Journal Articles
- Functional analysis of ascP in Aeromonas veronii TH0426 reveals a key role in the regulation of virulence
-
Yongchao Guan , Meng Zhang , Yingda Wang , Zhongzhuo Liu , Zelin Zhao , Hong Wang , Dingjie An , Aidong Qian , Yuanhuan Kang , Wuwen Sun , Xiaofeng Shan
-
J. Microbiol. 2022;60(12):1153-1161. Published online November 10, 2022
-
DOI: https://doi.org/10.1007/s12275-022-2373-8
-
-
42
View
-
0
Download
-
3
Web of Science
-
3
Crossref
-
Abstract
-
Aeromonas veronii is a pathogen which can induce diseases in
humans, animals and aquatic organisms, but its pathogenic
mechanism and virulence factors are still elusive. In this study,
we successfully constructed a mutant strain (ΔascP) by homologous
recombination. The results showed that the deletion
of the ascP gene significantly down-regulated the expression
of associated effector proteins in A. veronii compared
to its wild type. The adhesive and invasive abilities of ΔascP to
EPC cells were 0.82-fold lower in contrast to the wild strain.
The toxicity of ΔascP to cells was decreased by about 2.91-fold
(1 h) and 1.74-fold (2 h). Furthermore, the LD50 of the mutant
strain of crucian carp was reduced by 19.94-fold, and
the virulence was considerably attenuated. In contrast to the
wild strain, the ΔascP content in the liver and spleen was considerably
lower. The titers of serum cytokines (IL-8, TNF-α,
and IL-1β) in crucian carp after the infection of the ΔascP strain
were considerably lower in contrast to the wild strain. Hence,
the ascP gene is essential for the etiopathogenesis of A. veronii
TH0426.
-
Citations
Citations to this article as recorded by

- Complete genome sequence and genome-wide transposon mutagenesis enable the determination of genes required for sodium hypochlorite tolerance and drug resistance in pathogen Aeromonas veronii GD2019
Yifan Bu, Chengyu Liu, Yabo Liu, Wensong Yu, Tingjin Lv, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao
Microbiological Research.2024; 284: 127731. CrossRef - Construction of the flagellin F mutant of Vibrio parahaemolyticus and its toxic effects on silver pomfret (Pampus argenteus) cells
Yang Li, Chao Liu, Yuechen Sun, Ruijun Wang, Choufei Wu, Hanqu Zhao, Liqin Zhang, Dawei Song, Quanxin Gao
International Journal of Biological Macromolecules.2024; 259: 129395. CrossRef - Ferric uptake regulator (fur) affects the pathogenicity of Aeromonas veronii TH0426 by regulating flagellar assembly and biofilm formation
Jin-shuo Gong, Ying-da Wang, Yan-long Jiang, Di Zhang, Ya-nan Cai, Xiao-feng Shan, He Gong, Hao Dong
Aquaculture.2024; 580: 740361. CrossRef
- The synergy effect of arbuscular mycorrhizal fungi symbiosis and exogenous calcium on bacterial community composition and growth performance of peanut (Arachis hypogaea L.) in saline alkali soil
-
Dunwei Ci , Zhaohui Tang , Hong Ding , Li Cui , Guanchu Zhang , Shangxia Li , Liangxiang Dai , Feifei Qin , Zhimeng Zhang , Jishun Yang , Yang Xu
-
J. Microbiol. 2021;59(1):51-63. Published online November 17, 2020
-
DOI: https://doi.org/10.1007/s12275-021-0317-3
-
-
49
View
-
0
Download
-
19
Web of Science
-
19
Crossref
-
Abstract
-
Peanut (Arachis hypogaea. L) is an important oil seed crop.
Both arbuscular mycorrhizal fungi (AMF) symbiosis and calcium
(Ca2+) application can ameliorate the impact of saline
soil on peanut production, and the rhizosphere bacterial communities
are also closely correlated with peanut salt tolerance;
however, whether AMF and Ca2+ can withstand high-salinity
through or partially through modulating rhizosphere bacterial
communities is unclear. Here, we used the rhizosphere
bacterial DNA from saline alkali soil treated with AMF and
Ca2+ alone or together to perform high-throughput sequencing
of 16S rRNA genes. Taxonomic analysis revealed that
AMF and Ca2+ treatment increased the abundance of Proteobacteria
and Firmicutes at the phylum level. The nitrogenfixing
bacterium Sphingomonas was the dominant genus in
these soils at the genus level, and the soil invertase and urease
activities were also increased after AMF and Ca2+ treatment,
implying that AMF and Ca2+ effectively improved the living
environment of plants under salt stress. Moreover, AMF combined
with Ca2+ was better than AMF or Ca2+ alone at altering
the bacterial structure and improving peanut growth in saline
alkali soil. Together, AMF and Ca2+ applications are conducive
to peanut salt adaption by regulating the bacterial community
in saline alkali soil.
-
Citations
Citations to this article as recorded by

- Arbuscular mycorrhizal fungi drive bacterial community assembly in halophyte Suaeda salsa
Fengwei Diao, Bingbing Jia, Junqing Luo, Shengli Ding, Tai Liu, Wei Guo
Microbiological Research.2024; 282: 127657. CrossRef - Functional Characterization of Core and Unique Calcite-Dissolving Bacteria Communities from Peanut Fields
Alan Peper, Carter J. Newton, Sheena Lim, Wendy Zheng, Timothy Brenneman, Li Yang
Phytopathology®.2024; 114(5): 1011. CrossRef - Bacterial community composition of Hungarian salt-affected soils under different land uses
Ravi Kumar Gangwar, András Táncsics, Marianna Makádi, Milán Farkas, Mátyás Cserháti, Erika Michéli, Márta Fuchs, Tamás Szegi
Biologia Futura.2024; 75(3): 339. CrossRef - Peanut production in saline-alkali land of Yellow River Delta: influence of spatiotemporal changes of meteorological conditions and soil properties
Feifei Qin, Zhihong Xin, Jianguo Wang, Jialei Zhang, Jishun Yang, Feng Guo, Zhaohui Tang, Dunwei Ci
BMC Plant Biology.2024;[Epub] CrossRef - Multi-year crop rotation and quicklime application promote stable peanut yield and high nutrient-use efficiency by regulating soil nutrient availability and bacterial/fungal community
Liyu Yang, Caibin Wang, Xinhua He, Haiyan Liang, Qi Wu, Xuewu Sun, Miao Liu, Pu Shen
Frontiers in Microbiology.2024;[Epub] CrossRef - Arbuscular Mycorrhizal Fungi Restored the Saline–Alkali Soil and Promoted the Growth of Peanut Roots
Dunwei Ci, Feifei Qin, Zhaohui Tang, Guanchu Zhang, Jialei Zhang, Tong Si, Jishun Yang, Yang Xu, Tianyi Yu, Manlin Xu, Kang He
Plants.2023; 12(19): 3426. CrossRef - Green manure increases peanut production by shaping the rhizosphere bacterial community and regulating soil metabolites under continuous peanut production systems
Yang Xu, Hong Ding, Guanchu Zhang, Zelun Li, Qing Guo, Hao Feng, Feifei Qin, Liangxiang Dai, Zhimeng Zhang
BMC Plant Biology.2023;[Epub] CrossRef - The multifaceted roles of Arbuscular Mycorrhizal Fungi in peanut responses to salt, drought, and cold stress
Yuexu Liu, Jinhao Lu, Li Cui, Zhaohui Tang, Dunwei Ci, Xiaoxia Zou, Xiaojun Zhang, Xiaona Yu, Yuefu Wang, Tong Si
BMC Plant Biology.2023;[Epub] CrossRef - Advances and future research in ecological stoichiometry under saline-alkali stress
Keyi Zhang, Lei Chang, Guanghui Li, Yuefen Li
Environmental Science and Pollution Research.2023; 30(3): 5475. CrossRef - Arbuscular mycorrhizal fungi increased peanut (Arachis hypogaea L.) yield by changing the rhizosphere microbial community structure in saline-alkali soil
Jia Kang, Wenlong Yang, Shangwu Liu, Ning Xuan, Yahui Shao, Yun Geng, Muhammad Afzal, Yingxin Zhang, Shousong Yue, Rubina Mushtaq, Gao Chen
Frontiers in Microbiology.2023;[Epub] CrossRef - Distribution of microbial communities in seasonally frozen soil layers on the Tibetan Plateau and the driving environmental factors
Xiaojie Wang, Zhiqiang Yu, Guofeng Shen, Hefa Cheng, Shu Tao
Environmental Science and Pollution Research.2023; 30(1): 1919. CrossRef - Effects of phosphogypsum on enzyme activity and microbial community in acid soil
Changan Li, Yonggang Dong, Yun Yi, Juan Tian, Chao Xuan, Yan Wang, Yuanbo Wen, Jianxin Cao
Scientific Reports.2023;[Epub] CrossRef - Microbial keystone taxa drive crop productivity through shifting aboveground-belowground mineral element flows
Jia Lin Wang, Kai Lou Liu, Xue Qiang Zhao, Gui-Feng Gao, Yong Hong Wu, Ren Fang Shen
Science of The Total Environment.2022; 811: 152342. CrossRef - Peanut and cotton intercropping increases productivity and economic returns through regulating plant nutrient accumulation and soil microbial communities
Wei Xie, Kai Zhang, Xiaoying Wang, Xiaoxia Zou, Xiaojun Zhang, Xiaona Yu, Yuefu Wang, Tong Si
BMC Plant Biology.2022;[Epub] CrossRef -
Illumina MiSeq Sequencing Reveals Correlations among Fruit Ingredients, Environmental Factors, and AMF Communities in Three
Lycium Barbarum
Producing Regions of China
Kaili Chen, Gang Huang, Yuekun Li, Xinrui Zhang, Yonghui Lei, Yang Li, Jie Xiong, Yanfei Sun, Kristen M. DeAngelis
Microbiology Spectrum.2022;[Epub] CrossRef - Genome-Wide Identification of Auxin Response Factors in Peanut (Arachis hypogaea L.) and Functional Analysis in Root Morphology
Lu Luo, Qian Wan, Zipeng Yu, Kun Zhang, Xiurong Zhang, Suqing Zhu, Yongshan Wan, Zhaojun Ding, Fengzhen Liu
International Journal of Molecular Sciences.2022; 23(10): 5309. CrossRef - Impact of an arbuscular mycorrhizal fungal inoculum and exogenous methyl jasmonate on the performance of tall fescue under saline-alkali condition
Hui Liu, Huimin Tang, Xiaozhen Ni, Yajie Zhang, Yingchao Wang
Frontiers in Microbiology.2022;[Epub] CrossRef - The resistance of peanut to soil-borne pathogens improved by rhizosphere probiotics under calcium treatment
Wei Zhang, Bo-wen Zhang, Jie-fu Deng, Lin Li, Tu-yong Yi, Yan-yun Hong
BMC Microbiology.2021;[Epub] CrossRef - Arbuscular mycorrhizal fungi alleviate salinity stress in peanut: Evidence from pot‐grown and field experiments
Wenjie Qin, Hengyu Yan, Bingyin Zou, Runze Guo, Dunwei Ci, Zhaohui Tang, Xiaoxia Zou, Xiaojun Zhang, Xiaona Yu, Yuefu Wang, Tong Si
Food and Energy Security.2021;[Epub] CrossRef
Reviews
- REVIEW] Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system
-
Inseong Jo , Jin-Sik Kim , Yongbin Xu , Jaekyung Hyun , Kangseok Lee , Nam-Chul Ha
-
J. Microbiol. 2019;57(3):185-194. Published online February 26, 2019
-
DOI: https://doi.org/10.1007/s12275-019-8520-1
-
-
44
View
-
0
Download
-
9
Web of Science
-
7
Crossref
-
Abstract
-
Tripartite efflux pumps and the type I secretion system of
Gram-negative bacteria are large protein complexes that span
the entire cell envelope. These complexes expel antibiotics and
other toxic substances or transport protein toxins from bacterial
cells. Elucidating the binary and ternary complex structures
at an atomic resolution are crucial to understanding the
assembly and working mechanism. Recent advances in cryoelectron
microscopy along with the construction of chimeric
proteins drastically shifted the assembly models. In this review,
we describe the current assembly models from a historical
perspective and emphasize the common assembly mechanism
for the assembly of diverse tripartite pumps and type
I secretion systems.
-
Citations
Citations to this article as recorded by

- Molecular mechanisms of antibiotic resistance revisited
Elizabeth M. Darby, Eleftheria Trampari, Pauline Siasat, Maria Solsona Gaya, Ilyas Alav, Mark A. Webber, Jessica M. A. Blair
Nature Reviews Microbiology.2023; 21(5): 280. CrossRef - Permeation of Fosfomycin through the Phosphate-Specific Channels OprP and OprO of Pseudomonas aeruginosa
Vinaya Kumar Golla, Claudio Piselli, Ulrich Kleinekathöfer, Roland Benz
The Journal of Physical Chemistry B.2022; 126(7): 1388. CrossRef - Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability
Eric Mandela, Christopher J Stubenrauch, David Ryoo, Hyea Hwang, Eli J Cohen, Von L Torres, Pankaj Deo, Chaille T Webb, Cheng Huang, Ralf B Schittenhelm, Morgan Beeby, JC Gumbart, Trevor Lithgow, Iain D Hay
eLife.2022;[Epub] CrossRef - Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
Ilyas Alav, Jessica Kobylka, Miriam S. Kuth, Klaas M. Pos, Martin Picard, Jessica M. A. Blair, Vassiliy N. Bavro
Chemical Reviews.2021; 121(9): 5479. CrossRef - Biotechnological applications of type 1 secretion systems
Zohreh Pourhassan N., Sander H.J. Smits, Jung Hoon Ahn, Lutz Schmitt
Biotechnology Advances.2021; 53: 107864. CrossRef - Protein-Protein Interactions in the Cytoplasmic Membrane of Escherichia coli: Influence of the Overexpression of Diverse Transporter-Encoding Genes on the Activities of PTS Sugar Uptake Systems
Mohammad Aboulwafa, Zhongge Zhang, Milton H. Saier Jr.
Microbial Physiology.2020; 30(1-6): 36. CrossRef - Perspectives towards antibiotic resistance: from molecules to population
Joon-Hee Lee
Journal of Microbiology.2019; 57(3): 181. CrossRef
- [Minireview] Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
-
Bora Shin , Woojun Park
-
J. Microbiol. 2017;55(11):837-849. Published online October 27, 2017
-
DOI: https://doi.org/10.1007/s12275-017-7288-4
-
-
49
View
-
0
Download
-
38
Crossref
-
Abstract
-
The increasing antibiotic resistance of Acinetobacter species
in both natural and hospital environments has become a serious
problem worldwide in recent decades. Because of both
intrinsic and acquired antimicrobial resistance (AMR) against
last-resort antibiotics such as carbapenems, novel therapeutics
are urgently required to treat Acinetobacter-associated infectious
diseases. Among the many pathogenic Acinetobacter
species, A. baumannii has been reported to be resistant to all
classes of antibiotics and contains many AMR genes, such as
blaADC (Acinetobacter-derived cephalosporinase). The AMR
of pathogenic Acinetobacter species is the result of several
different mechanisms, including active efflux pumps, mutations
in antibiotic targets, antibiotic modification, and low
antibiotic membrane permeability. To overcome the limitations
of existing drugs, combination theraphy that can increase
the activity of antibiotics should be considered in the
treatment of Acinetobacter infections. Understanding the
molecular mechanisms behind Acinetobacter AMR resistance
will provide vital information for drug development and
therapeutic strategies using combination treatment. Here,
we summarize the classic mechanisms of Acinetobacter AMR,
along with newly-discovered genetic AMR factors and currently
available antimicrobial adjuvants that can enhance drug
efficacy in the treatment of A. baumannii infections.
-
Citations
Citations to this article as recorded by

- Disruption of bacterial interactions and community assembly in Babesia-infected Haemaphysalis longicornis following antibiotic treatment
Myriam Kratou, Apolline Maitre, Lianet Abuin-Denis, Elianne Piloto-Sardiñas, Ivan Corona-Guerrero, Ana Laura Cano-Argüelles, Alejandra Wu-Chuang, Timothy Bamgbose, Consuelo Almazan, Juan Mosqueda, Dasiel Obregón, Lourdes Mateos-Hernández, Mourad Ben Said,
BMC Microbiology.2024;[Epub] CrossRef - A 19-year longitudinal study to characterize carbapenem-nonsusceptible Acinetobacter isolated from patients with bloodstream infections and the contribution of conjugative plasmids to carbapenem resistance and virulence
Pek Kee Chen, Yi-Tzu Lee, Chia-Ying Liu, Tran Thi Dieu Thuy, Kieu Anh, Jiunn-Jong Wu, Chun-Hsing Liao, Yu-Tsung Huang, Yu-Chen Chen, Cheng-Yen Kao
Journal of Microbiology, Immunology and Infection.2024; 57(2): 288. CrossRef - MOLECULAR ANALYSIS OF THE MCR-1 GENE IN PSEUDOMONAS AERUGINOSA AND ACINETOBACTER BAUMANII STRAINS
Ömer Akgül
Ankara Universitesi Eczacilik Fakultesi Dergisi.2024; 48(3): 21. CrossRef - Effect of Phenylalanine–Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii
Stefany Plasencia-Rebata, Saul Levy-Blitchtein, Juana del Valle-Mendoza, Wilmer Silva-Caso, Isaac Peña-Tuesta, William Vicente Taboada, Fernando Barreda Bolaños, Miguel Angel Aguilar-Luis
Antibiotics.2023; 12(6): 1071. CrossRef - A comprehensive genomic analysis provides insights on the high environmental adaptability of Acinetobacter strains
Yang Zhao, Hua-Mei Wei, Jia-Li Yuan, Lian Xu, Ji-Quan Sun
Frontiers in Microbiology.2023;[Epub] CrossRef - Acinetobacter baumannii in blood-borne and central nervous system infections in intensive care unit children: molecular and genetic characteristics and clinical significance
Zulfirya Z. Sadeeva, Irina E. Novikova, Natalia M. Alyabyeva, Anna V. Lazareva, Tatiana M. Komyagina, Olga V. Karaseva, Marina G. Vershinina, Andrey P. Fisenko
Russian Journal of Infection and Immunity.2023; 13(2): 289. CrossRef - Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria
Anna Herman, Andrzej P. Herman
Planta Medica.2023; 89(02): 168. CrossRef - A Systematic Review of Culture-Based Methods for Monitoring Antibiotic-Resistant Acinetobacter, Aeromonas, and Pseudomonas as Environmentally Relevant Pathogens in Wastewater and Surface Water
Erin G. Milligan, Jeanette Calarco, Benjamin C. Davis, Ishi M. Keenum, Krista Liguori, Amy Pruden, Valerie J. Harwood
Current Environmental Health Reports.2023; 10(2): 154. CrossRef - Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee
Journal of Microbiology.2022; 60(1): 128. CrossRef - In vitro study to evaluate the antimicrobial activity of various multifunctional cosmetic ingredients and chlorphenesin on bacterial species at risk in the cosmetic industry
Benjamin Youenou, Amandine Chauviat, Chrisse Ngari, Valérie Poulet, Sylvie Nazaret
Journal of Applied Microbiology.2022; 132(2): 933. CrossRef - Profiles of Microbial Community and Antibiotic Resistome in Wild Tick Species
Nana Wei, Jinmiao Lu, Yi Dong, Shibo Li, Jack A. Gilbert
mSystems.2022;[Epub] CrossRef - Conventional and Real-Time PCR Targeting blaOXA Genes as Reliable Methods for a Rapid Detection of Carbapenem-Resistant Acinetobacter baumannii Clinical Strains
Dagmara Depka, Agnieszka Mikucka, Tomasz Bogiel, Mateusz Rzepka, Patryk Zawadka, Eugenia Gospodarek-Komkowska
Antibiotics.2022; 11(4): 455. CrossRef - In vitro synergistic activity of colistin and teicoplanin combination against multidrug-resistant Acinetobacter spp
Osama Mohamed Samy Mohamed Rady, Laila El-Attar, Amira Amine
The Journal of Antibiotics.2022; 75(3): 181. CrossRef -
Biogenic silver nanoparticle (Bio‐AgNP) has an antibacterial effect against carbapenem‐resistant
Acinetobacter baumannii
with synergism and additivity when combined with polymyxin B
Suzane Olachea Allend, Marcelle Oliveira Garcia, Kamila Furtado da Cunha, Déborah Trota Farias de Albernaz, Mirian Elert da Silva, Rodrigo Yudi Ishikame, Luciano Aparecido Panagio, Gerson Nakazaro, Guilherme Fonseca Reis, Daniela Brayer Pereira, Daiane Dr
Journal of Applied Microbiology.2022; 132(2): 1036. CrossRef - RapidResa Polymyxin Acinetobacter NP® Test for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii
Maxime Bouvier, Mustafa Sadek, Stefano Pomponio, Fernando D’Emidio, Laurent Poirel, Patrice Nordmann
Antibiotics.2021; 10(5): 558. CrossRef - Rapid detection of carbapenemase-producing Pseudomonas spp. using the NitroSpeed-Carba NP test
Mustafa Sadek, Laurent Poirel, Patrice Nordmann
Diagnostic Microbiology and Infectious Disease.2021; 99(3): 115280. CrossRef - Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective
Misung Kim, Jaeeun Park, Mingyeong Kang, Jihye Yang, Woojun Park
Journal of Microbiology.2021; 59(6): 535. CrossRef - OXA-23 and OXA-40 producing carbapenem-resistant Acinetobacter baumannii in Central Illinois
Janak Koirala, Isha Tyagi, Lohitha Guntupalli, Sameena Koirala, Udita Chapagain, Christopher Quarshie, Sami Akram, Vidya Sundareshan, Sajan Koirala, Jerry Lawhorn, Yohei Doi, Michael Olson
Diagnostic Microbiology and Infectious Disease.2020; 97(1): 114999. CrossRef - Rapid Polymyxin/Pseudomonas NP test for rapid detection of polymyxin susceptibility/resistance in Pseudomonas aeruginosa
Mustafa Sadek, Camille Tinguely, Laurent Poirel, Patrice Nordmann
European Journal of Clinical Microbiology & Infectious Diseases.2020; 39(9): 1657. CrossRef - Stress responses linked to antimicrobial resistance in Acinetobacter species
Bora Shin, Chulwoo Park, Woojun Park
Applied Microbiology and Biotechnology.2020; 104(4): 1423. CrossRef - Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace
Maria Soledad Ramirez, Robert A. Bonomo, Marcelo E. Tolmasky
Biomolecules.2020; 10(5): 720. CrossRef - Pharmacokinetics, Safety, and Tolerability of Intravenous Durlobactam and Sulbactam in Subjects with Renal Impairment and Healthy Matched Control Subjects
John O’Donnell, Richard A. Preston, Grigor Mamikonyan, Emily Stone, Robin Isaacs
Antimicrobial Agents and Chemotherapy.2019;[Epub] CrossRef - Efficient Delivery of Antisense Oligonucleotides by an Amphipathic Cell-Penetrating Peptide in Acinetobacter baumannii
Zhou Chen, Dan Nie, Yue Hu, Mingkai Li, Zheng Hou, Xinggang Mao, Xiaoxing Luo, Xiaoyan Xue
Current Drug Delivery.2019; 16(8): 728. CrossRef - Restoring the activity of the antibiotic aztreonam using the polyphenol epigallocatechin gallate (EGCG) against multidrug-resistant clinical isolates of Pseudomonas aeruginosa
Jonathan W. Betts, Michael Hornsey, Paul G. Higgins, Kai Lucassen, Julia Wille, Francisco J. Salguero, Harald Seifert, Roberto M. La Ragione
Journal of Medical Microbiology
.2019; 68(10): 1552. CrossRef - Antibiotic-resistant clones in Gram-negative pathogens: presence of global clones in Korea
Kwan Soo Ko
Journal of Microbiology.2019; 57(3): 195. CrossRef - Alternative fate of glyoxylate during acetate and hexadecane metabolism in Acinetobacter oleivorans DR1
Chulwoo Park, Bora Shin, Woojun Park
Scientific Reports.2019;[Epub] CrossRef - Nationwide surveillance of antimicrobial resistance among clinically important Gram-negative bacteria, with an emphasis on carbapenems and colistin: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2018
Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-
International Journal of Antimicrobial Agents.2019; 54(3): 318. CrossRef - The use of polymyxins to treat carbapenem resistant infections in neonates and children
Reenu Thomas, Sithembiso Velaphi, Sally Ellis, A. Sarah Walker, Joseph F. Standing, Paul Heath, Mike Sharland, Daniele Dona’
Expert Opinion on Pharmacotherapy.2019; 20(4): 415. CrossRef - Plasmid-mediated mcr-1 gene in Acinetobacter baumannii and Pseudomonas aeruginosa: first report from Pakistan
Fareeha Hameed, Muhammad Asif Khan, Hafsah Muhammad, Tahir Sarwar, Hazrat Bilal, Tayyab Ur Rehman
Revista da Sociedade Brasileira de Medicina Tropical.2019;[Epub] CrossRef - Identification of factors needed by a clinical isolate of Acinetobacter baumannii to resist antibacterial compounds
Celena M. Gwin, Natalia Prakash, Nathan W. Rigel
BIOS.2019; 90(3): 149. CrossRef - A Resazurin Reduction-Based Assay for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii and Pseudomonas aeruginosa
Mathilde Lescat, Laurent Poirel, Camille Tinguely, Patrice Nordmann, Nathan A. Ledeboer
Journal of Clinical Microbiology.2019;[Epub] CrossRef - Expansion of antibacterial spectrum of xanthorrhizol against Gram-negatives in combination with PMBN and food-grade antimicrobials
Man Su Kim, Ha-Rim Kim, Haebom Kim, Soo-Keun Choi, Chang-Hwan Kim, Jae-Kwan Hwang, Seung-Hwan Park
Journal of Microbiology.2019; 57(5): 405. CrossRef - Carbapenem-resistant Acinetobacter baumannii in patients with burn injury: A systematic review and meta-analysis
William Gustavo Lima, Geisa Cristina Silva Alves, Cristina Sanches, Simone Odília Antunes Fernandes, Magna Cristina de Paiva
Burns.2019; 45(7): 1495. CrossRef - Performances of the Rapid Polymyxin Acinetobacter and Pseudomonas Tests for Colistin Susceptibility Testing
Mathilde Lescat, Laurent Poirel, Aurélie Jayol, Patrice Nordmann
Microbial Drug Resistance.2019; 25(4): 520. CrossRef - In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates
Emel Mataracı Kara, Mesut Yılmaz, Berna Özbek Çelik
Journal of Global Antimicrobial Resistance.2019; 17: 137. CrossRef - Zoonotic Diseases and Phytochemical Medicines for Microbial Infections in Veterinary Science: Current State and Future Perspective
Bora Shin, Woojun Park
Frontiers in Veterinary Science.2018;[Epub] CrossRef - A formidable foe: carbapenem-resistant Acinetobacter baumannii and emerging nonantibiotic therapies
Richard R. Watkins
Expert Review of Anti-infective Therapy.2018; 16(8): 591. CrossRef - Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects
Keith A. Rodvold, Mark H. Gotfried, Robin D. Isaacs, John P. O'Donnell, Emily Stone
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef
Research Support, Non-U.S. Gov't
- Conditional probability analysis of multidrug resistance in Gram-negative bacilli isolated from tertiary medical institutions in South Korea during 1999–2009
-
Yong-Hak Kim
-
J. Microbiol. 2016;54(1):50-56. Published online January 5, 2016
-
DOI: https://doi.org/10.1007/s12275-016-5579-9
-
-
46
View
-
0
Download
-
6
Crossref
-
Abstract
-
Multidrug resistance of Gram-negative bacilli is a major problem
globally. However, little is known about the combined
probability of resistance to various antibiotics. In this study,
minimum inhibitory concentrations of widely used antibiotics
were determined using clinical isolates of Escherichia coli,
Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter
baumannii, randomly chosen from strain collections
created during 1999–2009 in tertiary medical institutions in
Seoul, South Korea. To analyze combined efficacy of antibiotics
against a subgroup of isolates, conditional probabilities
were determined based on arbitrary, non-independent patterns
of antimicrobial susceptibility and resistance. Multidrug
resistance, defined as resistance to three or more classes of
antibiotics, was observed in the following order: A. baumannii
(96%), P. aeruginosa (65%), E. coli (52%), and K. pneumoniae
(7%). A. baumannii strains resistant to gentamicin were found
to be resistant to a number of antibiotics, except for colistin
and polymyxin B. Resistance to gentamicin following exposure
to this antibiotic was highly likely to lead to multidrug
resistance in all four microbes. This study shows a causal
relationship between gentamicin resistance and the prevalence
of multidrug resistance in clinical isolates of Gramnegative
bacilli in South Korea during 1999–2009 and suggests
the importance of prudent use of gentamicin in hospitals.
-
Citations
Citations to this article as recorded by

- Analysis of Predictive Factors of Antibiotic Resistant Pseudomonas aeruginosa in Children with Acute Appendicitis
Mengqi Wan, Mengjie Yu, Juhua Xiao Jiangxi, Qiang Chen, Nuoya Li, Jun Lei, Weilong Chen, Shouhua Zhang, Qiang Tao
Iranian Journal of Pediatrics.2021;[Epub] CrossRef - Bacterial culture and antibiotic susceptibility in patients with acute appendicitis
Dae Woon Song, Byung Kwan Park, Suk Won Suh, Seung Eun Lee, Jong Won Kim, Joong-Min Park, Hye Ryoun Kim, Mi-Kyung Lee, Yoo Shin Choi, Beom Gyu Kim, Yong Gum Park
International Journal of Colorectal Disease.2018; 33(4): 441. CrossRef - Abrupt Increase in Rate of Imipenem Resistance in Acinetobacter baumannii Complex Strains Isolated from General Hospitals in Korea and Correlation With Carbapenem Administration During 2002?2013
Young Ah Kim, Yoon Soo Park, Taemi Youk, Hyukmin Lee, Kyungwon Lee
Annals of Laboratory Medicine.2018; 38(2): 179. CrossRef - Factors associated with in-hospital mortality among critically ill surgical patients with multidrug-resistant Gram-negative infections
Andrew S. Jarrell, Rachel M. Kruer, Loredana Diana Berescu, Peter J. Pronovost, Julie B. Trivedi
Journal of Critical Care.2018; 43: 321. CrossRef - Émergence de la résistance à la colistine chez les entérobactéries : une brèche dans le dernier rempart contre la pan-résistance !
L. Dortet, R. Bonnin, A. Jousset, L. Gauthier, T. Naas
Journal des Anti-infectieux.2016; 18(4): 139. CrossRef - Antimicrobial Resistance and the Presence of Virulence Genes in Escherichia coli Strains Isolated from Ruditapes philippinarum in Gomso Bay, Korea
Tae-Ok Kim, In-Seon Eom, Kwang-Ho Park, Kwon-Sam Park
Korean Journal of Fisheries and Aquatic Sciences.2016; 49(6): 800. CrossRef
Reviews
- MINIREVIEW] Multidrug efflux pumps in Staphylococcus aureus and their clinical implications
-
Soojin Jang
-
J. Microbiol. 2016;54(1):1-8. Published online January 5, 2016
-
DOI: https://doi.org/10.1007/s12275-016-5159-z
-
-
47
View
-
0
Download
-
78
Crossref
-
Abstract
-
Antibiotic resistance is rapidly spreading among bacteria
such as Staphylococcus aureus, an opportunistic bacterial
pathogen that causes a variety of diseases in humans. For
the last two decades, bacterial multidrug efflux pumps have
drawn attention due to their potential association with clinical
multidrug resistance. Numerous researchers have demonstrated
efflux-mediated resistance in vitro and in vivo
and found novel multidrug transporters using advanced
genomic information about bacteria. This article aims to
provide a concise summary of multidrug efflux pumps and
their important clinical implications, focusing on recent
findings concerning S. aureus efflux pumps.
-
Citations
Citations to this article as recorded by

- The role and mechanism of efflux pump norB in biofilm formation of Staphylococcus aureus
Wenjing Cui, Xuan Liang, Wenwei Xiao, Ying Wang, Fang Liu, Shuaiyin Chen, Jinzhao Long, Yuefei Jin, Guangcai Duan, Haiyan Yang
Gene.2025; 936: 149105. CrossRef - Description of Massilia orientalis sp. nov., Isolated from Rhizosphere Soil of Ageratina adenophora
Yun Xia, Xing-Feng Qian, Xin Chen, Bo Wang, Yong-Xia Wang
Current Microbiology.2025;[Epub] CrossRef - Evaluation of Antibiotic Resistance Mechanisms in Gram-Positive Bacteria
Pratiksing Rajput, Kazi S. Nahar, Khondaker Miraz Rahman
Antibiotics.2024; 13(12): 1197. CrossRef - Repeated Exposure of Vancomycin to Vancomycin-Susceptible Staphylococcus aureus (VSSA) Parent Emerged VISA and VRSA Strains with Enhanced Virulence Potentials
An Nguyen, J. Jean Sophy Roy, Ji-Hoon Kim, Kyung-Hee Yun, Wonsik Lee, Kyeong Kyu Kim, Truc Kim, Akhilesh Kumar Chaurasia
Journal of Microbiology.2024; 62(7): 535. CrossRef - Structural characterization, DFT calculations, ADMET studies, antibiotic potentiating activity, evaluation of efflux pump inhibition and molecular docking of heterocylcic chalcone (E)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one
Priscila Teixeira da Silva, Francisco Rogenio da Silva Mendes, Francisco Wagner Queiroz Almeida-Neto, Emmanuel Silva Marinho, Larissa da Silva, Murilo Sérgio da Silva Julião, Marcia Machado Marinho, Laura Maria Teodorio Vidal, Alejandro Pedro Ayala, Henri
Journal of Molecular Structure.2024; 1312: 138497. CrossRef - Recent advances in the use of resveratrol against Staphylococcus aureus infections (Review)
Wenjing Cui, Yadong Wang, Li Zhang, Fang Liu, Guangcai Duan, Shuaiyin Chen, Jinzhao Long, Yuefei Jin, Haiyan Yang
Medicine International.2024;[Epub] CrossRef - Tackling Nontuberculous Mycobacteria by Repurposable Drugs and
Potential Leads from Natural Products
Patil Amruta Adhikrao, Gudle Mayuri Motiram, Gautam Kumar
Current Topics in Medicinal Chemistry.2024; 24(15): 1291. CrossRef - Genomic analysis of Oceanotoga teriensis strain UFV_LIMV02, a multidrug-resistant thermophilic bacterium isolated from an offshore oil reservoir
Adriele Jéssica do Carmo Santos, Roberto Sousa Dias, Carlos Henrique Martins da Silva, Pedro Marcus Pereira Vidigal, Maíra Paula de Sousa, Cynthia Canedo da Silva, Sérgio Oliveira de Paula
Access Microbiology
.2024;[Epub] CrossRef - Plant-based Natural Products as inhibitors for Efflux Pumps to Reverse
Multidrug Resistance in Staphylococcus aureus: A Mini Review
Shalini Ramalingam, Moola Joghee Nanjan Chandrasekar, Ganesh G.N. Krishnan, Moola Joghee Nanjan
Mini-Reviews in Medicinal Chemistry.2024; 24(3): 272. CrossRef - Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
Priscilla R. Freitas, Ana C.J. de Araújo, Isaac M. Araújo, Ray S. de Almeida, João A.O. Borges, Cícera L.R. Paulo, Cícera D.M. Oliveira-Tintino, Gustavo M. Miranda, José B. Araújo-Neto, Igor J.S. Nascimento, João X. Araújo-Júnior, Julia M.A. Silva, Tereza
Biomedicine & Pharmacotherapy.2024; 179: 117291. CrossRef - Boron-Containing Compounds as Antimicrobial Agents to Tackle Drug-Resistant Bacteria
Zongkai Huang, Lang Bai, Jie Liu, Youfu Luo
Pharmaceutical Fronts.2024; 06(04): e336. CrossRef - Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Hospitalized Newborn Infants
Ching Hoong Chew, Chew Chieng Yeo, Ainal Mardziah Che Hamzah, Esra’a I. Al-Trad, Sherry Usun Jones, Kek Heng Chua, Suat Moi Puah
Diagnostics.2023; 13(6): 1050. CrossRef - Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors
Gautam Kumar, Asha Kiran Tudu
Bioorganic & Medicinal Chemistry.2023; 80: 117187. CrossRef - Emerging Strategies to Combat Methicillin-resistant Staphylococcus aureus
(MRSA): Natural Agents with High Potential
Jonata M. Ueda, Catarina Milho, Sandrina A. Heleno, Anton Soria-Lopez, Maria Carpena, Maria J. Alves, Tânia Pires, Miguel A. Prieto, Jesus Simal-Gandara, Ricardo C. Calhelha, Isabel C.F.R. Ferreira, Lillian Barros
Current Pharmaceutical Design.2023; 29(11): 837. CrossRef - Stingray epidermal microbiomes are species-specific with local adaptations
Emma N. Kerr, Bhavya Papudeshi, Miranda Haggerty, Natasha Wild, Asha Z. Goodman, Lais F. O. Lima, Ryan D. Hesse, Amber Skye, Vijini Mallawaarachchi, Shaili Johri, Sophia Parker, Elizabeth A. Dinsdale
Frontiers in Microbiology.2023;[Epub] CrossRef - Antibacterial potential of chalcones and its derivatives against Staphylococcus aureus
Larissa da Silva, Isydorio Alves Donato, Cicera Alane Coelho Gonçalves, Jackelyne Roberta Scherf, Hélcio Silva dos Santos, Edna Mori, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra da Cunha
3 Biotech.2023;[Epub] CrossRef - High-level delafloxacin resistance through the combination of two different mechanisms in Staphylococcus aureus
José Manuel Ortiz de la Rosa, María Aznar Fernández, Ángel Rodríguez-Villodres, Carlos S Casimiro-Soriguer, José Miguel Cisneros, José Antonio Lepe
International Journal of Antimicrobial Agents.2023; 61(6): 106795. CrossRef - Selective Bacteriocins: A Promising Treatment for Staphylococcus aureus Skin Infections Reveals Insights into Resistant Mutants, Vancomycin Resistance, and Cell Wall Alterations
Félix Jaumaux, Kenny Petit, Anandi Martin, Hector Rodriguez-Villalobos, Marjorie Vermeersch, David Perez-Morga, Philippe Gabant
Antibiotics.2023; 12(6): 947. CrossRef - Mechanisms of microbial resistance against cadmium – a review
Monu Sharma, Sonu Sharma, Paavan, Mahiti Gupta, Soniya Goyal, Daizee Talukder, Mohd. Sayeed Akhtar, Raman Kumar, Ahmad Umar, Abdulrab Ahmed M. Alkhanjaf, Sotirios Baskoutas
Journal of Environmental Health Science and Engineering.2023; 22(1): 13. CrossRef - Efflux Pump (QacA, QacB, and QacC) and β-Lactamase Inhibitors? An Evaluation of 1,8-Naphthyridines against Staphylococcus aureus Strains
Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Ana Carolina Justino de Araújo, Cristina Rodrigues dos Santos Barbosa, Priscilla Ramos Freitas, José Bezerra de Araújo Neto, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silv
Molecules.2023; 28(4): 1819. CrossRef - Chemical Composition, Antibacterial and Inhibitory Activity of the Efflux Pump of Essential Oils from Croton piauhiensis Müll.
Beatriz Gonçalves Cruz, Thiago Sampaio de Freitas, Maria do Socorro Costa, Ana Raquel Pereira da Silva, Henrique Douglas Melo Coutinho, Selene Maia de Morais, Emmanuel Silva Marinho, Alexandre Magno Rodrigues Teixeira, Hélcio Silva dos Santos
Nutraceuticals.2023; 3(4): 591. CrossRef - Photodynamic therapy-a promising treatment of oral mucosal infections
Ting Chen, Dan Yang, Shangxue Lei, Jiaxin Liu, Yansong Song, Hang Zhao, Xin Zeng, Hongxia Dan, Qianming Chen
Photodiagnosis and Photodynamic Therapy.2022; 39: 103010. CrossRef - Oxazolidine Compounds from Neocalytrocalyx Longifolium (Capparaceae) and Their Activity as Msra (ABC) Efflux Pump Inhibitors: An in Vitro and in Silico Approach
Thalisson Amorim de Souza, Joanda Paolla Raimundo e Silva, Damara Freitas Rodrigues, Chonny Herrera-Acevedo, Renata Priscila Barros de Menezes, Nathalie H. P. B. Borges, José Iranildo Miranda de Melo, José Pinto de Siqueira-Júnior, Marcus Tullius Scotti,
SSRN Electronic Journal .2022;[Epub] CrossRef - Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity
Kiratiya Eiamthaworn, Thida Kaewkod, Sakunnee Bovonsombut, Yingmanee Tragoolpua
Journal of Fungi.2022; 8(4): 327. CrossRef - Promising FDA-approved drugs with efflux pump inhibitory activities against clinical isolates of Staphylococcus aureus
Safaa Abdel-Aal Mohamed Abdel-Karim, Amira Mohamed Ali El-Ganiny, Mona Abdelmonem El-Sayed, Hisham Abdelmonem Abdelhamid Abbas, Taeok Bae
PLOS ONE.2022; 17(7): e0272417. CrossRef - Impeding efflux-mediated resistance in Staphylococcus aureus
Safaa A. M. Abdel-Karim, Amira M. A. El-Ganiny, Mona A. El-Sayed, Hisham A. Abbas
Research Journal of Pharmacy and Technology.2022; : 4300. CrossRef - Microbial Resistance to Antibiotics and Effective Antibiotherapy
Adriana Aurelia Chiș, Luca Liviu Rus, Claudiu Morgovan, Anca Maria Arseniu, Adina Frum, Andreea Loredana Vonica-Țincu, Felicia Gabriela Gligor, Maria Lucia Mureșan, Carmen Maximiliana Dobrea
Biomedicines.2022; 10(5): 1121. CrossRef - Urea-Based Ligand as an Efflux Pump Inhibitor: Warhead to Counter Ciprofloxacin Resistance and Inhibit Collagen Adhesion by MRSA
Basu Bhattacharjee, Asesh Das, Gopal Das, Aiyagari Ramesh
ACS Applied Bio Materials.2022; 5(4): 1710. CrossRef - Molecular Investigation of Enterotoxigenic Staphylococcus aureus Isolates from Restaurant Staff
Mahsa Tahaei, Leila Fozouni, Morteza Khademi
Middle East Journal of Rehabilitation and Health Studies.2022;[Epub] CrossRef - Plantaricin A reverses resistance to ciprofloxacin of multidrug‐resistant Staphylococcus aureus by inhibiting efflux pumps
Fanqiang Meng, Ting Nie, Yunbin Lyu, Fengxia Lyu, Xiaomei Bie, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu
Environmental Microbiology.2022; 24(10): 4818. CrossRef - Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus
Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim
Antibiotics.2022; 11(10): 1378. CrossRef -
Increased Expression of Efflux Pump
norA
Drives the Rapid Evolutionary Trajectory from Tolerance to Resistance against Ciprofloxacin in Staphylococcus aureus
X. H. Yu, Z. H. Hao, P. L. Liu, M. M. Liu, L. L. Zhao, X. Zhao
Antimicrobial Agents and Chemotherapy.2022;[Epub] CrossRef - Propolis in the control of bacterial bovine mastitis: a tool for the production of organic milk
Gabriel Michelutti do Nascimento, Marita Vedovelli Cardozo, Mylena Karoline Valmorbida, Natália Pereira, José Carlos Barbosa, Flávio Rubens Favaron Júnior, Fernando Antônio de Ávila
Semina: Ciências Agrárias.2022; 43(2): 869. CrossRef - Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: mechanism of action
Victoria M Wu, Eric Huynh, Sean Tang, Vuk Uskoković
Biomedical Materials.2021; 16(1): 015018. CrossRef - A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs
Anja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski
Antibiotics.2021; 10(7): 862. CrossRef - Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus
Harshad Lade, Jae-Seok Kim
Antibiotics.2021; 10(4): 398. CrossRef - Antibacterial properties of capsaicin and its derivatives and their potential to fight antibiotic resistance – A literature survey
Samuel Füchtbauer, Soraya Mousavi, Stefan Bereswill, Markus M. Heimesaat
European Journal of Microbiology and Immunology.2021; 11(1): 10. CrossRef - A Short Review on Advances in Nanosystems Emerging as an Effective Approaches to Control Pathogenesis of Staphylococcus spp
Giri Ved Prakash, Shukla Pallavi, Tripathi Ashutosh, Kumar Navinit, Verma Priya, Pandey Shipra, Mishra Aradhana
Global Journal of Infectious Diseases and Clinical Research.2021; : 049. CrossRef - Cystic Fibrosis Sputum Impairs the Ability of Neutrophils to Kill Staphylococcus aureus
Kayla Fantone, Samantha L. Tucker, Arthur Miller, Ruchi Yadav, Eryn E. Bernardy, Rachel Fricker, Arlene A. Stecenko, Joanna B. Goldberg, Balázs Rada
Pathogens.2021; 10(6): 703. CrossRef - Genetic traceability of Staphylococcus aureus strains isolated from primiparous dairy cows mastitis, humans and environment in the Northeast region of Brazil
Amanda Thaís Ferreira Silva, José Givanildo da Silva, Breno Bezerra Aragão, Núbia Michelle Vieira da Silva, Priscylla Carvalho Vasconcelos, Celso José Bruno de Oliveira, Rinaldo Aparecido Mota
Ciência Rural.2021;[Epub] CrossRef - Molecular Characteristics and Exotoxins of Methicillin-Resistant Staphylococcus aureus
Jinyoung Bae, Hyunwoo Jin, Jungho Kim, Min Park, Jiyoung Lee, Sunghyun Kim
Biomedical Science Letters.2021; 27(4): 195. CrossRef - Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives
Giada Cernicchi, Tommaso Felicetti, Stefano Sabatini
Molecules.2021; 26(22): 6996. CrossRef -
First report of a livestock‐associated methicillin‐resistant
Staphylococcus aureus
ST126 harbouring the
mecC
variant in Brazil
José Givanildo Silva, Wydemberg José Araujo, Elma Lima Leite, Larissa Maranhão Dias, Priscylla Carvalho Vasconcelos, Núbia Michelle Vieira Silva, Raylson Pereira Oliveira, Maria José Sena, Celso José Bruno Oliveira, Rinaldo Aparecido Mota
Transboundary and Emerging Diseases.2021; 68(3): 1019. CrossRef - Ribosome‐targeting antibacterial agents: Advances, challenges, and opportunities
Laiying Zhang, Jun He, Lang Bai, Shihua Ruan, Tao Yang, Youfu Luo
Medicinal Research Reviews.2021; 41(4): 1855. CrossRef - Effect of Carvacrol and Thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains
Cristina Rodrigues dos Santos Barbosa, Jackelyne Roberta Scherf, Thiago Sampaio de Freitas, Irwin Rose Alencar de Menezes, Raimundo Luiz Silva Pereira, Joycy Francely Sampaio dos Santos, Sarah Silva Patrício de Jesus, Thais Pereira Lopes, Zildene de Sousa
Journal of Bioenergetics and Biomembranes.2021; 53(4): 489. CrossRef - Disinfectant resistance in bacteria: Mechanisms, spread, and resolution strategies
Chaoyu Tong, Hong Hu, Gang Chen, Zhengyan Li, Aifeng Li, Jianye Zhang
Environmental Research.2021; 195: 110897. CrossRef - Antimicrobial activity of polypyrrole nanoparticles and aqueous extract ofMoringa oleiferaagainstStaphylococcusspp. carriers of multi-drug efflux system genes isolated from dairy farms
José Givanildo da Silva, Mariana de Barros, Nataly Diniz de Lima Santos, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão, Maria José de Sena, Mateus Matiuzzi da Costa, Helinando Pequeno de Oliveira, Maria Aparecida Scatamburlo Moreira, Rinaldo Apare
Journal of Dairy Research.2020; 87(3): 309. CrossRef - Evidence of Calcium Signaling and Modulation of the LmrS Multidrug Resistant Efflux Pump Activity by Ca2 + Ions in S. aureus
Amy R. Nava, Natalia Mauricio, Angel J. Sanca, Delfina C. Domínguez
Frontiers in Microbiology.2020;[Epub] CrossRef - Antibacterial Activity of Hexadecynoic Acid Isomers toward Clinical Isolates of Multidrug‐Resistant Staphylococcus aureus
David J. Sanabria‐Ríos, Christian Morales‐Guzmán, Joseph Mooney, Solymar Medina, Tomás Pereles‐De‐León, Ashley Rivera‐Román, Carlimar Ocasio‐Malavé, Damarith Díaz, Nataliya Chorna, Néstor M. Carballeira
Lipids.2020; 55(2): 101. CrossRef - Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps
Sanath Kumar, Manjusha Lekshmi, Ammini Parvathi, Manisha Ojha, Nicholas Wenzel, Manuel F. Varela
Microorganisms.2020; 8(2): 266. CrossRef - Epidemiology of efflux pumps genes mediating resistance among Staphylococcus aureus; A systematic review
Sepideh Hassanzadeh, Sara ganjloo, Mohammad Reza Pourmand, Rahil Mashhadi, Kiarash Ghazvini
Microbial Pathogenesis.2020; 139: 103850. CrossRef - Role of efflux in enhancing butanol tolerance of bacteria
Maryna Vasylkivska, Petra Patakova
Journal of Biotechnology.2020; 320: 17. CrossRef - Strategies for recombinant production of antimicrobial peptides with pharmacological potential
Kamila Botelho Sampaio de Oliveira, Michel Lopes Leite, Gisele Regina Rodrigues, Harry Morales Duque, Rosiane Andrade da Costa, Victor Albuquerque Cunha, Lorena Sousa de Loiola Costa, Nicolau Brito da Cunha, Octavio Luiz Franco, Simoni Campos Dias
Expert Review of Clinical Pharmacology.2020; 13(4): 367. CrossRef - Evaluation of the Antibacterial Activity and Efflux Pump Reversal of Thymol and Carvacrol against Staphylococcus aureus and Their Toxicity in Drosophila melanogaster
Zildene de Sousa Silveira, Nair Silva Macêdo, Joycy Francely Sampaio dos Santos, Thiago Sampaio de Freitas, Cristina Rodrigues dos Santos Barbosa, Dárcio Luiz de Sousa Júnior, Débora Feitosa Muniz, Lígia Claudia Castro de Oliveira, José Pinto Siqueira Jún
Molecules.2020; 25(9): 2103. CrossRef - Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
Andrei Papkou, Jessica Hedge, Natalia Kapel, Bernadette Young, R. Craig MacLean
Nature Communications.2020;[Epub] CrossRef - Pulmonary Staphylococcus aureus infection regulates breast cancer cell metastasis via neutrophil extracellular traps (NETs) formation
Jia‐Long Qi, Jin‐Rong He, Cun‐Bao Liu, Shu‐Mei Jin, Rui‐Yu Gao, Xu Yang, Hong‐Mei Bai, Yan‐Bing Ma
MedComm.2020; 1(2): 188. CrossRef - Capsaicin and Gut Microbiota in Health and Disease
Adrian Eugen Rosca, Mara Ioana Iesanu, Carmen Denise Mihaela Zahiu, Suzana Elena Voiculescu, Alexandru Catalin Paslaru, Ana-Maria Zagrean
Molecules.2020; 25(23): 5681. CrossRef - Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus
Yunlei Guo, Guanghui Song, Meiling Sun, Juan Wang, Yi Wang
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - Milk microbial composition of Brazilian dairy cows entering the dry period and genomic comparison between Staphylococcus aureus strains susceptible to the bacteriophage vB_SauM-UFV_DC4
Vinícius da Silva Duarte, Laura Treu, Cristina Sartori, Roberto Sousa Dias, Isabela da Silva Paes, Marcella Silva Vieira, Gabriele Rocha Santana, Marcos Inácio Marcondes, Alessio Giacomini, Viviana Corich, Stefano Campanaro, Cynthia Canedo da Silva, Sérgi
Scientific Reports.2020;[Epub] CrossRef - Phenotypic and genotypic methods for identification of slime layer production, efflux pump activity, and antimicrobial resistance genes as potential causes of the antimicrobial resistance of some mastitis pathogens from farms in Menoufia, Egypt
Mohamed Sabry Abd Elraheam Elsayed, Tamer Roshdey, Ahmed Salah, Reda Tarabees, Gamal Younis, Doaa Eldeep
Molecular Biology Reports.2019; 46(6): 6533. CrossRef - Essential Oil, Extracts, and Sesquiterpenes Obtained From the Heartwood of Pilgerodendron uviferum Act as Potential Inhibitors of the Staphylococcus aureus NorA Multidrug Efflux Pump
Javier Espinoza, Alejandro Urzúa, Loreto Sanhueza, Mariana Walter, Paola Fincheira, Patricia Muñoz, Leonora Mendoza, Marcela Wilkens
Frontiers in Microbiology.2019;[Epub] CrossRef - Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
Andraž Lamut, Lucija Peterlin Mašič, Danijel Kikelj, Tihomir Tomašič
Medicinal Research Reviews.2019; 39(6): 2460. CrossRef - Transcriptome analysis of silver nanoparticles treated Staphylococcus aureus reveals potential targets for biofilm inhibition
Nimisha Singh, Jyutika Rajwade, K.M. Paknikar
Colloids and Surfaces B: Biointerfaces.2019; 175: 487. CrossRef - Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus
Santosh K. Rath, Samsher Singh, Sunil Kumar, Naiem A. Wani, Rajkishor Rai, Surrinder Koul, Inshad A. Khan, Payare L. Sangwan
Bioorganic & Medicinal Chemistry.2019; 27(2): 343. CrossRef - Biosynthesis of Fe3O4@Ag Nanocomposite and Evaluation of Its Performance on Expression of norA and norB Efflux Pump Genes in Ciprofloxacin-Resistant Staphylococcus aureus
Nastaran Shokoofeh, Zeinab Moradi-Shoeili, Akram Sadat Naeemi, Amir Jalali, Mohammad Hedayati, Ali Salehzadeh
Biological Trace Element Research.2019; 191(2): 522. CrossRef - Antibacterial effect of S-Porphin sodium photodynamic therapy on Staphylococcus aureus and multiple drug resistance Staphylococcus aureus
Mengqi Jia, Bingjie Mai, Shupei Liu, Zhaozhao Li, Quanhong Liu, Pan Wang
Photodiagnosis and Photodynamic Therapy.2019; 28: 80. CrossRef - Targeted magnetic separation of biomolecules and cells using earthicle-based ferrofluids
Vuk Uskoković, Sean Tang, Victoria M. Wu
Nanoscale.2019; 11(23): 11236. CrossRef - Modulation of antimicrobial efflux pumps of the major facilitator superfamily in Staphylococcus aureus
Manjusha Lekshmi, Parvathi Ammini, Jones Adjei, Leslie M. Sanford, Ugina Shrestha, Sanath Kumar, Manuel F. Varela
AIMS Microbiology.2018; 4(1): 1. CrossRef - Graphene Oxide-Based Nanocomposites Decorated with Silver Nanoparticles as an Antibacterial Agent
Sławomir Jaworski, Mateusz Wierzbicki, Ewa Sawosz, Anna Jung, Grzegorz Gielerak, Joanna Biernat, Henryk Jaremek, Witold Łojkowski, Bartosz Woźniak, Jacek Wojnarowicz, Leszek Stobiński, Artur Małolepszy, Marta Mazurkiewicz-Pawlicka, Maciej Łojkowski, Natal
Nanoscale Research Letters.2018;[Epub] CrossRef - A review on mechanism and future perspectives of cadmium-resistant bacteria
S. Z. Abbas, M. Rafatullah, K. Hossain, N. Ismail, H. A. Tajarudin, H. P. S. Abdul Khalil
International Journal of Environmental Science and Technology.2018; 15(1): 243. CrossRef - Role and mechanism of cell-surface hydrophobicity in the adaptation of Sphingobium hydrophobicum to electronic-waste contaminated sediment
Xingjuan Chen, Da Song, Jingjing Xu, Enze Li, Guoping Sun, Meiying Xu
Applied Microbiology and Biotechnology.2018; 102(6): 2803. CrossRef - Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
Alan Hibbitts, Cian O’Leary
Materials.2018; 11(2): 321. CrossRef - Effect of Staphylococcus aureus Tet38 native efflux pump on in vivo response to tetracycline in a murine subcutaneous abscess model
Chunhui Chen, David C Hooper
Journal of Antimicrobial Chemotherapy.2018; 73(3): 720. CrossRef - New strategies for targeting and treatment of multi-drug resistant Staphylococcus aureus
L. Mayrink Assis, M. Nedeljković, A. Dessen
Drug Resistance Updates.2017; 31: 1. CrossRef - Modulation of Staphylococcus aureus Response to Antimicrobials by the Candida albicans Quorum Sensing Molecule Farnesol
Eric F. Kong, Christina Tsui, Sona Kucharíková, Patrick Van Dijck, Mary Ann Jabra-Rizk
Antimicrobial Agents and Chemotherapy.2017;[Epub] CrossRef - Amphiphilic Cargo‐Loaded Nanocarrier Enhances Antibiotic Uptake and Perturbs Efflux: Effective Synergy for Mitigation of Methicillin‐Resistant Staphylococcus aureus
Durairaj Thiyagarajan, Gopal Das, Aiyagari Ramesh
ChemMedChem.2017; 12(14): 1125. CrossRef - Eradication and Sensitization of Methicillin Resistant Staphylococcus aureus to Methicillin with Bioactive Extracts of Berry Pomace
Serajus Salaheen, Mengfei Peng, Jungsoo Joo, Hironori Teramoto, Debabrata Biswas
Frontiers in Microbiology.2017;[Epub] CrossRef - Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence
Manuel Alcalde-Rico, Sara Hernando-Amado, Paula Blanco, José L. Martínez
Frontiers in Microbiology.2016;[Epub] CrossRef
- MINIREVIEW] Molecular architecture of the bacterial tripartite multidrug efflux pump focusing on the adaptor bridging model
-
Saemee Song , Jin-Sik Kim , Kangseok Lee , Nam-Chul Ha
-
J. Microbiol. 2015;53(6):355-364. Published online May 30, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5248-4
-
-
48
View
-
0
Download
-
9
Crossref
-
Abstract
-
Gram-negative bacteria expel a wide range of toxic substances
through tripartite drug efflux pumps consisting of an inner
membrane transporter, an outer membrane channel protein,
and a periplasmic adaptor protein. These pumps form tripartite
assemblies which can span the entire cell envelope,
including the inner and outer membranes. There have been
controversial findings regarding the assembly of the individual
components in tripartite drug efflux pumps. Recent
structural and functional studies have advanced our understanding
of the assembly and working mechanisms of the
pumps. Here, we re-evaluate the assembly models based on
recent structural and functional studies. In particular, this
study focuses on the ‘adaptor bridging model’, highlighting
the intermeshing cogwheel-like interactions between the tip
regions of the outer membrane channel protein and the periplasmic
adaptor protein in the hexameric assembly.
-
Citations
Citations to this article as recorded by

- Structural Features and Energetics of the Periplasmic Entrance Opening of the Outer Membrane Channel TolC Revealed by Molecular Dynamics Simulation and Markov State Model Analysis
Jingwei Weng, Wenning Wang
Journal of Chemical Information and Modeling.2019; 59(5): 2359. CrossRef - Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system
Inseong Jo, Jin-Sik Kim, Yongbin Xu, Jaekyung Hyun, Kangseok Lee, Nam-Chul Ha
Journal of Microbiology.2019; 57(3): 185. CrossRef - Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?
Ronald Domalaon, Temilolu Idowu, George G. Zhanel, Frank Schweizer
Clinical Microbiology Reviews.2018;[Epub] CrossRef - Genetic identification of factors for extracellular cellulose accumulation in the thermophilic cyanobacterium Thermosynechococcus vulcanus: proposal of a novel tripartite secretion system
Kaisei Maeda, Jyunya Tamura, Yukiko Okuda, Rei Narikawa, Takafumi Midorikawa, Masahiko Ikeuchi
Molecular Microbiology.2018; 109(1): 121. CrossRef - Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump
Reinke T. Müller, Timothy Travers, Hi-jea Cha, Joshua L. Phillips, S. Gnanakaran, Klaas M. Pos
Journal of Molecular Biology.2017; 429(24): 3863. CrossRef - Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters
Venkata Krishnan Ramaswamy, Attilio V. Vargiu, Giuliano Malloci, Jürg Dreier, Paolo Ruggerone
Scientific Reports.2017;[Epub] CrossRef - Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump
Anthony W. P. Fitzpatrick, Salomé Llabrés, Arthur Neuberger, James N. Blaza, Xiao-Chen Bai, Ui Okada, Satoshi Murakami, Hendrik W. van Veen, Ulrich Zachariae, Sjors H. W. Scheres, Ben F. Luisi, Dijun Du
Nature Microbiology.2017;[Epub] CrossRef - Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain
Daichi Murata, Hiroyuki Okano, Clement Angkawidjaja, Masato Akutsu, Shun-ichi Tanaka, Kenyu Kitahara, Takuya Yoshizawa, Hiroyoshi Matsumura, Yuji Kado, Eiichi Mizohata, Tsuyoshi Inoue, Satoshi Sano, Yuichi Koga, Shigenori Kanaya, Kazufumi Takano
Biochemistry.2017; 56(47): 6281. CrossRef - The Crystal Structure of the YknZ Extracellular Domain of ABC Transporter YknWXYZ from Bacillus amyloliquefaciens
Yongbin Xu, Jianyun Guo, Lulu Wang, Rui Jiang, Xiaoling Jin, Jing Liu, Shengdi Fan, Chun-Shan Quan, Nam-Chul Ha, Bostjan Kobe
PLOS ONE.2016; 11(5): e0155846. CrossRef
Research Support, Non-U.S. Gov'ts
- Functional analysis of Vibrio vulnificus RND efflux pumps homologous to Vibrio cholerae VexAB and VexCD, and to Escherichia coli AcrAB
-
Seunghwa Lee , Ji-Hyun Yeom , Sojin Seo , Minho Lee , Sarang Kim , Jeehyeon Bae , Kangseok Lee , Jihwan Hwang
-
J. Microbiol. 2015;53(4):256-261. Published online March 4, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5037-0
-
-
55
View
-
0
Download
-
9
Crossref
-
Abstract
-
Resistance-nodulation-division (RND) efflux pumps are associated
with multidrug resistance in many gram-negative
pathogens. The genome of Vibrio vulnificus encodes 11 putative
RND pumps homologous to those of Vibrio cholerae
and Escherichia coli. In this study, we analyzed three putative
RND efflux pumps, showing homology to V. cholerae VexAB
and VexCD and to E. coli AcrAB, for their functional roles in
multidrug resistance of V. vulnificus. Deletion of the vexAB
homolog resulted in increased susceptibility of V. vulnificus
to bile acid, acriflavine, ethidium bromide, and erythromycin,
whereas deletion of acrAB homologs rendered V. vulnificus
more susceptible to acriflavine only. Deletion of vexCD had
no effect on susceptibility of V. vulnificus to these chemicals.
Upon exposure to these antibacterial chemicals, expression
of tolCV1 and tolCV2, which are putative outer membrane
factors of RND efflux pumps, was induced, whereas expression
levels of vexAB, vexCD, and acrAB homologs were not
significantly changed. Our results show that the V. vulnificus
homologs of VexAB largely contributed to in vitro antimicrobial
resistance with a broad substrate specificity that
was partially redundant with the AcrAB pump homologs.
-
Citations
Citations to this article as recorded by

- Dynamics of efflux pumps in antimicrobial resistance, persistence, and community living of Vibrionaceae
Sanath Kumar, Manjusha Lekshmi, Jerusha Stephen, Anely Ortiz-Alegria, Matthew Ayitah, Manuel F. Varela
Archives of Microbiology.2024;[Epub] CrossRef - Membrane Efflux Pumps of Pathogenic Vibrio Species: Role in Antimicrobial Resistance and Virulence
Jerusha Stephen, Manjusha Lekshmi, Parvathi Ammini, Sanath H. Kumar, Manuel F. Varela
Microorganisms.2022; 10(2): 382. CrossRef - TolCV1 Has Multifaceted Roles During Vibrio vulnificus Infection
Yue Gong, Rui Hong Guo, Joon Haeng Rhee, Young Ran Kim
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - The mechanisms that regulate Vibrio parahaemolyticus virulence gene expression differ between pathotypes
Nicholas Petronella, Jennifer Ronholm
Microbial Genomics
.2018;[Epub] CrossRef - ATP-Binding Cassette Transporter VcaM from Vibrio cholerae is Dependent on the Outer Membrane Factor Family for Its Function
Wen-Jung Lu, Hsuan-Ju Lin, Thamarai Janganan, Cheng-Yi Li, Wei-Chiang Chin, Vassiliy Bavro, Hong-Ting Lin
International Journal of Molecular Sciences.2018; 19(4): 1000. CrossRef - Contribution of efflux systems to the detergent resistance, cytotoxicity, and biofilm formation of Vibrio vulnificus
Chung-Cheng Lo, Pei-Ting Lin, Chuan Chiang-Ni, Kuan-Hua Lin, Shin-Luen Lee, Tzu-Fang Kuo, Horng-Ren Lo
Gene Reports.2017; 9: 115. CrossRef - Survival of the Fittest: How Bacterial Pathogens Utilize Bile To Enhance Infection
Jeticia R. Sistrunk, Kourtney P. Nickerson, Rachael B. Chanin, David A. Rasko, Christina S. Faherty
Clinical Microbiology Reviews.2016; 29(4): 819. CrossRef - MdsABC-Mediated Pathway for Pathogenicity in Salmonella enterica Serovar Typhimurium
Saemee Song, Boeun Lee, Ji-Hyun Yeom, Soonhye Hwang, Ilnam Kang, Jang-Cheon Cho, Nam-Chul Ha, Jeehyeon Bae, Kangseok Lee, Yong-Hak Kim, S. M. Payne
Infection and Immunity.2015; 83(11): 4266. CrossRef - Molecular architecture of the bacterial tripartite multidrug efflux pump focusing on the adaptor bridging model
Saemee Song, Jin-Sik Kim, Kangseok Lee, Nam-Chul Ha
Journal of Microbiology.2015; 53(6): 355. CrossRef
- Frequency of Antibiotic Resistance in Helicobacter pylori Strains Isolated from the Northern Population of Iran
-
Amin Talebi Bezmin Abadi , Tarang Taghvaei , Ashraf Mohabbati Mobarez , Beth M. Carpenter , D. Scott Merrell
-
J. Microbiol. 2011;49(6):987-993. Published online December 28, 2011
-
DOI: https://doi.org/10.1007/s12275-011-1170-6
-
-
28
View
-
0
Download
-
42
Scopus
-
Abstract
-
The purpose of this study was to evaluate the primary resistance rates of recent clinical Helicobacter pylori isolates to the most commonly used antibiotics in Iran. Two hundreds and ten patients presenting with gastric maladies between January and July of 2009 were enrolled in this study. Endoscopy was performed, and biopsy specimens were collected from each patient for subsequent bacterial culture of H. pylori. Single colony isolates from each patient were then used for antimicrobial susceptibility testing. The disk diffusion method was used to determine susceptibility patterns. One hundred and ninety-seven of the patients were H. pylori positive (93.8%). The rates of resistance to tetracycline, amoxicillin, ciprofloxacin, metronidazole, clarithromycin, and furizoladone were 37.1%, 23.9%, 34.5%, 65.5%, 45.2%, and 61.4%, respectively. A significant association between amoxicillin resistance and disease state (P<0.05) was identified. Furthermore, some double, triple, quadruple, and quintuple combinations of antibiotic resistance were found to be associated with disease state. This study evaluated the prevalence of H. pylori resistance to the most commonly prescribed antibiotics used in Iran and showed that resistance rates were generally higher than previously reported. This data adds to the growing body of evidence that suggests there is increasing antibiotic resistance among H. pylori isolates, which likely is responsible for the decreasing efficacy of anti-H. pylori therapy at the local and global level. Hence, there is a need for continued monitoring of resistance patterns, especially at the local level, and for incorporation of that information into treatment regimens for H. pylori infections.