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- Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone
- Qiudi Zhou, Lihui Feng
- J. Microbiol. 2024;62(5):367-379. Published online June 17, 2024
- DOI: https://doi.org/10.1007/s12275-024-00141-0
- 275 View
- 5 Download
- 2 Web of Science
- 1 Crossref
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Abstract
PDF - 2-piperidone is a crucial industrial raw material of high-value nylon-5 and nylon-6,5. Currently, a major bottleneck in the biosynthesis of 2-piperidone is the identification of highly efficient 2-piperidone synthases. In this study, we aimed to identify specific strains among 51 human gut bacterial strains capable of producing 2-piperidone and to elucidate its synthetic mechanism. Our findings revealed that four gut bacterial strains, namely Collinsella aerofaciens LFYP39, Collinsella intestinalis LFYP54, Clostridium bolteae LFYP116, and Clostridium hathewayi LFYP18, could produce 2-piperidone from 5-aminovaleric acid (5AVA). Additionally, we observed that 2-piperidone could be synthesized from proline through cross-feeding between Clostridium difficile LFYP43 and one of the four 2-piperidone producing strains, respectively. To identify the enzyme responsible for catalyzing the conversion of 5AVA to 2-piperidone, we utilized a gain-of-function library and identified avaC (5-aminovaleric acid cyclase) in C. intestinalis LFYP54. Moreover, homologous genes of avaC were validated in the other three bacterial strains. Notably, avaC were found to be widely distributed among environmental bacteria. Overall, our research delineated the gut bacterial strains and genes involved in 2-piperidone production, holding promise for enhancing the efficiency of industrial biosynthesis of this compound.
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- Metabolite biomarkers of screening neonatal congenital hypothyroidism based on dried blood spot metabolomics
Xingyu Guo, Feng Suo, Yuting Wang, Di Yu, Yi Wang, Bulian Dong, Lingshan Gou, Xinhui Gan, Benjing Wang, Chaowen Yu, Xiaoxiang Xie, Dandan Linghu, Xinyu Liu, Maosheng Gu, Guowang Xu
Analytical and Bioanalytical Chemistry.2025; 417(13): 2889. CrossRef
- Metabolite biomarkers of screening neonatal congenital hypothyroidism based on dried blood spot metabolomics
- Recombinant Protein Mimicking the Antigenic Structure of the Viral Surface Envelope Protein Reinforces Induction of an Antigen‑Specific and Virus‑Neutralizing Immune Response Against Dengue Virus
- Ju Kim , Tae Young Lim , Jisang Park , Yong&#
- J. Microbiol. 2023;61(1):131-143. Published online February 1, 2023
- DOI: https://doi.org/10.1007/s12275-023-00021-z
- 238 View
- 0 Download
- 2 Web of Science
- 2 Crossref
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Abstract
PDF
- Dengue virus (DENV), belonging to the family Flaviviridae, is the causative agent of dengue and comprises four serotypes. A second heterologous DENV infection is a critical risk factor for severe dengue, and no effective vaccine is available to prevent infection by all four DENV serotypes. Recombinant DENV vaccines are primarily based on the envelope proteins, prM and E. The E protein and its envelope domain III (EDIII) have been investigated as candidate antigens (Ags) for recombinant subunit vaccines. However, most EDIII-based Ags are monomers that do not display the cognate antigenic structure of E protein, which is essential for induction of virus-neutralizing immunity. Here, we developed recombinant DENV-2 envelope domain (r2ED) protein as an Ag that mimics the quaternary structure of E protein on the DENV surface. We confirmed that r2ED retained the conformational epitope displayed at the E-dimer interface, which reportedly exhibits broad virus-neutralizing capacity, without displaying the fusion loop epitope that causes antibody (Ab)-dependent enhancement. Furthermore, compared with EDIII alone, r2ED elicited stronger Ag-specific and cross-reactive neutralizing Ab and T cell-mediated immune responses in mice. This Ag-specific immunity was maintained at an elevated level 6 months after the last immunization, suggesting sustained Ag-specific immune memory. Taken together, these observations suggest that r2ED could be used to develop an improved subunit vaccine capable of inducing a broadly cross-reactive and long-lasting immune response against DENV infection.
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Citations
Citations to this article as recorded by- Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro
Jae-Hyeong Kim, Dong-Hwi Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Dong-Hun Lee, Do-Geun Kim, Hun-Young Yoon, In-Soo Choi
Journal of Microbiology.2025; 63(5): e2501029. CrossRef - Peptides of a Feather: How Computation Is Taking Peptide Therapeutics under Its Wing
Thomas David Daniel Kazmirchuk, Calvin Bradbury-Jost, Taylor Ann Withey, Tadesse Gessese, Taha Azad, Bahram Samanfar, Frank Dehne, Ashkan Golshani
Genes.2023; 14(6): 1194. CrossRef
- Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro
- Role of melatonin in murine “restraint stress”-induced dysfunction of colonic microbiota
- Rutao Lin , Zixu Wang , Jing Cao , Ting Gao , Yulan Dong , Yaoxing Chen
- J. Microbiol. 2021;59(5):500-512. Published online February 25, 2021
- DOI: https://doi.org/10.1007/s12275-021-0305-7
- 263 View
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- 16 Web of Science
- 17 Crossref
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Abstract
PDF
- Intestinal diseases caused by physiological stress have become a severe public health threat worldwide. Disturbances in the gut microbiota-host relationship have been associated with irritable bowel disease (IBD), while melatonin (MT) has antiinflammatory and antioxidant effects. The objective of this study was to investigate the mechanisms by which MT-mediated protection mitigated stress-induced intestinal microbiota dysbiosis and inflammation. We successfully established a murine restraint stress model with and without MT supplementation. Mice subjected to restraint stress had significantly elevated corticosterone (CORT) levels, decreased MT levels in their plasma, elevated colonic ROS levels and increased bacterial abundance, including Bacteroides and Tyzzerella, in their colon tract, which led to elevated expression of Toll-like receptor (TLR) 2/4, p-P65 and p-IκB. In contrast, supplementation with 20 mg/kg MT reversed the elevation of the plasma CORT levels, downregulated the colon ROS levels and inhibited the changes in the intestinal microbiota induced by restraint stress. These effects, in turn, inhibited the activities of TLR2 and TLR4, p-P65 and p-IκB, and decreased the inflammatory reaction induced by restraint stress. Our results suggested that MT may mitigate “restraint stress”-induced colonic microbiota dysbiosis and intestinal inflammation by inhibiting the activation of the NF-κB pathway.
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Citations
Citations to this article as recorded by- Tryptophan Attenuates Chronic Restraint Stress-Induced Intestinal Injury Through Modulation of Intestinal Barrier Integrity and Gut Microbiota Homeostasis
Jianhua Zheng, Tianqi Sun, Tongtong Qin, Yunpeng Wu, Wensheng Zhang, Yefeng Qiu, Jingqing Chen
Nutrients.2025; 17(6): 975. CrossRef - Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes
Ke Yang, Guangqin Li, Qihong Li, Wei Wang, Xu Zhao, Nan Shao, Hui Qiu, Jing Liu, Lin Xu, Juanjuan Zhao
Cell & Bioscience.2025;[Epub] CrossRef - Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders
Petra Zimmermann, Salome Kurth, Benoit Pugin, Nicholas A. Bokulich
npj Biofilms and Microbiomes.2024;[Epub] CrossRef - Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review
Xuemeng Wan, Liyuan Wang, Zhiling Wang, Chaomin Wan
Frontiers in Immunology.2024;[Epub] CrossRef - Christensenella minuta mitigates behavioral and cardiometabolic hallmarks of social defeat stress
A. Agusti, GV. Molina-Mendoza, M. Tamayo, V. Rossini, MC. Cenit, C. Frances-Cuesta, V. Tolosa-Enguis, EM. Gómez Del Pulgar, A. Flor-Duro, Y. Sanz
Biomedicine & Pharmacotherapy.2024; 180: 117377. CrossRef - The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes, Paula Sanchez‐Diaz, Cassandra E. Gheorghe, Michael S. Goodson, Nancy Kelley‐Loughnane, Niall P. Hyland, John F. Cryan, Gerard Clarke
The Journal of Physiology.2023; 601(20): 4491. CrossRef - Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease
María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
Antioxidants.2023; 13(1): 34. CrossRef - INVESTIGATION OF THE ROLE OF STRESS IN MALE INFERTILITY AND THE EFFECT OF CURRENT MELATONIN HORMONE TREATMENTS
İshak GÖKÇEK, Leyla AYDIN
Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni.2023; 14(1): 36. CrossRef - The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments
Alane N. Bezerra, Caroline L. Peixoto, Synara C. Lopes, Veralice M. S. Bruin, Pedro Felipe C. Bruin, Reinaldo B. Oriá
Frontiers in Nutrition.2023;[Epub] CrossRef - Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light
Dun-Xian Tan, Russel J. Reiter, Scott Zimmerman, Ruediger Hardeland
Biology.2023; 12(1): 89. CrossRef - Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice
Ichiro Chihara, Hiromitsu Negoro, Jin Kono, Yoshiyuki Nagumo, Haruki Tsuchiya, Kosuke Kojo, Masanobu Shiga, Ken Tanaka, Shuya Kandori, Bryan J. Mathis, Hiroyuki Nishiyama
Communications Biology.2023;[Epub] CrossRef - The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation
Jefferson Luiz da Silva, Lia Vezenfard Barbosa, Camila Figueiredo Pinzan, Viviani Nardini, Irislene Simões Brigo, Cássia Aparecida Sebastião, Jefferson Elias-Oliveira, Vânia Brazão, José Clóvis do Prado Júnior, Daniela Carlos, Cristina Ribeiro de Barros C
Microorganisms.2023; 11(2): 460. CrossRef - The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression
Mauritz F. Herselman, Sheree Bailey, Larisa Bobrovskaya
International Journal of Molecular Sciences.2022; 23(4): 2013. CrossRef - Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
Yiwen Zhang, Rui Lang, Shunyu Guo, Xiaoqin Luo, Huiting Li, Cencen Liu, Wei Dong, Changshun Bao, Yang Yu
Frontiers in Neuroscience.2022;[Epub] CrossRef - Protective Effects and Mechanisms of Melatonin on Stress Myocardial Injury in Rats
Jia-yao Chen, Ting Li, Jiao-ling Wang, Zhan-le Wang, Yun Zhang, Lin-quan Zang
Journal of Cardiovascular Pharmacology.2022; 80(3): 417. CrossRef - Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism
Xia Liu, Yi Cui, Yuhan Zhang, Guo Xiang, Meng Yu, Xianshu Wang, Bin Qiu, Xin-gang Li, Wei Liu, Di Zhang
Biomedicine & Pharmacotherapy.2022; 156: 113949. CrossRef - Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases
Pengwei Li, Mingxian Chang
International Journal of Molecular Sciences.2021; 22(14): 7688. CrossRef
- Tryptophan Attenuates Chronic Restraint Stress-Induced Intestinal Injury Through Modulation of Intestinal Barrier Integrity and Gut Microbiota Homeostasis
Review
- [MINIREVIEW]Regulation of gene expression by protein lysine acetylation in Salmonella
- Hyojeong Koo , Shinae Park , Min-Kyu Kwak , Jung-Shin Lee
- J. Microbiol. 2020;58(12):979-987. Published online November 17, 2020
- DOI: https://doi.org/10.1007/s12275-020-0483-8
- 305 View
- 0 Download
- 17 Web of Science
- 15 Crossref
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Abstract
PDF
- Protein lysine acetylation influences many physiological functions, such as gene regulation, metabolism, and disease in eukaryotes. Although little is known about the role of lysine acetylation in bacteria, several reports have proposed its importance in various cellular processes. Here, we discussed the function of the protein lysine acetylation and the post-translational modifications (PTMs) of histone-like proteins in bacteria focusing on Salmonella pathogenicity. The protein lysine residue in Salmonella is acetylated by the Pat-mediated enzymatic pathway or by the acetyl phosphate-mediated non-enzymatic pathway. In Salmonella, the acetylation of lysine 102 and lysine 201 on PhoP inhibits its protein activity and DNAbinding, respectively. Lysine acetylation of the transcriptional regulator, HilD, also inhibits pathogenic gene expression. Moreover, it has been reported that the protein acetylation patterns significantly differ in the drug-resistant and -sensitive Salmonella strains. In addition, nucleoid-associated proteins such as histone-like nucleoid structuring protein (H-NS) are critical for the gene silencing in bacteria, and PTMs in H-NS also affect the gene expression. In this review, we suggest that protein lysine acetylation and the post-translational modifications of H-NS are important factors in understanding the regulation of gene expression responsible for pathogenicity in Salmonella.
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Citations
Citations to this article as recorded by- Global Insights into the Lysine Acetylome Reveal the Role of Lysine Acetylation in the Adaptation of Bacillus altitudinis to Salt Stress
Xujian Li, Shanshan Dai, Shanshan Sun, Dongying Zhao, Hui Li, Junyi Zhang, Jie Ma, Binghai Du, Yanqin Ding
Journal of Proteome Research.2025; 24(1): 210. CrossRef - The concentration of medium-chain fatty acids in breast milk is influenced by maternal diet and associated with gut microbiota in infants
Menglu Xi, Ignatius Man-Yau Szeto, Sufang Duan, Ting Li, Yalu Yan, Xia Ma, Ting Sun, Weilian Hung, Celi Yang, Yonghua Zhang, Ai Zhao
Journal of Functional Foods.2025; 128: 106782. CrossRef - Reversible acetylation of ribosomal protein S1 serves as a smart switch for Salmonella to rapidly adapt to host stress
Yi-Lin Shen, Tian-Xian Liu, Lei Xu, Bang-Ce Ye, Ying Zhou
Nucleic Acids Research.2025;[Epub] CrossRef - Bacterial protein acetylation: mechanisms, functions, and methods for study
Jocelin Rizo, Sergio Encarnación-Guevara
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - Acetyl-proteome profiling revealed the role of lysine acetylation in erythromycin resistance of Staphylococcus aureus
Miao Feng, Xiaoyu Yi, Yanling Feng, Feng He, Zonghui Xiao, Hailan Yao
Heliyon.2024; 10(15): e35326. CrossRef - Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota
Menglu Xi, Yalu Yan, Sufang Duan, Ting Li, Ignatius Man-Yau Szeto, Ai Zhao
Frontiers in Microbiology.2024;[Epub] CrossRef - Acetylomics reveals an extensive acetylation diversity within Pseudomonas aeruginosa
Nand Broeckaert, Hannelore Longin, Hanne Hendrix, Jeroen De Smet, Mirita Franz-Wachtel, Boris Maček, Vera van Noort, Rob Lavigne
microLife.2024;[Epub] CrossRef - Lysine acetylation regulates the AT-rich DNA possession ability of H-NS
Yabo Liu, Mengqing Zhou, Yifan Bu, Liang Qin, Yuanxing Zhang, Shuai Shao, Qiyao Wang
Nucleic Acids Research.2024; 52(4): 1645. CrossRef -
Acetylation of K188 and K192 inhibits the DNA-binding ability of NarL to regulate
Salmonella
virulence
Liu-Qing Zhang, Yi-Lin Shen, Bang-Ce Ye, Ying Zhou, Christopher A. Elkins
Applied and Environmental Microbiology.2023;[Epub] CrossRef - Acetylome and Succinylome Profiling of Edwardsiella tarda Reveals Key Roles of Both Lysine Acylations in Bacterial Antibiotic Resistance
Yuying Fu, Lishan Zhang, Huanhuan Song, Junyan Liao, Li Lin, Wenjia Jiang, Xiaoyun Wu, Guibin Wang
Antibiotics.2022; 11(7): 841. CrossRef - Pat- and Pta-mediated protein acetylation is required for horizontally-acquired virulence gene expression in Salmonella Typhimurium
Hyojeong Koo, Eunna Choi, Shinae Park, Eun-Jin Lee, Jung-Shin Lee
Journal of Microbiology.2022; 60(8): 823. CrossRef -
Acetylation of CspC Controls the Las Quorum-Sensing System through Translational Regulation of
rsaL
in Pseudomonas aeruginosa
Shouyi Li, Xuetao Gong, Liwen Yin, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Un-Hwan Ha, Weihui Wu, Pierre Cornelis, Gerald B. Pier
mBio.2022;[Epub] CrossRef - Trans-acting regulators of ribonuclease activity
Jaejin Lee, Minho Lee, Kangseok Lee
Journal of Microbiology.2021; 59(4): 341. CrossRef - Acetylation of the CspA family protein CspC controls the type III secretion system through translational regulation ofexsAinPseudomonas aeruginosa
Shouyi Li, Yuding Weng, Xiaoxiao Li, Zhuo Yue, Zhouyi Chai, Xinxin Zhang, Xuetao Gong, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Weihui Wu
Nucleic Acids Research.2021; 49(12): 6756. CrossRef - Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review
Michał Wójcicki, Olga Świder, Kamila J. Daniluk, Paulina Średnicka, Monika Akimowicz, Marek Ł. Roszko, Barbara Sokołowska, Edyta Juszczuk-Kubiak
Pathogens.2021; 10(7): 801. CrossRef
- Global Insights into the Lysine Acetylome Reveal the Role of Lysine Acetylation in the Adaptation of Bacillus altitudinis to Salt Stress
Journal Articles
- Phosphorylation of tegument protein pp28 contributes to trafficking to the assembly compartment in human cytomegalovirus infection
- Jun-Young Seo , Jin Ah Heo , William J. Britt
- J. Microbiol. 2020;58(7):624-631. Published online June 27, 2020
- DOI: https://doi.org/10.1007/s12275-020-0263-5
- 233 View
- 0 Download
- 5 Web of Science
- 5 Crossref
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Abstract
PDF
- Human cytomegalovirus (HCMV) UL99 encodes a late tegument protein pp28 that is essential for envelopment and production of infectious virus. This protein is localized to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in transfected cells but it localizes to the cytoplasmic assembly compartment (AC) in HCMV-infected cells. Trafficking of pp28 to the AC is required for the assembly of infectious virus. The N-terminal domain (aa 1-61) of pp28 is sufficient for trafficking and function of the wild type protein during viral infection. However, residues required for authentic pp28 trafficking with the exception of the acidic cluster in the N-terminal domain of pp28 remain undefined. Monitoring protein migration on SDS-PAGE, we found that pp28 is phosphorylated in the virus-infected cells and dephosphorylated in the viral particles. By generating substitution mutants of pp28, we showed that three serine residues (aa 41–43) and a tyrosine residue (aa 34) account for its phosphorylation. The mutant forms of pp28 were localized to the plasma membrane as well as the ERGIC in transfected cells. Likewise, these mutant proteins were localized to the plasma membrane as well as the AC in virus-infected cells. These results suggested that phosphorylation of pp28 contributes to its intracellular trafficking and efficient viral assembly and incorporation.
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Citations
Citations to this article as recorded by- Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer
Yang Yang, Jiayi Chen, Fuhong Gong, Jingge Miao, Mengping Lin, Ruimin Liu, Chenxi Wang, Fei Ge, Wenlin Chen
Scientific Reports.2024;[Epub] CrossRef - Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons
Jacob W. Adelman, Suzette Rosas-Rogers, Megan L. Schumacher, Rebekah L. Mokry, Scott S. Terhune, Allison D. Ebert, Thomas Shenk
mBio.2023;[Epub] CrossRef - Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review
Janine Zeng, Di Cao, Shaomin Yang, Dabbu Kumar Jaijyan, Xiaolian Liu, Songbin Wu, Ruth Cruz-Cosme, Qiyi Tang, Hua Zhu
Viruses.2023; 15(8): 1703. CrossRef - Features and Functions of the Conserved Herpesvirus Tegument Protein UL11 and Its Binding Partners
Linjiang Yang, Mingshu Wang, Anchun Cheng, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun
Frontiers in Microbiology.2022;[Epub] CrossRef - The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction
Declan L. Turner, Rommel A. Mathias
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
- Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer
- Light affects picocyanobacterial grazing and growth response of the mixotrophic flagellate Poterioochromonas malhamensis
- Thomas Weisse , Michael Moser
- J. Microbiol. 2020;58(4):268-278. Published online January 28, 2020
- DOI: https://doi.org/10.1007/s12275-020-9567-8
- 238 View
- 0 Download
- 6 Web of Science
- 4 Crossref
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Abstract
PDF
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We measured the grazing and growth response of the mixotrophic
chrysomonad flagellate Poterioochromonas malhamensis
on four closely related picocyanobacterial strains isolated
from subalpine lakes in central Europe. The picocyanobacteria
represented different pigment types (phycoerythrin-
rich, PE, and phycocyanin-rich, PC) and phylogenetic
clusters. The grazing experiments were conducted with laboratory
cultures acclimated to 10 μmol photon/m2/sec (low
light, LL) and 100 μmol photon/m2/sec (moderate light, ML),
either in the dark or at four different irradiances ranging from
low (6 μmol photon/m2/sec) to high (1,500 μmol photon/m2/
sec) light intensity. Poterioochromonas malhamensis preferred
the larger, green PC-rich picocyanobacteria to the smaller,
red PE-rich picocyanobacterial, and heterotrophic bacteria.
The feeding and growth rates of P. malhamensis were sensitive
to the actual light conditions during the experiments;
the flagellate performed relatively better in the dark and at
LL conditions than at high light intensity. In summary, our
results
found strain-specific ingestion and growth rates of the flagellate; an effect of the preculturing conditions, and, unexpectedly, a direct adverse effect of high light levels. We conclude that this flagellate may avoid exposure to high surface light intensities commonly encountered in temperate lakes during the summer. -
Citations
Citations to this article as recorded by- A systematic review of the predatory contaminant Poterioochromonas in microalgal culture
Mingyang Ma, Chaojun Wei, Wenjie Huang, Yue He, Yingchun Gong, Qiang Hu
Journal of Applied Phycology.2023; 35(3): 1103. CrossRef - Transcriptional profile reveals the physiological responses to prey availability in the mixotrophic chrysophyte Poterioochromonas malhamensis
Mingyang Ma, Wentao Yang, Hong Chen, Wanwan Ke, Yingchun Gong, Qiang Hu
Frontiers in Microbiology.2023;[Epub] CrossRef - Microbial consortia in an ice‐covered high‐altitude lake impacted by additions of dissolved organic carbon and nutrients
Flavia Dory, Laurent Cavalli, Evelyne Franquet, Magalie Claeys‐Bruno, Benjamin Misson, Thierry Tatoni, Céline Bertrand
Freshwater Biology.2021; 66(8): 1648. CrossRef - Picoplankton feeding by the ciliate Vorticella similis in comparison to other peritrichs emphasizes their significance in the water purification process
Thomas Weisse, Jitka Jezberova, Michael Moser
Ecological Indicators.2021; 121: 106992. CrossRef
- A systematic review of the predatory contaminant Poterioochromonas in microalgal culture
- Overexpression and characterization of a novel cold-adapted and salt-tolerant GH1 β-glucosidase from the marine bacterium Alteromonas sp. L82
- Jingjing Sun , Wei Wang , Congyu Yao , Fangqun Dai , Xiangjie Zhu , Junzhong Liu , Jianhua Hao
- J. Microbiol. 2018;56(9):656-664. Published online August 23, 2018
- DOI: https://doi.org/10.1007/s12275-018-8018-2
- 245 View
- 0 Download
- 36 Crossref
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Abstract
PDF
- A novel gene (bgl) encoding a cold-adapted β-glucosidase was cloned from the marine bacterium Alteromonas sp. L82. Based on sequence analysis and its putative catalytic conserved region, Bgl belonged to the glycoside hydrolase family 1. Bgl was overexpressed in E. coli and purified by Ni2+ affinity chromatography. The purified recombinant β- glucosidase showed maximum activity at temperatures between 25°C to 45°C and over the pH range 6 to 8. The enzyme lost activity quickly after incubation at 40°C. Therefore, recombinant β-glucosidase appears to be a cold-adapted enzyme. The addition of reducing agent doubled its activity and 2 M NaCl did not influence its activity. Recombinant β-glucosidase was also tolerant of 700 mM glucose and some organic solvents. Bgl had a Km of 0.55 mM, a Vmax of 83.6 U/mg, a kcat of 74.3 s-1 and kcat/Km of 135.1 at 40°C, pH 7 with 4-nitrophenyl-β-D-glucopyranoside as a substrate. These properties indicate Bgl may be an interesting candidate for biotechnological and industrial applications.
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Citations
Citations to this article as recorded by- A novel cold-active GH1 β-galactosidase from psychrotolerant Microbacterium phyllosphaerae LW106 suitable for lactose hydrolysis and galactooligosaccharides synthesis in milk at low temperature
Aiguo Li, Wenlu Liu, Xuehua Yu, Rui Han, Xinyu Xiong, Bo Guan, Youzhen Hu, Yongqin Ni, Jun Zeng
LWT.2025; 229: 118218. CrossRef -
Streptomyces beigongshangae sp. nov., isolated from baijiu fermented grains, could transform ginsenosides of Panax notoginseng
Bo Liu, Haoyue Gu, Rui Shi, Xiahong He, Zhanbin Sun, Qing Ren, Hanxu Pan
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef - A novel GH1 β-glucosidase from an Arctic bacterium: Characterization and secretory expression in Bacillus subtilis
Jingjing Sun, Wei Wang, Jianhua Hao
Process Biochemistry.2024; 140: 108. CrossRef - Screening, cloning, immobilization and application prospects of a novel β-glucosidase from the soil metagenome
Qian Yao, Jin Xu, Nan Tang, Weiji Chen, Quliang Gu, He Li
Environmental Research.2024; 244: 117676. CrossRef - Characterization of a novel cold-adapted GH1 β-glucosidase from Psychrobacillus glaciei and its application in the hydrolysis of soybean isoflavone glycosides
Jinjian He, Jiajing Duan, Pinglian Yu, Yuying Li, Mansheng Wang, Xiu Zhang, Zishu Chen, Pengjun Shi
Current Research in Food Science.2024; 8: 100777. CrossRef - Biochemical and in silico structural properties of a thermo-acid stable β-glucosidase from Beauveria bassiana
Buka Magwaza, Ayodeji Amobonye, Prashant Bhagwat, Santhosh Pillai
Heliyon.2024; 10(7): e28667. CrossRef - Moderately thermostable GH1 β-glucosidases from hyperacidophilic archaeon Cuniculiplasma divulgatum S5
Anna N Khusnutdinova, Hai Tran, Saloni Devlekar, Marco A Distaso, Ilya V Kublanov, Tatiana Skarina, Peter Stogios, Alexei Savchenko, Manuel Ferrer, Olga V Golyshina, Alexander F Yakunin, Peter N Golyshin
FEMS Microbiology Ecology.2024;[Epub] CrossRef - Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1
Louise Jane Gourlay, Marco Mangiagalli, Elisabetta Moroni, Marina Lotti, Marco Nardini
The FEBS Journal.2024; 291(13): 2897. CrossRef - Partial characterization of β-glucosidase, β-xylosidase, and α-l-arabinofuranosidase from Jiangella alba DSM 45237 and their potential in lignocellulose-based biorefining
Zeynep Gül Aytaş, Münir Tunçer, Çağrı Seda Kul, Sümeyye Cilmeli, Nurayan Aydın, Tuğrul Doruk, Ali Osman Adıgüzel
Sustainable Chemistry and Pharmacy.2023; 31: 100900. CrossRef - Heterologous expression and characterization of salt-tolerant β-glucosidase from xerophilic Aspergillus chevalieri for hydrolysis of marine biomass
Hironori Senba, Daisuke Saito, Yukihiro Kimura, Shinichi Tanaka, Mikiharu Doi, Shinji Takenaka
Archives of Microbiology.2023;[Epub] CrossRef - Expression of β-Glucosidases from the Yak Rumen in Lactic Acid Bacteria: A Genetic Engineering Approach
Chuan Wang, Yuze Yang, Chunjuan Ma, Yongjie Sunkang, Shaoqing Tang, Zhao Zhang, Xuerui Wan, Yaqin Wei
Microorganisms.2023; 11(6): 1387. CrossRef - Structural and functional insights of a cold-adaptive β-glucosidase with very high glucose tolerance from Microbacterium sp. CIAB417
Anjali Purohit, Lata Pawar, Sudesh Kumar Yadav
Enzyme and Microbial Technology.2023; 169: 110284. CrossRef - Advances in cold-adapted enzymes derived from microorganisms
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Amanda S. de Sousa, Ricardo R. de Melo, Renan Y. Miyamoto, Mariana A. B. Morais, Liliane P. Andrade, Natália Milan, Mayara C. de Avila, Cláudia M. de Souza, Regina C. Adão, Josiane A. Scarpassa, Plínio S. Vieira, Leandro V. dos Santos, Carlos H. I. Ramos,
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Jaejin Lee, Dong-Ho Lee, Che Ok Jeon, Kangseok Lee
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Comparison between irradiating and autoclaving citrus wastes as substrate for solid‐state fermentation by
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Research Support, Non-U.S. Gov'ts
- Molecular characterization of mammalian-adapted Korean-type avian H9N2 virus and evaluation of its virulence in mice
- Kuk Jin Park , Min-Suk Song , Eun-Ha Kim , Hyeok-il Kwon , Yun Hee Baek , Eun-hye Choi , Su-Jin Park , Se Mi Kim , Young-il Kim , Won-Suk Choi , Dae-Won Yoo , Chul-Joong Kim , Young Ki Choi
- J. Microbiol. 2015;53(8):570-577. Published online July 31, 2015
- DOI: https://doi.org/10.1007/s12275-015-5329-4
- 238 View
- 0 Download
- 15 Crossref
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Abstract
- Avian influenza A virus (AIV) is commonly isolated from domestic poultry and wild migratory birds, and the H9N2 subtype is the most prevalent and the major cause of severe disease in poultry in Korea. In addition to the veterinary concerns regarding the H9N2 subtype, it is also considered to be the next potential human pandemic strain due to its rapid evolution and interspecies transmission. In this study, we utilize serial lung-to-lung passage of a low pathogenic avian influenza virus (LPAI) H9N2 (A/Ck/Korea/163/04, WT163) (Y439-lineage) in mice to increase pathogenicity and investigate the potential virulence marker. Mouse-adapted H9N2 virus obtained high virulence (100% mortality) in mice after 98 serial passages. Sequence results show that the mouse adaptation (ma163) possesses several mutations within seven gene segments (PB2, PA, HA, NP, NA, M, and NS) relative to the wild-type strain. The HA gene showed the most mutations (at least 11) with one resulting in the loss of an N-glycosylation site (at amino acid 166). Moreover, reverse genetic studies established that an E627K substitution in PB2 and the loss of the N-glycosylation site in the HA protein (aa166) are critical virulence markers in the mouse-adapted H9N2 virus. Thus, these results add to the increasing body of mutational analysis data defining the function of the viral polymerase and HA genes and their roles in mammalian host adaptation. To our knowledge, this is first report of the generation of a mammalian-adapted Korea H9N2 virus (Y493-lineages). Therefore, this study offers valuable insights into the molecular evolution of the LPAI Korean H9N2 in a new host and adds to the current knowledge of the molecular markers associated with increased virulence.
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Citations
Citations to this article as recorded by- Genetic Characterization of Kazakhstan Isolates: Avian Influenza H9N2 Viruses Demonstrate Their Potential to Infect Mammals
Barshagul Baikara, Kobey Karamendin, Yermukhammet Kassymbekov, Klara Daulbayeva, Temirlan Sabyrzhan, Sardor Nuralibekov, Yelizaveta Khan, Nurlan Sandybayev, Sasan Fereidouni, Aidyn Kydyrmanov
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Mingeun Sagong, Kwang-Nyeong Lee, Eun-Kyoung Lee, Hyunmi Kang, Young Ki Choi, Youn-Jeong Lee
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Qingzheng Liu, Lingcai Zhao, Yanna Guo, Yongzhen Zhao, Yingfei Li, Na Chen, Yuanlu Lu, Mengqi Yu, Lulu Deng, Jihui Ping
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- Genetic Characterization of Kazakhstan Isolates: Avian Influenza H9N2 Viruses Demonstrate Their Potential to Infect Mammals
- DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation
- Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park
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- DOI: https://doi.org/10.1007/s12275-013-3428-7
- 231 View
- 0 Download
- 15 Crossref
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Abstract
PDF
- Influenza viruses are seasonally recurring human pathogens. Vaccines and antiviral drugs are available for influenza. However, the viruses, which often change themselves via antigenic drift and shift, demand constant efforts to update vaccine antigens every year and develop new agents with broad-spectrum antiviral efficacy. An animal model is critical for such efforts. While most human influenza viruses are unable to kill BALB/c mice, some strains have been shown to kill DBA/2 mice without prior adaptation. Therefore, in this study, we explored the feasibility of employing DBA/2 mice as a model in the development of anti-influenza drugs. Unlike the BALB/c strain, DBA/2 mice were highly susceptible and could be killed with a relatively low titer (50% DBA/2 lethal dose = 102.83 plaque-forming units) of the A/ Korea/01/2009 virus (2009 pandemic H1N1 virus). When treated with a neuraminidase inhibitor, oseltamivir phosphate, infected DBA/2 mice survived until 14 days postinfection. The reduced morbidity of the infected DBA/2 mice was also consistent with the oseltamivir treatment. Taking these data into consideration, we propose that the DBA/2 mouse is an excellent animal model to evaluate antiviral efficacy against influenza infection and can be further utilized for combination therapies or bioactivity models of existing and newly developed anti-influenza drugs.
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Citations
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Kevin Liaw, Kylie M. Konrath, Abigail R. Trachtman, Nicholas J. Tursi, Ebony N. Gary, Cory Livingston, Kaitlyn Flowers, Jacqueline D. Chu, Casey E. Hojecki, Niklas Laenger, Madison E. McCanna, Colby J. Agostino, Neethu Chokkalingam, Kelly Bayruns, Sinja K
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- Complete Genome of Leptospirillum ferriphilum ML-04 Provides Insight into Its Physiology and Environmental Adaptation
- Shuang Mi , Jian Song , Jianqun Lin , Yuanyuan Che , Huajun Zheng , Jianqiang Lin
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- DOI: https://doi.org/10.1007/s12275-011-1099-9
- 180 View
- 0 Download
- 42 Crossref
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Abstract
PDF
- Leptospirillum ferriphilum has been identified as the dominant, moderately thermophilic, bioleaching microorganism in bioleaching processes. It is an acidic and chemolithoautrophic bacterium that gains electrons from ferrous iron oxidation for energy production and cell growth. Genetic information about this microorganism has been limited until now, which has hindered its further exploration. In this study, the complete genome of L. ferripilum ML-04 is sequenced and annotated. The bacterium has a single circular chromosome of 2,406,157 bp containing 2,471 coding sequences (CDS), 2 rRNA operons, 48 tRNA genes, a large number of mobile genetic elements and 2 genomic islands. In silico analysis shows L. ferriphilum ML-04 fixes carbon through a reductive citric acid (rTCA) cycle, and obtains nitrogen through ammonium assimilation. The genes related to “cell envelope biogenesis, outer membrane” (6.9%) and “DNA replication, recombination and repair” (5.6%) are abundant, and a large number of genes related to heavy metal detoxification, oxidative and acidic stress defense, and signal transduction pathways were detected. The genomic plasticity, plentiful cell envelope components, inorganic element metabolic abilities and stress response mechanisms found the base for this organism’s survival in the bioleaching niche.
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Citations
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Multi-omics Reveals the Lifestyle of the Acidophilic, Mineral-Oxidizing Model Species Leptospirillum ferriphilum
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- Adaptation and Cross-Adaptation of Listeria monocytogenes and Salmonella enterica to Poultry Decontaminants
- Alicia Alonso-Hernando , Rosa Capita , Miguel Prieto , Carlos Alonso-Calleja
- J. Microbiol. 2009;47(2):142-146. Published online May 2, 2009
- DOI: https://doi.org/10.1007/s12275-008-0237-5
- 171 View
- 0 Download
- 22 Crossref
-
Abstract
PDF
- Information on the potential for acquired reduced susceptibility of bacteria to poultry decontaminants occurring is lacking. Minimal Inhibitory Concentrations (MICs) were established for assessing the initial susceptibility and the adaptative and cross-adaptative responses of four bacterial strains (Listeria monocytogenes serovar 1/2a, L. monocytogenes serovar 4b, Salmonella enterica serotype Typhimurium, and S. enterica serotype Enteritidis) to four poultry decontaminants (trisodium phosphate, acidified sodium chlorite -ASC-, citric acid, and peroxyacetic acid). The initial susceptibility was observed to differ among species (all decontaminants) and between Salmonella strains (ASC). These inter- and intra-specific variations highlight (1) the need for strict monitoring of decontaminant concentrations to inactivate all target pathogens of concern, and (2) the importance of selecting adequate test strains in decontamination studies. MICs of ASC (0.17±0.02 to 0.21±0.02 mg/ml) were higher than the U.S. authorized concentration when applied as a pre-chiller or chiller solution (0.05 to 0.15 mg/ml). Progressively increasing decontaminant concentrations resulted in reduced susceptibility of strains. The highest increase in MIC was 1.88 to 2.71-fold (ASC). All decontaminants were shown to cause cross-adaptation of strains between both related and unrelated compounds, the highest increase in MIC being 1.82-fold (ASC). Our results suggest that the in-use concentrations of ASC could, in certain conditions, be ineffective against Listeria and Salmonella strains. The adaptative and cross-adaptative responses of strains tested to poultry decontaminants are of minor concern. However, the observations being presented here are based on in vitro studies, and further research into practical applications are needed in order to confirm these findings.
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Citations
Citations to this article as recorded by- Exposure to Low Doses of Biocides Increases Resistance to Other Biocides and to Antibiotics in Strains of Listeria monocytogenes
Cristina Rodríguez-Melcón, Rosa Capita, Carlos Alonso-Calleja
Biology.2025; 14(5): 495. CrossRef - Pseudomonadaceae increased the tolerance of Listeria monocytogenes to sanitizers in multi-species biofilms
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Ricardo A. Wu, Jinsong Feng, Min Yue, Donghong Liu, Tian Ding
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Cristina Rodríguez-Melcón, Víctor Serrano-Galán, Rosa Capita, Carlos Alonso-Calleja
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Cristina Rodríguez-Melcón, Carlos Alonso-Calleja, Rosa Capita
Food Control.2023; 149: 109602. CrossRef - Exploring Peracetic Acid and Acidic pH Tolerance of Antibiotic-Resistant Non-Typhoidal Salmonella and Enterococcus faecium from Diverse Epidemiological and Genetic Backgrounds
Andreia Rebelo, Bárbara Duarte, Ana R. Freitas, Luísa Peixe, Patrícia Antunes, Carla Novais
Microorganisms.2023; 11(9): 2330. CrossRef - Unraveling the Role of Metals and Organic Acids in Bacterial Antimicrobial Resistance in the Food Chain
Andreia Rebelo, Agostinho Almeida, Luísa Peixe, Patrícia Antunes, Carla Novais
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- Identification and Expression of the cym, cmt, and tod Catabolic Genes from Pseudomonas putida KL47: Expression of the Regulatory todST Genes as a Factor for Catabolic Adaptation
- Kyoung Lee , Eun Kyeong Ryu , Kyung Soon Choi , Min Chul Cho , Jae Jun Jeong , Eun Na Choi , Soo O Lee , Do-Young Yoon , Ingyu Hwang , Chi-Kyung Kim
- J. Microbiol. 2006;44(2):192-199.
- DOI: https://doi.org/2365 [pii]
- 164 View
- 0 Download
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Abstract
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- Pseudomonas putida KL47 is a natural isolate that assimilates benzene, 1-alkylbenzene (C1-C4), biphenyl, p-cumate, and p-cymene. The genetic background of strain KL47 underlying the broad range of growth substrates was examined. It was found that the cym and cmt operons are constitutively expressed due to a lack of the cymR gene, and the tod operon is still inducible by toluene and biphenyl. The entire array of gene clusters responsible for the catabolism of toluene and p-cymene/p-cumate has been cloned in a cosmid vector, pLAFR3, and were named pEK6 and pEK27, respectively. The two inserts overlap one another and the nucleotide sequence (42,505 bp) comprising the cym, cmt, and tod operons and its flanking genes in KL47 are almost identical (>99%) to those of P. putida F1. In the cloned DNA fragment, two genes with unknown functions, labeled cymZ and cmtR, were newly identified and show high sequence homology to dienelactone hydrolase and CymR proteins, respectively. The cmtR gene was identified in the place of the cmtI gene of previous annotation. Western blot analysis showed that, in strains F1 and KL47, the todT gene is not expressed during growth on Luria Bertani medium. In minimal basal salt medium, expression of the todT gene is inducible by toluene, but not by biphenyl in strain F1; however, it is constantly expressed in strain KL47, indicating that high levels of expression of the todST genes with one amino acid substitution in TodS might provide strain KL47 with a means of adaptation of the tod catabolic operon to various aromatic hydrocarbons.
Review
- The Use of the Rare UUA Codon to Define "Expression Space" for Genes Involved in Secondary Metabolism, Development and Environmental Adaptation in Streptomyces
- Keith F. Chater , Govind Chandra
- J. Microbiol. 2008;46(1):1-11.
- DOI: https://doi.org/10.1007/s12275-007-0233-1
- 243 View
- 0 Download
- 110 Crossref
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Abstract
PDF
- In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development, as revealed by the phenotypes of bldA mutants in diverse streptomycetes. This article is a comprehensive review of out understanding of this unusual situation. Based on information from four sequenced genomes it now appears that, typically, about 2~3% of genes in any one streptomycete contain a TTA codon, most having been acquired through species-specific horizontal gene transfer. Among the few widely conserved TTA-containing genes, mutations in just one, the pleiotropic regulatory gene adpA, give an obvious phenotype: such mutants are defective in aerial growth and sporulation, but vary in the extent of their impairment in secondary metabolism in different streptomycetes. The TTA codon in adpA is largely responsible for the morphological phenotype of a bldA mutant of S. coelicolor. AdpA-dependent targets include several genes involved in the integrated action of extracellular proteases that, at least in some species, are involved in the conversion of primary biomass into spores. The effects of bldA mutations on secondary metabolism are mostly attributable to the presence of TTA codons in pathway-specific genes, particularly in transcriptional activator genes. This is not confined to S. coelicolor-it is true for about half of all known antibiotic biosynthetic gene sets from streptomycetes. Combined microarray and proteomic analysis of liquid (and therefore non-sporulating) S. coelicolor bldA mutant cultures revealed effects of the mutation during rapid growth, during transition phase, and in stationary phase. Some of these effects may be secondary consequences of changes in the pattern of ppGpp accumulation. It is argued that the preferential accumulation of the bldA tRNA under conditions in which growth is significantly constrained has evolved to favour the expression of genes that confer adaptive benefits in intermittently encountered sub-optimal environments. The evolution of this system may have been a secondary consequence of the selective pressure exerted by bacteriophage attack. Some biotechnological implications of bldA phenomenology are considered.
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Physiological and Molecular Plant Pathology.2020; 110: 101480. CrossRef - The Identification and Conservation of Tunicaminyluracil-Related Biosynthetic Gene Clusters in Several Rathayibacter Species Collected From Australia, Africa, Eurasia, and North America
Matthew A. Tancos, Aaron J. Sechler, Edward W. Davis, Jeff H. Chang, Brenda K. Schroeder, Timothy D. Murray, Elizabeth E. Rogers
Frontiers in Microbiology.2020;[Epub] CrossRef - Gene miaA for post‐transcriptional modification of tRNAXXA is important for morphological and metabolic differentiation in Streptomyces
Oksana Koshla, Oleksandr Yushchuk, Iryna Ostash, Yuriy Dacyuk, Maksym Myronovskyi, Gunilla Jäger, Roderich D. Süssmuth, Andriy Luzhetskyy, Anders Byström, Leif A. Kirsebom, Bohdan Ostash
Molecular Microbiology.2019; 112(1): 249. CrossRef - Gene ssfg_01967 (miaB) for tRNA modification influences morphogenesis and moenomycin biosynthesis in Streptomyces ghanaensis ATCC14672
Yuliia Sehin, Oksana Koshla, Yuriy Dacyuk, Ruoxia Zhao, Robert Ross, Maksym Myronovskyi, Patrick A. Limbach, Andriy Luzhetskyy, Suzanne Walker, Victor Fedorenko, Bohdan Ostash
Microbiology.2019; 165(2): 233. CrossRef - LeuRS can leucylate type I and type II tRNALeus in Streptomyces coelicolor
Jia-Yi Fan, Qian Huang, Quan-Quan Ji, En-Duo Wang
Nucleic Acids Research.2019; 47(12): 6369. CrossRef - Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452
Songya Zhang, Dennis Klementz, Jing Zhu, Roman Makitrynskyy, A.R. Ola Pasternak, Stefan Günther, David L. Zechel, Andreas Bechthold
Journal of Biotechnology.2019; 292: 23. CrossRef - Genomic Insights into Evolution of AdpA Family Master Regulators of Morphological Differentiation and Secondary Metabolism in Streptomyces
Mariia Rabyk, Oleksandr Yushchuk, Ihor Rokytskyy, Maria Anisimova, Bohdan Ostash
Journal of Molecular Evolution.2018; 86(3-4): 204. CrossRef - Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis
Bingbing Hou, Liyuan Tao, Xiaoyu Zhu, Wei Wu, Meijin Guo, Jiang Ye, Haizhen Wu, Huizhan Zhang
Applied Microbiology and Biotechnology.2018; 102(9): 4101. CrossRef - Genome-guided exploration of metabolic features of Streptomyces peucetius ATCC 27952: past, current, and prospect
Nguyen Huy Thuan, Dipesh Dhakal, Anaya Raj Pokhrel, Luan Luong Chu, Thi Thuy Van Pham, Anil Shrestha, Jae Kyung Sohng
Applied Microbiology and Biotechnology.2018; 102(10): 4355. CrossRef - Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters
Dimitris Kallifidas, Guangde Jiang, Yousong Ding, Hendrik Luesch
Microbial Cell Factories.2018;[Epub] CrossRef - In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24
Lan Yan, Qizhong Zhang, Marie-Joelle Virolle, Delin Xu, Dongsheng Zhou
PLOS ONE.2017; 12(3): e0174781. CrossRef -
Tracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen
Streptomyces scabies
Samuel Jourdan, Isolde M. Francis, Benoit Deflandre, Rosemary Loria, Sébastien Rigali, Karen L. Visick
mSphere.2017;[Epub] CrossRef - Properties of Streptomyces albus J1074 mutant deficient in tRNALeu UAA gene bldA
Oksana Koshla, Maria Lopatniuk, Ihor Rokytskyy, Oleksandr Yushchuk, Yuriy Dacyuk, Victor Fedorenko, Andriy Luzhetskyy, Bohdan Ostash
Archives of Microbiology.2017; 199(8): 1175. CrossRef - Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis
Nestor Zaburannyi, Boyke Bunk, Josef Maier, Jörg Overmann, Rolf Müller, C. Vieille
Applied and Environmental Microbiology.2016; 82(6): 1945. CrossRef - Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation
Barbara Gorgoni, Luca Ciandrini, Matthew R. McFarland, M. Carmen Romano, Ian Stansfield
Nucleic Acids Research.2016; : gkw630. CrossRef - Overexpression of a pathway specific negative regulator enhances production of daunorubicin in bldA deficient Streptomyces peucetius ATCC 27952
Anaya Raj Pokhrel, Amit Kumar Chaudhary, Hue Thi Nguyen, Dipesh Dhakal, Tuoi Thi Le, Anil Shrestha, Kwangkyoung Liou, Jae Kyung Sohng
Microbiological Research.2016; 192: 96. CrossRef - Identification and engineering of regulation-related genes toward improved kasugamycin production
Chenchen Zhu, Qianjin Kang, Linquan Bai, Lin Cheng, Zixin Deng
Applied Microbiology and Biotechnology.2016; 100(4): 1811. CrossRef - Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
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Nucleic Acids Research.2016; : gkw530. CrossRef - Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439
Jingxuan He, Briana Van Treeck, Han B. Nguyen, Charles E. Melançon
ACS Synthetic Biology.2016; 5(2): 125. CrossRef - The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5
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Frontiers in Microbiology.2016;[Epub] CrossRef - Recent advances in understanding Streptomyces
Keith F. Chater
F1000Research.2016; 5: 2795. CrossRef - Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains
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ChemBioChem.2015; 16(15): 2244. CrossRef - Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway
Carolina Cano‐Prieto, Raúl García‐Salcedo, Marina Sánchez‐Hidalgo, Alfredo F. Braña, Hans‐Peter Fiedler, Carmen Méndez, José A. Salas, Carlos Olano
ChemBioChem.2015; 16(10): 1461. CrossRef - Identification of BagI as a positive transcriptional regulator of bagremycin biosynthesis in engineered Streptomyces sp. Tü 4128
Feng Liu, Dakui Xu, Yuchen Zhang, Yunxia Zhu, Jiang Ye, Huizhan Zhang
Microbiological Research.2015; 173: 18. CrossRef - Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering
Pietro Alifano, Carla Palumbo, Daniela Pasanisi, Adelfia Talà
Journal of Biotechnology.2015; 202: 60. CrossRef - Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning
Pavel V. Baranov, John F. Atkins, Martina M. Yordanova
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Stefanie Hackl, Andreas Bechthold
Archiv der Pharmazie.2015; 348(7): 455. CrossRef - Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor
Corey L. Compton, Michael S. Fernandopulle, Rohith T. Nagari, Jason K. Sello, W. W. Metcalf
Journal of Bacteriology.2015; 197(17): 2747. CrossRef - c-di-GMP signalling and the regulation of developmental transitions in streptomycetes
Matthew J. Bush, Natalia Tschowri, Susan Schlimpert, Klas Flärdh, Mark J. Buttner
Nature Reviews Microbiology.2015; 13(12): 749. CrossRef - Construction and development of a novel expression system of Streptomyces
Chengran Guan, Wenjing Cui, Xiaotian He, Xu Hu, Jun Xu, Guocheng Du, Jian Chen, Zhemin Zhou
Protein Expression and Purification.2015; 113: 17. CrossRef - Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism
Aurélie Guyet, Nadia Benaroudj, Caroline Proux, Myriam Gominet, Jean-Yves Coppée, Philippe Mazodier
BMC Microbiology.2014;[Epub] CrossRef - Thaxtomin A Production and Virulence Are Controlled by Several bld Gene Global Regulators in Streptomyces scabies
Dawn R. D. Bignell, Isolde M. Francis, Joanna K. Fyans, Rosemary Loria
Molecular Plant-Microbe Interactions®.2014; 27(8): 875. CrossRef - Developmental biology ofStreptomycesfrom the perspective of 100 actinobacterial genome sequences
Govind Chandra, Keith F. Chater
FEMS Microbiology Reviews.2014; 38(3): 345. CrossRef - The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control
Zahra Salehi-Najafabadi, Carlos Barreiro, Antonio Rodríguez-García, Anthony Cruz, Gustavo E. López, Juan F. Martín
Applied Microbiology and Biotechnology.2014; 98(11): 4919. CrossRef - Gene networks regulating secondary metabolism in actinomycetes: Pleiotropic regulators
M. V. Rabyk, B. O. Ostash, V. O. Fedorenko
Cytology and Genetics.2014; 48(1): 55. CrossRef - Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei
M. Moutiez, J. Seguin, M. Fonvielle, P. Belin, I. B. Jacques, E. Favry, M. Arthur, M. Gondry
Nucleic Acids Research.2014; 42(11): 7247. CrossRef - Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?
Yuriy Rebets, Elke Brötz, Bogdan Tokovenko, Andriy Luzhetskyy
Journal of Industrial Microbiology and Biotechnology.2014; 41(2): 387. CrossRef - Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA
Barbara Gorgoni, Elizabeth Marshall, Matthew R. McFarland, M. Carmen Romano, Ian Stansfield
Biochemical Society Transactions.2014; 42(1): 160. CrossRef - Collismycin A biosynthesis in Streptomyces sp. CS40 is regulated by iron levels through two pathway-specific regulators
Natalia M. Vior, Carlos Olano, Ignacio García, Carmen Méndez, José A. Salas
Microbiology.2014; 160(3): 467. CrossRef - Genes Required for Aerial Growth, Cell Division, and Chromosome Segregation Are Targets of WhiA before Sporulation in Streptomyces venezuelae
Matthew J. Bush, Maureen J. Bibb, Govind Chandra, Kim C. Findlay, Mark J. Buttner, Yves V. Brun
mBio.2013;[Epub] CrossRef -
Pleiotropic regulatory genes
bldA
,
adpA
and
absB
are implicated in production of phosphoglycolipid antibiotic moenomycin
Roman Makitrynskyy, Bohdan Ostash, Olga Tsypik, Yuriy Rebets, Emma Doud, Timothy Meredith, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko
Open Biology.2013; 3(10): 130121. CrossRef - A Microbial Metagenome (Leucobactersp.) inCaenorhabditisWhole Genome Sequences
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Bioinformatics and Biology Insights.2013; 7: BBI.S11064. CrossRef - Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
Gang Liu, Keith F. Chater, Govind Chandra, Guoqing Niu, Huarong Tan
Microbiology and Molecular Biology Reviews.2013; 77(1): 112. CrossRef - Towards a new science of secondary metabolism
Arryn Craney, Salman Ahmed, Justin Nodwell
The Journal of Antibiotics.2013; 66(7): 387. CrossRef - Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
Gulay Ozcengiz, Arnold L. Demain
Biotechnology Advances.2013; 31(2): 287. CrossRef - 5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus
Thomas Kwong, Nathan J. Zelyas, Hui Cai, Kapil Tahlan, Annie Wong, Susan E. Jensen
Antimicrobial Agents and Chemotherapy.2012; 56(9): 4845. CrossRef - Interspecies modulation of bacterial development through iron competition and siderophore piracy
Matthew F. Traxler, Mohammad R. Seyedsayamdost, Jon Clardy, Roberto Kolter
Molecular Microbiology.2012; 86(3): 628. CrossRef - FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
Dušan Goranovič, Marko Blažič, Vasilka Magdevska, Jaka Horvat, Enej Kuščer, Tomaž Polak, Javier Santos-Aberturas, Miriam Martínez-Castro, Carlos Barreiro, Peter Mrak, Gregor Kopitar, Gregor Kosec, Štefan Fujs, Juan F Martín, Hrvoje Petković
BMC Microbiology.2012;[Epub] CrossRef - Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A
Adam C. Jones, Sabine Ottilie, Alessandra S. Eustáquio, Daniel J. Edwards, Lena Gerwick, Bradley S. Moore, William H. Gerwick
The FEBS Journal.2012; 279(7): 1243. CrossRef - Signals and regulators that governStreptomycesdevelopment
Joseph R. McCormick, Klas Flärdh
FEMS Microbiology Reviews.2012; 36(1): 206. CrossRef - Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus
Cristina Gómez, Carlos Olano, Carmen Méndez, José A. Salas
Microbiology.2012; 158(10): 2504. CrossRef -
Roles of
fkbN
in Positive Regulation and
tcs7
in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP
SangJoon Mo, Young Ji Yoo, Yeon Hee Ban, Sung-Kwon Lee, Eunji Kim, Joo-Won Suh, Yeo Joon Yoon
Applied and Environmental Microbiology.2012; 78(7): 2249. CrossRef - Expression of the chaplin and rodlin hydrophobic sheath proteins in Streptomyces venezuelae is controlled by σBldN and a cognate anti‐sigma factor, RsbN
Maureen J. Bibb, Ágota Domonkos, Govind Chandra, Mark J. Buttner
Molecular Microbiology.2012; 84(6): 1033. CrossRef - tRNA accumulation and suppression of the bldA phenotype during development in Streptomyces coelicolor
B. M. Fredrik Pettersson, Leif A. Kirsebom
Molecular Microbiology.2011; 79(6): 1602. CrossRef - Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor
Ana Yepes, Sergio Rico, Antonio Rodríguez-García, Ramón I. Santamaría, Margarita Díaz, Ching-Hong Yang
PLoS ONE.2011; 6(5): e19980. CrossRef - The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
Gilles P. van Wezel, Kenneth J. McDowall
Natural Product Reports.2011; 28(7): 1311. CrossRef - Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus
Akiyoshi Higo, Sueharu Horinouchi, Yasuo Ohnishi
Molecular Microbiology.2011; 81(6): 1607. CrossRef - The Level of AdpA Directly Affects Expression of Developmental Genes in Streptomyces coelicolor
Marcin Wolański, Rafał Donczew, Agnieszka Kois-Ostrowska, Paweł Masiewicz, Dagmara Jakimowicz, Jolanta Zakrzewska-Czerwińska
Journal of Bacteriology.2011; 193(22): 6358. CrossRef - SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN–sanO intergenic region in Streptomyces ansochromogenes
Xihong He, Rui Li, Yuanyuan Pan, Gang Liu, Huarong Tan
Microbiology .2010; 156(3): 828. CrossRef - Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina
Giuseppe Gallo, Giovanni Renzone, Rosa Alduina, Efthimia Stegmann, Tilmann Weber, Anna Eliasson Lantz, Jette Thykaer, Fabio Sangiorgi, Andrea Scaloni, Anna Maria Puglia
PROTEOMICS.2010; 10(7): 1336. CrossRef -
Adaptation of the Highly Productive T7 Expression System to
Streptomyces lividans
François-Xavier Lussier, François Denis, François Shareck
Applied and Environmental Microbiology.2010; 76(3): 967. CrossRef - Autoregulation of hpdR and its effect on CDA biosynthesis in Streptomyces coelicolor
Haihua Yang, Yang An, Linqi Wang, Shuli Zhang, Yue Zhang, Yuqing Tian, Gang Liu, Huarong Tan
Microbiology .2010; 156(9): 2641. CrossRef -
Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in
Streptomyces ambofaciens
Fatma Karray, Emmanuelle Darbon, Hoang Chuong Nguyen, Josette Gagnat, Jean-Luc Pernodet
Journal of Bacteriology.2010; 192(21): 5813. CrossRef - Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity
Bohdan Ostash, Suzanne Walker
Natural Product Reports.2010; 27(11): 1594. CrossRef - Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant
M. T. Lopez-Garcia, I. Santamarta, P. Liras
Microbiology.2010; 156(8): 2354. CrossRef - Quantitative Proteome Analysis of Streptomyces coelicolor Nonsporulating Liquid Cultures Demonstrates a Complex Differentiation Process Comparable to That Occurring in Sporulating Solid Cultures
Angel Manteca, Hye R. Jung, Veit Schwämmle, Ole N. Jensen, Jesus Sanchez
Journal of Proteome Research.2010; 9(9): 4801. CrossRef - Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties
Kien T. Nguyen, Xiaowei He, Dylan C. Alexander, Chen Li, Jian-Qiao Gu, Carmela Mascio, Andrew Van Praagh, Larry Mortin, Min Chu, Jared A. Silverman, Paul Brian, Richard H. Baltz
Antimicrobial Agents and Chemotherapy.2010; 54(4): 1404. CrossRef - Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth
Chris D. Den Hengst, Ngat T. Tran, Maureen J. Bibb, Govind Chandra, Brenda K. Leskiw, Mark J. Buttner
Molecular Microbiology.2010; 78(2): 361. CrossRef - The complex extracellular biology ofStreptomyces
Keith F. Chater, Sandor Biró, Kye Joon Lee, Tracy Palmer, Hildgund Schrempf
FEMS Microbiology Reviews.2010; 34(2): 171. CrossRef - Streptomyces scabies 87-22 Contains a Coronafacic Acid-Like Biosynthetic Cluster That Contributes to Plant–Microbe Interactions
Dawn R. D. Bignell, Ryan F. Seipke, José C. Huguet-Tapia, Alan H. Chambers, Ronald J. Parry, Rosemary Loria
Molecular Plant-Microbe Interactions®.2010; 23(2): 161. CrossRef - Characterization of γ-Butyrolactone Autoregulatory Signaling Gene Homologs in the Angucyclinone Polyketide WS5995B ProducerStreptomyces acidiscabies
Frank G. Healy, Kevin P. Eaton, Prajit Limsirichai, Joel F. Aldrich, Alaina K. Plowman, Russell R. King
Journal of Bacteriology.2009; 191(15): 4786. CrossRef - The pleiotropic regulator AdpA‐L directly controls the pathway‐specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes
Yuanyuan Pan, Gang Liu, Haihua Yang, Yuqing Tian, Huarong Tan
Molecular Microbiology.2009; 72(3): 710. CrossRef - The SmpB-tmRNA Tagging System Plays Important Roles in Streptomyces coelicolor Growth and Development
Chunzhong Yang, John R. Glover, Christophe Herman
PLoS ONE.2009; 4(2): e4459. CrossRef - Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives
Carlos Olano, Cristina Gómez, María Pérez, Martina Palomino, Antonio Pineda-Lucena, Rodrigo J. Carbajo, Alfredo F. Braña, Carmen Méndez, José A. Salas
Chemistry & Biology.2009; 16(10): 1031. CrossRef - Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor
Sean O'Rourke, Andreas Wietzorrek, Kay Fowler, Christophe Corre, Greg L. Challis, Keith F. Chater
Molecular Microbiology.2009; 71(3): 763. CrossRef - Evolutionary flux of potentially bldA-dependent Streptomyces genes containing the rare leucine codon TTA
Govind Chandra, Keith F. Chater
Antonie van Leeuwenhoek.2008; 94(1): 111. CrossRef - novE and novG act as positive regulators of novobiocin biosynthesis
Volker Dangel, Alessandra S. Eustáquio, Bertolt Gust, Lutz Heide
Archives of Microbiology.2008; 190(5): 509. CrossRef - SarA influences the sporulation and secondary metabolism inStreptomyces coelicolorM145
Xijun Ou, Bo Zhang, Lin Zhang, Kai Dong, Chun Liu, Guoping Zhao, Xiaoming Ding
Acta Biochimica et Biophysica Sinica.2008; 40(10): 877. CrossRef
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