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- Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
- Junsoo Park , Rackhyun Park , Minsu Jang , Yea-In Park , Yeonjeong Park
- J. Microbiol. 2022;60(3):347-354. Published online January 28, 2022
- DOI: https://doi.org/10.1007/s12275-022-1499-z
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Abstract
- Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNAdependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds.
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