Journal of Microbiology

Journal Articles

Impact of feeding regimens on the composition of gut microbiota and metabolite profiles of plasma and feces from Mongolian sheep: Bohui Wang , Yulong Luo , Rina Su , Duo Yao , Yanru Hou , Chang Liu , Rui Du , Ye Jin; J. Microbiol. 2020;58(6):472-482. Published online April 22, 2020; DOI: https://doi.org/10.1007/s12275-020-9501-0

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Mongolian sheep are an indigenous ruminant raised for wool and meat production in China. The gut microbial community plays an important role in animal performance and metabolism. The objective of this study was to investigate the effects of two feeding regimens on the diversity and composition of gut microbiota and metabolite profiles of feces and plasma from Mongolian sheep. A total of 20 Mongolian sheep were assigned to one of two feeding regimens: free grazing (FG) and barn confinement (BC). When samples were collected, the average live weights of the sheep were 31.28 ± 1.56 kg and 34.18 ± 1.87 kg for the FG and BC groups, respectively. At the genus level, the FG group showed higher levels of Bacteroides, RC9_gut_group, Alistipes, Phocaeicola, Barnesiella, and Oscillibacter, and lower levels of Succinivibrio, Treponema, and Prevotella, compared to the BC group. The butyric acid content in feces was lower in the FG group (P < 0.05). Higher levels of palmitic acid, oleic acid, alpha-linolenic acid, L-carnitine, L-citrulline, and L-histidine, and lower levels of L-tyrosine, L-phenylalanine, and L-kynurenine were found in the plasma of the FG sheep. Moreover, there were substantial associations between several gut microbiota genera and alterations in feces and plasma metabolites especially those involved in the metabolism of butyric acid, linolenic acid, and L-tyrosine. Feeding regimens can not only influence the composition of gut microbiota, but also alter metabolic homeostasis in sheep.

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Repeated use of 3,4-methylenedioxymethamphetamine is associated with the resilience in mice after chronic social defeat stress: A role of gut–microbiota–brain axis
Youge Qu, Akifumi Eguchi, Xiayun Wan, Li Ma, Lijia Chang, Jiajing Shan, Yong Yang, Chisato Mori, Kenji Hashimoto
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Yuhao Ma, Xue Yang, Guoying Hua, Xiaotian Deng, Tianlan Xia, Xinhai Li, Dengzhen Feng, Xuemei Deng
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Intestinal Microbial Diversity of Free-Range and Captive Yak in Qinghai Province
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Gentic overexpression increases production of hypocrellin A in Shiraia bambusicola S4201: Dan Li , Ning Zhao , Bing-Jing Guo , Xi Lin , Shuang-Lin Chen , Shu-Zhen Yan; J. Microbiol. 2019;57(2):154-162. Published online January 31, 2019; DOI: https://doi.org/10.1007/s12275-019-8259-8

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Abstract

Hypocrellin A (HA) is a perylenequinone (PQ) isolated from Shiraia bambusicola that shows antiviral and antitumor activities, but its application is limited by the low production from wild fruiting body. A gene overexpressing method was expected to augment the production rate of HA in S. bambusicola. However, the application of this molecular biology technology in S. bambusicola was impeded by a low genetic transformation efficiency and little genomic information. To enhance the plasmid transformant ratio, the Polyethylene Glycol-mediated transformation system was established and optimized. The following green fluorescent protein (GFP) analysis showed that the gene fusion expression system we constructed with a GAPDH promoter Pgpd1 and a rapid 2A peptide was successfully expressed in the S. bambusicola S4201 strain. We successfully obtained the HA high-producing strains by overexpressing O-methyltransferase/FAD-dependent monooxygenase gene (mono) and the hydroxylase gene (hyd), which were the essential genes involved in our putative HA biosynthetic pathway. The overexpression of these two genes increased the production of HA by about 200% and 100%, respectively. In general, this study will provide a basis to identify the genes involved in the hypocrellin A biosynthesis. This improved transformation method can also be used in genetic transformation studies of other fungi.

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Optimisation of hypocrellin production in Shiraia -like fungi via genetic modification involving a transcription factor gene and a putative monooxygenase gene
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Urea-Induced Enhancement of Hypocrellin A Synthesis in Shiraia bambusicola GDMCC 60438: Strategies and Mechanisms
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Zhuanying Bao, Yunchang Xie, Chenglong Xu, Zhibin Zhang, Du Zhu
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Process Biochemistry.2021; 108: 69. CrossRef
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Nitric oxide regulates perylenequinones biosynthesis in Shiraia bambusicola S4201 induced by hydrogen peroxide
Ning Zhao, Yingying Yu, Yunxia Yue, Mingzhu Dou, Bingjing Guo, Shuzhen Yan, Shuanglin Chen
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Global identification of alternative splicing in Shiraia bambusicola and analysis of its regulation in hypocrellin biosynthesis
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Efficient agrobacterium-mediated transformation ofShiraia bambusicolaand activation of a specific transcription factor for hypocrellin production
Tong Li, Cheng-Lin Hou, Xiao-Ye Shen
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Response mechanism of hypocrellin colorants biosynthesis by Shiraia bambusicola to elicitor PB90
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AMB Express.2019;[Epub] CrossRef

Research Support, Non-U.S. Gov'ts

Potentiation of Bacterial Killing Activity of Zinc Chloride by Pyrrolidine Dithiocarbamate: Eun-Kyoung Choi , Hye-Hyang Lee , Mi-Sun Kang , Byung-Gook Kim , Hoi-Soon Lim , Seon-Mi Kim , In-Chol Kang; J. Microbiol. 2010;48(1):40-43. Published online March 11, 2010; DOI: https://doi.org/10.1007/s12275-009-0049-2

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Abstract: Zinc has antimicrobial activity and zinc salts including zinc chloride (ZnCl2) have been used for the control of oral malodor. In this study, we hypothesized that pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, may enhance antimicrobial efficacy of ZnCl2. The bactericidal effectiveness of ZnCl2 alone (0.5-8 mM) or in combination with PDTC (1 or 10 μM) was evaluated by in vitro short (1 h) time-killing assays against Fusobacterium nucleatum and Porphyromonas gingivalis. Only a slight viability decrease was observed with ZnCl2 or PDTC alone after 1-h incubation. By contrast, combination of ZnCl2 and PDTC could achieve a more than 100-fold viability reduction compared with ZnCl2 or PDTC alone in F. nucleatum and P. gingivalis. Therefore, PDTC greatly enhanced the bactericidal activity of ZnCl2 against the oral malodor-producing bacteria. These results suggest that use of PDTC may be useful for enhancing bactericidal activity of antimalodor regimens of zinc salts.

Sphingobacterium bambusae sp. nov., Isolated from Soil of Bamboo Plantation: Shengwen Duan , Zhengchu Liu , Xiangyuan Feng , Ke Zheng , Lifeng Cheng; J. Microbiol. 2009;47(6):693-698. Published online February 4, 2010; DOI: https://doi.org/10.1007/s12275-009-0296-2

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Abstract: A Gram-negative, non-motile, non-spore-forming bacterial strain designated IBFC2009T was isolated from soil of a bamboo plantation. The strain could grow at 11°C~39°C, pH 6.0~9.0, and in the presence of 0~5% NaCl. Based on 16S rRNA gene sequence analysis, Strain IBFC2009T belonged to the genus Sphingobacterium and showed the highest sequence similarity of 94.6% (S. composti T5-12T) with the type strains within the genus. The major fatty acids were summed feature 3 (iso-C15:0 2-OH and/or C16:1 ω7c, 34.4%), iso-C15:0 (22.4%), C16:0 3-OH (15.2%), and iso-C17:0 3-OH (12.8%). The G+C content of the genomic DNA was 41.0 mol%. According to the phenotypic and genotypic characteristics, Strain IBFC2009T should represent a novel species of the genus Sphingobacterium, for which the name Sphingobacterium bambusae sp. nov. is proposed. The type strain is IBFC2009T (=CCTCC AB 209162T =KCTC 22814T).

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