Shirzadi
Journal de Mycologie Médicale.2018; 28(2): 294. CrossRef - Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms
Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin
Journal of Chemistry.2017; 2017: 1. CrossRef - Bridging the Gap to Non-toxic Fungal Control: Lupinus-Derived Blad-Containing Oligomer as a Novel Candidate to Combat Human Pathogenic Fungi
Ana M. Pinheiro, Alexandra Carreira, Thomas A. K. Prescott, Ricardo B. Ferreira, Sara A. Monteiro
Frontiers in Microbiology.2017;[Epub] CrossRef - An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses
Irene A. I. Hampe, Justin Friedman, Mira Edgerton, Joachim Morschhäuser, Julia Ruth Koehler
PLOS Pathogens.2017; 13(9): e1006655. CrossRef -
Antimicrobial activity of
Buchenavia tetraphylla
against
Candida albicans
strains isolated from vaginal secretions
José Robson Neves Cavalcanti Filho, Tiago Fonseca Silva, Woah Queiroz Nobre, Larissa Isabela Oliveira de Souza, Cristiane Santos Silva e Silva Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, Norma Buarque de Gusmão, Márcia Vanusa Silva, Luís Cláud
Pharmaceutical Biology.2017; 55(1): 1521. CrossRef - Antifungal Resistance: An Emerging Reality and A Global Challenge
Dimitrios P Kontoyiannis
The Journal of Infectious Diseases.2017; 216(suppl_3): S431. CrossRef -
Candida albicans Swi/Snf and Mediator Complexes Differentially Regulate Mrr1-Induced
MDR1
Expression and Fluconazole Resistance
Zhongle Liu, Lawrence C. Myers
Antimicrobial Agents and Chemotherapy.2017;[Epub] CrossRef - Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis
Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Aidong Qi, William J. Hoekstra, Robert J. Schotzinger, John D. York, F. Peter Guengerich, Galina I. Lepesheva
Journal of Biological Chemistry.2017; 292(16): 6728. CrossRef - The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates
Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
Microbial Pathogenesis.2017; 113: 209. CrossRef - The Structure of Thymidylate Kinase from Candida albicans Reveals a Unique Structural Element
Kaustubh Sinha, Gordon S. Rule
Biochemistry.2017; 56(33): 4360. CrossRef -
Histone Acetyltransferase Encoded by
NGG1
is Required for Morphological Conversion and Virulence of
Candida Albicans
De-Dong Li, Beth Burgwyn Fuchs, Yan Wang, Xiao-Wen Huang, Dan-Dan Hu, Yan Sun, Dong Chai, Yuan-Ying Jiang, Eleftherios Mylonakis
Future Microbiology.2017; 12(16): 1497. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Candidaspecies isolated from different body sites and their antifungal susceptibility pattern: Cross-analysis ofCandida albicansandCandida glabratabiofilms
Valentina Cataldi, Emanuela Di Campli, Paolo Fazii, Tonino Traini, Luigina Cellini, Mara Di Giulio
Medical Mycology.2016; : myw126. CrossRef
- REVIEW] Innate host defenses against Cryptococcus neoformans
-
Camaron Hole , Floyd L. Wormley Jr.
-
J. Microbiol. 2016;54(3):202-211. Published online February 27, 2016
-
DOI: https://doi.org/10.1007/s12275-016-5625-7
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44
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17
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Abstract
-
Cryptococcus neoformans, the predominant etiological agent
of cryptococcosis, can cause life-threatening infections of the
central nervous system in immunocompromised and immunocompetent
individuals. Cryptococcal meningoencephalitis
is the most common disseminated fungal infection in AIDS
patients, and remains the third most common invasive fungal
infection among organ transplant recipients. The administration
of highly active antiretroviral therapy (HAART) has
result
ed in a decrease in the number of cases of AIDS-related
cryptococcosis in developed countries, but in developing
countries where HAART is not readily available, Cryptococcus
is still a major concern. Therefore, there is an urgent
need for the development of novel therapies and/or vaccines
to combat cryptococcosis. Understanding the protective immune
responses against Cryptococcus is critical for development
of vaccines and immunotherapies to combat cryptococcosis.
Consequently, this review focuses on our current
knowledge of protective immune responses to C. neoformans,
with an emphasis on innate immune responses.
-
Citations
Citations to this article as recorded by

- Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis
Shiqin Tang, Ruiying Hao, Xin Liu, Huina He, Yanan Tian, Tingting Jing, Zhao Liu, Yanyan Xu, Xiaojing Li
Frontiers in Immunology.2024;[Epub] CrossRef - The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways
Jennifer L. O'Connor, Jillian C. Nissen
International Journal of Molecular Sciences.2023; 24(5): 4739. CrossRef - Microglia are not protective against cryptococcal meningitis
Sally H. Mohamed, Man Shun Fu, Sofia Hain, Alanoud Alselami, Eliane Vanhoffelen, Yanjian Li, Ebrima Bojang, Robert Lukande, Elizabeth R. Ballou, Robin C. May, Chen Ding, Greetje Vande Velde, Rebecca A. Drummond
Nature Communications.2023;[Epub] CrossRef - Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
Yanjian Li, Hailong Li, Tianshu Sun, Chen Ding
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis
Tao Zhu, Wan-Ting Luo, Gui-Hua Chen, Yue-Sheng Tu, Shuo Tang, Huo-Jin Deng, Wei Xu, Wei Zhang, Di Qi, Dao-Xin Wang, Chang-Yi Li, He Li, Yan-Qiao Wu, Shen-Jin Li
Chinese Medical Journal.2018; 131(18): 2210. CrossRef - A case report of fatal disseminated Mycobacterium colombiense infection in a renal transplant recipient
Jasmine Gosal, B. Craig Lee
Transplant Infectious Disease.2018;[Epub] CrossRef - The Major Surface Glycoprotein of Pneumocystis murina Does Not Activate Dendritic Cells
Monica Sassi, Geetha Kutty, Gabriela A Ferreyra, Lisa R Bishop, Yueqin Liu, Ju Qiu, Da Wei Huang, Joseph A Kovacs
The Journal of Infectious Diseases.2018; 218(10): 1631. CrossRef - Disseminated Cryptococcosis With Severe Increased Intracranial Pressure Complicated With Cranial Nerve Palsy in a Child
Bilge Aldemir Kocabaş, Mehmet Emin Parlak, Betil Özhak Baysan, Kamil Karaali, Ayşen Bingöl, Şenay Haspolat
Pediatric Infectious Disease Journal.2018; 37(4): 373. CrossRef - Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection
Mitra Shourian, Ben Ralph, Isabelle Angers, Donald C. Sheppard, Salman T. Qureshi
Frontiers in Immunology.2018;[Epub] CrossRef - Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome
Irina Vlasova-St. Louis, Christina C Chang, Samar Shahid, Martyn A French, Paul R Bohjanen
Open Forum Infectious Diseases.2018;[Epub] CrossRef - Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection
Jintao Xu, Adam Flaczyk, Lori M. Neal, Zhenzong Fa, Alison J. Eastman, Antoni N. Malachowski, Daphne Cheng, Bethany B. Moore, Jeffrey L. Curtis, John J. Osterholzer, Michal A. Olszewski
The Journal of Immunology.2017; 198(9): 3548. CrossRef - Neuro-Immune Mechanisms of Anti-Cryptococcal Protection
Rebecca Drummond
Journal of Fungi.2017; 4(1): 4. CrossRef - Role of microglia in fungal infections of the central nervous system
George W. Koutsouras, Raddy L. Ramos, Luis R. Martinez
Virulence.2017; 8(6): 705. CrossRef - Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection
Althea Campuzano, Natalia Castro-Lopez, Karen L. Wozniak, Chrissy M. Leopold Wager, Floyd L. Wormley, Kirsten Nielsen
PLOS ONE.2017; 12(1): e0169347. CrossRef - Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pedro Pais, Catarina Costa, Mafalda Cavalheiro, Daniela Romão, Miguel C. Teixeira
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Activation strategies for invariant natural killer T cells
Ayano C. Kohlgruber, Carlos A. Donado, Nelson M. LaMarche, Michael B. Brenner, Patrick J. Brennan
Immunogenetics.2016; 68(8): 649. CrossRef
- REVIEW] All about that fat: Lipid modification of proteins in Cryptococcus neoformans
-
Felipe H. Santiago-Tirado , Tamara L. Doering
-
J. Microbiol. 2016;54(3):212-222. Published online February 27, 2016
-
DOI: https://doi.org/10.1007/s12275-016-5626-6
-
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53
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0
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8
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Abstract
-
Lipid modification of proteins is a widespread, essential process
whereby fatty acids, cholesterol, isoprenoids, phospholipids,
or glycosylphospholipids are attached to polypeptides.
These hydrophobic groups may affect protein structure, function,
localization, and/or stability; as a consequence such modifications
play critical regulatory roles in cellular systems.
Recent advances in chemical biology and proteomics have
allowed the profiling of modified proteins, enabling dissection
of the functional consequences of lipid addition. The
enzymes that mediate lipid modification are specific for both
the lipid and protein substrates, and are conserved from fungi
to humans. In this article we review these enzymes, their substrates,
and the processes involved in eukaryotic lipid modification
of proteins. We further focus on its occurrence in
the fungal pathogen Cryptococcus neoformans, highlighting
unique features that are both relevant for the biology of the
organism and potentially important in the search for new
therapies.
-
Citations
Citations to this article as recorded by

- Acylation of non‐specific phospholipase C4 determines its function in plant response to phosphate deficiency
Bao Yang, Ke Zhang, Xiong Jin, Jiayu Yan, Shaoping Lu, Qingwen Shen, Lei Guo, Yueyun Hong, Xuemin Wang, Liang Guo
The Plant Journal.2021; 106(6): 1647. CrossRef - Genome Sequence, Assembly, and Characterization of the Antagonistic Yeast Candida oleophila Used as a Biocontrol Agent Against Post-harvest Diseases
Yuan Sui, Michael Wisniewski, Samir Droby, Edoardo Piombo, Xuehong Wu, Junyang Yue
Frontiers in Microbiology.2020;[Epub] CrossRef - Peeling the onion: the outer layers of Cryptococcus neoformans
Daniel P Agustinho, Liza C Miller, Lucy X Li, Tamara L Doering
Memórias do Instituto Oswaldo Cruz.2018;[Epub] CrossRef - The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics
María-Eugenia Zaballa, F. Gisou van der Goot
Critical Reviews in Biochemistry and Molecular Biology.2018; 53(4): 420. CrossRef - Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation
Xinping Xu, Jianfeng Lin, Youbao Zhao, Elyssa Kirkman, Yee-Seul So, Yong-Sun Bahn, Xiaorong Lin, Aaron P. Mitchell
PLOS Genetics.2017; 13(9): e1006982. CrossRef - Alpha-helicoidal HEAT-like Repeat Proteins (αRep) Selected as Interactors of HIV-1 Nucleocapsid Negatively Interfere with Viral Genome Packaging and Virus Maturation
Sudarat Hadpech, Sawitree Nangola, Koollawat Chupradit, Kanda Fanhchaksai, Wilhelm Furnon, Agathe Urvoas, Marie Valerio-Lepiniec, Philippe Minard, Pierre Boulanger, Saw-See Hong, Chatchai Tayapiwatana
Scientific Reports.2017;[Epub] CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation
Srijana Upadhyay, Xinping Xu, Xiaorong Lin, J. Andrew Alspaugh
mBio.2016;[Epub] CrossRef
- REVIEW] Developmental regulators in Aspergillus fumigatus
-
Hee-Soo Park , Jae-Hyuk Yu
-
J. Microbiol. 2016;54(3):223-231. Published online February 27, 2016
-
DOI: https://doi.org/10.1007/s12275-016-5619-5
-
-
49
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-
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-
51
Crossref
-
Abstract
-
The filamentous fungus Aspergillus fumigatus is the most prevalent
airborne fungal pathogen causing severe and usually
fatal invasive aspergillosis in immunocompromised patients.
This fungus produces a large number of small hydrophobic
asexual spores called conidia as the primary means of reproduction,
cell survival, propagation, and infectivity. The initiation,
progression, and completion of asexual development
(conidiation) is controlled by various regulators that govern
expression of thousands of genes associated with formation
of the asexual developmental structure conidiophore, and
biogenesis of conidia. In this review, we summarize key regulators
that directly or indirectly govern conidiation in this
important pathogenic fungus. Better understanding these
developmental regulators may provide insights into the improvement
in controlling both beneficial and detrimental
aspects of various Aspergillus species.
-
Citations
Citations to this article as recorded by

-
Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus
Aspergillus fumigatus
Ye-Eun Son, Jiwoo Han, Kyung-Tae Lee, Hee-Soo Park
Mycology.2024; 15(2): 238. CrossRef - Regulation of Conidiation and Aflatoxin B1 Biosynthesis by a Blue Light Sensor LreA in Aspergillus flavus
Kunzhi Jia, Yipu Jia, Qianhua Zeng, Zhaoqi Yan, Shihua Wang
Journal of Fungi.2024; 10(9): 650. CrossRef - Comprehensive Insights into the Remarkable Function and Regulatory Mechanism of FluG during Asexual Development in Beauveria bassiana
Fang Li, Juefeng Zhang, Haiying Zhong, Kaili Yu, Jianming Chen
International Journal of Molecular Sciences.2024; 25(11): 6261. CrossRef - Genome-wide patterns of noncoding and protein-coding sequence variation in the major fungal pathogen Aspergillus fumigatus
Alec Brown, Jacob L Steenwyk, Antonis Rokas, J Comeron
G3: Genes, Genomes, Genetics.2024;[Epub] CrossRef - Cellular communication and fusion regulate cell fusion, trap morphogenesis, conidiation, and secondary metabolism in Arthrobotrys oligospora
Wenjie Wang, Yankun Liu, Shipeng Duan, Na Bai, Meichen Zhu, Jinkui Yang
Microbiological Research.2024; 278: 127516. CrossRef - The Cryptochrome CryA Regulates Lipid Droplet Accumulation, Conidiation, and Trap Formation via Responses to Light in Arthrobotrys oligospora
Yanmei Shen, Xuewei Yang, Meichen Zhu, Shipeng Duan, Qianqian Liu, Jinkui Yang
Journal of Fungi.2024; 10(9): 626. CrossRef - The CfKOB1 gene related to cell apoptosis is required for pathogenicity and involved in mycovirus-induced hypovirulence in Colletotrichum fructicola
Jun Zi Zhu, Ping Li, Zhuo Zhang, Xiao Gang Li, Jie Zhong
International Journal of Biological Macromolecules.2024; 271: 132437. CrossRef - Functional and Quality Assessment of a Spore Harvester for Entomopathogenic Fungi for Biopesticide Production
Fidel Diego-Nava, Carlos Granados-Echegoyen, Jaime Ruíz-Vega, Teodulfo Aquino-Bolaños, Rafael Pérez-Pacheco, Alejo Díaz-Ramos, Nancy Alonso-Hernández, Fabián Arroyo-Balán, Mónica Beatriz López-Hernández
AgriEngineering.2023; 5(2): 801. CrossRef - Verticillium dahliae Asp1 regulates the transition from vegetative growth to asexual reproduction by modulating microtubule dynamic organization
Juan Tian, Mengli Pu, Bin Chen, Guangda Wang, Chunli Li, Xiaxia Zhang, Yanjun Yu, Zhi Wang, Zhaosheng Kong
Environmental Microbiology.2023; 25(3): 738. CrossRef - Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
Andleeb Khan, Sivakumar Sivagurunathan Moni, M. Ali, Syam Mohan, Huma Jan, Saiema Rasool, Mohammad A Kamal, Saeed Alshahrani, Maryam Halawi, Hassan A Alhazmi
Current Molecular Pharmacology.2023; 16(1): 15. CrossRef - Chitin Biosynthesis in Aspergillus Species
Veronica S. Brauer, André M. Pessoni, Mateus S. Freitas, Marinaldo P. Cavalcanti-Neto, Laure N. A. Ries, Fausto Almeida
Journal of Fungi.2023; 9(1): 89. CrossRef - Transcription factor CreA is involved in the inverse regulation of biofilm formation and asexual development through distinct pathways in Aspergillus fumigatus
Shuai Liu, Xiaoyan Lu, Mengyao Dai, Shizhu Zhang
Molecular Microbiology.2023; 120(6): 830. CrossRef - A new butenolide with antifungal activity from solid co-cultivation of Irpex lacteus and Nigrospora oryzae
Ya-Mei Wu, Xue-Qiong Yang, Jing-Xin Chen, Ting Wang, Tai-Ran Li, Fan-Rong Liao, Run-Tong Liu, Ya-Bin Yang, Zhong-Tao Ding
Natural Product Research.2023; 37(13): 2243. CrossRef - A Network of Sporogenesis-Responsive Genes Regulates the Growth, Asexual Sporogenesis, Pathogenesis and Fusaric Acid Production of Fusarium oxysporum f. sp. cubense
Songmao Lu, Huobing Deng, Yaqi Lin, Meimei Huang, Haixia You, Yan Zhang, Weijian Zhuang, Guodong Lu, Yingzi Yun
Journal of Fungi.2023; 10(1): 1. CrossRef - Light regulates the degradation of the regulatory protein VE-1 in the fungus Neurospora crassa
María del Mar Gil-Sánchez, Sara Cea-Sánchez, Eva M. Luque, David Cánovas, Luis M. Corrochano
BMC Biology.2022;[Epub] CrossRef - The C-22 sterol desaturase Erg5 is responsible for ergosterol biosynthesis and conidiation in Aspergillus fumigatus
Nanbiao Long, Guowei Zhong
Journal of Microbiology.2022; 60(6): 620. CrossRef - Comparative Transcriptomic Analyses Reveal the Regulatory Mechanism of Nutrient Limitation-Induced Sporulation of Antrodia cinnamomea in Submerged Fermentation
Huaxiang Li, Dan Ji, Zhishan Luo, Yilin Ren, Zhenming Lu, Zhenquan Yang, Zhenghong Xu
Foods.2022; 11(17): 2715. CrossRef - Azole‐resistant Aspergillus fumigatus as an emerging worldwide pathogen
Sofia Marisel Rivelli Zea, Takahito Toyotome
Microbiology and Immunology.2022; 66(3): 135. CrossRef - Transcriptional Regulation by the Velvet Protein VE-1 during Asexual Development in the Fungus Neurospora crassa
Sara Cea-Sánchez, María Corrochano-Luque, Gabriel Gutiérrez, N. Louise Glass, David Cánovas, Luis M. Corrochano, Reinhard Fischer
mBio.2022;[Epub] CrossRef - The secondary metabolite regulator, BbSmr1, is a central regulator of conidiation via the BrlA‐AbaA‐WetA pathway in Beauveria bassiana
Jin‐Feng Chen, Yu Liu, Gui‐Rong Tang, Dan Jin, Xi Chen, Yan Pei, Yan‐Hua Fan
Environmental Microbiology.2021; 23(2): 810. CrossRef - BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana
Lei Qiu, Tong-Sheng Zhang, Ji-Zheng Song, Jing Zhang, Ze Li, Juan-Juan Wang, Christina A. Cuomo
Microbiology Spectrum.2021;[Epub] CrossRef - The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
Yanxia Zhao, Mi-Kyung Lee, Jieyin Lim, Heungyun Moon, Hee-Soo Park, Weifa Zheng, Jae-Hyuk Yu
Journal of Microbiology.2021; 59(8): 746. CrossRef - Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus
Patrícia Alves de Castro, Clara Valero, Jéssica Chiaratto, Ana Cristina Colabardini, Lakhansing Pardeshi, Lilian Pereira Silva, Fausto Almeida, Marina Campos Rocha, Roberto Nascimento Silva, Iran Malavazi, Wenyue Du, Paul S. Dyer, Matthias Brock, Flávio V
mBio.2021;[Epub] CrossRef -
The Heterotrimeric Transcription Factor CCAAT-Binding Complex and Ca
2+
-CrzA Signaling Reversely Regulate the Transition between Fungal Hyphal Growth and Asexual Reproduction
Yiran Ren, Chi Zhang, Ziqing Chen, Ling Lu, Reinhard Fischer
mBio.2021;[Epub] CrossRef - The fungal‐specific histone acetyltransferase Rtt109 regulates development, DNA damage response, and virulence in Aspergillus fumigatus
Yuanwei Zhang, Jialu Fan, Jing Ye, Ling Lu
Molecular Microbiology.2021; 115(6): 1191. CrossRef - Deep convolutional neural network: a novel approach for the detection of Aspergillus fungi via stereomicroscopy
Haozhong Ma, Jinshan Yang, Xiaolu Chen, Xinyu Jiang, Yimin Su, Shanlei Qiao, Guowei Zhong
Journal of Microbiology.2021; 59(6): 563. CrossRef - The Arf-GAP AoGlo3 regulates conidiation, endocytosis, and pathogenicity in the nematode-trapping fungus Arthrobotrys oligospora
Yuxin Ma, Xuewei Yang, Meihua Xie, Guosheng Zhang, Le Yang, Na Bai, Yining Zhao, Dongni Li, Ke-Qin Zhang, Jinkui Yang
Fungal Genetics and Biology.2020; 138: 103352. CrossRef - The Autophagy-Related Gene Aolatg4 Regulates Hyphal Growth, Sporulation, Autophagosome Formation, and Pathogenicity in Arthrobotrys oligospora
Duanxu Zhou, Meihua Xie, Na Bai, Le Yang, Ke-Qin Zhang, Jinkui Yang
Frontiers in Microbiology.2020;[Epub] CrossRef -
Molecular Mechanisms of Conidial Germination in
Aspergillus
spp
Tim J. H. Baltussen, Jan Zoll, Paul E. Verweij, Willem J. G. Melchers
Microbiology and Molecular Biology Reviews.2020;[Epub] CrossRef - Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway
James I. P. Stewart, Vinicius M. Fava, Joshua D. Kerkaert, Adithya S. Subramanian, Fabrice N. Gravelat, Melanie Lehoux, P. Lynne Howell, Robert A. Cramer, Donald C. Sheppard, James W. Kronstad
mBio.2020;[Epub] CrossRef - Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans
Mi-Kyung Lee, Ye-Eun Son, Hee-Soo Park, Ahmad Alshannaq, Kap-Hoon Han, Jae-Hyuk Yu
Scientific Reports.2020;[Epub] CrossRef - The Transcriptional Regulator HbxA Governs Development, Secondary Metabolism, and Virulence in Aspergillus fumigatus
Timothy Satterlee, Binita Nepal, Sophie Lorber, Olivier Puel, Ana M. Calvo, Irina S. Druzhinina
Applied and Environmental Microbiology.2020;[Epub] CrossRef -
The Cell Wall Integrity Pathway Contributes to the Early Stages of
Aspergillus fumigatus
Asexual Development
Marina Campos Rocha, João Henrique Tadini Marilhano Fabri, Isabelle Taira Simões, Rafael Silva-Rocha, Daisuke Hagiwara, Anderson Ferreira da Cunha, Gustavo Henrique Goldman, David Cánovas, Iran Malavazi, Irina S. Druzhinina
Applied and Environmental Microbiology.2020;[Epub] CrossRef -
In vitro and in vivo characterization of two nonsporulating Aspergillus fumigatus clinical isolates from immunocompetent patients
Zheng Zhang, Yuan Jiang, Jun Chen, Peiying Chen, Qingtao Kong, Ling Lu, Hong Sang
Medical Mycology.2020; 58(4): 543. CrossRef - The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum
Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
International Journal of Molecular Sciences.2020; 21(18): 6660. CrossRef - Recurrent Loss of abaA, a Master Regulator of Asexual Development in Filamentous Fungi, Correlates with Changes in Genomic and Morphological Traits
Matthew E Mead, Alexander T Borowsky, Bastian Joehnk, Jacob L Steenwyk, Xing-Xing Shen, Anita Sil, Antonis Rokas, Jason E Stajich
Genome Biology and Evolution.2020; 12(7): 1119. CrossRef - The histone acetyltransferase GcnE regulates conidiation and biofilm formation in Aspergillus fumigatus
Chi-Jan Lin, Yi-Hsuan Hou, Ying-Lien Chen
Medical Mycology.2019;[Epub] CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Identification of a Novel Transcription Factor TP05746 Involved in Regulating the Production of Plant-Biomass-Degrading Enzymes in Talaromyces pinophilus
Ting Zhang, Lu-Sheng Liao, Cheng-Xi Li, Gui-Yan Liao, Xiong Lin, Xue-Mei Luo, Shuai Zhao, Jia-Xun Feng
Frontiers in Microbiology.2019;[Epub] CrossRef - The Velvet Proteins VosA and VelB Play Different Roles in Conidiation, Trap Formation, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora
Guosheng Zhang, Yaqing Zheng, Yuxin Ma, Le Yang, Meihua Xie, Duanxu Zhou, Xuemei Niu, Ke-Qin Zhang, Jinkui Yang
Frontiers in Microbiology.2019;[Epub] CrossRef - An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus
Abigail L. Lind, Fang Yun Lim, Alexandra A. Soukup, Nancy P. Keller, Antonis Rokas, Aaron P. Mitchell
mSphere.2018;[Epub] CrossRef - MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus
Özlem Sarikaya Bayram, Jean Paul Latgé, Özgür Bayram
Current Genetics.2018; 64(1): 141. CrossRef - C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus
Qusai Al Abdallah, Adela Martin-Vicente, Ana Camila Oliveira Souza, Wenbo Ge, Jarrod R. Fortwendel
Frontiers in Microbiology.2018;[Epub] CrossRef - Aspergillus fumigatus -induced early inflammatory response in pulmonary microvascular endothelial cells: Role of p38 MAPK and inhibition by silibinin
Jun Song, Weihua Pan, Yue Sun, Jing Han, Weimin Shi, Wanqing Liao
International Immunopharmacology.2017; 49: 195. CrossRef - Comparative Transcriptomic and Proteomic Analyses Reveal a FluG‐Mediated Signaling Pathway Relating to Asexual Sporulation of Antrodia camphorata
Hua‐Xiang Li, Zhen‐Ming Lu, Qing Zhu, Jin‐Song Gong, Yan Geng, Jin‐Song Shi, Zheng‐Hong Xu, Yan‐He Ma
PROTEOMICS.2017;[Epub] CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Aspergillus fumigatus spore proteomics and genetics reveal that VeA represses DefA-mediated DNA damage response
Kwang-Soo Shin, Hee-Soo Park, Young Kim, In-Beom Heo, Young Hwan Kim, Jae-Hyuk Yu
Journal of Proteomics.2016; 148: 26. CrossRef - Utilization of a Conidia-Deficient Mutant to Study Sexual Development in Fusarium graminearum
Hokyoung Son, Jae Yun Lim, Yoonji Lee, Yin-Won Lee, Sung-Hwan Yun
PLOS ONE.2016; 11(5): e0155671. CrossRef - Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression
Xiujun Zhang, Yingying Zhu, Longfei Bao, Liwei Gao, Guangshan Yao, Yanan Li, Zhifeng Yang, Zhonghai Li, Yaohua Zhong, Fuli Li, Heng Yin, Yinbo Qu, Yuqi Qin
Fungal Genetics and Biology.2016; 94: 32. CrossRef - How to invade a susceptible host: cellular aspects of aspergillosis
Sven Krappmann
Current Opinion in Microbiology.2016; 34: 136. CrossRef - Negative regulation and developmental competence in Aspergillus
Mi-Kyung Lee, Nak-Jung Kwon, Im-Soon Lee, Seunho Jung, Sun-Chang Kim, Jae-Hyuk Yu
Scientific Reports.2016;[Epub] CrossRef
- REVIEW] Recent advances in the understanding of the Aspergillus fumigatus cell wall
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Mark J. Lee , Donald C. Sheppard
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J. Microbiol. 2016;54(3):232-242. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-6045-4
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Abstract
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Over the past several decades, research on the synthesis and
organization of the cell wall polysaccharides of Aspergillus
fumigatus has expanded our knowledge of this important
fungal structure. Besides protecting the fungus from environmental
stresses and maintaining structural integrity of
the organism, the cell wall is also the primary site for interaction
with host tissues during infection. Cell wall polysaccharides
are important ligands for the recognition of fungi
by the innate immune system and they can mediate potent
immunomodulatory effects. The synthesis of cell wall polysaccharides
is a complicated process that requires coordinated
regulation of many biosynthetic and metabolic pathways.
Continuous synthesis and remodeling of the polysaccharides
of the cell wall is essential for the survival of the
fungus during development, reproduction, colonization and
invasion. As these polysaccharides are absent from the human
host, these biosynthetic pathways are attractive targets
for antifungal development. In this review, we present recent
advances in our understanding of Aspergillus fumigatus cell
wall polysaccharides, including the emerging role of cell
wall polysaccharides in the host-pathogen interaction.
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Citations
Citations to this article as recorded by

- Fungal β-1, 3-glucanosyltransferases: A comprehensive review on classification, catalytic mechanism and functional role
Ting-Ting Wen, Zhuo-Yu Qian, Lei Sun, Feng-Jie Cui, Xin-Yi Zan, Li-Juan Meng, Wen-Jing Sun
International Journal of Biological Macromolecules.2025; 289: 138651. CrossRef - The yeast–human coevolution: Fungal transition from passengers, colonizers, and invaders
Stefano Nenciarini, Sonia Renzi, Monica di Paola, Niccolò Meriggi, Duccio Cavalieri
WIREs Mechanisms of Disease.2024;[Epub] CrossRef - The postbiotic potential of Aspergillus oryzae – a narrative review
Yvonne Seidler, Gerald Rimbach, Kai Lüersen, Gabriel Vinderola, Ignacio R. Ipharraguerre
Frontiers in Microbiology.2024;[Epub] CrossRef - Roles of α-1,3-glucosyltransferase in growth and polysaccharides biosynthesis of Ganoderma lucidum
Haixiu Chen, Liting Zhao, Cuiping You, Jingyun Liu, Lei Chen, Zhenghua Gu, Guiyang Shi, Junxun Li, Zhongyang Ding
International Journal of Biological Macromolecules.2024; 276: 134031. CrossRef -
The basic leucine zipper transcription factor MeaB is critical for biofilm formation, cell wall integrity, and virulence in
Aspergillus fumigatus
Yuan Chen, Fei Gao, Xiaojin Chen, Siyuan Tao, Peiying Chen, Wei Lin, Aaron P. Mitchell
mSphere.2024;[Epub] CrossRef - Antifungal mechanism of p-anisaldehyde against Aspergillus flavus based on transcriptome analysis
Yanli Xin, Wei Zhang, Yang Lei, Shan Wei, Shuaibing Zhang, Na Li, Yuansen Hu, Yangyong Lv
LWT.2024; 195: 115844. CrossRef - Aspergillus Cell Surface Structural Analysis and Its Applications to Industrial and Medical Use
Ken Miyazawa, Takashi Umeyama, Akira Yoshimi, Keietsu Abe, Yoshitsugu Miyazaki
Medical Mycology Journal.2024; 65(3): 75. CrossRef - Structural adaptation of fungal cell wall in hypersaline environment
Liyanage D. Fernando, Yordanis Pérez-Llano, Malitha C. Dickwella Widanage, Anand Jacob, Liliana Martínez-Ávila, Andrew S. Lipton, Nina Gunde-Cimerman, Jean-Paul Latgé, Ramón Alberto Batista-García, Tuo Wang
Nature Communications.2023;[Epub] CrossRef - The Lipid Raft-Associated Protein Stomatin Is Required for Accumulation of Dectin-1 in the Phagosomal Membrane and for Full Activity of Macrophages against Aspergillus fumigatus
Marie Goldmann, Franziska Schmidt, Zoltán Cseresnyés, Thomas Orasch, Susanne Jahreis, Susann Hartung, Marc Thilo Figge, Marie von Lilienfeld-Toal, Thorsten Heinekamp, Axel A. Brakhage, Aaron P. Mitchell
mSphere.2023;[Epub] CrossRef - Antifungal effect of triclosan on Aspergillus fumigatus: quorum quenching role as a single agent and synergy with liposomal amphotericin-B
Roya Tamimi, Godfrey Kyazze, Tajalli Keshavarz
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - Quantitative Monitoring of Mycelial Growth of Aspergillus fumigatus in Liquid Culture by Optical Density
Ken Miyazawa, Takashi Umeyama, Yasutaka Hoshino, Keietsu Abe, Yoshitsugu Miyazaki, Slavena Vylkova, Xiaoxiao He, Takuji Oka
Microbiology Spectrum.2022;[Epub] CrossRef - Pharmacokinetic profile of sarcin and thionin from Aspergillus giganteus and in vitro validation against human fungal pathogen
Ramya Ravindhiran, Ramya Krishnamurthy, Karthiga Sivarajan, Jothi Nayaki Sekar, Kumarappan Chidambaram, Ali M Alqahtani, Kavitha Dhandapani
Bioscience Reports.2022;[Epub] CrossRef - Solid-state NMR analysis of unlabeled fungal cell walls from Aspergillus and Candida species
Liyanage D. Fernando, Malitha C. Dickwella Widanage, S. Chandra Shekar, Frederic Mentink-Vigier, Ping Wang, Sungsool Wi, Tuo Wang
Journal of Structural Biology: X.2022; 6: 100070. CrossRef - Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms
Sayema Rahman, Norman van Rhijn, Panagiotis Papastamoulis, Darren D. Thomson, Zorana Carter, Rachael Fortune-Grant, Magnus Rattray, Michael John Bromley, Elaine Bignell
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef - A 13C three-dimensional DQ-SQ-SQ correlation experiment for high-resolution analysis of complex carbohydrates using solid-state NMR
S. Chandra Shekar, Wancheng Zhao, Liyanage D. Fernando, Ivan Hung, Tuo Wang
Journal of Magnetic Resonance.2022; 336: 107148. CrossRef - MicroRNA regulation and host interaction in response to Aspergillus exposure
MANSI SHRIVASTAVA, DIKSHA PANDEY, POONAM SHARMA, RAMBIR SINGH
BIOCELL.2022; 46(2): 339. CrossRef - SfgA Renders Aspergillus flavus More Stable to the External Environment
Xiao-Yu Yuan, Jie-Ying Li, Qing-Qing Zhi, Sheng-Da Chi, Su Qu, Yan-Feng Luo, Zhu-Mei He
Journal of Fungi.2022; 8(6): 638. CrossRef - Online Biomass Monitoring Enables Characterization of the Growth Pattern of Aspergillus fumigatus in Liquid Shake Conditions
Ingo Bauer, Beate Abt, Annie Yap, Bernd Leuchtle, Hubertus Haas
Journal of Fungi.2022; 8(10): 1013. CrossRef - The putative polysaccharide synthase AfCps1 regulates Aspergillus fumigatus morphogenesis and conidia immune response in mouse bone marrow-derived macrophages
Sha Wang, Anjie Yuan, Liping Zeng, Sikai Hou, Meng Wang, Lei Li, Zhendong Cai, Guowei Zhong
Journal of Microbiology.2021; 59(1): 64. CrossRef - Unraveling the sugar code: the role of microbial extracellular glycans in plant–microbe interactions
Alan Wanke, Milena Malisic, Stephan Wawra, Alga Zuccaro, Andreas Weber
Journal of Experimental Botany.2021; 72(1): 15. CrossRef - Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence
Brandon S. Ross, Lotus A. Lofgren, Alix Ashare, Jason E. Stajich, Robert A. Cramer, J. Andrew Alspaugh
mBio.2021;[Epub] CrossRef - Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella
Sylwia Stączek, Agnieszka Zdybicka-Barabas, Iwona Wojda, Adrian Wiater, Paweł Mak, Piotr Suder, Krzysztof Skrzypiec, Małgorzata Cytryńska
Molecules.2021; 26(16): 5097. CrossRef - Genetic and structural validation of phosphomannomutase as a cell wall target in Aspergillus fumigatus
Yuanwei Zhang, Wenxia Fang, Olawale G. Raimi, Deborah E. A. Lockhart, Andrew T. Ferenbach, Ling Lu, Daan M. F. van Aalten
Molecular Microbiology.2021; 116(1): 245. CrossRef - The Influence of Anomeric Configuration and Aglycone Structure on the Outcome of Acid‐Promoted Ring Contraction in 2,3‐Di‐O‐Silylated S‐Galactopyranosides
Polina I. Abronina, Alexander I. Zinin, Nelly N. Malysheva, Maxim Y. Karpenko, Natalya G. Kolotyrkina, Leonid O. Kononov
ChemistrySelect.2021; 6(24): 6223. CrossRef - Effect of Carbohydrate Substrate from Starch-Containing Raw Materials on the Composition of Glucans in the Micromycete Aspergillus niger VKPM F-171 Biomass
N.Yu. Sharova, B.S. Manzhieva, A.A. Printseva, T.V. Vybornova, A.S. Miroshnik, I.V. Kruchina-Bogdanov, I.A. Orekhova
Biotekhnologiya.2020; 36(5): 41. CrossRef - Cell wall polysaccharides from pathogenic fungi for diagnosis of fungal infectious disease
Dandy Ahamefula Osibe, Shuhan Lei, Bin Wang, Cheng Jin, Wenxia Fang
Mycoses.2020; 63(7): 644. CrossRef - What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?
Isabelle Mouyna, Sarah Dellière, Anne Beauvais, Fabrice Gravelat, Brendan Snarr, Mélanie Lehoux, Caitlin Zacharias, Yan Sun, Steven de Jesus Carrion, Eric Pearlman, Donald C. Sheppard, Jean-Paul Latgé
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species
Rocio Garcia-Rubio, Haroldo C. de Oliveira, Johanna Rivera, Nuria Trevijano-Contador
Frontiers in Microbiology.2020;[Epub] CrossRef - Usefulness of serum galactomannan in initiating and modifying antifungal therapy in children with cancer and persistent high‐risk febrile neutropenia
Matías Delgado‐Araneda, Romina Valenzuela, Verónica de la Maza, Marcela Rabello, Ana M. Álvarez, Verónica Contardo, Marcela Zubieta, Valentina Gutierrez, Ximena Claverie, Juan P. Torres, Carmen Salgado, Juan Tordecilla, Mónica Varas, Carmen L. Avilés, Mar
Mycoses.2020; 63(8): 802. CrossRef - The mechanisms of hyphal pellet formation mediated by polysaccharides, α-1,3-glucan and galactosaminogalactan, in Aspergillus species
Ken Miyazawa, Akira Yoshimi, Keietsu Abe
Fungal Biology and Biotechnology.2020;[Epub] CrossRef - Dimethylformamide Inhibits Fungal Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus by Down-Regulating Glucose Metabolism and Amino Acid Biosynthesis
Lin Pan, Peng Chang, Jing Jin, Qingli Yang, Fuguo Xing
Toxins.2020; 12(11): 683. CrossRef - Overview of the Interplay Between Cell Wall Integrity Signaling Pathways and Membrane Lipid Biosynthesis in Fungi: Perspectives forAspergillus fumigatus
João Henrique T.M. Fabri, Marina C. Rocha, Iran Malavazi
Current Protein & Peptide Science.2020; 21(3): 265. CrossRef - The Myosin Motor Domain-Containing Chitin Synthases Are Involved in Cell Wall Integrity and Sensitivity to Antifungal Proteins in Penicillium digitatum
Mónica Gandía, Sandra Garrigues, Begoña Bolós, Paloma Manzanares, Jose F. Marcos
Frontiers in Microbiology.2019;[Epub] CrossRef - Cell surface display of proteins on filamentous fungi
Jesús Urbar-Ulloa, Paul Montaño-Silva, Ana Sofía Ramírez-Pelayo, Elisa Fernández-Castillo, Lorena Amaya-Delgado, Benjamín Rodríguez-Garay, Jorge Verdín
Applied Microbiology and Biotechnology.2019; 103(17): 6949. CrossRef - Transcriptomic Insights into Benzenamine Effects on the Development, Aflatoxin Biosynthesis, and Virulence of Aspergillus flavus
Mingguan Yang, Laifeng Lu, Shuhua Li, Jing Zhang, Zhenjing Li, Shufen Wu, Qingbin Guo, Huanhuan Liu, Changlu Wang
Toxins.2019; 11(2): 70. CrossRef - Both Galactosaminogalactan and α-1,3-Glucan Contribute to Aggregation of Aspergillus oryzae Hyphae in Liquid Culture
Ken Miyazawa, Akira Yoshimi, Motoaki Sano, Fuka Tabata, Asumi Sugahara, Shin Kasahara, Ami Koizumi, Shigekazu Yano, Tasuku Nakajima, Keietsu Abe
Frontiers in Microbiology.2019;[Epub] CrossRef - Aspergillus fumigatus Mnn9 is responsible for mannan synthesis and required for covalent linkage of mannoprotein to the cell wall
Ting Du, Haomiao Ouyang, Josef Voglmeir, Iain B.H. Wilson, Cheng Jin
Fungal Genetics and Biology.2019; 128: 20. CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species
M. F. Nogueira, L. Pereira, S. Jenull, K. Kuchler, T. Lion
Scientific Reports.2019;[Epub] CrossRef - Overexpression of Aspergillus nidulans α-1,3-glucan synthase increases cellular adhesion and causes cell wall defects
Xiaoxiao He, Shengnan Li, Susan G W Kaminskyj
Medical Mycology.2018; 56(5): 645. CrossRef - The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice
Jason R. Nesbitt, Elizabeth Y. Steves, Cole R. Schonhofer, Alissa Cait, Sukhbir S. Manku, Juliana H. F. Yeung, Andrew J. Bennet, Kelly M. McNagny, Jonathan C. Choy, Michael R. Hughes, Margo M. Moore
Frontiers in Microbiology.2018;[Epub] CrossRef -
Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in
Aspergillus fumigatus
Leandro José de Assis, Adriana Manfiolli, Eliciane Mattos, João H. T. Marilhano Fabri, Iran Malavazi, Ilse D. Jacobsen, Matthias Brock, Robert A. Cramer, Arsa Thammahong, Daisuke Hagiwara, Laure Nicolas Annick Ries, Gustavo Henrique Goldman, Reinhard Fisc
mBio.2018;[Epub] CrossRef - A Ring Contraction of 2,3-Di-O-Silylated Thiopyranosides To Give Thiofuranosides under Mildly Acidic Conditions
Polina I. Abronina, Nelly N. Malysheva, Veronika V. Litvinenko, Alexander I. Zinin, Natalya G. Kolotyrkina, Leonid O. Kononov
Organic Letters.2018; 20(19): 6051. CrossRef - Aspergillus-specific antibodies – Targets and applications
Max Schubert, Holger Spiegel, Stefan Schillberg, Greta Nölke
Biotechnology Advances.2018; 36(4): 1167. CrossRef - Molecular Mass and Localization of α-1,3-Glucan in Cell Wall Control the Degree of Hyphal Aggregation in Liquid Culture of Aspergillus nidulans
Ken Miyazawa, Akira Yoshimi, Shin Kasahara, Asumi Sugahara, Ami Koizumi, Shigekazu Yano, Satoshi Kimura, Tadahisa Iwata, Motoaki Sano, Keietsu Abe
Frontiers in Microbiology.2018;[Epub] CrossRef - Aspergillusin chronic lung disease: Modeling what goes on in the airways
Takahiro Takazono, Donald C. Sheppard
Medical Mycology.2017; 55(1): 39. CrossRef - Sporothrix schenckii sensu stricto and Sporothrix brasiliensis Are Differentially Recognized by Human Peripheral Blood Mononuclear Cells
José A. Martínez-Álvarez, Luis A. Pérez-García, Erika Mellado-Mojica, Mercedes G. López, Iván Martínez-Duncker, Leila M. Lópes-Bezerra, Héctor M. Mora-Montes
Frontiers in Microbiology.2017;[Epub] CrossRef - Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities
Tobias M. Hohl
Current Opinion in Infectious Diseases.2017; 30(4): 364. CrossRef - Host Soluble Mediators: Defying the Immunological Inertness of Aspergillus fumigatus Conidia
Sarah Sze Wah Wong, Vishukumar Aimanianda
Journal of Fungi.2017; 4(1): 3. CrossRef - Immune Recognition of Fungal Polysaccharides
Brendan Snarr, Salman Qureshi, Donald Sheppard
Journal of Fungi.2017; 3(3): 47. CrossRef - The Role of the Fungal Cell Wall in the Infection of Plants
Ivey Geoghegan, Gero Steinberg, Sarah Gurr
Trends in Microbiology.2017; 25(12): 957. CrossRef - Immunity against fungi
Michail S. Lionakis, Iliyan D. Iliev, Tobias M. Hohl
JCI Insight.2017;[Epub] CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Proteomic analysis of Aspergillus fumigatus – clinical implications
Nicola M. Moloney, Rebecca A. Owens, Sean Doyle
Expert Review of Proteomics.2016; 13(7): 635. CrossRef - How to invade a susceptible host: cellular aspects of aspergillosis
Sven Krappmann
Current Opinion in Microbiology.2016; 34: 136. CrossRef - The Use of Pyranoside-into-Furanoside Rearrangement and Controlled O(5) → O(6) Benzoyl Migration as the Basis of a Synthetic Strategy To Assemble (1→5)- and (1→6)-Linked Galactofuranosyl Chains
Dmitry A. Argunov, Vadim B. Krylov, Nikolay E. Nifantiev
Organic Letters.2016; 18(21): 5504. CrossRef
- REVIEW] The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance
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Neil A. Brown , Gustavo H. Goldman
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J. Microbiol. 2016;54(3):243-253. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5510-4
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Abstract
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Invasive aspergillosis has emerged as one of the most common
life-threatening fungal disease of humans. The emergence
of antifungal resistant pathogens represents a current
and increasing threat to society. In turn, new strategies to
combat fungal infection are urgently required. Fungal adaptations
to stresses experienced within the human host are a
prerequisite for the survival and virulence strategies of the
pathogen. Here, we review the latest information on the
signalling pathways in Aspergillus fumigatus that contribute
to stress adaptations and virulence, while highlighting their
potential as targets for the development of novel combinational
antifungal therapies.
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Citations
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- The Expanding Mycovirome of Aspergilli
Josephine L. Battersby, David A. Stevens, Robert H. A. Coutts, Vladimír Havlíček, Joe L. Hsu, Gabriele Sass, Ioly Kotta-Loizou
Journal of Fungi.2024; 10(8): 585. CrossRef - Synergistic effects of putative Ca2+-binding sites of calmodulin in fungal development, temperature stress and virulence ofAspergillus fumigatus
Xingyue Li, Ruoyun Feng, Pan Luo, Yuanwei Zhang, Ling Lu
Virulence.2024;[Epub] CrossRef - MicroRNA (miRNA) profiling of maize genotypes with differential response to Aspergillus flavus implies zma-miR156–squamosa promoter binding protein (SBP) and zma-miR398/zma-miR394–F -box combinations involved in resistance mechanisms
Prasad Gandham, Kanniah Rajasekaran, Christine Sickler, Harikrishnan Mohan, Matthew Gilbert, Niranjan Baisakh
Stress Biology.2024;[Epub] CrossRef -
Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus
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Ye-Eun Son, Jiwoo Han, Kyung-Tae Lee, Hee-Soo Park
Mycology.2024; 15(2): 238. CrossRef - The Oxidative Stress Response Highly Depends on Glucose and Iron Availability in Aspergillus fumigatus
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Journal of Fungi.2024; 10(3): 221. CrossRef - Response of Fusarium oxysporum soil isolate to amphotericin B and fluconazole at the proteomic level
I. V. da S. Amatto, F. A. de O. Simões, N. G. da R. Garzon, C. L. Marciano, R. R. da Silva, H. Cabral
Brazilian Journal of Microbiology.2024; 55(3): 2557. CrossRef - tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus
Alexander Bruch, Valentina Lazarova, Maximilian Berg, Thomas Krüger, Sascha Schäuble, Abdulrahman A Kelani, Birte Mertens, Pamela Lehenberger, Olaf Kniemeyer, Stefanie Kaiser, Gianni Panagiotou, Fabio Gsaller, Matthew G Blango
Nucleic Acids Research.2024;[Epub] CrossRef - A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Thaila Fernanda dos Reis, Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F. N. Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S. Ibrahim, Hyunil Jo, Jorge D. Lightfoot, Emily
Nature Communications.2023;[Epub] CrossRef -
Pathogenicity and virulence of
Aspergillus fumigatus
Kayleigh Earle, Clara Valero, Daniel P. Conn, George Vere, Peter C. Cook, Michael J. Bromley, Paul Bowyer, Sara Gago
Virulence.2023;[Epub] CrossRef - Putative Core Transcription Factors Affecting Virulence in Aspergillus flavus during Infection of Maize
Matthew K. Gilbert, Brian M. Mack, Matthew D. Lebar, Perng-Kuang Chang, Stephanie R. Gross, Rebecca R. Sweany, Jeffrey W. Cary, Kanniah Rajasekaran
Journal of Fungi.2023; 9(1): 118. CrossRef - Fungi’s Swiss Army Knife: Pleiotropic Effect of Melanin in Fungal Pathogenesis during Cattle Mycosis
Víctor Romero, Carolina Kalinhoff, Luis Rodrigo Saa, Aminael Sánchez
Journal of Fungi.2023; 9(9): 929. CrossRef - Afu-Emi1 Contributes to Stress Adaptation and Voriconazole Susceptibility in Aspergillus fumigatus
Jufang Tan, Heng Zhang, Yi Sun, Lujuan Gao, Cezar M. Khursigara
Microbiology Spectrum.2023;[Epub] CrossRef - COVID-19-Associated Pulmonary Aspergillosis Isolates Are Genomically Diverse but Similar to Each Other in Their Responses to Infection-Relevant Stresses
Matthew E. Mead, Patrícia Alves de Castro, Jacob L. Steenwyk, Jean-Pierre Gangneux, Martin Hoenigl, Juergen Prattes, Riina Rautemaa-Richardson, Hélène Guegan, Caroline B. Moore, Cornelia Lass-Flörl, Florian Reizine, Clara Valero, Norman Van Rhijn, Michael
Microbiology Spectrum.2023;[Epub] CrossRef - Host-derived reactive oxygen species trigger activation of the Candida albicans transcription regulator Rtg1/3
Mazen Oneissi, Melissa R. Cruz, Bernardo Ramírez-Zavala, Elena Lindemann-Perez, Joachim Morschhäuser, Danielle A. Garsin, J. Christian Perez, Aaron P. Mitchell
PLOS Pathogens.2023; 19(9): e1011692. CrossRef - The high osmolarity glycerol (HOG) pathway in fungi†
Hajar Yaakoub, Norma Silvia Sanchez, Laura Ongay-Larios, Vincent Courdavault, Alphonse Calenda, Jean-Philippe Bouchara, Roberto Coria, Nicolas Papon
Critical Reviews in Microbiology.2022; 48(6): 657. CrossRef - Stress Responses Elicited by Glucose Withdrawal in Aspergillus fumigatus
Tamás Emri, Károly Antal, Barnabás Gila, Andrea P. Jónás, István Pócsi
Journal of Fungi.2022; 8(11): 1226. CrossRef - PHYTONICIDIC PROPERTIES OF PLANTS REGARDING FUNGI OF THE ASPERGILLUS GENUS
A. Karasenko, S. Peredera
Sučasne ptahìvnictvo.2022;[Epub] CrossRef - Strategies Shaping the Transcription of Carbohydrate-Active Enzyme Genes in Aspergillus nidulans
Barnabás Cs. Gila, Károly Antal, Zsuzsanna Birkó, Judit Sz. Keserű, István Pócsi, Tamás Emri
Journal of Fungi.2022; 8(1): 79. CrossRef - An evolutionary genomic approach reveals both conserved and species-specific genetic elements related to human disease in closely related Aspergillus fungi
Matthew E Mead, Jacob L Steenwyk, Lilian P Silva, Patrícia A de Castro, Nauman Saeed, Falk Hillmann, Gustavo H Goldman, Antonis Rokas, A Mitchell
Genetics.2021;[Epub] CrossRef - Flavonoids Modulate the Accumulation of Toxins From Aspergillus flavus in Maize Kernels
Lina Castano-Duque, Matthew K. Gilbert, Brian M. Mack, Matthew D. Lebar, Carol H. Carter-Wientjes, Christine M. Sickler, Jeffrey W. Cary, Kanniah Rajasekaran
Frontiers in Plant Science.2021;[Epub] CrossRef - Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus
Patrícia Alves de Castro, Clara Valero, Jéssica Chiaratto, Ana Cristina Colabardini, Lakhansing Pardeshi, Lilian Pereira Silva, Fausto Almeida, Marina Campos Rocha, Roberto Nascimento Silva, Iran Malavazi, Wenyue Du, Paul S. Dyer, Matthias Brock, Flávio V
mBio.2021;[Epub] CrossRef - Fungal G-Protein-Coupled Receptors: A Promising Mediator of the Impact of Extracellular Signals on Biosynthesis of Ochratoxin A
Jing Gao, Xinge Xu, Kunlun Huang, Zhihong Liang
Frontiers in Microbiology.2021;[Epub] CrossRef - The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target
Jasmin Binder, Yana Shadkchan, Nir Osherov, Sven Krappmann
Frontiers in Microbiology.2020;[Epub] CrossRef - Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources
Lilian Pereira Silva, Dean Frawley, Leandro José de Assis, Ciara Tierney, Alastair B. Fleming, Ozgur Bayram, Gustavo Henrique Goldman, Aaron P. Mitchell
mSphere.2020;[Epub] CrossRef - Evolving moldy murderers: Aspergillus section Fumigati as a model for studying the repeated evolution of fungal pathogenicity
Antonis Rokas, Matthew E. Mead, Jacob L. Steenwyk, Nicholas H. Oberlies, Gustavo H. Goldman, Donald C. Sheppard
PLOS Pathogens.2020; 16(2): e1008315. CrossRef - Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence
Aílton Pereira da Costa Filho, Guilherme Thomaz Pereira Brancini, Patrícia Alves de Castro, Clara Valero, Jaire Alves Ferreira Filho, Lilian Pereira Silva, Marina Campos Rocha, Iran Malavazi, João Guilherme de Moraes Pontes, Taícia Fill, Roberto Nasciment
mBio.2020;[Epub] CrossRef - Phenotypic plasticity and the evolution of azole resistance in Aspergillus fumigatus; an expression profile of clinical isolates upon exposure to itraconazole
Margriet W. J. Hokken, Jan Zoll, Jordy P. M. Coolen, Bas J. Zwaan, Paul E. Verweij, Willem J. G. Melchers
BMC Genomics.2019;[Epub] CrossRef - Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance
Patrícia Alves de Castro, Ana Cristina Colabardini, Adriana Oliveira Manfiolli, Jéssica Chiaratto, Lilian Pereira Silva, Eliciane Cevolani Mattos, Giuseppe Palmisano, Fausto Almeida, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Laura Mellado, Mari
PLOS Genetics.2019; 15(12): e1008551. CrossRef - How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts
Steven T. Denham, Morgan A. Wambaugh, Jessica C.S. Brown
Journal of Molecular Biology.2019; 431(16): 2982. CrossRef - Aspergillus fumigatus High Osmolarity Glycerol Mitogen Activated Protein Kinases SakA and MpkC Physically Interact During Osmotic and Cell Wall Stresses
Adriana Oliveira Manfiolli, Eliciane Cevolani Mattos, Leandro José de Assis, Lilian Pereira Silva, Mevlüt Ulaş, Neil Andrew Brown, Rafael Silva-Rocha, Özgür Bayram, Gustavo H. Goldman
Frontiers in Microbiology.2019;[Epub] CrossRef -
Characterizing the Pathogenic, Genomic, and Chemical Traits of
Aspergillus fischeri
, a Close Relative of the Major Human Fungal Pathogen
Aspergillus fumigatus
Matthew E. Mead, Sonja L. Knowles, Huzefa A. Raja, Sarah R. Beattie, Caitlin H. Kowalski, Jacob L. Steenwyk, Lilian P. Silva, Jessica Chiaratto, Laure N. A. Ries, Gustavo H. Goldman, Robert A. Cramer, Nicholas H. Oberlies, Antonis Rokas, Aaron P. Mitchell
mSphere.2019;[Epub] CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis
Hazal Boral, Banu Metin, Aylin Döğen, Seyedmojtaba Seyedmousavi, Macit Ilkit
Fungal Genetics and Biology.2018; 111: 92. CrossRef - Heavy Metal-Induced Expression of PcaA Provides Cadmium Tolerance to Aspergillus fumigatus and Supports Its Virulence in the Galleria mellonella Model
Fruzsina Bakti, Christoph Sasse, Thorsten Heinekamp, István Pócsi, Gerhard H. Braus
Frontiers in Microbiology.2018;[Epub] CrossRef - Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus
Chi Zhang, Xiuhua Meng, Huiyu Gu, Zhihua Ma, Ling Lu
G3 Genes|Genomes|Genetics.2018; 8(7): 2291. CrossRef - Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates
Daisuke Hagiwara, Hiroki Takahashi, Hiroshi Takagi, Akira Watanabe, Katsuhiko Kamei
Medical Mycology Journal.2018; 59(4): E63. CrossRef - Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion
Vivien Kurucz, Thomas Krüger, Károly Antal, Anna-Maria Dietl, Hubertus Haas, István Pócsi, Olaf Kniemeyer, Tamás Emri
BMC Genomics.2018;[Epub] CrossRef - Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control
Neil Andrew Brown, Sanne Schrevens, Patrick van Dijck, Gustavo Henrique Goldman
Nature Microbiology.2018; 3(4): 402. CrossRef - Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion
Alex Hopke, Alistair J.P. Brown, Rebecca A. Hall, Robert T. Wheeler
Trends in Microbiology.2018; 26(4): 284. CrossRef - A cytosine methyltransferase ortholog dmtA is involved in the sensitivity of Aspergillus flavus to environmental stresses
Qing-Qing Zhi, Jie-Ying Li, Qiu-Yun Liu, Zhu-Mei He
Fungal Biology.2017; 121(5): 501. CrossRef - Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia
Hiroki Takahashi, Yoko Kusuya, Daisuke Hagiwara, Azusa Takahashi-Nakaguchi, Kanae Sakai, Tohru Gonoi
BMC Genomics.2017;[Epub] CrossRef - The putative flavin carrier family FlcA-C is important forAspergillus fumigatusvirulence
Patrícia A. de Castro, Jéssica Chiaratto, Enyara Rezende Morais, Thaila Fernanda dos Reis, Thomas K. Mitchell, Neil A. Brown, Gustavo H. Goldman
Virulence.2017; 8(6): 797. CrossRef - Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks inAspergillus nidulans
Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri
International Journal of Genomics.2017; 2017: 1. CrossRef - Genome-wide transcriptome analysis ofAspergillus fumigatusexposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1and MpkC dependent
Lilian Pereira Silva, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Mario Henrique Paziani, Márcia Regina Von Zeska Kress, Diego M. Riaño-Pachón, Daisuke Hagiwara, Laure N. A. Ries, Neil Andrew Brown, Gustavo H. Goldman
Cellular Microbiology.2017; 19(4): e12681. CrossRef - Aspergillus fumigatus morphology and dynamic host interactions
Frank L. van de Veerdonk, Mark S. Gresnigt, Luigina Romani, Mihai G. Netea, Jean-Paul Latgé
Nature Reviews Microbiology.2017; 15(11): 661. CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Mitogen activated protein kinases SakAHOG1 and MpkC collaborate for Aspergillus fumigatus virulence
Ariane Cristina Mendes de Oliveira Bruder Nascimento, Thaila Fernanda dos Reis, Patrícia Alves de Castro, Juliana I. Hori, Vinícius Leite Pedro Bom, Leandro José de Assis, Leandra Naira Zambelli Ramalho, Marina Campos Rocha, Iran Malavazi, Neil Andrew Bro
Molecular Microbiology.2016; 100(5): 841. CrossRef - Proteomic analysis of Aspergillus fumigatus – clinical implications
Nicola M. Moloney, Rebecca A. Owens, Sean Doyle
Expert Review of Proteomics.2016; 13(7): 635. CrossRef - Aspergillus fumigatusMADS-Box Transcription FactorrlmAIs Required for Regulation of the Cell Wall Integrity and Virulence
Marina Campos Rocha, João Henrique Tadini Marilhano Fabri, Krissia Franco de Godoy, Patrícia Alves de Castro, Juliana Issa Hori, Anderson Ferreira da Cunha, Mark Arentshorst, Arthur F J Ram, Cees A M J J van den Hondel, Gustavo Henrique Goldman, Iran Mala
G3 Genes|Genomes|Genetics.2016; 6(9): 2983. CrossRef - Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pedro Pais, Catarina Costa, Mafalda Cavalheiro, Daniela Romão, Miguel C. Teixeira
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef - How to invade a susceptible host: cellular aspects of aspergillosis
Sven Krappmann
Current Opinion in Microbiology.2016; 34: 136. CrossRef - Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi
Daisuke Hagiwara, Akira Watanabe, Katsuhiko Kamei, Gustavo H. Goldman
Frontiers in Microbiology.2016;[Epub] CrossRef - Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies
Nadia Al-Bader, Donald C. Sheppard
Virulence.2016; 7(8): 950. CrossRef
- REVIEW] Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity
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Gregory J. Fischer , Nancy P. Keller
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J. Microbiol. 2016;54(3):254-264. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5620-z
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Abstract
-
Oxylipins are a class of molecules derived from the incorporation
of oxygen into polyunsaturated fatty acid substrates
through the action of oxygenases. While extensively investigated
in the context of mammalian immune responses, over
the last decade it has become apparent that oxylipins are a
common means of communication among and between plants,
animals, and fungi to control development and alter hostmicrobe
interactions. In fungi, some oxylipins are derived nonenzymatically
while others are produced by lipoxygenases,
cyclooxygenases, and monooxygenases with homology to
plant and human enzymes. Recent investigations of numerous
plant and human fungal pathogens have revealed oxylipins
to be involved in the establishment and progression of disease.
This review highlights oxylipin production by pathogenic
fungi and their role in fungal development and pathogen/
host interactions.
-
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Leidy Esther Sánchez-Rey, Nubia Moreno-Sarmiento, Erika Paola Grijalba-Bernal, Ginna Quiroga-Cubides
Fungal Biology.2024; 128(4): 1827. CrossRef - The gut-lung axis: the impact of the gut mycobiome on pulmonary diseases and infections
Emily A Sey, Adilia Warris
Oxford Open Immunology.2024;[Epub] CrossRef - The volatile components from Bacillus cereus N4 can restrain brown rot of peach fruit by inhibiting sporulation of Monilinia fructicola and inducing disease resistance
Yingying Shi, Song Zhang, Jinghan Zhang, Xiaorui Wang, Yuan He, Xiongde Han, Zunyang Song, Jingying Shi
Postharvest Biology and Technology.2024; 210: 112755. CrossRef - Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot mess driving immunopathology
Kar On Cheng, Dolly E Montaño, Teresa Zelante, Axel Dietschmann, Mark S Gresnigt
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Priya Ramasamy, Balachandar Subbu, Prabhakaran Narayanasamy
Asian Journal of Biological Sciences.2023; 16(3): 202. CrossRef - Mutational Analysis of Aspergillus fumigatus Volatile Oxylipins in a Drosophila Eclosion Assay
Hadeel S. Almaliki, Mengyao Niu, Nancy P. Keller, Guohua Yin, Joan W. Bennett
Journal of Fungi.2023; 9(4): 402. CrossRef - Plant Host Traits Mediated by Foliar Fungal Symbionts and Secondary Metabolites
Moriah Sandy, Tina I. Bui, Kenia Segura Abá, Nestor Ruiz, John Paszalek, Elise W. Connor, Christine V. Hawkes
Microbial Ecology.2023; 86(1): 408. CrossRef - Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen
Yi Ding, Donald M. Gardiner, Kemal Kazan
Microbiological Research.2022; 256: 126951. CrossRef - Phenotypic plasticity of Monilinia spp. in response to light wavelengths: From in vitro development to virulence on nectarines
Lucía Verde-Yáñez, Núria Vall-llaura, Josep Usall, Neus Teixidó, Rosario Torres
International Journal of Food Microbiology.2022; 373: 109700. CrossRef - Light and mycelial injury influences the volatile and non-volatile metabolites and the biocontrol properties of Trichoderma atroviride
Hexon Angel Contreras-Cornejo, Omar Orozco-Granados, Arturo Ramírez-Ordorica, Perla García-Juárez, José López-Bucio, Lourdes Macías-Rodríguez
Rhizosphere.2022; 22: 100511. CrossRef - Editorial: Lipid metabolism and membrane structure in plant biotic interactions
Fiona L. Goggin, Jyoti Shah, Glenda Gillaspy
Frontiers in Plant Science.2022;[Epub] CrossRef - Biotic stress caused by in vitro co-inoculation enhances the expression of acetylcholinesterase inhibitors by fungi
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Natural Product Research.2022; 36(16): 4266. CrossRef - Towards understanding of fungal biocontrol mechanisms of different yeasts antagonistic to Botrytis cinerea through exometabolomic analysis
Alicia Fernandez-San Millan, Jordi Gamir, Luis Larraya, Inmaculada Farran, Jon Veramendi
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Giuseppe Ianiri, Salomé LeibundGut-Landmann, Thomas L. Dawson
Annual Review of Microbiology.2022; 76(1): 757. CrossRef - Bacterial lipoxygenases: Biochemical characteristics, molecular structure and potential applications
Ruth Chrisnasari, Marie Hennebelle, Jean-Paul Vincken, Willem J.H. van Berkel, Tom A. Ewing
Biotechnology Advances.2022; 61: 108046. CrossRef - Mechanisms of Plant Natural Immunity and the Role of Selected Oxylipins as Molecular Mediators in Plant Protection
Piotr Barbaś, Dominika Skiba, Piotr Pszczółkowski, Barbara Sawicka
Agronomy.2022; 12(11): 2619. CrossRef - Iron and manganese lipoxygenases of plant pathogenic fungi and their role in biosynthesis of jasmonates
Ernst H. Oliw
Archives of Biochemistry and Biophysics.2022; 722: 109169. CrossRef - Eight-carbon volatiles: prominent fungal and plant interaction compounds
Kayla K Pennerman, Guohua Yin, Joan W Bennett, Maaria Rosenkranz
Journal of Experimental Botany.2022; 73(2): 487. CrossRef - Unfolded Protein Response and Scaffold Independent Pheromone MAP Kinase Signaling Control Verticillium dahliae Growth, Development, and Plant Pathogenesis
Jessica Starke, Rebekka Harting, Isabel Maurus, Miriam Leonard, Rica Bremenkamp, Kai Heimel, James W. Kronstad, Gerhard H. Braus
Journal of Fungi.2021; 7(4): 305. CrossRef - WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
Ernst H. Oliw
Fungal Genetics and Biology.2021; : 103603. CrossRef - FgPKS7 is an essential player in mating‐type‐mediated regulatory pathway required for completing sexual cycle in Fusarium graminearum
Da‐Woon Kim, Yoo‐Kyoung Shin, Sang‐Won Lee, Kanphassorn Wimonmuang, Kyo Bin Kang, Young‐Sang Lee, Sung‐Hwan Yun
Environmental Microbiology.2021; 23(4): 1972. CrossRef - Dietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits
Bharat Kapoor, Dhriti Kapoor, Shristy Gautam, Rahul Singh, Savita Bhardwaj
Current Nutrition Reports.2021; 10(3): 232. CrossRef - Molecular insights into lipoxygenases for biocatalytic synthesis of diverse lipid mediators
Jung-Ung An, Seong-Eun Kim, Deok-Kun Oh
Progress in Lipid Research.2021; 83: 101110. CrossRef - Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic
Timothy C. Cairns, Xiaomei Zheng, Ping Zheng, Jibin Sun, Vera Meyer
Journal of Fungi.2021; 7(7): 535. CrossRef - Emission of novel volatile biomarkers for wheat powdery mildew
Kamirán Áron Hamow, Zsuzsanna Ambrózy, Katalin Puskás, Imre Majláth, Mónika Cséplő, Réka Mátyus, Katalin Posta, Péter Lukács, László Sági
Science of The Total Environment.2021; 781: 146767. CrossRef - Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens
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Fungal Genetics and Biology.2021; 157: 103623. CrossRef - Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review
Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin
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Physiological and Molecular Plant Pathology.2020; 109: 101444. CrossRef - Molecular crosstalk between the endophyte Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum – Modulation of lipoxygenase activity and beauvericin production during the interaction
Margot Bärenstrauch, Stéphane Mann, Chloé Jacquemin, Sarra Bibi, Oum-Kalthoum Sylla, Emmanuel Baudouin, Didier Buisson, Soizic Prado, Caroline Kunz
Fungal Genetics and Biology.2020; 139: 103383. CrossRef - Fungal evolution: cellular, genomic and metabolic complexity
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Biological Reviews.2020; 95(5): 1198. CrossRef - Plant Antifungal Lectins: Mechanism of Action and Targets on Human Pathogenic Fungi
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Current Protein & Peptide Science.2020; 21(3): 284. CrossRef - Critical thresholds of 1-Octen-3-ol shape inter-species Aspergillus interactions modulating the growth and secondary metabolism
Digar Singh, Su Young Son, Choong Hwan Lee
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Marine Drugs.2020; 18(8): 379. CrossRef - Understanding Host–Pathogen Interactions in Brassica napus in the Omics Era
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Plants.2020; 9(10): 1336. CrossRef - The novel bZIP transcription factor Fpo1 negatively regulates perithecial development by modulating carbon metabolism in the ascomycete fungus Fusarium graminearum
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Environmental Microbiology.2020; 22(7): 2596. CrossRef - Co‐opting oxylipin signals in microbial disease
Mengyao Niu, Nancy P. Keller
Cellular Microbiology.2019; 21(6): e13025. CrossRef - Fathoming Aspergillus oryzae metabolomes in formulated growth matrices
Digar Singh, Sunmin Lee, Choong Hwan Lee
Critical Reviews in Biotechnology.2019; 39(1): 35. CrossRef - Metabolomic variation in wild and cultured cordyceps and mycelia of Isaria cicadae
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Biomedical Chromatography.2019;[Epub] CrossRef - An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere
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Protein Science.2019; 28(5): 920. CrossRef - Differential expression analysis of Trichoderma virens RNA reveals a dynamic transcriptome during colonization of Zea mays roots
Elizabeth A. Malinich, Ken Wang, Prasun K. Mukherjee, Michael Kolomiets, Charles M. Kenerley
BMC Genomics.2019;[Epub] CrossRef - Carbohydrate, glutathione, and polyamine metabolism are central to Aspergillus flavus oxidative stress responses over time
Jake C. Fountain, Liming Yang, Manish K. Pandey, Prasad Bajaj, Danny Alexander, Sixue Chen, Robert C. Kemerait, Rajeev K. Varshney, Baozhu Guo
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Current Genetics.2019; 65(3): 759. CrossRef - Recombinant Lipoxygenases and Hydroperoxide Lyases for the Synthesis of Green Leaf Volatiles
Holly Stolterfoht, Claudia Rinnofner, Margit Winkler, Harald Pichler
Journal of Agricultural and Food Chemistry.2019; 67(49): 13367. CrossRef - Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus
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Plant Biotechnology Journal.2018; 16(9): 1616. CrossRef - Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum
Jiyoung Shin, Jung-Eun Kim, Yin-Won Lee, Hokyoung Son
Toxins.2018; 10(3): 112. CrossRef - De novo assembly and comparative transcriptome analysis of Monilinia fructicola, Monilinia laxa and Monilinia fructigena, the causal agents of brown rot on stone fruits
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BMC Genomics.2018;[Epub] CrossRef - Root Exudates of Stressed Plants Stimulate and AttractTrichodermaSoil Fungi
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Molecular Plant-Microbe Interactions®.2018; 31(10): 982. CrossRef - Comprehensive Secondary Metabolite Profiling Toward Delineating the Solid and Submerged-State Fermentation of Aspergillus oryzae KCCM 12698
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Biochimica et Biophysica Acta (BBA) - General Subjects.2018; 1862(10): 2174. CrossRef - Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures
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Microbiology and Molecular Biology Reviews.2018;[Epub] CrossRef - Eicosanoid biosynthesis influences the virulence of Candida parapsilosis
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Virulence.2018; 9(1): 1019. CrossRef - Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus
Gregory J. Fischer, William Bacon, Jun Yang, Jonathan M. Palmer, Taylor Dagenais, Bruce D. Hammock, Nancy P. Keller
Frontiers in Microbiology.2017;[Epub] CrossRef - Oxylipins and oxylipin synthesis pathways in fungi
N. N. Gessler, S. Yu. Filippovich, G. P. Bachurina, E. A. Kharchenko, N. V. Groza, T. A. Belozerskaya
Applied Biochemistry and Microbiology.2017; 53(6): 628. CrossRef - Fungal manipulation of hormone-regulated plant defense
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PLOS Pathogens.2017; 13(6): e1006334. CrossRef - Functional characterization of cytochrome P450 monooxygenases in the cereal head blight fungus Fusarium graminearum
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Environmental Microbiology.2017; 19(5): 2053. CrossRef - Human fungal pathogens: Why should we learn?
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Journal of Microbiology.2016; 54(3): 145. CrossRef - Secondary metabolism in Trichoderma – Chemistry meets genomics
Susanne Zeilinger, Sabine Gruber, Ravindra Bansal, Prasun K. Mukherjee
Fungal Biology Reviews.2016; 30(2): 74. CrossRef
- REVIEW] Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis
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Jon P. Woods
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J. Microbiol. 2016;54(3):265-276. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-6044-5
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Abstract
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Histoplasma capsulatum is a dimorphic pathogenic fungus
and causative agent of histoplasmosis, which is a respiratory
and systemic infection that is particularly severe in immunocompromised
hosts and represents the fungal homolog of
tuberculosis. In highly endemic regions, the majority of individuals
have been infected and carry the organism in a persistent
latent form that is a danger for reactivation if host
defenses are suppressed. H. capsulatum has been a model
organism for intracellular pathogenesis and fungal morphogenesis
for decades. New genomic information and application
of approaches for molecular genetic manipulation are
shedding new light on virulence mechanisms.
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- Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report
Ruth C. Angrand, Lauren Telesca, Muhammad Aslam
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Houari Aissaoui, Morgane Bourne-Watrin, Benoit Lemarie, Genevieve Guillot, Alolia Aboikoni, Piseth Chhorn, Dana Gaudard, Ghazi Hadj-Amara, Ricardo Manasse, Mahamado Ouedraogo, Charles Salloum, Magalie Demar, Loïc Epelboin, Hatem Kallel, Antoine Adenis, Ma
Journal of Fungi.2024; 10(6): 400. CrossRef - “We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes
Johannes Sonnberger, Lydia Kasper, Theresa Lange, Sascha Brunke, Bernhard Hube
Molecular Microbiology.2024; 121(3): 341. CrossRef - The influence of a copper efflux pump in Histoplasma capsulatum virulence
Dayane Moraes, Gabriel Brum Tristão, Chad A. Rappleye, Stephanie C. Ray, Fátima Ribeiro‐Dias, Rodrigo Saar Gomes, Leandro do Prado Assunção, Juliano Domiraci Paccez, Rosely Maria Zancopé‐Oliveira, Mirelle Garcia Silva‐Bailão, Célia Maria de Almeida Soares
The FEBS Journal.2024; 291(4): 744. CrossRef - Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis
Anastasia Wasylyshyn, Gina Maki, Kathleen A. Linder, Erica S. Herc
Infectious Diseases in Clinical Practice.2022;[Epub] CrossRef - Important Mycoses of Wildlife: Emphasis on Etiology, Epidemiology, Diagnosis, and Pathology—A Review: PART 1
Iniobong Chukwuebuka Ikenna Ugochukwu, Chioma Inyang Aneke, Nuhu Abdulazeez Sani, Jacinta Ngozi Omeke, Madubuike Umunna Anyanwu, Amienwanlen Eugene Odigie, Remigius Ibe Onoja, Ohiemi Benjamin Ocheja, Miracle Oluchukwu Ugochukwu, Iasmina Luca, Olabisi Amin
Animals.2022; 12(15): 1874. CrossRef - Key thermally dimorphic fungal pathogens: shaping host immunity
Maxine A. Höft, Lucian Duvenage, J. Claire Hoving
Open Biology.2022;[Epub] CrossRef - Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages
Allison Cohen, Edwin E. Jeng, Mark Voorhies, Jane Symington, Nebat Ali, Rosa A. Rodriguez, Michael C. Bassik, Anita Sil, Alex Andrianopoulos
PLOS Pathogens.2022; 18(9): e1010237. CrossRef - Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis
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PLOS Pathogens.2022; 18(6): e1010417. CrossRef - Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis
Alfredo G. Puing, Shyam S. Raghavan, Maria A. Aleshin, Dora Y. Ho
Medical Mycology Case Reports.2021; 33: 18. CrossRef - Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella
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Molecules.2021; 26(16): 5097. CrossRef - Comparative Proteomic Analysis of Histoplasma capsulatum Yeast and Mycelium Reveals Differential Metabolic Shifts and Cell Wall Remodeling Processes in the Different Morphotypes
Marcos Abreu Almeida, Lilian Cristiane Baeza, Rodrigo Almeida-Paes, Alexandre Melo Bailão, Clayton Luiz Borges, Allan Jefferson Guimarães, Célia Maria Almeida Soares, Rosely Maria Zancopé-Oliveira
Frontiers in Microbiology.2021;[Epub] CrossRef - Neutrophil and Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi
Juliana da Costa Silva, Glaucia de Azevedo Thompson-Souza, Marina Valente Barroso, Josiane Sabbadini Neves, Rodrigo Tinoco Figueiredo
Frontiers in Microbiology.2021;[Epub] CrossRef - Aspergillus niger α-1,3-glucan acts as a virulence factor by inhibiting the insect phenoloxidase system
Sylwia Stączek, Agnieszka Zdybicka-Barabas, Małgorzata Pleszczyńska, Adrian Wiater, Małgorzata Cytryńska
Journal of Invertebrate Pathology.2020; 171: 107341. CrossRef - Fungal Pathogens: Shape-Shifting Invaders
Kyunghun Min, Aaron M. Neiman, James B. Konopka
Trends in Microbiology.2020; 28(11): 922. CrossRef - Crohn's disease or histoplasmosis? A case of severe disseminated histoplasmosis mimicking Crohn's disease and literature review
Ahmed Ahmed, Nora Homsi, Rajendra Kapila
Medical Mycology Case Reports.2020; 30: 8. CrossRef - Capacity ofHistoplasma capsulatumto Survive the Composting Process
Luisa Fernanda Gómez Londoño, Laura Carolina Pérez León, Juan Guillermo McEwen Ochoa, Alejandra Zuluaga Rodriguez, Carlos Alberto Peláez Jaramillo, Jose Miguel Acevedo Ruiz, María Lucia Taylor, Myrtha Arango Arteaga, María del Pilar Jiménez Alzate
Applied and Environmental Soil Science.2019; 2019: 1. CrossRef - Sensing the heat and the host: Virulence determinants ofHistoplasma capsulatum
Sinem Beyhan, Anita Sil
Virulence.2019; 10(1): 793. CrossRef - Fungal Extracellular Vesicles as Potential Targets for Immune Interventions
Mateus Silveira Freitas, Vânia Luiza Deperon Bonato, Andre Moreira Pessoni, Marcio L. Rodrigues, Arturo Casadevall, Fausto Almeida, Aaron P. Mitchell
mSphere.2019;[Epub] CrossRef - Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents.
Leila M Lopes-Bezerra, Hector M Mora-Montes, Yu Zhang, Gustavo Nino-Vega, Anderson Messias Rodrigues, Zoilo Pires de Camargo, Sybren de Hoog
Medical Mycology.2018; 56(suppl_1): S126. CrossRef - Reactivation of dormant/latent fungal infection
Kevin Brunet, Alexandre Alanio, Olivier Lortholary, Blandine Rammaert
Journal of Infection.2018; 77(6): 463. CrossRef - Disseminated histoplasmosis mimicking relapsed chronic lymphocytic leukaemia
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BMJ Case Reports.2018; : bcr-2018-224498. CrossRef - The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum
Bevin C. English, Nancy Van Prooyen, Tiit Örd, Tõnis Örd, Anita Sil, Robert A. Cramer
PLOS Pathogens.2017; 13(9): e1006589. CrossRef - Histoplasmosis hepatitis after orthotopic liver transplantation
Laura Washburn, N Thao Galván, Sadhna Dhingra, Abbas Rana, John A Goss
Journal of Surgical Case Reports.2017;[Epub] CrossRef - Fungal infections in HIV/AIDS
Andrew H Limper, Antoine Adenis, Thuy Le, Thomas S Harrison
The Lancet Infectious Diseases.2017; 17(11): e334. CrossRef - Use of Fungal Diagnostics and Therapy in Pediatric Cancer Patients in Resource-Limited Settings
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Current Clinical Microbiology Reports.2016; 3(3): 120. CrossRef - Human fungal pathogens: Why should we learn?
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