Respiratory syncytial virus (RSV) causes severe respiratory
disease in both the very young and the elderly. Nearly all
individuals become infected in early childhood, and reinfections
with the virus are common throughout life. Despite its
clinical impact, there remains no licensed RSV vaccine. RSV
infection in the respiratory tract induces an inflammatory
response by the host to facilitate efficient clearance of the
virus. However, the host immune response also contributes
to the respiratory disease observed following an RSV infection.
RSV has evolved several mechanisms to evade the host
immune response and promote virus replication through
interactions between RSV proteins and immune components.
In contrast, some RSV proteins also play critical roles in activating,
rather than suppressing, host immunity. In this review,
we discuss the interactions between individual RSV proteins
and host factors that modulate the immune response
and the implications of these interactions for the course of
an RSV infection.
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Rapidly emerging infectious disease outbreaks place a great
strain on laboratories to develop and implement sensitive
and specific diagnostic tests for patient management and
infection control in a timely manner. Furthermore, laboratories
also play a role in real-time zoonotic, environmental,
and epidemiological investigations to identify the ultimate
source of the epidemic, facilitating measures to eventually
control the outbreak. Each assay modality has unique pros
and cons; therefore, incorporation of a battery of tests using
traditional culture-based, molecular and serological diagnostics
into diagnostic algorithms is often required. As such,
laboratories face challenges in assay development, test evaluation,
and subsequent quality assurance. In this review, we
describe the different testing modalities available for the ongoing
Middle East respiratory syndrome (MERS) epidemic
including cell culture, nucleic acid amplification, antigen detection,
and antibody detection assays. Applications of such
tests in both acute clinical and epidemiological investigation
settings are highlighted. Using the MERS epidemic as an example,
we illustrate the various challenges faced by laboratories
in test development and implementation in the setting
of a rapidly emerging infectious disease. Future directions in
the diagnosis of MERS and other emerging infectious disease
investigations are also highlighted.
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Zika virus (ZIKV) is a previously little-known flavivirus closely
related to Japanese encephalitis, West Nile, dengue, and
yellow fever viruses, all of which are primarily transmitted
by blood-sucking mosquitoes. Since its discovery in Uganda
in 1947, ZIKV has continued to expand its geographic range,
from equatorial Africa and Asia to the Pacific Islands, then
further afield to South and Central America and the Caribbean.
Currently, ZIKV is actively circulating not only in much
of Latin America and its neighbors but also in parts of the
Pacific Islands and Southeast Asia. Although ZIKV infection
generally causes only mild symptoms in some infected individuals,
it is associated with a range of neuroimmunological
disorders, including Guillain-Barré syndrome, meningoencephalitis,
and myelitis. Recently, maternal ZIKV infection during
pregnancy has been linked to neonatal malformations, result ing in various degrees of congenital abnormalities, microcephaly,
and even abortion. Despite its emergence as an
important public health problem, however, little is known
about ZIKV biology, and neither vaccine nor drug is available
to control ZIKV infection. This article provides a brief
introduction to ZIKV with a major emphasis on its molecular
virology, in order to help facilitate the development of diagnostics,
therapeutics, and vaccines.
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Emerging viruses pose a major threat to humans and livestock
with global public health and economic burdens. Vaccination
remains an effective tool to reduce this threat, and
yet, the conventional cell culture often fails to produce sufficient
vaccine dose. As an alternative to cell-culture based
vaccine, virus-like particles (VLPs) are considered as a highpriority
vaccine strategy against emerging viruses. VLPs represent
highly ordered repetitive structures via macromolecular
assemblies of viral proteins. The particulate nature allows efficient
uptake into antigen presenting cells stimulating both
innate and adaptive immune responses towards enhanced
vaccine efficacy. Increasing research activity and translation
opportunity necessitate the advances in the design of VLPs
and new bioprocessing modalities for efficient and cost-effective
production. Herein, we describe major achievements
and challenges in this endeavor, with respect to designing
strategies to harnessing the immunogenic potential, production
platforms, downstream processes, and some exemplary case s in developing VLP-based vaccines.
Citations
Citations to this article as recorded by
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Bacterial Production of Barley Stripe Mosaic Virus Biotemplates for Palladium Nanoparticle Growth Yu-Hsuan Lee, Kok Zhi Lee, Rachel G. Susler, Corren A. Scott, Longfei Wang, L. Sue Loesch-Fries, Michael T. Harris, Kevin V. Solomon ACS Applied Nano Materials.2020; 3(12): 12080. CrossRef
Current State and Challenges in Developing Respiratory Syncytial Virus Vaccines Carlotta Biagi, Arianna Dondi, Sara Scarpini, Alessandro Rocca, Silvia Vandini, Giulia Poletti, Marcello Lanari Vaccines.2020; 8(4): 672. CrossRef
Virus-like particle-display of the enterotoxigenic Escherichia coli heat-stable toxoid STh-A14T elicits neutralizing antibodies in mice Morten L. Govasli, Yuleima Diaz, Pål Puntervoll Vaccine.2019; 37(43): 6405. CrossRef
Protein and Peptide Biomaterials for Engineered Subunit Vaccines and Immunotherapeutic Applications Alexandra N. Tsoras, Julie A. Champion Annual Review of Chemical and Biomolecular Engineering.2019; 10(1): 337. CrossRef
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Nanoparticle vaccines against viral infections Fernando B. Sulczewski, Raquel B. Liszbinski, Pedro R. T. Romão, Luiz Carlos Rodrigues Junior Archives of Virology.2018; 163(9): 2313. CrossRef
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Questions of bioethics and biosafety in the problem of biotechnology and
use of vaccine for prevention of human infectious diseases V. Zadorozhna, N. Vynnyk Bulletin "Veterinary biotechnology".2018; 32(1): 459. CrossRef
MultiBac: from protein complex structures to synthetic viral nanosystems Martin Pelosse, Hannah Crocker, Barbara Gorda, Paul Lemaire, Jens Rauch, Imre Berger BMC Biology.2017;[Epub] CrossRef
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