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Volume 55(3); March 2017
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Reviews
REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins
Megan E. Schmidt , Steven M. Varga
J. Microbiol. 2017;55(3):161-171.   Published online February 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7045-8
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  • 25 Crossref
AbstractAbstract
Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early childhood, and reinfections with the virus are common throughout life. Despite its clinical impact, there remains no licensed RSV vaccine. RSV infection in the respiratory tract induces an inflammatory response by the host to facilitate efficient clearance of the virus. However, the host immune response also contributes to the respiratory disease observed following an RSV infection. RSV has evolved several mechanisms to evade the host immune response and promote virus replication through interactions between RSV proteins and immune components. In contrast, some RSV proteins also play critical roles in activating, rather than suppressing, host immunity. In this review, we discuss the interactions between individual RSV proteins and host factors that modulate the immune response and the implications of these interactions for the course of an RSV infection.

Citations

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  • Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort
    Dylan Lawless, Christopher G McKennan, Suman R Das, Thomas Junier, Zhi Ming Xu, Larry J Anderson, Tebeb Gebretsadik, Meghan H Shilts, Emma Larkin, Christian Rosas-Salazar, James D Chappell, Jacques Fellay, Tina V Hartert
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  • Circulation pattern and genetic variation of human respiratory syncytial virus in China during 2008–2021
    Jingjing Song, Zhen Zhu, Jinhua Song, Naiying Mao, Aili Cui, Wenbo Xu, Yan Zhang
    Journal of Medical Virology.2023;[Epub]     CrossRef
  • Repurposing Axl Kinase Inhibitors for the Treatment of Respiratory Syncytial Virus Infection
    Dan Zhang, Yuanhui Zhao, Xiaoxin You, Susu He, Erguang Li
    Antimicrobial Agents and Chemotherapy.2023;[Epub]     CrossRef
  • Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies
    Jiao Li, Ling Xue, Jiachao Wang, Aihong Meng, Jiajun Qiao, Miao Li, Xiuli Wang, Lingtong Meng, Jingyuan Ning, Xue Gao, Wenjian Li, Cuiqing Ma, Lin Wei, Bryan R. G. Williams
    Journal of Virology.2022;[Epub]     CrossRef
  • Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study
    Abu Hamza, Abdus Samad, Zahoor Ahmad Parray, Sajda Ara, Anwar Ahmed, Fahad N. Almajhdi, Tajamul Hussain, Asimul Islam, Shama Parveen
    International Journal of Molecular Sciences.2022; 23(4): 1950.     CrossRef
  • Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions
    Xu Zheng, Ke Wang, Lang Pan, Wenjing Hao, Yaoyao Xue, Attila Bacsi, Spiros A. Vlahopoulos, Zsolt Radak, Tapas K. Hazra, Allan R. Brasier, Lloyd Tanner, Xueqing Ba, Istvan Boldogh
    Journal of Innate Immunity.2022; 14(6): 593.     CrossRef
  • Enhancing Anti-G Antibody Induction by a Live Single-Cycle Prefusion F—Expressing RSV Vaccine Improves In Vitro and In Vivo Efficacy
    Pramila Lamichhane, Megolhubino Terhüja, Timothy A. Snider, Antonius G. P. Oomens
    Viruses.2022; 14(11): 2474.     CrossRef
  • Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment
    Dan Zhang, Yuanhui Zhao, Lingling Wang, Xiaoxin You, Jingjing Li, Guohai Zhang, Yayi Hou, Hongwei Wang, Susu He, Erguang Li
    American Journal of Respiratory Cell and Molecular Biology.2022; 67(2): 227.     CrossRef
  • A live single-cycle RSV vaccine expressing prefusion F protein
    Pramila Lamichhane, Megan E. Schmidt, Megolhubino Terhüja, Steven M. Varga, Timothy A. Snider, Christina A. Rostad, Antonius G.P. Oomens
    Virology.2022; 577: 51.     CrossRef
  • Biophysical studies of the interaction of hRSV Non-Structural 1 protein with natural flavonoids and their acetylated derivatives by spectroscopic techniques and computational simulations
    Isabella Ottenio de Lourenço, Evelyn Toscano Pedroso Quintino, Matheus Henrique Pereira, Caroline Sprengel Lima, Gabriela Campos Araújo, Luis Octávio Regasini, Fernando Alves de Melo, Fátima Pereira de Souza, Marcelo Andres Fossey, Ícaro Putinhon Caruso
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 283: 121751.     CrossRef
  • Pratensein glycoside attenuates respiratory syncytial virus infection-induced oxidative and inflammatory injury via TGF-β signaling pathway
    Qiong Zhang, Si Li, Qiong Huang
    Molecular & Cellular Toxicology.2022; 18(3): 329.     CrossRef
  • Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies
    Harrison C. Bergeron, Jackelyn Murray, Ana M. Nuñez Castrejon, Rebecca M. DuBois, Ralph A. Tripp
    Viruses.2021; 13(2): 352.     CrossRef
  • Juvenile, but Not Adult, Mice Display Increased Myeloid Recruitment and Extracellular Matrix Remodeling during Respiratory Syncytial Virus Infection
    Gerald G. Kellar, Stephen R. Reeves, Kaitlyn A. Barrow, Jason S. Debley, Thomas N. Wight, Steven F. Ziegler
    The Journal of Immunology.2020; 205(11): 3050.     CrossRef
  • Double-edged role of natural killer cells during RSV infection
    Rauf Bhat, Mohamed A. Farrag, Fahad N. Almajhdi
    International Reviews of Immunology.2020; 39(5): 233.     CrossRef
  • Disease severity of respiratory syncytial virus (RSV) infection correlate to a novel set of five amino acid substitutions in the RSV attachment glycoprotein (G) in China
    Wanwei Li, Yanlan Wang, Bo Yu, Qiqi Tan, Jijian Zhou, Jingjing Hu, Yuanbin Wu, Bo Wang, Hongjian Li
    Virus Research.2020; 281: 197937.     CrossRef
  • Revisiting respiratory syncytial virus’s interaction with host immunity, towards novel therapeutics
    C. Efstathiou, S. H. Abidi, J. Harker, N. J. Stevenson
    Cellular and Molecular Life Sciences.2020; 77(24): 5045.     CrossRef
  • Ephedrannin B exerts anti-viral and anti-inflammatory properties in BEAS-2B cells infected with respiratory syncytial virus
    Shu Hou, Xiaoyan Xu, Yating Wang, Yan Yang
    Journal of Biosciences.2020;[Epub]     CrossRef
  • Vaccine containing G protein fragment and recombinant baculovirus expressing M2 protein induces protective immunity to respiratory syncytial virus
    Yeong-Min Jo, Jungwoo Kim, Jun Chang
    Clinical and Experimental Vaccine Research.2019; 8(1): 43.     CrossRef
  • VITAMIN D LEVEL IN CRITICALLY ILL CHILDREN 6 MONTHS–5 YEARS AGE ADMITTED TO INTENSIVE CARE UNIT IN TERTIARY CARE HOSPITAL OF CENTRAL INDIA
    AKSHAY ASHOK ., MANJUSHA GOEL ., BHARTI CHAUBEY ., RAJESH PATIL .
    Indian Journal of Child Health.2019; 06(04): 413.     CrossRef
  • Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
    Mariana Guerra-Maupome, Mitchell V. Palmer, Jodi L. McGill, Randy E. Sacco
    Vaccines.2019; 7(1): 7.     CrossRef
  • Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development
    Seyhan Boyoglu-Barnum, Tatiana Chirkova, Larry J. Anderson
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze
    Kedir N. Turi, Jyoti Shankar, Larry J. Anderson, Devi Rajan, Kelsey Gaston, Tebeb Gebretsadik, Suman R. Das, Cosby Stone, Emma K. Larkin, Christian Rosas-Salazar, Steven M. Brunwasser, Martin L. Moore, R. Stokes Peebles, Tina V. Hartert
    American Journal of Respiratory and Critical Care Medicine.2018; 198(8): 1064.     CrossRef
  • Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses
    Virender Kumar Pal, Parijat Bandyopadhyay, Amit Singh
    IUBMB Life.2018; 70(5): 393.     CrossRef
REVIEW] The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic
Jasper F. W. Chan , Siddharth Sridhar , Cyril C. Y. Yip , Susanna K. P. Lau , Patrick C. Y. Woo
J. Microbiol. 2017;55(3):172-182.   Published online February 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7026-y
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AbstractAbstract
Rapidly emerging infectious disease outbreaks place a great strain on laboratories to develop and implement sensitive and specific diagnostic tests for patient management and infection control in a timely manner. Furthermore, laboratories also play a role in real-time zoonotic, environmental, and epidemiological investigations to identify the ultimate source of the epidemic, facilitating measures to eventually control the outbreak. Each assay modality has unique pros and cons; therefore, incorporation of a battery of tests using traditional culture-based, molecular and serological diagnostics into diagnostic algorithms is often required. As such, laboratories face challenges in assay development, test evaluation, and subsequent quality assurance. In this review, we describe the different testing modalities available for the ongoing Middle East respiratory syndrome (MERS) epidemic including cell culture, nucleic acid amplification, antigen detection, and antibody detection assays. Applications of such tests in both acute clinical and epidemiological investigation settings are highlighted. Using the MERS epidemic as an example, we illustrate the various challenges faced by laboratories in test development and implementation in the setting of a rapidly emerging infectious disease. Future directions in the diagnosis of MERS and other emerging infectious disease investigations are also highlighted.

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REVIEW] Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies
Brian B. Gowen , Brady T. Hickerson
J. Microbiol. 2017;55(3):183-195.   Published online February 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7029-8
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  • 12 Crossref
AbstractAbstract
A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use. Here, we review recent progress in animal models of severe bunyaviral infections essential to this mission, as well as promising antivirals and biologicals that are at various stages of the development process.

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REVIEW] H5 influenza, a global update
Rhodri Harfoot , Richard J. Webby
J. Microbiol. 2017;55(3):196-203.   Published online February 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7062-7
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AbstractAbstract
H5 influenza viruses have caused much alarm globally due to their high pathogenic potential. As yet we have not seen sustained spread of the virus amongst humans despite a high prevalence of the virus in avian populations. Nevertheless, isolated human cases of infection have demonstrated high mortality and there are substantial efforts being taken to monitor the evolution of the virus and to undertake preparedness activities. Here we review and discuss the evolution of the A/goose/Guangdong/1/96 (H5N1) virus with emphasis on recent events.

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REVIEW] Zika virus: An emerging flavivirus
Sang-Im Yun , Young-Min Lee
J. Microbiol. 2017;55(3):204-219.   Published online February 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7063-6
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AbstractAbstract
Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific Islands, then further afield to South and Central America and the Caribbean. Currently, ZIKV is actively circulating not only in much of Latin America and its neighbors but also in parts of the Pacific Islands and Southeast Asia. Although ZIKV infection generally causes only mild symptoms in some infected individuals, it is associated with a range of neuroimmunological disorders, including Guillain-Barré syndrome, meningoencephalitis, and myelitis. Recently, maternal ZIKV infection during pregnancy has been linked to neonatal malformations,
result
ing in various degrees of congenital abnormalities, microcephaly, and even abortion. Despite its emergence as an important public health problem, however, little is known about ZIKV biology, and neither vaccine nor drug is available to control ZIKV infection. This article provides a brief introduction to ZIKV with a major emphasis on its molecular virology, in order to help facilitate the development of diagnostics, therapeutics, and vaccines.

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REVIEW] Exploiting virus-like particles as innovative vaccines against emerging viral infections
Hotcherl Jeong , Baik Lin Seong
J. Microbiol. 2017;55(3):220-230.   Published online February 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7058-3
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AbstractAbstract
Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine dose. As an alternative to cell-culture based vaccine, virus-like particles (VLPs) are considered as a highpriority vaccine strategy against emerging viruses. VLPs represent highly ordered repetitive structures via macromolecular assemblies of viral proteins. The particulate nature allows efficient uptake into antigen presenting cells stimulating both innate and adaptive immune responses towards enhanced vaccine efficacy. Increasing research activity and translation opportunity necessitate the advances in the design of VLPs and new bioprocessing modalities for efficient and cost-effective production. Herein, we describe major achievements and challenges in this endeavor, with respect to designing strategies to harnessing the immunogenic potential, production platforms, downstream processes, and some exemplary
case
s in developing VLP-based vaccines.

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