- Volume 54(3); March 2016
- 
				    
Research Support, Non-U.S. Gov't
	
	
				- EDITORIAL] Human fungal pathogens: Why should we learn?
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		Jeong-Yoon Kim 		
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			J. Microbiol. 2016;54(3):145-148. 		
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							DOI: https://doi.org/10.1007/s12275-016-0647-8
					
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						 Abstract Abstract PDF PDF
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		Human fungal pathogens that cause invasive infections are
hidden killers, taking lives of one and a half million people
every year. However, research progress in this field has not
been rapid enough to effectively prevent or treat life-threatening
fungal diseases. To update recent research progress
and promote more active research in the field of human fungal
pathogens, eleven review articles concerning the virulence
mechanisms and host interactions of four major human fungal
pathogens–Candida albicans, Cryptococcus neoformans,
Aspergillus fumigatus, and Histoplasma capsulatum–are
presented in this special issue.	
		
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			Citations Citations to this article as recorded by    
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 Ariane Pinheiro Cruz Bergamini, Brendo Victor Siqueira de Almeida Bergamini, Iana Soares Pessoa, Thiago Antônio de Sousa Cutrim, Tamires Cruz dos Santos, Matheus Campos dos Santos, Victor da Rocha Fonseca, Wanderson Romão, Rodrigo Scherer, Denise Coutinho
 Brazilian Journal of Microbiology.2025; 56(1): 251.     CrossRef
- The unfolded protein response is a potential therapeutic target in pathogenic fungi
 Hao Zhou, Jinping Zhang, Rong Wang, Ju Huang, Caiyan Xin, Zhangyong Song
 The FEBS Journal.2025; 292(19): 5008.     CrossRef
- Formulation Optimization and Characterization of Bifonazole-Loaded Transethosomal Gel by 32 Factorial Design for the Treatment of Topical Fungal Infection
 Umeshkumar Dinesh Patel, Vinayak Shivamurthi Mastiholimath
 BioNanoScience.2025;[Epub]     CrossRef
- Evaluation of Ultraviolet Light-Based Oxidative Systems for the Inactivation and Change in Susceptibility of a Fluconazole-Resistant Candida albicans Strain
 Luz Dary Caicedo-Bejarano, Adriana María Correa-Bermúdez, Sandra Patricia Castro-Narváez, Efraím A. Serna-Galvis
 Water.2025; 17(16): 2448.     CrossRef
- Reactive Halogen Species Boost Fungal Spore Inactivation in Seawater during UV/PMS Treatment
 Ye Chen, Muke Lin, Zhuoyun Tang, Yuqin Wang, Dehua Xia, Zhechao Hua, Jingyun Fang, Ran Yin
 Environmental Science & Technology.2025; 59(36): 19537.     CrossRef
- Transferosomes As A Promising Platform for Targeted Antifungal Drug Delivery
 Yashmi Jain, Geetika Jain, Dakshita Dutta, Manish Yadav
 Current Fungal Infection Reports.2025;[Epub]     CrossRef
- Torsade de Pointes and QT Prolongation Among Antifungal Triazoles: A Real-World, Retrospective, Observational, Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS) Database
 Long Chen, Ming-Jia Liu, Song Wang, Dan Yang, Nan-Nan Ding, Ji Zhang
 Cardiovascular Toxicology.2025; 25(10): 1616.     CrossRef
- Humans vs. Fungi: An Overview of Fungal Pathogens against Humans
 Kasun M. Thambugala, Dinushani A. Daranagama, Danushka S. Tennakoon, Dona Pamoda W. Jayatunga, Sinang Hongsanan, Ning Xie
 Pathogens.2024; 13(5): 426.     CrossRef
- Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method
 Xiao Meng, Yaozhou Wu, Zixuan Liu, Yifan Chen, Zhizhou Dou, Li Wei
 Frontiers in Pharmacology.2024;[Epub]     CrossRef
- Interplay of host-immunity in fungal eye infections
 Piyush Baindara, Santi M. Mandal
 Fungal Biology Reviews.2024; 48: 100357.     CrossRef
- Cytotoxicity, antifungal and antioxidant properties of Lonchocarpus capassa leaf extracts
 Tambudzani C. Machaba, Salome Mahlo, Jacobus Eloff, Winston Nxumalo, Lyndy McGaw
 Journal of Medicinal Plants for Economic Development.2024;[Epub]     CrossRef
- Alternative and Classical Processes for Disinfection of Water Polluted by Fungi: A Systematic Review
 Luz Dary Caicedo-Bejarano, Alejandra Morante-Caicedo, Sandra Patricia Castro-Narváez, Efraím A. Serna-Galvis
 Water.2024; 16(7): 936.     CrossRef
- IRF7 Exacerbates Candida albicans Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages
 Furong Qing, Lina Sui, Wenji He, Yayun Chen, Li Xu, Liangmei He, Qiuxiang Xiao, Tianfu Guo, Zhiping Liu
 The Journal of Immunology.2024; 212(12): 1932.     CrossRef
- Verapamil enhances the activity of Caspofungin against Cryptococcus neoformans, coinciding with inhibited Ca2+/CN pathway and damage to cell wall integrity
 Xinyuan Peng, Qingtao Kong, Qian Wei, Shilin Guo, Qiying Chen, Min Peng, Binyi An, Xiaoyu Wang, Chen Zhang, Hong Sang
 International Journal of Antimicrobial Agents.2024; 64(4): 107303.     CrossRef
- 
            Cathelicidin boosts the antifungal activity of neutrophils and improves prognosis during
            Aspergillus fumigatus
            keratitis
          
 Xiaochen Hou, Cui Li, Jingyi Liu, Shanshan Yang, Xudong Peng, Qian Wang, Chengxiu Liu, Xing Liu, Junjie Luan, Guiqiu Zhao, Jing Lin, Mairi C. Noverr
 Infection and Immunity.2024;[Epub]     CrossRef
- Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity
 Ali M. Nasr, Noha M. Badawi, Yasmine H. Tartor, Nader M. Sobhy, Shady A. Swidan
 Antibiotics.2023; 12(4): 707.     CrossRef
- PU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response
 Min Wang, Ming Zhang, Jiayong Qiu, Chenyang Liu, Yao Lou, Tongsheng Wang, Yingmin Zhang, Yimin Mao
 BMC Immunology.2023;[Epub]     CrossRef
- Matrix-assisted laser desorption/ionisation-time of flight mass spectrometry azole susceptibility assessment in Candida and Aspergillus species
 Ana Luisa Perini Leme Giordano, Lais Pontes, Caio Augusto Gualtieri Beraquet, Luzia Lyra, Angelica Zaninelli Schreiber
 Memórias do Instituto Oswaldo Cruz.2023;[Epub]     CrossRef
- A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic
 Suriya Rehman
 Journal of Infection and Public Health.2023; 16(4): 611.     CrossRef
- Current Insights in Fungal Importance—A Comprehensive Review
 Viorica Maria Corbu, Irina Gheorghe-Barbu, Andreea Ștefania Dumbravă, Corneliu Ovidiu Vrâncianu, Tatiana Eugenia Șesan
 Microorganisms.2023; 11(6): 1384.     CrossRef
- Clinical infections in neurosurgical oncology: An overview
 Tomaz Velnar, Nina Kocivnik, Roman Bosnjak
 World Journal of Clinical Cases.2023; 11(15): 3418.     CrossRef
- The effect of herbal medicine in innate immunity to Candida albicans
 Meng-Yuan Bao, Ming Li, Qing-Ru Bu, Yue Yang, Hang Song, Chang-Zhong Wang, Tian-Ming Wang, Ning Li
 Frontiers in Immunology.2023;[Epub]     CrossRef
- Betulinic acid and Drummondin E: Potential inhibitors of Unfolded Protein Response Pathway of Candida auris
 Nahid Akhtar, Amit Joshi, Vikas Kaushik, Sangeetha Mohan, M. Amin-ul Mannan
 Research Journal of Pharmacy and Technology.2023; : 2867.     CrossRef
- Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants
 Ju Kim, Byeol-Hee Cho, Yong-Suk Jang
 Journal of Microbiology and Biotechnology.2023; 33(3): 288.     CrossRef
- Bacillus Metabolites: Compounds, Identification and Anti-Candida albicans Mechanisms
 Weichen Wang, Jin Zhao, Zhizi Zhang
 Microbiology Research.2022; 13(4): 972.     CrossRef
- Uncommon case of histoplasmosis with oral manifestation: A case report of diagnosis in a South American patient
 Letícia Copatti Dogenski, Eduarda Mafaciolli Pasqualotto, Mateus José Dutra, Gisele Rovani, Micheline Sandini Trentin, João Paulo De Carli
 International Journal of Surgery Case Reports.2022; 93: 106920.     CrossRef
- Oral delivery of butoconazole nitrate nanoparticles for systemic treatment of chronic paracoccidioidomycosis: A future aspect
 Tasleem, Nithya Shanthi, Arun Kumar Mahato, Richa Bahuguna
 Journal of Drug Delivery Science and Technology.2022; 77: 103808.     CrossRef
- Time to Conquer Fungal Infectious Diseases: Employing Nanoparticles as Powerful and Versatile Antifungal Nanosystems against a Wide Variety of Fungal Species
 Ali Jangjou, Zahra Zareshahrabadi, Milad Abbasi, Amirreza Talaiekhozani, Hesam Kamyab, Shreeshivadasan Chelliapan, Ahmad Vaez, Ali Golchin, Lobat Tayebi, Ehsan Vafa, Ali Mohammad Amani, Hossein Faramarzi
 Sustainability.2022; 14(19): 12942.     CrossRef
- Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?
 Mahmoud M. El-Sonbaty, Mohamed A. Akl, Khalid M. El-Say, Alaa A. Kassem
 Journal of Drug Delivery Science and Technology.2022; 68: 103096.     CrossRef
- Guanylated Hyperbranched Polylysines with High In Vitro and In Vivo Antifungal Activity
 Xiao Liu, Yilong Yang, Miaomiao Han, Jianwei Guo, Hui Liu, Yadong Liu, Junjie Xu, Shengxiang Ji, Xuesi Chen
 Advanced Healthcare Materials.2022;[Epub]     CrossRef
- The Role of the Glutathione System in Stress Adaptation, Morphogenesis and Virulence of Pathogenic Fungi
 Tanaporn Wangsanut, Monsicha Pongpom
 International Journal of Molecular Sciences.2022; 23(18): 10645.     CrossRef
- HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3
 Han Wu, Xiaofan Yin, Xibao Zhao, Zherui Wu, Yue Xiao, Qianqian Di, Ping Sun, Haimei Tang, Jiazheng Quan, Weilin Chen
 Redox Biology.2022; 56: 102461.     CrossRef
- Pre-Exposure With Extracellular Vesicles From Aspergillus fumigatus Attenuates Inflammatory Response and Enhances Fungal Clearance in a Murine Model Pulmonary Aspergillosis
 Jéssica Amanda Marques Souza, Isabella Luísa da Silva Gurgel, Nathália Luísa Sousa de Oliveira Malacco, Flávia Rayssa Braga Martins, Celso Martins Queiroz-Junior, Mauro Martins Teixeira, Frederico Marianetti Soriani
 Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
- The emerging role of neutrophil extracellular traps in fungal infection
 Chuting Liang, Ni Lian, Min Li
 Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
- Permanent, Antimicrobial Coating to Rapidly Kill and Prevent Transmission of Bacteria, Fungi, Influenza, and SARS-CoV-2
 Sreyan Ghosh, Riya Mukherjee, Vinay S. Mahajan, Julie Boucau, Shiv Pillai, Jayanta Haldar
 ACS Applied Materials & Interfaces.2022; 14(37): 42483.     CrossRef
- Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect on Candida albicans Virulence Factors
 Felicia Diodata D’Auria, Bruno Casciaro, Marta De Angelis, Maria Elena Marcocci, Anna Teresa Palamara, Lucia Nencioni, Maria Luisa Mangoni
 International Journal of Molecular Sciences.2022; 23(11): 6345.     CrossRef
- WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
 Ernst H. Oliw
 Fungal Genetics and Biology.2021; : 103603.     CrossRef
- MYO1F regulates antifungal immunity by regulating acetylation of microtubules
 Wanwei Sun, Xiaojian Ma, Heping Wang, Yanyun Du, Jianwen Chen, Huijun Hu, Ru Gao, Ruirui He, Qianwen Peng, Zhihui Cui, Huazhi Zhang, Junhan Wang, Xinming Jia, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang
 Proceedings of the National Academy of Sciences.2021;[Epub]     CrossRef
- Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system
 Ashish Kumar Garg, Balaji Maddiboyina, Mohammed Hamed Saeed Alqarni, Aftab Alam, Hibah M. Aldawsari, Pinki Rawat, Sima Singh, Prashant Kesharwani
 Journal of Biomaterials Science, Polymer Edition.2021; 32(8): 1009.     CrossRef
- Preclinical safety evaluation of amphotericin A21: A novel antifungal
 Ivan Ortega‐Blake, Mario Fernández‐Zertuche, Ignacio Regla, Walfred Sánchez‐Peña, Antonieta Gómez‐Solis, Paola Jaimes‐Chavez, Arturo Galván‐Hernández, Erika Tovar‐Garduño, Lourdes Rodríguez‐Fragoso
 Basic & Clinical Pharmacology & Toxicology.2021; 129(1): 72.     CrossRef
- Antimicrobial Peptides: The Promising Therapeutics for Cutaneous Wound Healing
 Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
 Macromolecular Bioscience.2021;[Epub]     CrossRef
- The transcription factor Cas5 suppresses hyphal morphogenesis during yeast-form growth in Candida albicans
 Jong-Myeong Kim, Hye Yun Moon, Dong Wook Lee, Hyun Ah Kang, Jeong-Yoon Kim
 Journal of Microbiology.2021; 59(10): 911.     CrossRef
- Antifungal activity of thiosemicarbazones, bis(thiosemicarbazones), and their metal complexes
 Kritika Bajaj, Robert M. Buchanan, Craig A. Grapperhaus
 Journal of Inorganic Biochemistry.2021; 225: 111620.     CrossRef
- Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens
 Ernst H. Oliw
 Fungal Genetics and Biology.2021; 157: 103623.     CrossRef
- Membrane-Interacting Antifungal Peptides
 Caroline Struyfs, Bruno P. A. Cammue, Karin Thevissen
 Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
- Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence
 Brandon S. Ross, Lotus A. Lofgren, Alix Ashare, Jason E. Stajich, Robert A. Cramer, J. Andrew Alspaugh
 mBio.2021;[Epub]     CrossRef
- Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis
 Angel León-Buitimea, Javier A. Garza-Cervantes, Diana Y. Gallegos-Alvarado, Macario Osorio-Concepción, José Ruben Morones-Ramírez
 Pathogens.2021; 10(10): 1303.     CrossRef
- Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds
 Martin van Eijk, Stephanie Boerefijn, Lida Cen, Marisela Rosa, Marnix J H Morren, Cornelis K van der Ent, Bart Kraak, Jan Dijksterhuis, Ivan D Valdes, Henk P Haagsman, Hans de Cock
 Medical Mycology.2020; 58(8): 1073.     CrossRef
- Broad-Spectrum Antimicrobial and Antibiofilm Activity of a Natural Clay Mineral from British Columbia, Canada
 Shekooh Behroozian, Sarah L. Svensson, Loretta Y. Li, Julian E. Davies, Pascale F. Cossart
 mBio.2020;[Epub]     CrossRef
- Antimicrobial host defence peptides: functions and clinical potential
 Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson
 Nature Reviews Drug Discovery.2020; 19(5): 311.     CrossRef
- Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence
 Sharel P. Díaz-Pérez, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Adolfo López-Torres, Irvin E. Jácome-Galarza, Verónica Anaya-Martínez, Verónica Gómez-Ruiz, Jesús Campos-García, Rosa E. Nuñez-Anita, Rafael Ortiz-Alvarado, Martha I. Ramírez-Díaz,
 Infection and Immunity.2020;[Epub]     CrossRef
- Fungal evolution: major ecological adaptations and evolutionary transitions
 Miguel A. Naranjo‐Ortiz, Toni Gabaldón
 Biological Reviews.2019; 94(4): 1443.     CrossRef
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            Acute Lung Injury and Repair Induced by Single Exposure of
            Aspergillus Fumigatus
            in Immunocompetent Mice
          
 Nathália L S O Malacco, Jéssica A M Souza, Aline C Mendes, Milene A Rachid, Lucas R Kraemer, Matheus S Mattos, Graziele N Lima, Lirlândia P Sousa, Daniele G Souza, Vanessa Pinho, Mauro M Teixeira, Remo C Russo, Frederico M Soriani
 Future Microbiology.2019; 14(17): 1511.     CrossRef
- Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
 Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
 Scientific Reports.2019;[Epub]     CrossRef
- Characterization of fungal biodiversity and communities associated with the reef macroalga Sargassum ilicifolium reveals fungal community differentiation according to geographic locality and algal structure
 Benjamin J. Wainwright, Andrew G. Bauman, Geoffrey L. Zahn, Peter A. Todd, Danwei Huang
 Marine Biodiversity.2019; 49(6): 2601.     CrossRef
- Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development
 Danielle J. Lee, Holly O’Donnell, Françoise H. Routier, Joe Tiralongo, Thomas Haselhorst
 Cells.2019; 8(11): 1348.     CrossRef
- Fungal dissemination is limited by liver macrophage filtration of the blood
 Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang, Meiqing Shi
 Nature Communications.2019;[Epub]     CrossRef
- Intracellular cAMP Measurements in Candida albicans Biofilms
 Liuliu Jiang, Shengyan Chen, Kairui Sun, Peng Zhou, Xin Wei
 BIO-PROTOCOL.2019;[Epub]     CrossRef
- Linolenic Acid-Modified MPEG-PEI Micelles for Encapsulation of Amphotericin B
 Hongmei Xu, Fangfang Teng, Feilong Zhou, Li Zhu, Yi Wen, Runliang Feng, Zhimei Song
 Future Medicinal Chemistry.2019; 11(20): 2647.     CrossRef
- Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens
 Daiane Flores Dalla Lana, Bruna Gerardon Batista, Gabriella da Rosa Machado, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, William Lopes, Marilene Henning Vainstein, Alejandro Peixoto de Abreu L
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 Asian Journal of Pharmaceutical Sciences.2019; 14(2): 117.     CrossRef
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 Patricia Postina, Julian Skladny, Tobias Boch, Oliver A. Cornely, Axel Hamprecht, Peter-Michael Rath, Jörg Steinmann, Oliver Bader, Thomas Miethke, Anne Dietz, Natalia Merker, Wolf-Karsten Hofmann, Dieter Buchheidt, Birgit Spiess
 Frontiers in Microbiology.2018;[Epub]     CrossRef
- Cryptic Aspergillus from clinical samples in the USA and description of a new species in section Flavipedes
 João P. Z. Siqueira, Nathan Wiederhold, Josepa Gené, Dania García, Margarete T. G. Almeida, Josep Guarro
 Mycoses.2018; 61(11): 814.     CrossRef
- Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
 Ewa Bielska, Marta Arch Sisquella, Maha Aldeieg, Charlotte Birch, Eloise J. O’Donoghue, Robin C. May
 Nature Communications.2018;[Epub]     CrossRef
- Fungi-Induced Upper and Lower Respiratory Tract Allergic Diseases: One Entity
 Aleksandra Barac, David S. Y. Ong, Ljiljana Jovancevic, Aleksandar Peric, Pavol Surda, Vesna Tomic Spiric, Salvatore Rubino
 Frontiers in Microbiology.2018;[Epub]     CrossRef
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 Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos del Fresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, M
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 Surabhi Goyal, Juan Camilo Castrillón-Betancur, Esther Klaile, Hortense Slevogt
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 Xueqiang Zhao, Yahui Guo, Changying Jiang, Qing Chang, Shilei Zhang, Tianming Luo, Bin Zhang, Xinming Jia, Mien-Chie Hung, Chen Dong, Xin Lin
 Nature Medicine.2017; 23(3): 337.     CrossRef
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 Ghareb M. Soliman
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- Conclusion and future perspectives on antifungal stewardship
 Jose María Aguado, Jose Tiago Silva, Emilio Bouza
 Journal of Antimicrobial Chemotherapy.2016; 71(suppl 2): ii43.     CrossRef
 
 Reviews
	
	
				- REVIEW] Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota
- 
		Sarah Höfs , Selene Mogavero , Bernhard Hube 		
- 
			J. Microbiol. 2016;54(3):149-169.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-5514-0
					
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			718
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		- 
						
						 Abstract Abstract PDF PDF
- 
		The interaction between Candida albicans and its host cells is
characterized by a complex interplay between the expression
of fungal virulence factors, which results in adherence, invasion
and cell damage, and the host immune system, which
responds by secreting proinflammatory cytokines, activating
antimicrobial activities and killing the fungal pathogen. In
this review we describe this interplay by taking a closer look
at how C. albicans pathogenicity is induced and executed,
how the host responds in order to prevent and clear an infection,
and which mechanisms C. albicans has evolved to
bypass these immune responses to avoid clearance. Furthermore,
we review studies that show how the presence of other
microorganisms affects this interplay.	
		
- 
			Citations Citations to this article as recorded by    
 
	
	
				- REVIEW] Hgc1-Cdc28–how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?
- 
		Yue Wang 		
- 
			J. Microbiol. 2016;54(3):170-177.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-5550-9
					
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			273
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			0
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			18
			Crossref
		
		- 
						
						 Abstract Abstract PDF PDF
- 
		The fungal human pathogen Candida albicans can cause invasive
infection with high mortality rates. A key virulence
factor is its ability to switch between three morphologies:
yeast, pseudohyphae and hyphae. In contrast to the ovalshaped
unicellular yeast cells, hyphae are highly elongated,
tube-like, and multicellular. A long-standing question is what
coordinates all the cellular machines to construct cells with
distinct shapes. Hyphal-specific genes (HSGs) are thought
to hold the answer. Among the numerous HSGs found, only
UME6 and HGC1 are required for hyphal development.
UME6 encodes a transcription factor that regulates many
HSGs including HGC1. HGC1 encodes a G1 cyclin which
partners with the Cdc28 cyclin-dependent kinase. Hgc1-
Cdc28 simultaneously phosphorylates and regulates multiple
substrates, thus controlling multiple cellular apparatuses for
morphogenesis. This review is focused on major progresses
made in the past decade on Hgc1’s roles and regulation in
C. albicans hyphal development and other traits important
for infection.	
		
- 
			Citations Citations to this article as recorded by    
- 
            Systematic analysis of the
            Candida albicans
            kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation
            in vitro
            and
            in vivo
 
 Juraj Kramara, Min-Ju Kim, Tomye L. Ollinger, Laura C. Ristow, Rohan S. Wakade, Robert Zarnowski, Melanie Wellington, David R. Andes, Aaron G. Mitchell, Damian J. Krysan, Judith Berman
 mBio.2024;[Epub]     CrossRef
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 Anupam Sharma, Norma V. Solis, Manning Y. Huang, Frederick Lanni, Scott G. Filler, Aaron P. Mitchell, Yong-Sun Bahn
 mBio.2023;[Epub]     CrossRef
- Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans
               
 Anupam Sharma, Aaron P Mitchell, J Berman
 G3: Genes, Genomes, Genetics.2023;[Epub]     CrossRef
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            Use of the Iron-Responsive
            RBT5
            Promoter for Regulated Expression in Candida albicans
          
 Yinhe Mao, Norma V. Solis, Anupam Sharma, Max V. Cravener, Scott G. Filler, Aaron P. Mitchell, Michael Lorenz
 mSphere.2022;[Epub]     CrossRef
- 
            Systematic Metabolic Profiling Identifies
            De Novo
            Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation
          
 Enrico Garbe, Franziska Gerwien, Dominik Driesch, Tina Müller, Bettina Böttcher, Markus Gräler, Slavena Vylkova, Manuel Liebeke
 mSystems.2022;[Epub]     CrossRef
- The Antimicrobial Peptide AMP-17 Derived from Musca domestica Inhibits Biofilm Formation and Eradicates Mature Biofilm in Candida albicans
 Chaoqin Sun, Xinyu Zhao, Zhenglong Jiao, Jian Peng, Luoxiong Zhou, Longbing Yang, Mingjiao Huang, Chunren Tian, Guo Guo
 Antibiotics.2022; 11(11): 1474.     CrossRef
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 Kyunghun Min, Thomas F. Jannace, Haoyu Si, Krishna R. Veeramah, John D. Haley, James B. Konopka, Joachim Morschhäuser
 PLOS Pathogens.2021; 17(8): e1009861.     CrossRef
- The Ndr/LATS Kinase Cbk1 Regulates a Specific Subset of Ace2 Functions and Suppresses the Hypha-to-Yeast Transition in Candida albicans
 Rohan S. Wakade, Laura C. Ristow, Mark A. Stamnes, Anuj Kumar, Damian J. Krysan, James W. Kronstad
 mBio.2020;[Epub]     CrossRef
- The regulation of hyphae growth in Candida albicans
 Hui Chen, Xuedong Zhou, Biao Ren, Lei Cheng
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				- REVIEW] Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans
- 
		Lois M. Douglas , James B. Konopka 		
- 
			J. Microbiol. 2016;54(3):178-191.   Published online February 27, 2016		
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							DOI: https://doi.org/10.1007/s12275-016-5621-y
					
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						 Abstract Abstract PDF PDF
- 
		Candida albicans is a human fungal pathogen capable of causing
lethal systemic infections. The plasma membrane plays key
roles in virulence because it not only functions as a protective
barrier, it also mediates dynamic functions including secretion
of virulence factors, cell wall synthesis, invasive hyphal
morphogenesis, endocytosis, and nutrient uptake. Consistent
with this functional complexity, the plasma membrane is
composed of a wide array of lipids and proteins. These components
are organized into distinct domains that will be the
topic of this review. Some of the plasma membrane domains
that will be described are known to act as scaffolds or barriers
to diffusion, such as MCC/eisosomes, septins, and sites
of contact with the endoplasmic reticulum. Other zones mediate
dynamic processes, including secretion, endocytosis, and
a special region at hyphal tips that facilitates rapid growth.
The highly organized architecture of the plasma membrane
facilitates the coordination of diverse functions and promotes
the pathogenesis of C. albicans.	
		
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				- REVIEW] The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogen
- 
		Joachim Morschhäuser 		
- 
			J. Microbiol. 2016;54(3):192-201.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-5628-4
					
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		- 
						
						 Abstract Abstract PDF PDF
- 
		The yeast Candida albicans is a member of the microbiota
in the gastrointestinal and urogenital tracts of most healthy
persons, but it can also cause symptomatic infections, especially
in immunocompromised patients. During the life-long
association with its human host, C. albicans generates genetically
altered variants that are better adapted to changes in
their environment. A prime example of this microevolution
is the development of resistance to the commonly used drug
fluconazole, which inhibits ergosterol biosynthesis, during
antimycotic therapy. Fluconazole resistance can be caused by
mutations in the drug target, by changes in the sterol biosynthesis
pathway, and by gain-of-function mutations in transcription
factors that result in the constitutive upregulation
of ergosterol biosynthesis genes and multidrug efflux pumps.
Fluconazole also induces genomic rearrangements that result
in gene amplification and loss of heterozygosity for resistance
mutations, which further increases drug resistance.
These genome alterations may affect extended chromosomal
regions and have additional phenotypic consequences. A
striking case is the loss of heterozygosity for the mating type
locus MTL in many fluconazole-resistant clinical isolates,
which allows the cells to switch to the mating-competent opaque
phenotype. This, in turn, raises the possibility that sexual
recombination between different variants of an originally clonal,
drug-susceptible population may contribute to the generation
of highly fluconazole-resistant strains with multiple
resistance mechanisms. The gain-of-function mutations in
transcription factors, which result in deregulated gene expression,
also cause reduced fitness. In spite of this, many clinical
isolates that contain such mutations do not exhibit fitness defects,
indicating that they have overcome the costs of drug
resistance with further evolution by still unknown mechanisms.	
		
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            Overexpression and Beauvericin Resistance in Candida albicans
          
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				- REVIEW] Innate host defenses against Cryptococcus neoformans
- 
		Camaron Hole , Floyd L. Wormley Jr. 		
- 
			J. Microbiol. 2016;54(3):202-211.   Published online February 27, 2016		
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							DOI: https://doi.org/10.1007/s12275-016-5625-7
					
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		- 
						
						 Abstract Abstract PDF PDF
- 
		Cryptococcus neoformans, the predominant etiological agent
of cryptococcosis, can cause life-threatening infections of the
central nervous system in immunocompromised and immunocompetent
individuals. Cryptococcal meningoencephalitis
is the most common disseminated fungal infection in AIDS
patients, and remains the third most common invasive fungal
infection among organ transplant recipients. The administration
of highly active antiretroviral therapy (HAART) has
 result
 ed in a decrease in the number of cases of AIDS-related
cryptococcosis in developed countries, but in developing
countries where HAART is not readily available, Cryptococcus
is still a major concern. Therefore, there is an urgent
need for the development of novel therapies and/or vaccines
to combat cryptococcosis. Understanding the protective immune
responses against Cryptococcus is critical for development
of vaccines and immunotherapies to combat cryptococcosis.
Consequently, this review focuses on our current
knowledge of protective immune responses to C. neoformans,
with an emphasis on innate immune responses.
- 
			Citations Citations to this article as recorded by    
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				- REVIEW] All about that fat: Lipid modification of proteins in Cryptococcus neoformans
- 
		Felipe H. Santiago-Tirado , Tamara L. Doering 		
- 
			J. Microbiol. 2016;54(3):212-222.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-5626-6
					
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		- 
						
						 Abstract Abstract PDF PDF
- 
		Lipid modification of proteins is a widespread, essential process
whereby fatty acids, cholesterol, isoprenoids, phospholipids,
or glycosylphospholipids are attached to polypeptides.
These hydrophobic groups may affect protein structure, function,
localization, and/or stability; as a consequence such modifications
play critical regulatory roles in cellular systems.
Recent advances in chemical biology and proteomics have
allowed the profiling of modified proteins, enabling dissection
of the functional consequences of lipid addition. The
enzymes that mediate lipid modification are specific for both
the lipid and protein substrates, and are conserved from fungi
to humans. In this article we review these enzymes, their substrates,
and the processes involved in eukaryotic lipid modification
of proteins. We further focus on its occurrence in
the fungal pathogen Cryptococcus neoformans, highlighting
unique features that are both relevant for the biology of the
organism and potentially important in the search for new
therapies.	
		
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				- REVIEW] Developmental regulators in Aspergillus fumigatus
- 
		Hee-Soo Park , Jae-Hyuk Yu 		
- 
			J. Microbiol. 2016;54(3):223-231.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-5619-5
					
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			55
			Crossref
		
		- 
						
						 Abstract Abstract PDF PDF
- 
		The filamentous fungus Aspergillus fumigatus is the most prevalent
airborne fungal pathogen causing severe and usually
fatal invasive aspergillosis in immunocompromised patients.
This fungus produces a large number of small hydrophobic
asexual spores called conidia as the primary means of reproduction,
cell survival, propagation, and infectivity. The initiation,
progression, and completion of asexual development
(conidiation) is controlled by various regulators that govern
expression of thousands of genes associated with formation
of the asexual developmental structure conidiophore, and
biogenesis of conidia. In this review, we summarize key regulators
that directly or indirectly govern conidiation in this
important pathogenic fungus. Better understanding these
developmental regulators may provide insights into the improvement
in controlling both beneficial and detrimental
aspects of various Aspergillus species.	
		
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				- REVIEW] Recent advances in the understanding of the Aspergillus fumigatus cell wall
- 
		Mark J. Lee , Donald C. Sheppard 		
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			J. Microbiol. 2016;54(3):232-242.   Published online February 27, 2016		
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							DOI: https://doi.org/10.1007/s12275-016-6045-4
					
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						 Abstract Abstract PDF PDF
- 
		Over the past several decades, research on the synthesis and
organization of the cell wall polysaccharides of Aspergillus
fumigatus has expanded our knowledge of this important
fungal structure. Besides protecting the fungus from environmental
stresses and maintaining structural integrity of
the organism, the cell wall is also the primary site for interaction
with host tissues during infection. Cell wall polysaccharides
are important ligands for the recognition of fungi
by the innate immune system and they can mediate potent
immunomodulatory effects. The synthesis of cell wall polysaccharides
is a complicated process that requires coordinated
regulation of many biosynthetic and metabolic pathways.
Continuous synthesis and remodeling of the polysaccharides
of the cell wall is essential for the survival of the
fungus during development, reproduction, colonization and
invasion. As these polysaccharides are absent from the human
host, these biosynthetic pathways are attractive targets
for antifungal development. In this review, we present recent
advances in our understanding of Aspergillus fumigatus cell
wall polysaccharides, including the emerging role of cell
wall polysaccharides in the host-pathogen interaction.	
		
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				- REVIEW] The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance
- 
		Neil A. Brown , Gustavo H. Goldman 		
- 
			J. Microbiol. 2016;54(3):243-253.   Published online February 27, 2016		
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							DOI: https://doi.org/10.1007/s12275-016-5510-4
					
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						 Abstract Abstract PDF PDF
- 
		Invasive aspergillosis has emerged as one of the most common
life-threatening fungal disease of humans. The emergence
of antifungal resistant pathogens represents a current
and increasing threat to society. In turn, new strategies to
combat fungal infection are urgently required. Fungal adaptations
to stresses experienced within the human host are a
prerequisite for the survival and virulence strategies of the
pathogen. Here, we review the latest information on the
signalling pathways in Aspergillus fumigatus that contribute
to stress adaptations and virulence, while highlighting their
potential as targets for the development of novel combinational
antifungal therapies.	
		
- 
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				- REVIEW] Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity
- 
		Gregory J. Fischer , Nancy P. Keller 		
- 
			J. Microbiol. 2016;54(3):254-264.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-5620-z
					
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						 Abstract Abstract PDF PDF
- 
		Oxylipins are a class of molecules derived from the incorporation
of oxygen into polyunsaturated fatty acid substrates
through the action of oxygenases. While extensively investigated
in the context of mammalian immune responses, over
the last decade it has become apparent that oxylipins are a
common means of communication among and between plants,
animals, and fungi to control development and alter hostmicrobe
interactions. In fungi, some oxylipins are derived nonenzymatically
while others are produced by lipoxygenases,
cyclooxygenases, and monooxygenases with homology to
plant and human enzymes. Recent investigations of numerous
plant and human fungal pathogens have revealed oxylipins
to be involved in the establishment and progression of disease.
This review highlights oxylipin production by pathogenic
fungi and their role in fungal development and pathogen/
host interactions.	
		
- 
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				- REVIEW] Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis
- 
		Jon P. Woods 		
- 
			J. Microbiol. 2016;54(3):265-276.   Published online February 27, 2016		
- 
							DOI: https://doi.org/10.1007/s12275-016-6044-5
					
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						 Abstract Abstract PDF PDF
- 
		Histoplasma capsulatum is a dimorphic pathogenic fungus
and causative agent of histoplasmosis, which is a respiratory
and systemic infection that is particularly severe in immunocompromised
hosts and represents the fungal homolog of
tuberculosis. In highly endemic regions, the majority of individuals
have been infected and carry the organism in a persistent
latent form that is a danger for reactivation if host
defenses are suppressed. H. capsulatum has been a model
organism for intracellular pathogenesis and fungal morphogenesis
for decades. New genomic information and application
of approaches for molecular genetic manipulation are
shedding new light on virulence mechanisms.	
		
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