MSK
Search
- Page Path
- HOME > Search
Journal Articles
- Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone
- Qiudi Zhou, Lihui Feng
- J. Microbiol. 2024;62(5):367-379. Published online June 17, 2024
- DOI: https://doi.org/10.1007/s12275-024-00141-0
- 400 View
- 5 Download
- 2 Web of Science
- 2 Crossref
-
Abstract
PDF - 2-piperidone is a crucial industrial raw material of high-value nylon-5 and nylon-6,5. Currently, a major bottleneck in the biosynthesis of 2-piperidone is the identification of highly efficient 2-piperidone synthases. In this study, we aimed to identify specific strains among 51 human gut bacterial strains capable of producing 2-piperidone and to elucidate its synthetic mechanism. Our findings revealed that four gut bacterial strains, namely Collinsella aerofaciens LFYP39, Collinsella intestinalis LFYP54, Clostridium bolteae LFYP116, and Clostridium hathewayi LFYP18, could produce 2-piperidone from 5-aminovaleric acid (5AVA). Additionally, we observed that 2-piperidone could be synthesized from proline through cross-feeding between Clostridium difficile LFYP43 and one of the four 2-piperidone producing strains, respectively. To identify the enzyme responsible for catalyzing the conversion of 5AVA to 2-piperidone, we utilized a gain-of-function library and identified avaC (5-aminovaleric acid cyclase) in C. intestinalis LFYP54. Moreover, homologous genes of avaC were validated in the other three bacterial strains. Notably, avaC were found to be widely distributed among environmental bacteria. Overall, our research delineated the gut bacterial strains and genes involved in 2-piperidone production, holding promise for enhancing the efficiency of industrial biosynthesis of this compound.
-
Citations
Citations to this article as recorded by
- Metabolite biomarkers of screening neonatal congenital hypothyroidism based on dried blood spot metabolomics
Xingyu Guo, Feng Suo, Yuting Wang, Di Yu, Yi Wang, Bulian Dong, Lingshan Gou, Xinhui Gan, Benjing Wang, Chaowen Yu, Xiaoxiang Xie, Dandan Linghu, Xinyu Liu, Maosheng Gu, Guowang Xu
Analytical and Bioanalytical Chemistry.2025; 417(13): 2889. CrossRef - Scarless gene disruption enabled by a dual-plasmid knockout platform in a clinical infant-derived Bifidobacterium breve strain
Zhenxuan Gao, Lihui Feng
Frontiers in Microbiology.2025;[Epub] CrossRef
- Metabolite biomarkers of screening neonatal congenital hypothyroidism based on dried blood spot metabolomics
- Repeated Exposure of Vancomycin to Vancomycin-Susceptible Staphylococcus aureus (VSSA) Parent Emerged VISA and VRSA Strains with Enhanced Virulence Potentials
- An Nguyen, J Jean Sophy Roy, Ji-Hoon Kim, Kyung-Hee Yun, Wonsik Lee, Kyeong Kyu Kim, Truc Kim, Akhilesh Kumar Chaurasia
- J. Microbiol. 2024;62(7):535-553. Published online May 30, 2024
- DOI: https://doi.org/10.1007/s12275-024-00139-8
- 425 View
- 8 Download
- 2 Web of Science
- 2 Crossref
-
Abstract
PDF
- The emergence of resistance against the last-resort antibiotic vancomycin in staphylococcal infections is a serious concern for human health. Although various drug-resistant pathogens of diverse genetic backgrounds show higher virulence potential, the underlying mechanism behind this is not yet clear due to variability in their genetic dispositions. In this study, we investigated the correlation between resistance and virulence in adaptively evolved isogenic strains. The vancomycin-susceptible Staphylococcus aureus USA300 was exposed to various concentrations of vancomycin repeatedly as a mimic of the clinical regimen to obtain mutation(s)-accrued-clonally-selected (MACS) strains. The phenotypic analyses followed by expression of the representative genes responsible for virulence and resistance of MACS strains were investigated. MACS strains obtained under 2 and 8 µg/ml vancomycin, named Van2 and Van8, respectively; showed enhanced vancomycin minimal inhibitory concentrations (MIC) to 4 and 16 µg/ml, respectively. The cell adhesion and invasion of MACS strains increased in proportion to their MICs. The correlation between resistance and virulence potential was partially explained by the differential expression of genes known to be involved in both virulence and resistance in MACS strains compared to parent S. aureus USA300. Repeated treatment of vancomycin against vancomycin-susceptible S. aureus (VSSA) leads to the emergence of vancomycin-resistant strains with variable levels of enhanced virulence potentials.
-
Citations
Citations to this article as recorded by- Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim
Journal of Biomedical Science.2025;[Epub] CrossRef - Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods
Ju Hye Baek, Dong Min Han, Dae Gyu Choi, Chae Yeong Moon, Jae Kyeong Lee, Chul-Hong Kim, Jung-Woong Kim, Che Ok Jeon
Journal of Microbiology.2025; 63(8): e2503003. CrossRef
- Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
- Recombinant Protein Mimicking the Antigenic Structure of the Viral Surface Envelope Protein Reinforces Induction of an Antigen‑Specific and Virus‑Neutralizing Immune Response Against Dengue Virus
- Ju Kim , Tae Young Lim , Jisang Park , Yong&#
- J. Microbiol. 2023;61(1):131-143. Published online February 1, 2023
- DOI: https://doi.org/10.1007/s12275-023-00021-z
- 372 View
- 0 Download
- 3 Web of Science
- 3 Crossref
-
Abstract
PDF
- Dengue virus (DENV), belonging to the family Flaviviridae, is the causative agent of dengue and comprises four serotypes. A second heterologous DENV infection is a critical risk factor for severe dengue, and no effective vaccine is available to prevent infection by all four DENV serotypes. Recombinant DENV vaccines are primarily based on the envelope proteins, prM and E. The E protein and its envelope domain III (EDIII) have been investigated as candidate antigens (Ags) for recombinant subunit vaccines. However, most EDIII-based Ags are monomers that do not display the cognate antigenic structure of E protein, which is essential for induction of virus-neutralizing immunity. Here, we developed recombinant DENV-2 envelope domain (r2ED) protein as an Ag that mimics the quaternary structure of E protein on the DENV surface. We confirmed that r2ED retained the conformational epitope displayed at the E-dimer interface, which reportedly exhibits broad virus-neutralizing capacity, without displaying the fusion loop epitope that causes antibody (Ab)-dependent enhancement. Furthermore, compared with EDIII alone, r2ED elicited stronger Ag-specific and cross-reactive neutralizing Ab and T cell-mediated immune responses in mice. This Ag-specific immunity was maintained at an elevated level 6 months after the last immunization, suggesting sustained Ag-specific immune memory. Taken together, these observations suggest that r2ED could be used to develop an improved subunit vaccine capable of inducing a broadly cross-reactive and long-lasting immune response against DENV infection.
-
Citations
Citations to this article as recorded by- Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro
Jae-Hyeong Kim, Dong-Hwi Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Dong-Hun Lee, Do-Geun Kim, Hun-Young Yoon, In-Soo Choi
Journal of Microbiology.2025; 63(5): e2501029. CrossRef - A retrospective computational validation of a clinically evaluated recombinant envelope protein tetravalent dengue vaccine
Jesús Reiné, Rosaria Tinnirello, Alberto Cagigi, Chiuan Yee Leow, Chiuan Herng Leow, Gioacchin Iannolo, Bruno Douradinha
International Journal of Biological Macromolecules.2025; 329: 147688. CrossRef - Peptides of a Feather: How Computation Is Taking Peptide Therapeutics under Its Wing
Thomas David Daniel Kazmirchuk, Calvin Bradbury-Jost, Taylor Ann Withey, Tadesse Gessese, Taha Azad, Bahram Samanfar, Frank Dehne, Ashkan Golshani
Genes.2023; 14(6): 1194. CrossRef
- Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro
- Characterization and bioefficacy of green nanosilver particles derived from fungicide-tolerant Tricho-fusant for efficient biocontrol of stem rot (Sclerotium rolfsii Sacc.) in groundnut (Arachis hypogaea L.)
- Darshna G. Hirpara , Harsukh P. Gajera , Disha D. Savaliya , Rushita V. Bhadani
- J. Microbiol. 2021;59(11):1031-1043. Published online October 6, 2021
- DOI: https://doi.org/10.1007/s12275-021-1344-9
- 369 View
- 0 Download
- 8 Web of Science
- 7 Crossref
-
Abstract
PDF
- An efficient and eco-friendly bioefficacy of potent Trichofusant (Fu21) and its green nanosilver formulation against stem rot (Sclerotium rolfsii) in groundnut was established. Fu21 demonstrated higher in-vitro growth inhibition of pathogen with better fungicide tolerance than the parental strains. The green nanosilver particles were synthesized from the extracellular metabolites of Fu21 and characterized for shape (spherical, 59.34 nm in scanning electron microscope), purity (3.00 KeV, energy dispersive X-ray analysis), size (54.3 nm in particle size analyzer), and stability (53.7 mv, zeta). The field efficacy study exhibited that the seedling emergence was high in seeds treated with green nanosilver (minimum inhibitory concentration-[MIC] 20 μg Ag/ml), and a low disease severity index of stem rot during the crop growth was followed by the live antagonist (Fu21) in addition to seed treatment with a fungicide mix under pathogen infestation. The seed quality analysis of harvested pods revealed a high oil content with balanced fatty acid composition (3.10 oleic/linoleic acid ratio) in green nanosilver treatment under pathogen infestation. The residual analysis suggested that green nanosilver applied at the MIC level as seed treatment yielded similar effects as the control for silver residue in the harvested groundnut seeds. The green nanosilver at MIC has a high pod-yield under S. rolfsii infestation, demonstrating green chemistry and sustainability of the nanoproduct.
-
Citations
Citations to this article as recorded by- Comparative impact of seed priming with zinc oxide nanoparticles and zinc sulphate on biocompatibility, zinc uptake, germination, seedling vitality, and antioxidant modulation in groundnut
M. N. Ashwini, H. P. Gajera, Darshna G. Hirpara, Disha D. Savaliya, U. K. Kandoliya
Journal of Nanoparticle Research.2024;[Epub] CrossRef - Biotechnological trends and optimization of Arachis hypogaea residues valorization: A bibliometric analysis and comprehensive review
Oyetola Ogunkunle, Micheal Olusoji Olusanya
Bioresource Technology.2024; 414: 131585. CrossRef - Intracellular metabolomics and microRNAomics unveil new insight into the regulatory network for potential biocontrol mechanism of stress‐tolerant Tricho‐fusants interacting with phytopathogen Sclerotium rolfsii Sacc
Darshna G. Hirpara, Harsukh P. Gajera
Journal of Cellular Physiology.2023; 238(6): 1288. CrossRef - Antifungal Properties of Nanosilver Clay Composites Against Fungal Pathogens of Agaricus bisporus
Tebogo Levy Ramakutoane, Magaretha Petronella Roux‐van der Merwe, Jacqueline Badenhorst, Sreejarani Kesavan Pillai, Suprakas Sinha Ray
ChemistrySelect.2023;[Epub] CrossRef - Exploring conserved and novel MicroRNA-like small RNAs from stress tolerant Trichoderma fusants and parental strains during interaction with fungal phytopathogen Sclerotium rolfsii Sacc.
Darshna G. Hirpara, H.P. Gajera, Disha D. Savaliya, M.V. Parakhia
Pesticide Biochemistry and Physiology.2023; 191: 105368. CrossRef - Biochemical and molecular depictions to develop ech42 gene-specific SCAR markers for recognition of chitinolytic Trichoderma inhibiting Macrophomina phaseolina (Maubl.) Ashby
H. P. Gajera, Darshna G. Hirpara, Disha D. Savaliya, M. V. Parakhia
Archives of Microbiology.2023;[Epub] CrossRef - Salicylic acid-functionalised chitosan nanoparticles restore impaired sucrose metabolism in the developing anther of cotton (Gossypium hirsutum) under heat stress
Khyati R. Savani, H. P. Gajera, Darshna G. Hirpara, Disha D. Savaliya, U. K. Kandoliya, Honghong Wu
Functional Plant Biology.2023; 50(9): 736. CrossRef
- Comparative impact of seed priming with zinc oxide nanoparticles and zinc sulphate on biocompatibility, zinc uptake, germination, seedling vitality, and antioxidant modulation in groundnut
- Incomplete autophagy promotes the replication of Mycoplasma hyopneumoniae
- Zhaodi Wang† , Yukang Wen† , Bingqian Zhou , Yaqin Tian , Yaru Ning , Honglei Ding
- J. Microbiol. 2021;59(8):782-792. Published online July 5, 2021
- DOI: https://doi.org/10.1007/s12275-021-1232-3
- 341 View
- 0 Download
- 7 Web of Science
- 7 Crossref
-
Abstract
PDF
- Autophagy is an important cellular homeostatic mechanism for recycling of degradative proteins and damaged organelles. Autophagy has been shown to play an important role in cellular responses to bacteria and bacterial replication. However, the role of autophagy in Mycoplasma hyopneumoniae infection and the pathogenic mechanism is not well characterized. In this study, we showed that M. hyopneumoniae infection significantly increases the number of autophagic vacuoles in host cells. Further, we found significantly enhanced expressions of autophagy marker proteins (LC3-II, ATG5, and Beclin 1) in M. hyopneumoniae-infected cells. Moreover, immunofluorescence analysis showed colocalization of P97 protein with LC3 during M. hyopneumoniae infection. Interestingly, autophagic flux marker, p62, accumulated with the induction of infection. Conversely, the levels of p62 and LC3-II were decreased after treatment with 3-MA, inhibiting the formation of autophagosomes, during infection. In addition, accumulation of autophagosomes promoted the expression of P97 protein and the survival of M. hyopneumoniae in PK- 15 cells, as the replication of M. hyopneumoniae was downregulated by adding 3-MA. Collectively, these findings provide strong evidence that M. hyopneumoniae induces incomplete autophagy, which in turn enhances its reproduction in host cells. These findings provide novel insights into the interaction of M. hyopneumoniae and host.
-
Citations
Citations to this article as recorded by- Proteomics Reveals the Response Mechanism of Embryonic Bovine Lung Cells to Mycoplasma bovis Infection
Li Wang, Qing Wang, Yudong Liu, Yunxia Chen, Shijun Bao, Xiaoli Zhang, Chuan Wang
International Journal of Molecular Sciences.2025; 26(2): 823. CrossRef - Omega-3 PUFAs improve cognitive function in heat-stressed mice by enhancing autophagy via inhibition of the phosphorylation of the PI3K–Akt–mTOR pathway
Zifu Ren, Mengyu Cai, Xinyao Liu, Xin Li, Wenjing Shi, Hongtao Lu, Hui Shen, Gen Miao, Qicheng Zhou, Hongxia Li
Food & Function.2025; 16(5): 1931. CrossRef - The DHH-DHHA1 domain phosphodiesterase of Mycoplasma bovis employs multiple strategies to modulate macrophage cellular processes
Xifang Zhu, Ye Chen, Doukun Lu, Gang Zhao, Yankai Liu, Aiping Wang, Aizhen Guo
International Journal of Biological Macromolecules.2025; 306: 141585. CrossRef - Research Progress on Immune Evasion of Mycoplasma hyopneumoniae
Bin Jiang, Ying Zhang, Gaojian Li, Yanping Quan, Jianhong Shu, Huapeng Feng, Yulong He
Microorganisms.2024; 12(7): 1439. CrossRef - The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
Huijie Zhao, Yihan Yang, Xinya Si, Huiyang Liu, Honggang Wang
Biomolecules.2022; 12(7): 1010. CrossRef - Mycoplasma bovis inhibits autophagy in bovine mammary epithelial cells via a PTEN/PI3K-Akt-mTOR-dependent pathway
Maolin Xu, Yang Liu, Tuerdi Mayinuer, Yushan Lin, Yue Wang, Jian Gao, Dong Wang, John P. Kastelic, Bo Han
Frontiers in Microbiology.2022;[Epub] CrossRef - Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages
Yukang Wen, Zhengkun Chen, Yaqin Tian, Mei Yang, Qingshuang Dong, Yujiao Yang, Honglei Ding
Veterinary Research.2022;[Epub] CrossRef
- Proteomics Reveals the Response Mechanism of Embryonic Bovine Lung Cells to Mycoplasma bovis Infection
- Different distribution patterns of microorganisms between aquaculture pond sediment and water
- Lili Dai , Chengqing Liu , Liang Peng , Chaofeng Song , Xiaoli Li , Ling Tao
- J. Microbiol. 2021;59(4):376-388. Published online February 25, 2021
- DOI: https://doi.org/10.1007/s12275-021-0635-5
- 401 View
- 0 Download
- 31 Web of Science
- 31 Crossref
-
Abstract
PDF
- Aquatic microorganisms in the sediment and water column are closely related; however, their distribution patterns between these two habitats still remain largely unknown. In this study, we compared sediment and water microeukaryotic and bacterial microorganisms in aquaculture ponds from different areas in China, and analyzed the influencing environmental factors as well as the inter-taxa relationships. We found that bacteria were significantly more abundant than fungi in both sediment and water, and the bacterial richness and diversity in sediment were higher than in water in all the sampling areas, but no significant differences were found between the two habitats for microeukaryotes. Bacterial taxa could be clearly separated through cluster analysis between the sediment and water, while eukaryotic taxa at all classification levels could not. Spirochaetea, Deltaproteobacteria, Nitrospirae, Ignavibacteriae, Firmicutes, Chloroflexi, and Lentimicrobiaceae were more abundantly distributed in sediment, while Betaproteobacteria, Alphaproteobacter, Cyanobacteria, Roseiflexaceae, Dinghuibacter, Cryomorphaceae, and Actinobacteria were more abundant in water samples. For eukaryotes, only Cryptomonadales were found to be distributed differently between the two habitats. Microorganisms in sediment were mainly correlated with enzymes related to organic matter decomposition, while water temperature, pH, dissolved oxygen, and nutrient levels all showed significant correlation with the microbial communities in pond water. Intensive interspecific relationships were also found among eukaryotes and bacteria. Together, our results indicated that eukaryotic microorganisms are distributed less differently between sediment and water in aquaculture ponds compared to bacteria. This study provides valuable data for evaluating microbial distributions in aquatic environments, which may also be of practical use in aquaculture pond management.
-
Citations
Citations to this article as recorded by- Heterogeneous bacterial communities in gills and intestine of Nile tilapia (Oreochromis niloticus) and in water and sediments of aquaculture ponds in Bangladesh
Anwar Hossain, Md Al Zahid, Santonu Kumar Sanyal, Md Inja-Mamun Haque, Md Habibullah-Al-Mamun, Shankar Chandra Mandal, Kozo Watanabe
Aquaculture and Fisheries.2025; 10(4): 696. CrossRef - Bacterial Community Composition and Prevalence of Aeromonas dhakensis in Four Tilapia Freshwater Aquaculture Systems in Malaysia
Sook Ling Lim, Suat Moi Puah, Siti Nursyuhada Baharudin, Nur Insyirah Mohd Razalan, Kieng Soon Hii, Wei Ching Khor, Yen Ching Lim, Kyaw Thu Aung, Kek Heng Chua, Po Teen Lim, Chui Pin Leaw
Fishes.2025; 10(5): 204. CrossRef - Dynamics of soil properties and pathogen levels in Pacific white shrimp ponds during a production cycle: Implications for aquaculture management
Suwanit Chainark, Vanida Sumetlux, Pitchaya Chainark
Journal of the World Aquaculture Society.2025;[Epub] CrossRef - Deciphering the temporal and dose-responsive dynamics of microbial communities in aquaculture mesocosms under florfenicol treatment
Xiaoxi Deng, Chengqian Liang, Yu Wang, Yanni Geng, Jian Han, Ke Yu
Aquaculture.2025; 599: 742143. CrossRef - Efficacy of the ‘three ponds and two dams’ ecological treatment system in purifying shrimp pond wastewater and mitigating antibiotic resistance
Bin Wei, Jie Fang, Dongxian Zhou, Xuelin Gu, Bingyao Sun, Xuehong Song
Science of The Total Environment.2025; 992: 179928. CrossRef - Positive relationship between Clostridium abundance and bacterial community diversity in the aquaculture water of hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) in coastal areas of Hainan Island
Minjing Zheng, Zhen Li, Yonggan Chen
Israeli Journal of Aquaculture - Bamidgeh.2025;[Epub] CrossRef - Intestinal microbiota responses to environmental microbiomes and factors across populations of the Manila clam Ruditapes philippinarum
Longzhen Liu, Lulei Liu, Haonan Zhuang, Ang Li, Zirong Liu, Minghui Jiao, Jiamin Li, Suyan Xue, Jiaqi Li, Yushui Ren, Yuze Mao
Marine Environmental Research.2025; 210: 107296. CrossRef - Protistan assemblages in natural and man-made intermittent ponds of the New Jersey Pinelands
Micaela Kersey, Mihaela D. Enache, Nicholas A. Procopio, Patrick Burritt, Marina Potapova
Hydrobiologia.2025;[Epub] CrossRef - Bacterial community characterization of water and sediment in different culture systems of prawn Macrobrachium rosenbergii
Meng Ni, Songbao Zou, Mei Liu, Dan Zhou, Julin Yuan
Israeli Journal of Aquaculture - Bamidgeh.2025;[Epub] CrossRef - Bacterial hazards in urban stream irrigation in peri-urban interface of Nairobi-Machakos counties, Kenya
Arcadius Martinien Agassin Ahogle, Nicholas K. Korir, Pascal Houngnandan, Lina Abu-Ghunmi, Sammy Letema
International Journal of Environmental Studies.2024; 81(4): 1836. CrossRef - Metagenomic Insight into the Effect of Probiotics on Nitrogen Cycle in the Coilia nasus Aquaculture Pond Water
Qi Mang, Jun Gao, Quanjie Li, Yi Sun, Gangchun Xu, Pao Xu
Microorganisms.2024; 12(3): 627. CrossRef - Carbon and Nutrient Limitations of Microbial Metabolism in Xingkai Lake, China: Abiotic and Biotic Drivers
Xingting Chen, Weizhen Zhang, Mengdie Geng, Ji Shen, Jianjun Wang
Microbial Ecology.2024;[Epub] CrossRef - Biofilm formation and chlorine resistance of microbial communities in household drinking water system: Preliminary idea of using bacteria to control bacteria
Lili Shan, Xiajun Bao, Siyang Xu, Zebing Zhu, Yunyan Pei, Wanjun Zheng, Yixing Yuan
Process Biochemistry.2024; 141: 179. CrossRef - Profiling sediment bacterial communities and the response to pattern-driven variations of total nitrogen and phosphorus in long-term polyculture ponds
Yan Zhang, Tiejun Li, Guangzhi Li, Tao Yuan, Yao Zhang, Lei Jin
Frontiers in Marine Science.2024;[Epub] CrossRef - From small water bodies to lakes: Exploring the diversity of freshwater bacteria in an Alpine Biosphere Reserve
Sara Vettorazzo, Adriano Boscaini, Leonardo Cerasino, Nico Salmaso
Science of The Total Environment.2024; 954: 176495. CrossRef - Effects of Coal Mining Activities on the Changes in Microbial Community and Geochemical Characteristics in Different Functional Zones of a Deep Underground Coal Mine
Zhimin Xu, Li Zhang, Yating Gao, Xianfeng Tan, Yajun Sun, Weixiao Chen
Water.2024; 16(13): 1836. CrossRef - Effect of Pond-Based Rice Floating Bed on the Microbial Community Structure and Quality of Water in Pond of Mandarin Fish Fed Using Artificial Diet
Lijin Jiang, Mengmeng Yi, Zhiyong Jiang, Yuli Wu, Jianmeng Cao, Zhigang Liu, Zhang Wang, Maixin Lu, Xiaoli Ke, Miao Wang
Biology.2024; 13(7): 549. CrossRef - Temporal dynamics of protist communities and environmental factors in the horizontal flow-polyculture pond aquaculture model of Sinonovacula constricta
Minhai Liu, Zhongneng Yan, Chengwei Huang, Zhihua Lin, Zhilan Peng, Chenxi Zhao, Xiafei Zheng
Aquacultural Engineering.2024; 107: 102477. CrossRef - Bacterial and microalgal communities in carp polyculture systems: Composition, affecting factors and further perspectives
Ngoc Minh Ngan Bui, Jasmine Heyse, Jérôme Delamare-Deboutteville, Tom Defoirdt, Ruben Props, Colin Shelley
Aquaculture.2024; 582: 740505. CrossRef - Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease Outcomes via Their Interaction with Gut–Liver–Brain Axis
Saurabh Chatterjee, Madhura More
Toxins.2023; 15(4): 289. CrossRef - Significant tipping points of sediment microeukaryotes forewarn increasing antibiotic pollution
Chaohua Wang, Zhiyuan Yao, Pingping Zhan, Xianghua Yi, Jiong Chen, Jinbo Xiong
Journal of Environmental Sciences.2023; 124: 429. CrossRef - Red mark syndrome: Is the aquaculture water microbiome a keystone for understanding the disease aetiology?
Antonia Bruno, Alessandra Cafiso, Anna Sandionigi, Andrea Galimberti, Davide Magnani, Amedeo Manfrin, Giulio Petroni, Maurizio Casiraghi, Chiara Bazzocchi
Frontiers in Microbiology.2023;[Epub] CrossRef - Effect of outdoor pipe materials and community-intrinsic properties on biofilm formation and chlorine resistance: Black sheep or team leader
Zebing Zhu, Siyang Xu, Xiajun Bao, Lili Shan, Yunyan Pei, Wanjun Zheng, Yixing Yuan
Journal of Cleaner Production.2023; 411: 137308. CrossRef - The Responses of Sediment Bacterial Communities in Chinese Mitten Crab (Eriocheir sinensis) Culture Ponds to Changes in Physicochemical Properties Caused by Sediment Improvement
Tianheng Gao, Nannan Li, Wenlei Xue, Yuning Hu, Hai Lin
Fishes.2023; 8(2): 98. CrossRef - Antibiotic resistance gene-free probiont administration to tilapia for growth performance and Streptococcus agalactiae resistance
Mira Mawardi, Agustin Indrawati, Angela Mariana Lusiastuti, I Wayan Teguh Wibawan
Veterinary World.2023; : 2504. CrossRef - Analysis of the structure and function of microbial community in late-stage of grass carp (Ctenopharyngodon idella) farming ponds
Shuhui Niu, Kai Zhang, Zhifei Li, Jun Xie, Guangjun Wang, Hongyan Li, Ermeng Yu, Yun Xia, Jingjing Tian, Wangbao Gong
Aquaculture Reports.2023; 30: 101556. CrossRef - Case study on the aptness of in-pond raceways for pikeperch, Sander lucioperca, grow-out
Zoltán Nagy, László Ardó, Ferenc Demény, Dénes Gál, Zsuzsanna J. Sándor, Uroš Ljubobratović
Aquaculture Reports.2022; 27: 101356. CrossRef - Structural and functional comparisons of the environmental microbiota of pond and tank environments at different locations for the commercial aquaculture of American shad
J. Du, Q.H. Liu, J.S. Liu, K.-Q. Zhang, W.F. Huang
Letters in Applied Microbiology.2022; 75(1): 51. CrossRef - The responses of soil bacterial and archaeal communities to coastal embankments in three typical salt marshes of Eastern China
Hongyu Feng, Yajun Qiao, Lu Xia, Wen Yang, Yongqiang Zhao, Nasreen Jeelani, Shuqing An
Plant and Soil.2022; 477(1-2): 439. CrossRef - Improvement of fish production and water quality in a recirculating aquaculture pond enhanced with bacteria-microalgae association
Chu Wang, Cancan Jiang, Tianming Gao, Xiawei Peng, Shuanglong Ma, Qian Sun, Bing Xia, Xiangming Xie, Zhihui Bai, Shengjun Xu, Xuliang Zhuang
Aquaculture.2022; 547: 737420. CrossRef - Microbial Community Structure and Its Driving Environmental Factors in Black Carp (Mylopharyngodon piceus) Aquaculture Pond
Xuemei Li, Lu Liu, Yongjiu Zhu, Tingbing Zhu, Xingbing Wu, Deguo Yang
Water.2021; 13(21): 3089. CrossRef
- Heterogeneous bacterial communities in gills and intestine of Nile tilapia (Oreochromis niloticus) and in water and sediments of aquaculture ponds in Bangladesh
- Role of melatonin in murine “restraint stress”-induced dysfunction of colonic microbiota
- Rutao Lin , Zixu Wang , Jing Cao , Ting Gao , Yulan Dong , Yaoxing Chen
- J. Microbiol. 2021;59(5):500-512. Published online February 25, 2021
- DOI: https://doi.org/10.1007/s12275-021-0305-7
- 379 View
- 0 Download
- 17 Web of Science
- 18 Crossref
-
Abstract
PDF
- Intestinal diseases caused by physiological stress have become a severe public health threat worldwide. Disturbances in the gut microbiota-host relationship have been associated with irritable bowel disease (IBD), while melatonin (MT) has antiinflammatory and antioxidant effects. The objective of this study was to investigate the mechanisms by which MT-mediated protection mitigated stress-induced intestinal microbiota dysbiosis and inflammation. We successfully established a murine restraint stress model with and without MT supplementation. Mice subjected to restraint stress had significantly elevated corticosterone (CORT) levels, decreased MT levels in their plasma, elevated colonic ROS levels and increased bacterial abundance, including Bacteroides and Tyzzerella, in their colon tract, which led to elevated expression of Toll-like receptor (TLR) 2/4, p-P65 and p-IκB. In contrast, supplementation with 20 mg/kg MT reversed the elevation of the plasma CORT levels, downregulated the colon ROS levels and inhibited the changes in the intestinal microbiota induced by restraint stress. These effects, in turn, inhibited the activities of TLR2 and TLR4, p-P65 and p-IκB, and decreased the inflammatory reaction induced by restraint stress. Our results suggested that MT may mitigate “restraint stress”-induced colonic microbiota dysbiosis and intestinal inflammation by inhibiting the activation of the NF-κB pathway.
-
Citations
Citations to this article as recorded by- Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice
Chahrazed Mekadim, Jakub Mrázek, Martin Vodička, Peter Ergang, Kateřina Olša Fliegerová, Tiziana Maria Mahayri, Kallayanee Chawengsaksophak, Jiří Pácha
Molecular Neurobiology.2026;[Epub] CrossRef - Tryptophan Attenuates Chronic Restraint Stress-Induced Intestinal Injury Through Modulation of Intestinal Barrier Integrity and Gut Microbiota Homeostasis
Jianhua Zheng, Tianqi Sun, Tongtong Qin, Yunpeng Wu, Wensheng Zhang, Yefeng Qiu, Jingqing Chen
Nutrients.2025; 17(6): 975. CrossRef - Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes
Ke Yang, Guangqin Li, Qihong Li, Wei Wang, Xu Zhao, Nan Shao, Hui Qiu, Jing Liu, Lin Xu, Juanjuan Zhao
Cell & Bioscience.2025;[Epub] CrossRef - Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders
Petra Zimmermann, Salome Kurth, Benoit Pugin, Nicholas A. Bokulich
npj Biofilms and Microbiomes.2024;[Epub] CrossRef - Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review
Xuemeng Wan, Liyuan Wang, Zhiling Wang, Chaomin Wan
Frontiers in Immunology.2024;[Epub] CrossRef - Christensenella minuta mitigates behavioral and cardiometabolic hallmarks of social defeat stress
A. Agusti, GV. Molina-Mendoza, M. Tamayo, V. Rossini, MC. Cenit, C. Frances-Cuesta, V. Tolosa-Enguis, EM. Gómez Del Pulgar, A. Flor-Duro, Y. Sanz
Biomedicine & Pharmacotherapy.2024; 180: 117377. CrossRef - The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes, Paula Sanchez‐Diaz, Cassandra E. Gheorghe, Michael S. Goodson, Nancy Kelley‐Loughnane, Niall P. Hyland, John F. Cryan, Gerard Clarke
The Journal of Physiology.2023; 601(20): 4491. CrossRef - Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease
María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
Antioxidants.2023; 13(1): 34. CrossRef - INVESTIGATION OF THE ROLE OF STRESS IN MALE INFERTILITY AND THE EFFECT OF CURRENT MELATONIN HORMONE TREATMENTS
İshak GÖKÇEK, Leyla AYDIN
Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni.2023; 14(1): 36. CrossRef - The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments
Alane N. Bezerra, Caroline L. Peixoto, Synara C. Lopes, Veralice M. S. Bruin, Pedro Felipe C. Bruin, Reinaldo B. Oriá
Frontiers in Nutrition.2023;[Epub] CrossRef - Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light
Dun-Xian Tan, Russel J. Reiter, Scott Zimmerman, Ruediger Hardeland
Biology.2023; 12(1): 89. CrossRef - Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice
Ichiro Chihara, Hiromitsu Negoro, Jin Kono, Yoshiyuki Nagumo, Haruki Tsuchiya, Kosuke Kojo, Masanobu Shiga, Ken Tanaka, Shuya Kandori, Bryan J. Mathis, Hiroyuki Nishiyama
Communications Biology.2023;[Epub] CrossRef - The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation
Jefferson Luiz da Silva, Lia Vezenfard Barbosa, Camila Figueiredo Pinzan, Viviani Nardini, Irislene Simões Brigo, Cássia Aparecida Sebastião, Jefferson Elias-Oliveira, Vânia Brazão, José Clóvis do Prado Júnior, Daniela Carlos, Cristina Ribeiro de Barros C
Microorganisms.2023; 11(2): 460. CrossRef - The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression
Mauritz F. Herselman, Sheree Bailey, Larisa Bobrovskaya
International Journal of Molecular Sciences.2022; 23(4): 2013. CrossRef - Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
Yiwen Zhang, Rui Lang, Shunyu Guo, Xiaoqin Luo, Huiting Li, Cencen Liu, Wei Dong, Changshun Bao, Yang Yu
Frontiers in Neuroscience.2022;[Epub] CrossRef - Protective Effects and Mechanisms of Melatonin on Stress Myocardial Injury in Rats
Jia-yao Chen, Ting Li, Jiao-ling Wang, Zhan-le Wang, Yun Zhang, Lin-quan Zang
Journal of Cardiovascular Pharmacology.2022; 80(3): 417. CrossRef - Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism
Xia Liu, Yi Cui, Yuhan Zhang, Guo Xiang, Meng Yu, Xianshu Wang, Bin Qiu, Xin-gang Li, Wei Liu, Di Zhang
Biomedicine & Pharmacotherapy.2022; 156: 113949. CrossRef - Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases
Pengwei Li, Mingxian Chang
International Journal of Molecular Sciences.2021; 22(14): 7688. CrossRef
- Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice
Review
- [MINIREVIEW]Regulation of gene expression by protein lysine acetylation in Salmonella
- Hyojeong Koo , Shinae Park , Min-Kyu Kwak , Jung-Shin Lee
- J. Microbiol. 2020;58(12):979-987. Published online November 17, 2020
- DOI: https://doi.org/10.1007/s12275-020-0483-8
- 468 View
- 0 Download
- 17 Web of Science
- 15 Crossref
-
Abstract
PDF
- Protein lysine acetylation influences many physiological functions, such as gene regulation, metabolism, and disease in eukaryotes. Although little is known about the role of lysine acetylation in bacteria, several reports have proposed its importance in various cellular processes. Here, we discussed the function of the protein lysine acetylation and the post-translational modifications (PTMs) of histone-like proteins in bacteria focusing on Salmonella pathogenicity. The protein lysine residue in Salmonella is acetylated by the Pat-mediated enzymatic pathway or by the acetyl phosphate-mediated non-enzymatic pathway. In Salmonella, the acetylation of lysine 102 and lysine 201 on PhoP inhibits its protein activity and DNAbinding, respectively. Lysine acetylation of the transcriptional regulator, HilD, also inhibits pathogenic gene expression. Moreover, it has been reported that the protein acetylation patterns significantly differ in the drug-resistant and -sensitive Salmonella strains. In addition, nucleoid-associated proteins such as histone-like nucleoid structuring protein (H-NS) are critical for the gene silencing in bacteria, and PTMs in H-NS also affect the gene expression. In this review, we suggest that protein lysine acetylation and the post-translational modifications of H-NS are important factors in understanding the regulation of gene expression responsible for pathogenicity in Salmonella.
-
Citations
Citations to this article as recorded by- Global Insights into the Lysine Acetylome Reveal the Role of Lysine Acetylation in the Adaptation of Bacillus altitudinis to Salt Stress
Xujian Li, Shanshan Dai, Shanshan Sun, Dongying Zhao, Hui Li, Junyi Zhang, Jie Ma, Binghai Du, Yanqin Ding
Journal of Proteome Research.2025; 24(1): 210. CrossRef - The concentration of medium-chain fatty acids in breast milk is influenced by maternal diet and associated with gut microbiota in infants
Menglu Xi, Ignatius Man-Yau Szeto, Sufang Duan, Ting Li, Yalu Yan, Xia Ma, Ting Sun, Weilian Hung, Celi Yang, Yonghua Zhang, Ai Zhao
Journal of Functional Foods.2025; 128: 106782. CrossRef - Reversible acetylation of ribosomal protein S1 serves as a smart switch for Salmonella to rapidly adapt to host stress
Yi-Lin Shen, Tian-Xian Liu, Lei Xu, Bang-Ce Ye, Ying Zhou
Nucleic Acids Research.2025;[Epub] CrossRef - Bacterial protein acetylation: mechanisms, functions, and methods for study
Jocelin Rizo, Sergio Encarnación-Guevara
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - Acetyl-proteome profiling revealed the role of lysine acetylation in erythromycin resistance of Staphylococcus aureus
Miao Feng, Xiaoyu Yi, Yanling Feng, Feng He, Zonghui Xiao, Hailan Yao
Heliyon.2024; 10(15): e35326. CrossRef - Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota
Menglu Xi, Yalu Yan, Sufang Duan, Ting Li, Ignatius Man-Yau Szeto, Ai Zhao
Frontiers in Microbiology.2024;[Epub] CrossRef - Acetylomics reveals an extensive acetylation diversity within Pseudomonas aeruginosa
Nand Broeckaert, Hannelore Longin, Hanne Hendrix, Jeroen De Smet, Mirita Franz-Wachtel, Boris Maček, Vera van Noort, Rob Lavigne
microLife.2024;[Epub] CrossRef - Lysine acetylation regulates the AT-rich DNA possession ability of H-NS
Yabo Liu, Mengqing Zhou, Yifan Bu, Liang Qin, Yuanxing Zhang, Shuai Shao, Qiyao Wang
Nucleic Acids Research.2024; 52(4): 1645. CrossRef -
Acetylation of K188 and K192 inhibits the DNA-binding ability of NarL to regulate
Salmonella
virulence
Liu-Qing Zhang, Yi-Lin Shen, Bang-Ce Ye, Ying Zhou, Christopher A. Elkins
Applied and Environmental Microbiology.2023;[Epub] CrossRef - Acetylome and Succinylome Profiling of Edwardsiella tarda Reveals Key Roles of Both Lysine Acylations in Bacterial Antibiotic Resistance
Yuying Fu, Lishan Zhang, Huanhuan Song, Junyan Liao, Li Lin, Wenjia Jiang, Xiaoyun Wu, Guibin Wang
Antibiotics.2022; 11(7): 841. CrossRef - Pat- and Pta-mediated protein acetylation is required for horizontally-acquired virulence gene expression in Salmonella Typhimurium
Hyojeong Koo, Eunna Choi, Shinae Park, Eun-Jin Lee, Jung-Shin Lee
Journal of Microbiology.2022; 60(8): 823. CrossRef -
Acetylation of CspC Controls the Las Quorum-Sensing System through Translational Regulation of
rsaL
in Pseudomonas aeruginosa
Shouyi Li, Xuetao Gong, Liwen Yin, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Un-Hwan Ha, Weihui Wu, Pierre Cornelis, Gerald B. Pier
mBio.2022;[Epub] CrossRef - Trans-acting regulators of ribonuclease activity
Jaejin Lee, Minho Lee, Kangseok Lee
Journal of Microbiology.2021; 59(4): 341. CrossRef - Acetylation of the CspA family protein CspC controls the type III secretion system through translational regulation ofexsAinPseudomonas aeruginosa
Shouyi Li, Yuding Weng, Xiaoxiao Li, Zhuo Yue, Zhouyi Chai, Xinxin Zhang, Xuetao Gong, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Weihui Wu
Nucleic Acids Research.2021; 49(12): 6756. CrossRef - Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review
Michał Wójcicki, Olga Świder, Kamila J. Daniluk, Paulina Średnicka, Monika Akimowicz, Marek Ł. Roszko, Barbara Sokołowska, Edyta Juszczuk-Kubiak
Pathogens.2021; 10(7): 801. CrossRef
- Global Insights into the Lysine Acetylome Reveal the Role of Lysine Acetylation in the Adaptation of Bacillus altitudinis to Salt Stress
Journal Articles
- Phosphorylation of tegument protein pp28 contributes to trafficking to the assembly compartment in human cytomegalovirus infection
- Jun-Young Seo , Jin Ah Heo , William J. Britt
- J. Microbiol. 2020;58(7):624-631. Published online June 27, 2020
- DOI: https://doi.org/10.1007/s12275-020-0263-5
- 326 View
- 0 Download
- 5 Web of Science
- 5 Crossref
-
Abstract
PDF
- Human cytomegalovirus (HCMV) UL99 encodes a late tegument protein pp28 that is essential for envelopment and production of infectious virus. This protein is localized to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) in transfected cells but it localizes to the cytoplasmic assembly compartment (AC) in HCMV-infected cells. Trafficking of pp28 to the AC is required for the assembly of infectious virus. The N-terminal domain (aa 1-61) of pp28 is sufficient for trafficking and function of the wild type protein during viral infection. However, residues required for authentic pp28 trafficking with the exception of the acidic cluster in the N-terminal domain of pp28 remain undefined. Monitoring protein migration on SDS-PAGE, we found that pp28 is phosphorylated in the virus-infected cells and dephosphorylated in the viral particles. By generating substitution mutants of pp28, we showed that three serine residues (aa 41–43) and a tyrosine residue (aa 34) account for its phosphorylation. The mutant forms of pp28 were localized to the plasma membrane as well as the ERGIC in transfected cells. Likewise, these mutant proteins were localized to the plasma membrane as well as the AC in virus-infected cells. These results suggested that phosphorylation of pp28 contributes to its intracellular trafficking and efficient viral assembly and incorporation.
-
Citations
Citations to this article as recorded by- Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer
Yang Yang, Jiayi Chen, Fuhong Gong, Jingge Miao, Mengping Lin, Ruimin Liu, Chenxi Wang, Fei Ge, Wenlin Chen
Scientific Reports.2024;[Epub] CrossRef - Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons
Jacob W. Adelman, Suzette Rosas-Rogers, Megan L. Schumacher, Rebekah L. Mokry, Scott S. Terhune, Allison D. Ebert, Thomas Shenk
mBio.2023;[Epub] CrossRef - Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review
Janine Zeng, Di Cao, Shaomin Yang, Dabbu Kumar Jaijyan, Xiaolian Liu, Songbin Wu, Ruth Cruz-Cosme, Qiyi Tang, Hua Zhu
Viruses.2023; 15(8): 1703. CrossRef - Features and Functions of the Conserved Herpesvirus Tegument Protein UL11 and Its Binding Partners
Linjiang Yang, Mingshu Wang, Anchun Cheng, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun
Frontiers in Microbiology.2022;[Epub] CrossRef - The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction
Declan L. Turner, Rommel A. Mathias
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
- Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer
- Light affects picocyanobacterial grazing and growth response of the mixotrophic flagellate Poterioochromonas malhamensis
- Thomas Weisse , Michael Moser
- J. Microbiol. 2020;58(4):268-278. Published online January 28, 2020
- DOI: https://doi.org/10.1007/s12275-020-9567-8
- 377 View
- 0 Download
- 6 Web of Science
- 5 Crossref
-
Abstract
PDF
-
We measured the grazing and growth response of the mixotrophic
chrysomonad flagellate Poterioochromonas malhamensis
on four closely related picocyanobacterial strains isolated
from subalpine lakes in central Europe. The picocyanobacteria
represented different pigment types (phycoerythrin-
rich, PE, and phycocyanin-rich, PC) and phylogenetic
clusters. The grazing experiments were conducted with laboratory
cultures acclimated to 10 μmol photon/m2/sec (low
light, LL) and 100 μmol photon/m2/sec (moderate light, ML),
either in the dark or at four different irradiances ranging from
low (6 μmol photon/m2/sec) to high (1,500 μmol photon/m2/
sec) light intensity. Poterioochromonas malhamensis preferred
the larger, green PC-rich picocyanobacteria to the smaller,
red PE-rich picocyanobacterial, and heterotrophic bacteria.
The feeding and growth rates of P. malhamensis were sensitive
to the actual light conditions during the experiments;
the flagellate performed relatively better in the dark and at
LL conditions than at high light intensity. In summary, our
results
found strain-specific ingestion and growth rates of the flagellate; an effect of the preculturing conditions, and, unexpectedly, a direct adverse effect of high light levels. We conclude that this flagellate may avoid exposure to high surface light intensities commonly encountered in temperate lakes during the summer. -
Citations
Citations to this article as recorded by- Numerical and functional response of phagotrophic aquatic protists: the ideal experiment—and why we cannot get it
Thomas Weisse
Frontiers in Microbiology.2025;[Epub] CrossRef - A systematic review of the predatory contaminant Poterioochromonas in microalgal culture
Mingyang Ma, Chaojun Wei, Wenjie Huang, Yue He, Yingchun Gong, Qiang Hu
Journal of Applied Phycology.2023; 35(3): 1103. CrossRef - Transcriptional profile reveals the physiological responses to prey availability in the mixotrophic chrysophyte Poterioochromonas malhamensis
Mingyang Ma, Wentao Yang, Hong Chen, Wanwan Ke, Yingchun Gong, Qiang Hu
Frontiers in Microbiology.2023;[Epub] CrossRef - Microbial consortia in an ice‐covered high‐altitude lake impacted by additions of dissolved organic carbon and nutrients
Flavia Dory, Laurent Cavalli, Evelyne Franquet, Magalie Claeys‐Bruno, Benjamin Misson, Thierry Tatoni, Céline Bertrand
Freshwater Biology.2021; 66(8): 1648. CrossRef - Picoplankton feeding by the ciliate Vorticella similis in comparison to other peritrichs emphasizes their significance in the water purification process
Thomas Weisse, Jitka Jezberova, Michael Moser
Ecological Indicators.2021; 121: 106992. CrossRef
- Numerical and functional response of phagotrophic aquatic protists: the ideal experiment—and why we cannot get it
- Overexpression and characterization of a novel cold-adapted and salt-tolerant GH1 β-glucosidase from the marine bacterium Alteromonas sp. L82
- Jingjing Sun , Wei Wang , Congyu Yao , Fangqun Dai , Xiangjie Zhu , Junzhong Liu , Jianhua Hao
- J. Microbiol. 2018;56(9):656-664. Published online August 23, 2018
- DOI: https://doi.org/10.1007/s12275-018-8018-2
- 384 View
- 0 Download
- 37 Crossref
-
Abstract
PDF
- A novel gene (bgl) encoding a cold-adapted β-glucosidase was cloned from the marine bacterium Alteromonas sp. L82. Based on sequence analysis and its putative catalytic conserved region, Bgl belonged to the glycoside hydrolase family 1. Bgl was overexpressed in E. coli and purified by Ni2+ affinity chromatography. The purified recombinant β- glucosidase showed maximum activity at temperatures between 25°C to 45°C and over the pH range 6 to 8. The enzyme lost activity quickly after incubation at 40°C. Therefore, recombinant β-glucosidase appears to be a cold-adapted enzyme. The addition of reducing agent doubled its activity and 2 M NaCl did not influence its activity. Recombinant β-glucosidase was also tolerant of 700 mM glucose and some organic solvents. Bgl had a Km of 0.55 mM, a Vmax of 83.6 U/mg, a kcat of 74.3 s-1 and kcat/Km of 135.1 at 40°C, pH 7 with 4-nitrophenyl-β-D-glucopyranoside as a substrate. These properties indicate Bgl may be an interesting candidate for biotechnological and industrial applications.
-
Citations
Citations to this article as recorded by- A novel cold-active GH1 β-galactosidase from psychrotolerant Microbacterium phyllosphaerae LW106 suitable for lactose hydrolysis and galactooligosaccharides synthesis in milk at low temperature
Aiguo Li, Wenlu Liu, Xuehua Yu, Rui Han, Xinyu Xiong, Bo Guan, Youzhen Hu, Yongqin Ni, Jun Zeng
LWT.2025; 229: 118218. CrossRef - Identification and characterization of a novel β-galactosidase active at low temperatures from the Antarctic fungus Tetracladium sp., expressed in Saccharomyces cerevisiae
Fernando Gutierrez, Jennifer Alcaino, Victor Cifuentes, Marcelo Baeza
Microbial Cell Factories.2025;[Epub] CrossRef -
Streptomyces beigongshangae sp. nov., isolated from baijiu fermented grains, could transform ginsenosides of Panax notoginseng
Bo Liu, Haoyue Gu, Rui Shi, Xiahong He, Zhanbin Sun, Qing Ren, Hanxu Pan
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef - A novel GH1 β-glucosidase from an Arctic bacterium: Characterization and secretory expression in Bacillus subtilis
Jingjing Sun, Wei Wang, Jianhua Hao
Process Biochemistry.2024; 140: 108. CrossRef - Screening, cloning, immobilization and application prospects of a novel β-glucosidase from the soil metagenome
Qian Yao, Jin Xu, Nan Tang, Weiji Chen, Quliang Gu, He Li
Environmental Research.2024; 244: 117676. CrossRef - Characterization of a novel cold-adapted GH1 β-glucosidase from Psychrobacillus glaciei and its application in the hydrolysis of soybean isoflavone glycosides
Jinjian He, Jiajing Duan, Pinglian Yu, Yuying Li, Mansheng Wang, Xiu Zhang, Zishu Chen, Pengjun Shi
Current Research in Food Science.2024; 8: 100777. CrossRef - Biochemical and in silico structural properties of a thermo-acid stable β-glucosidase from Beauveria bassiana
Buka Magwaza, Ayodeji Amobonye, Prashant Bhagwat, Santhosh Pillai
Heliyon.2024; 10(7): e28667. CrossRef - Moderately thermostable GH1 β-glucosidases from hyperacidophilic archaeon Cuniculiplasma divulgatum S5
Anna N Khusnutdinova, Hai Tran, Saloni Devlekar, Marco A Distaso, Ilya V Kublanov, Tatiana Skarina, Peter Stogios, Alexei Savchenko, Manuel Ferrer, Olga V Golyshina, Alexander F Yakunin, Peter N Golyshin
FEMS Microbiology Ecology.2024;[Epub] CrossRef - Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1
Louise Jane Gourlay, Marco Mangiagalli, Elisabetta Moroni, Marina Lotti, Marco Nardini
The FEBS Journal.2024; 291(13): 2897. CrossRef - Partial characterization of β-glucosidase, β-xylosidase, and α-l-arabinofuranosidase from Jiangella alba DSM 45237 and their potential in lignocellulose-based biorefining
Zeynep Gül Aytaş, Münir Tunçer, Çağrı Seda Kul, Sümeyye Cilmeli, Nurayan Aydın, Tuğrul Doruk, Ali Osman Adıgüzel
Sustainable Chemistry and Pharmacy.2023; 31: 100900. CrossRef - Heterologous expression and characterization of salt-tolerant β-glucosidase from xerophilic Aspergillus chevalieri for hydrolysis of marine biomass
Hironori Senba, Daisuke Saito, Yukihiro Kimura, Shinichi Tanaka, Mikiharu Doi, Shinji Takenaka
Archives of Microbiology.2023;[Epub] CrossRef - Expression of β-Glucosidases from the Yak Rumen in Lactic Acid Bacteria: A Genetic Engineering Approach
Chuan Wang, Yuze Yang, Chunjuan Ma, Yongjie Sunkang, Shaoqing Tang, Zhao Zhang, Xuerui Wan, Yaqin Wei
Microorganisms.2023; 11(6): 1387. CrossRef - Structural and functional insights of a cold-adaptive β-glucosidase with very high glucose tolerance from Microbacterium sp. CIAB417
Anjali Purohit, Lata Pawar, Sudesh Kumar Yadav
Enzyme and Microbial Technology.2023; 169: 110284. CrossRef - Advances in cold-adapted enzymes derived from microorganisms
Yehui Liu, Na Zhang, Jie Ma, Yuqi Zhou, Qiang Wei, Chunjie Tian, Yi Fang, Rongzhen Zhong, Guang Chen, Sitong Zhang
Frontiers in Microbiology.2023;[Epub] CrossRef - Improving the catalytic activity of β-glucosidase from Coniophora puteana via semi-rational design for efficient biomass cellulose degradation
Hai-Yan Zhou, Qi Chen, Yi-Feng Zhang, Dou-Dou Chen, Xiao-Nan Yi, De-Shui Chen, Xin-Ping Cheng, Mian Li, Hong-Yan Wang, Kai-Qian Chen, Zhi-Qiang Liu, Yu-Guo Zheng
Enzyme and Microbial Technology.2023; 164: 110188. CrossRef - Study on the Biochemical Characterization and Selectivity of Three β-Glucosidases From Bifidobacterium adolescentis ATCC15703
Yanbo Hu, Liyuan Zhai, Huili Hong, Zenghui Shi, Jun Zhao, Duo Liu
Frontiers in Microbiology.2022;[Epub] CrossRef - Biochemical characterization of a novel glucose-tolerant GH3 β-glucosidase (Bgl1973) from Leifsonia sp. ZF2019
Yi He, Chenxi Wang, Ronghu Jiao, Qinxue Ni, Yan Wang, Qianxin Gao, Youzuo Zhang, Guangzhi Xu
Applied Microbiology and Biotechnology.2022; 106(13-16): 5063. CrossRef - Spatial variability of bacterial community compositions in the Mariana Trench
Wei Wang, Jingjing Sun, Jianhua Hao
Canadian Journal of Microbiology.2022; 68(10): 633. CrossRef - Life from a Snowflake: Diversity and Adaptation of Cold-Loving Bacteria among Ice Crystals
Carmen Rizzo, Angelina Lo Giudice
Crystals.2022; 12(3): 312. CrossRef - Cold-Active β-Galactosidases: Insight into Cold Adaptation Mechanisms and Biotechnological Exploitation
Marco Mangiagalli, Marina Lotti
Marine Drugs.2021; 19(1): 43. CrossRef - Two Key Amino Acids Variant of α-l-arabinofuranosidase from Bacillus subtilis Str. 168 with Altered Activity for Selective Conversion Ginsenoside Rc to Rd
Ru Zhang, Shi Quan Tan, Bian Ling Zhang, Zi Yu Guo, Liang Yu Tian, Pei Weng, Zhi Yong Luo
Molecules.2021; 26(6): 1733. CrossRef - Cloning, expression, biochemical characterization, and molecular docking studies of a novel glucose tolerant β-glucosidase from Saccharomonospora sp. NB11
Numan Saleh Zada, Ali Osman Belduz, Halil Ibrahim Güler, Anum Khan, Miray Sahinkaya, Arife Kaçıran, Hilal Ay, Malik Badshah, Aamer Ali Shah, Samiullah Khan
Enzyme and Microbial Technology.2021; 148: 109799. CrossRef - A novel β-glucosidase from a hot-spring metagenome shows elevated thermal stability and tolerance to glucose and ethanol
Girija Kaushal, Amit K. Rai, Sudhir P. Singh
Enzyme and Microbial Technology.2021; 145: 109764. CrossRef - Homology analysis of 35 β-glucosidases in Oenococcus oeni and biochemical characterization of a novel β-glucosidase BGL0224
Jie Zhang, Ning Zhao, Junnan Xu, Yiman Qi, Xinyuan Wei, Mingtao Fan
Food Chemistry.2021; 334: 127593. CrossRef - A glucose tolerant β-glucosidase from Thermomicrobium roseum that can hydrolyze biomass in seawater
Sushant K. Sinha, Maithili Datta, Supratim Datta
Green Chemistry.2021; 23(18): 7299. CrossRef - An overview on marine cellulolytic enzymes and their potential applications
Noora Barzkar, Muhammad Sohail
Applied Microbiology and Biotechnology.2020; 104(16): 6873. CrossRef - A Novel Glucose-Tolerant GH1 β-Glucosidase and Improvement of Its Glucose Tolerance Using Site-Directed Mutation
Jingjing Sun, Wei Wang, Yu Ying, Jianhua Hao
Applied Biochemistry and Biotechnology.2020; 192(3): 999. CrossRef - Magnetically recyclable catalytic nanoparticles grafted with Bacillus subtilis β-glucosidase for efficient cellobiose hydrolysis
Shivangi Chamoli, Ekta Yadav, Hemansi, Jitendra Kumar Saini, Ashok Kumar Verma, Naveen Kumar Navani, Piyush Kumar
International Journal of Biological Macromolecules.2020; 164: 1729. CrossRef - Engineering of β-Glucosidase Bgl15 with Simultaneously Enhanced Glucose Tolerance and Thermostability To Improve Its Performance in High-Solid Cellulose Hydrolysis
Lichuang Cao, Ran Chen, Xin Huang, Shuifeng Li, Sufang Zhang, Xiangpeng Yang, Zongmin Qin, Wei Kong, Wei Xie, Yuhuan Liu
Journal of Agricultural and Food Chemistry.2020; 68(19): 5391. CrossRef - A d-glucose- and d-xylose-tolerant GH1 β-glucosidase from Cellulosimicrobium funkei HY-13, a fibrolytic gut bacterium of Eisenia fetida
Do Young Kim, Jonghoon Kim, Sun Hwa Lee, Chungwook Chung, Dong-Ha Shin, Bon-Hwan Ku, Kwang-Hee Son, Ho-Yong Park
Process Biochemistry.2020; 94: 282. CrossRef - A rationally identified marine GH1 β‐glucosidase has distinguishing functional features for simultaneous saccharification and fermentation
Amanda S. de Sousa, Ricardo R. de Melo, Renan Y. Miyamoto, Mariana A. B. Morais, Liliane P. Andrade, Natália Milan, Mayara C. de Avila, Cláudia M. de Souza, Regina C. Adão, Josiane A. Scarpassa, Plínio S. Vieira, Leandro V. dos Santos, Carlos H. I. Ramos,
Biofuels, Bioproducts and Biorefining.2020; 14(6): 1163. CrossRef - Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest
Stefano Varrella, Michael Tangherlini, Cinzia Corinaldesi
Marine Drugs.2020; 18(2): 91. CrossRef - Aroma enhancement of instant green tea infusion using β-glucosidase and β-xylosidase
Ting Zhang, Ke Fang, Hui Ni, Ting Li, Li Jun Li, Qing Biao Li, Feng Chen
Food Chemistry.2020; 315: 126287. CrossRef - RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli
Jaejin Lee, Dong-Ho Lee, Che Ok Jeon, Kangseok Lee
Journal of Microbiology.2019; 57(10): 910. CrossRef -
Comparison between irradiating and autoclaving citrus wastes as substrate for solid‐state fermentation by
Aspergillus aculeatus
H. Ni, T. Zhang, X. Guo, Y. Hu, A. Xiao, Z. Jiang, L. Li, Q. Li
Letters in Applied Microbiology.2019;[Epub] CrossRef - The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli
Minho Lee, Minju Joo, Minji Sim, Se-Hoon Sim, Hyun-Lee Kim, Jaejin Lee, Minkyung Ryu, Ji-Hyun Yeom, Yoonsoo Hahn, Nam-Chul Ha, Jang-Cheon Cho, Kangseok Lee
Scientific Reports.2019;[Epub] CrossRef - Identification and molecular characterization of a psychrophilic GH1 β-glucosidase from the subtropical soil microorganism Exiguobacterium sp. GXG2
Bangqiao Yin, Hengsen Gu, Xueyan Mo, Yue Xu, Bing Yan, Quanwen Li, Qian Ou, Bo Wu, Chen Guo, Chengjian Jiang
AMB Express.2019;[Epub] CrossRef
- A novel cold-active GH1 β-galactosidase from psychrotolerant Microbacterium phyllosphaerae LW106 suitable for lactose hydrolysis and galactooligosaccharides synthesis in milk at low temperature
- The inability of Bacillus licheniformis perR mutant to grow is mainly due to the lack of PerR-mediated fur repression
- Jung-Hoon Kim , Yoon-Mo Yang , Chang-Jun Ji , Su-Hyun Ryu , Young-Bin Won , Shin-Yeong Ju , Yumi Kwon , Yeh-Eun Lee , Hwan Youn , Jin-Won Lee
- J. Microbiol. 2017;55(6):457-463. Published online April 22, 2017
- DOI: https://doi.org/10.1007/s12275-017-7051-x
- 339 View
- 2 Download
- 5 Crossref
-
Abstract
PDF
- PerR, a member of Fur family protein, is a metal-dependent H2O2 sensing transcription factor that regulates genes in-volved in peroxide stress response. Industrially important bac-terium Bacillus licheniformis contains three PerR-like pro-teins (PerRBL, PerR2, and PerR3) compared to its close rela-tive Bacillus subtilis. Interestingly, unlike other bacteria in-cluding B. subtilis, no authentic perRBL null mutant could be established for B. licheniformis. Thus, we constructed a con-ditional perRBL mutant using a xylose-inducible promoter, and investigated the genes under the control of PerRBL. PerRBL regulon genes include katA, mrgA, ahpC, pfeT, hemA, fur, and perR as observed for PerRBS. However, there is some variation in the expression levels of fur and hemA genes be-tween B. subtilis and B. licheniformis in the derepressed state. Furthermore, katA, mrgA, and ahpC are strongly induced, whereas the others are only weakly or not induced by H2O2 treatment. In contrast to the B. subtilis perR null mutant which frequently gives rise to large colony phenotype mainly due to the loss of katA, the suppressors of B. licheniformis perR mutant, which can form colonies on LB agar, were all cata-lase-positive. Instead, many of the suppressors showed in-creased levels of siderophore production, suggesting that the suppressor mutation is linked to the fur gene. Consistent with this, perR fur double mutant could grow on LB agar without Fe supplementation, whereas perR katA double mutant could only grow on LB agar with Fe supplementation. Taken toge-ther, our data suggest that in B. licheniformis, despite the si-milarity in PerRBL and PerRBS regulon genes, perR is an essen-tial gene required for growth and that the inability of perR null mutant to grow is mainly due to elevated expression of Fur.
-
Citations
Citations to this article as recorded by-
Characterization of the dual regulation by a c-di-GMP riboswitch Bc1 with a long expression platform from
Bacillus thuringiensis
Lu Liu, Dehua Luo, Yongji Zhang, Dingqi Liu, Kang Yin, Qing Tang, Shan-Ho Chou, Jin He, Beile Gao
Microbiology Spectrum.2024;[Epub] CrossRef - Meddling with Metal Sensors: Fur-Family Proteins as Signaling Hubs
Caroline H. Steingard, John D. Helmann, Tina M. Henkin
Journal of Bacteriology.2023;[Epub] CrossRef - Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance
Si Hyoung Park, Umji Choi, Su-Hyun Ryu, Han Byeol Lee, Jin-Won Lee, Chang-Ro Lee, Krisztina M. Papp-Wallace
Microbiology Spectrum.2022;[Epub] CrossRef - Microbial Redox Regulator-Enabled Pulldown for Rapid Analysis of Plasma Low-Molecular-Weight Biothiols
Jin Oh Lee, Yoon-Mo Yang, Jae-Hoon Choi, Tae-Wuk Kim, Jin-Won Lee, Young-Pil Kim
Analytical Chemistry.2019; 91(15): 10064. CrossRef - Redox Sensing by Fe2+in Bacterial Fur Family Metalloregulators
Azul Pinochet-Barros, John D. Helmann
Antioxidants & Redox Signaling.2018; 29(18): 1858. CrossRef
-
Characterization of the dual regulation by a c-di-GMP riboswitch Bc1 with a long expression platform from
Bacillus thuringiensis
Research Support, Non-U.S. Gov'ts
- Molecular characterization of mammalian-adapted Korean-type avian H9N2 virus and evaluation of its virulence in mice
- Kuk Jin Park , Min-Suk Song , Eun-Ha Kim , Hyeok-il Kwon , Yun Hee Baek , Eun-hye Choi , Su-Jin Park , Se Mi Kim , Young-il Kim , Won-Suk Choi , Dae-Won Yoo , Chul-Joong Kim , Young Ki Choi
- J. Microbiol. 2015;53(8):570-577. Published online July 31, 2015
- DOI: https://doi.org/10.1007/s12275-015-5329-4
- 359 View
- 0 Download
- 15 Crossref
-
Abstract
- Avian influenza A virus (AIV) is commonly isolated from domestic poultry and wild migratory birds, and the H9N2 subtype is the most prevalent and the major cause of severe disease in poultry in Korea. In addition to the veterinary concerns regarding the H9N2 subtype, it is also considered to be the next potential human pandemic strain due to its rapid evolution and interspecies transmission. In this study, we utilize serial lung-to-lung passage of a low pathogenic avian influenza virus (LPAI) H9N2 (A/Ck/Korea/163/04, WT163) (Y439-lineage) in mice to increase pathogenicity and investigate the potential virulence marker. Mouse-adapted H9N2 virus obtained high virulence (100% mortality) in mice after 98 serial passages. Sequence results show that the mouse adaptation (ma163) possesses several mutations within seven gene segments (PB2, PA, HA, NP, NA, M, and NS) relative to the wild-type strain. The HA gene showed the most mutations (at least 11) with one resulting in the loss of an N-glycosylation site (at amino acid 166). Moreover, reverse genetic studies established that an E627K substitution in PB2 and the loss of the N-glycosylation site in the HA protein (aa166) are critical virulence markers in the mouse-adapted H9N2 virus. Thus, these results add to the increasing body of mutational analysis data defining the function of the viral polymerase and HA genes and their roles in mammalian host adaptation. To our knowledge, this is first report of the generation of a mammalian-adapted Korea H9N2 virus (Y493-lineages). Therefore, this study offers valuable insights into the molecular evolution of the LPAI Korean H9N2 in a new host and adds to the current knowledge of the molecular markers associated with increased virulence.
-
Citations
Citations to this article as recorded by- Genetic Characterization of Kazakhstan Isolates: Avian Influenza H9N2 Viruses Demonstrate Their Potential to Infect Mammals
Barshagul Baikara, Kobey Karamendin, Yermukhammet Kassymbekov, Klara Daulbayeva, Temirlan Sabyrzhan, Sardor Nuralibekov, Yelizaveta Khan, Nurlan Sandybayev, Sasan Fereidouni, Aidyn Kydyrmanov
Viruses.2025; 17(5): 685. CrossRef - An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization
Carol M. Sheppard, Daniel H. Goldhill, Olivia C. Swann, Ecco Staller, Rebecca Penn, Olivia K. Platt, Ksenia Sukhova, Laury Baillon, Rebecca Frise, Thomas P. Peacock, Ervin Fodor, Wendy S. Barclay
Nature Communications.2023;[Epub] CrossRef - Current situation and control strategies of H9N2 avian influenza in South Korea
Mingeun Sagong, Kwang-Nyeong Lee, Eun-Kyoung Lee, Hyunmi Kang, Young Ki Choi, Youn-Jeong Lee
Journal of Veterinary Science.2023;[Epub] CrossRef - Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994–2019 in China
Qingzheng Liu, Lingcai Zhao, Yanna Guo, Yongzhen Zhao, Yingfei Li, Na Chen, Yuanlu Lu, Mengqi Yu, Lulu Deng, Jihui Ping
Viruses.2022; 14(4): 726. CrossRef - Molecular epidemiology and pathogenicity of H5N1 and H9N2 avian influenza viruses in clinically affected chickens on farms in Bangladesh
Ripatun Nahar Ripa, Joshua E. Sealy, Jayna Raghwani, Tridip Das, Himel Barua, Md. Masuduzzaman, A. K. M. Saifuddin, Md. Reajul Huq, Mohammad Inkeyas Uddin, Munir Iqbal, Ian Brown, Nicola S. Lewis, Dirk Pfeiffer, Guillaume Fournie, Paritosh Kumar Biswas
Emerging Microbes & Infections.2021; 10(1): 2223. CrossRef - Mouse adaptation of the H9N2 avian influenza virus causes the downregulation of genes related to innate immune responses and ubiquitin-mediated proteolysis in mice
Jing Guo, Xinxin Gao, Baotao Liu, Yubao Li, Wenqiang Liu, Jianbiao Lu, Cheng Liu, Rui Xue, Xuyong Li
Medical Microbiology and Immunology.2020; 209(2): 151. CrossRef - H9 Influenza Viruses: An Emerging Challenge
Silvia Carnaccini, Daniel R. Perez
Cold Spring Harbor Perspectives in Medicine.2020; 10(6): a038588. CrossRef - Adaptive amino acid substitutions enable transmission of an H9N2 avian influenza virus in guinea pigs
Liu Lina, Chen Saijuan, Wang Chengyu, Lu Yuefeng, Dong Shishan, Chen Ligong, Guo Kangkang, Guo Zhendong, Li Jiakai, Zhang Jianhui, Luo Qingping, Zhang Wenting, Shang Yu, Wang Honglin, Zhang Tengfei, Wen Guoyuan, Zhu Jiping, Zhang Chunmao, Jin Meilin, Gao
Scientific Reports.2019;[Epub] CrossRef - A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice
Haruhiko Kamiki, Hiromichi Matsugo, Tomoya Kobayashi, Hiroho Ishida, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto
Viruses.2018; 10(11): 653. CrossRef - Genetics and biological property analysis of Korea lineage of influenza A H9N2 viruses
Min Kang, Hyung-Kwan Jang
Veterinary Microbiology.2017; 204: 96. CrossRef - The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents
Won-Suk Choi, Khristine Kaith S. Lloren, Yun Hee Baek, Min-Suk Song
Clinical and Experimental Vaccine Research.2017; 6(2): 83. CrossRef - Rapid acquisition of polymorphic virulence markers during adaptation of highly pathogenic avian influenza H5N8 virus in the mouse
Won-Suk Choi, Yun Hee Baek, Jin Jung Kwon, Ju Hwan Jeong, Su-Jin Park, Young-il Kim, Sun-Woo Yoon, Jungwon Hwang, Myung Hee Kim, Chul-Joong Kim, Richard J. Webby, Young Ki Choi, Min-Suk Song
Scientific Reports.2017;[Epub] CrossRef - Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy
Se Mi Kim, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Hyeok-il Kwon, Young-Jae Si, In-Won Lee, Min-Suk Song, Young Ki Choi, Jae U. Jung
Journal of Virology.2017;[Epub] CrossRef - Prevalence and diversity of H9N2 avian influenza in chickens of Northern Vietnam, 2014
Duong Mai Thuy, Thomas P. Peacock, Vu Thi Ngoc Bich, Thomas Fabrizio, Dang Nguyen Hoang, Nguyen Dang Tho, Nguyen Thi Diep, Minh Nguyen, Le Nguyen Minh Hoa, Hau Thi Thu Trang, Marc Choisy, Ken Inui, Scott Newman, Nguyen vu Trung, Rogier van Doorn, Thanh Lo
Infection, Genetics and Evolution.2016; 44: 530. CrossRef - PB2 subunit of avian influenza virus subtype H9N2: a pandemic risk factor
Hanna Sediri, Swantje Thiele, Folker Schwalm, Gülsah Gabriel, Hans-Dieter Klenk
Journal of General Virology.2016; 97(1): 39. CrossRef
- Genetic Characterization of Kazakhstan Isolates: Avian Influenza H9N2 Viruses Demonstrate Their Potential to Infect Mammals
- From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors
- Lijia Xu , Nicole Grandi , Claudia Del Vecchio , Daniela Mandas , Angela Corona , Dario Piano , Francesca Esposito , Cristina Parolin , Enzo Tramontano
- J. Microbiol. 2015;53(4):288-293. Published online March 4, 2015
- DOI: https://doi.org/10.1007/s12275-015-4652-0
- 362 View
- 0 Download
- 48 Crossref
-
Abstract
PDF
- HIV-1 reverse transcriptase (RT) is still an extremely attractive pharmaceutical target for the identification of new inhibitors possibly active on drug resistant strains. Medicinal plants are a rich source of chemical diversity and can be used to identify novel scaffolds to be further developed by chemical modifications. We investigated the ability of the main lignans from Schisandra chinensis (Turcz.) Baill. fruits, commonly used in Traditional Chinese Medicine, to affect HIV-1 RT functions. We purified 6 lignans from Schisandra chinensis fruits and assayed their effects on HIV-1 RT and viral replication. Among the S. chinensis fruit lignans, Schisandrin B and Deoxyschizandrin selectively inhibited the HIV-1 RTassociated DNA polymerase activity. Structure activity relationship revealed the importance of cyclooctadiene ring substituents for efficacy. In addition, Schisandrin B was also able to impair HIV-1 RT drug resistant mutants and the early phases of viral replication. We identified Schisandrin B and Deoxyschizandrin as new scaffold for the further development of novel HIV-1 RT inhibitors.
-
Citations
Citations to this article as recorded by- Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology
Karolina Jafernik, Sara Motyka, Daniela Calina, Javad Sharifi-Rad, Agnieszka Szopa
Chinese Medicine.2024;[Epub] CrossRef - Effect of pinoresinol-lariciresinol reductases on biosynthesis of lignans with substrate selectivity in Schisandra chinensis
Jingxian Feng, Yuan Yao, Yuqi Qiao, Xueqi Ma, Zongtai Wu, Yonghao Duan, Peng Di, Wansheng Chen, Ying Xiao
Phytochemistry.2024; 221: 114053. CrossRef - The influence of storage conditions on the quality of Schisandra chinensis fruits: A integrated investigation of constituent and antioxidant activity
Yanhua Sheng, Jinxu Dong, Rui Wang, Yikai Wang, Xin Huang, Changbao Chen
Heliyon.2024; 10(11): e32194. CrossRef - Down-regulation of human papillomavirus E6 oncogene and antiproliferative effect of Schisandra chinensis and Pueraria lobata natural extracts on Hela cell line
Andrés Cardona-Mendoza, Angela Fonseca-Benitez, Diana Marcela Buitrago, Ericsson Coy-Barrera, Sandra J. Perdomo
Journal of Ethnopharmacology.2024; 319: 117225. CrossRef - Systems pharmacology dissection of pharmacological mechanisms of Xiaochaihu decoction against human coronavirus
Lvjie Xu, Chuipu Cai, Jiansong Fang, Qihui Wu, Jun Zhao, Zhe Wang, Pengfei Guo, Lishu Zheng, Ailin Liu
BMC Complementary Medicine and Therapies.2023;[Epub] CrossRef - Schisandra henryi—A Rare Species with High Medicinal Potential
Karolina Jafernik, Halina Ekiert, Agnieszka Szopa
Molecules.2023; 28(11): 4333. CrossRef - The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy
Mohamad Hesam Shahrajabian, Wenli Sun
Current HIV Research.2023; 21(6): 331. CrossRef - Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds
Ibrahim S. Al Nasr, Angela Corona, Waleed S. Koko, Tariq A. Khan, Ridha Ben Said, Ismail Daoud, Seyfeddine Rahali, Enzo Tramontano, Rainer Schobert, Noureddine Amdouni, Bernhard Biersack
Bioorganic & Medicinal Chemistry.2023; 90: 117376. CrossRef - Characteristics of Schisandra chinensis (Turcz.) Baillon Collected in Habitats of South Korea
Beung Sung Kim, Jong Soo Kim, Young Jin Seo, Tae Young Oh, Jeong-Dong Lee
Agriculture.2023; 13(6): 1256. CrossRef - A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment
Chinmayee Priyadarsani Mandhata, Chita Ranjan Sahoo, Rabindra Nath Padhy
Journal of Integrative Medicine.2023; 21(4): 332. CrossRef - Statistical optimization and characterization of fucose-rich polysaccharides extracted from pumpkin (Cucurbita maxima) along with antioxidant and antiviral activities
Hamada El-Gendi, Marwa M. Abu-Serie, Elbadawy A. Kamoun, Ahmed K. Saleh, Esmail M. El-Fakharany
International Journal of Biological Macromolecules.2023; 232: 123372. CrossRef - Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis
Yanhua Fang, Lingling Zhang, Zhe Wang, Ruoyu Wang, Shanshan Liang
Frontiers in Pharmacology.2022;[Epub] CrossRef - Biological effects of schisandra chinensis medicines and prospects of their use in clinical medicine (literature review)
Yatsyk Yelyzaveta, Oleksandr Kozlov, Svitlana Tkachenko
The Journal of V. N. Karazin Kharkiv National University, Series "Medicine".2022; (44): 127. CrossRef - Recent Advances in the Discovery and Development of Anti-HIV Natural Products
Xinyu Ma, Hongjia Zhang, Shirui Wang, Rui Deng, Dan Luo, Meng Luo, Qing Huang, Su Yu, Chunlan Pu, Yuanyuan Liu, Yu Tong, Rui Li
The American Journal of Chinese Medicine.2022; 50(05): 1173. CrossRef - Metabolic profiling on the analysis of different parts of Schisandra chinensis based on UPLC-QTOF-MS with comparative bioactivity assays
Jiushi Liu, Xinlu Mu, Jinmei Liang, Jianuo Zhang, Tingyan Qiang, Hongbo Li, Bin Li, Haitao Liu, Bengang Zhang
Frontiers in Plant Science.2022;[Epub] CrossRef - Garcinol from Garcinia indica inhibits HIV‐1 reverse transcriptase‐associated ribonuclease H
Angela Corona, Sebastian Seibt, David Schaller, Rainer Schobert, Andrea Volkamer, Bernhard Biersack, Enzo Tramontano
Archiv der Pharmazie.2021;[Epub] CrossRef - Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation
Huihui Ti, Zixi Zhuang, Qian Yu, Shumei Wang
Drug Design, Development and Therapy.2021; Volume 15: 1385. CrossRef - Preclinical Pharmacokinetics of Lamivudine and Its Interaction with Schisandra chinensis Extract in Rats
Chi-Lin Li, Chen-Hsi Hsieh, Tung-Hu Tsai
ACS Omega.2020; 5(4): 1997. CrossRef - Antibacterial Effects of Schisandra chinensis Extract on Escherichia coli and its Applications in Cosmetic
S. Mei Cui, T. Li, Q. Wang, K. Ke He, Y. Mei Zheng, H. Yun Liang, L. Ya Song
Current Microbiology.2020; 77(5): 865. CrossRef - Screening and Identification of the Main Metabolites of Schisantherin a In Vivo and In Vitro by Using UHPLC-Q-TOF-MS/MS
Wei Feng, Ling-Yu Zhou, Rui-Feng Mu, Le Gao, Bing-Yuan Xu, Ming-Liang Liu, Li-Ying Niu, Xin-Guo Wang
Molecules.2020; 25(2): 258. CrossRef - 1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini
Molecules.2020; 25(5): 1183. CrossRef - Lignans and Their Derivatives from Plants as Antivirals
Qinghua Cui, Ruikun Du, Miaomiao Liu, Lijun Rong
Molecules.2020; 25(1): 183. CrossRef - Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants
Kazhila C. Chinsembu
Revista Brasileira de Farmacognosia.2019; 29(4): 504. CrossRef - Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation
Adem Demir, Halbay Turumtay, Mustafa Emirik, Cemal Sandalli, Şeyda Kanbolat, Ufuk Özgen, Emine Akyuz Turumtay
Medicinal Chemistry Research.2019; 28(12): 2232. CrossRef - Schisandra chinensis and its phytotherapeutical applications
Michal Rybnikář, Karel Šmejkal, Milan Žemlička
Česká a slovenská farmacie.2019; 68(3): 95. CrossRef - Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)
Cinzia Sanna, Daniela Rigano, Angela Corona, Dario Piano, Carmen Formisano, Domenica Farci, Genni Franzini, Mauro Ballero, Giuseppina Chianese, Enzo Tramontano, Orazio Taglialatela-Scafati, Francesca Esposito
Natural Product Research.2019; 33(12): 1798. CrossRef - Neuroprotective Effect of Schisandra Chinensis on Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonian Syndrome in C57BL/6 Mice
Chi-Lin Li, Yang-Hwei Tsuang, Tung-Hu Tsai
Nutrients.2019; 11(7): 1671. CrossRef - Deoxyschizandrin, Isolated from Schisandra Berries, Induces Cell Cycle Arrest in Ovarian Cancer Cells and Inhibits the Protumoural Activation of Tumour-Associated Macrophages
Kijun Lee, Ji-Hye Ahn, Kyung-Tae Lee, Dae Jang, Jung-Hye Choi
Nutrients.2018; 10(1): 91. CrossRef - Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method
Chi-Lin Li, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
Molecules.2018; 23(1): 173. CrossRef - Harnessing the Properties of Natural Products
Asmaa Boufridi, Ronald J. Quinn
Annual Review of Pharmacology and Toxicology.2018; 58(1): 451. CrossRef - Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases
Minyu Zhang, Liping Xu, Hongjun Yang
International Journal of Molecular Sciences.2018; 19(7): 1970. CrossRef - Targeted Lignan Profiling and Anti-Inflammatory Properties of Schisandra rubriflora and Schisandra chinensis Extracts
Agnieszka Szopa, Michał Dziurka, Angelika Warzecha, Paweł Kubica, Marta Klimek-Szczykutowicz, Halina Ekiert
Molecules.2018; 23(12): 3103. CrossRef - Identification of Myricetin as an Ebola Virus VP35–Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay
Gian Luca Daino, Aldo Frau, Cinzia Sanna, Daniela Rigano, Simona Distinto, Veronica Madau, Francesca Esposito, Elisa Fanunza, Giulia Bianco, Orazio Taglialatela-Scafati, Luca Zinzula, Elias Maccioni, Angela Corona, Enzo Tramontano
Biochemistry.2018; 57(44): 6367. CrossRef - Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds
C. Sanna, D. Rigano, P. Cortis, A. Corona, M. Ballero, C. Parolin, C. Del Vecchio, G. Chianese, E. Saccon, C. Formisano, E. Tramontano, F. Esposito
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology.2018; 152(6): 1274. CrossRef - Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication
Cinzia Sanna, Monica Scognamiglio, Antonio Fiorentino, Angela Corona, Vittoria Graziani, Alessia Caredda, Pierluigi Cortis, Mariofilippo Montisci, Elisa Rita Ceresola, Filippo Canducci, Ferruccio Poli, Enzo Tramontano, Francesca Esposito, Chandravanu Dash
PLOS ONE.2018; 13(3): e0195168. CrossRef - Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions
Alvine Ngoutane Mfopa, Angela Corona, Kodjo Eloh, Enzo Tramontano, Aldo Frau, Fabrice Fekam Boyom, Pierluigi Caboni, Graziella Tocco
Natural Product Research.2018; 32(6): 640. CrossRef - Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding
Riccardo Martini, Francesca Esposito, Angela Corona, Roberto Ferrarese, Elisa Rita Ceresola, Laura Visconti, Cristina Tintori, Alessandro Barbieri, Andrea Calcaterra, Valentina Iovine, Filippo Canducci, Enzo Tramontano, Maurizio Botta
ChemBioChem.2017; 18(4): 374. CrossRef - Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies
Agnieszka Szopa, Radosław Ekiert, Halina Ekiert
Phytochemistry Reviews.2017; 16(2): 195. CrossRef - Human Immunodeficiency Virus and Herbal Medicine
Carolyn Williams-Orlando
Alternative and Complementary Therapies.2017; 23(2): 51. CrossRef - Schisandra lignans production regulated by different bioreactor type
Agnieszka Szopa, Adam Kokotkiewicz, Maria Luczkiewicz, Halina Ekiert
Journal of Biotechnology.2017; 247: 11. CrossRef - Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway
Jung-Sheng Yu, Yu-Hsuan Wu, Chin-Kai Tseng, Chun-Kuang Lin, Yao-Chin Hsu, Yen-Hsu Chen, Jin-Ching Lee
Scientific Reports.2017;[Epub] CrossRef - Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach
Minyu Zhang, Hongwei Wu, Feifei Guo, Yangyang Yu, Junying Wei, Ya Geng, Shifeng Wang, Shiyou Li, Hongjun Yang
Molecular BioSystems.2017; 13(8): 1469. CrossRef - Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication
Francesca Esposito, Ilaria Carli, Claudia Del Vecchio, Lijia Xu, Angela Corona, Nicole Grandi, Dario Piano, Elias Maccioni, Simona Distinto, Cristina Parolin, Enzo Tramontano
Phytomedicine.2016; 23(12): 1383. CrossRef - Inhibition of HIV‐1 Reverse Transcriptase Dimerization by Small Molecules
Cristina Tintori, Angela Corona, Francesca Esposito, Annalaura Brai, Nicole Grandi, Elisa Rita Ceresola, Massimo Clementi, Filippo Canducci, Enzo Tramontano, Maurizio Botta
ChemBioChem.2016; 17(8): 683. CrossRef - Biological Activities of Aerial Parts Extracts ofEuphorbia characias
Maria Barbara Pisano, Sofia Cosentino, Silvia Viale, Delia Spanò, Angela Corona, Francesca Esposito, Enzo Tramontano, Paola Montoro, Carlo Ignazio Giovanni Tuberoso, Rosaria Medda, Francesca Pintus
BioMed Research International.2016; 2016: 1. CrossRef - Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors
Angela Corona, Jenny Desantis, Serena Massari, Simona Distinto, Takashi Masaoka, Stefano Sabatini, Francesca Esposito, Giuseppe Manfroni, Elias Maccioni, Violetta Cecchetti, Christophe Pannecouque, Stuart F. J. Le Grice, Enzo Tramontano, Oriana Tabarrini
ChemMedChem.2016; 11(16): 1709. CrossRef - De novo transcriptome assembly of Schisandra chinensis Turcz. (Baill.)
Zhang qing-tian, Fan shu-tian, Yang yi-ming, Xu pei-lei, Ai jun
Genomics Data.2016; 10: 153. CrossRef - Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation
Francesca Esposito, Cristina Tintori, Riccardo Martini, Frauke Christ, Zeger Debyser, Roberto Ferrarese, Gianluigi Cabiddu, Angela Corona, Elisa Rita Ceresola, Andrea Calcaterra, Valentina Iovine, Bruno Botta, Massimo Clementi, Filippo Canducci, Maurizio
ChemBioChem.2015; 16(17): 2507. CrossRef
- Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology
- DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation
- Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park
- J. Microbiol. 2013;51(6):866-871. Published online December 19, 2013
- DOI: https://doi.org/10.1007/s12275-013-3428-7
- 363 View
- 0 Download
- 15 Crossref
-
Abstract
PDF
- Influenza viruses are seasonally recurring human pathogens. Vaccines and antiviral drugs are available for influenza. However, the viruses, which often change themselves via antigenic drift and shift, demand constant efforts to update vaccine antigens every year and develop new agents with broad-spectrum antiviral efficacy. An animal model is critical for such efforts. While most human influenza viruses are unable to kill BALB/c mice, some strains have been shown to kill DBA/2 mice without prior adaptation. Therefore, in this study, we explored the feasibility of employing DBA/2 mice as a model in the development of anti-influenza drugs. Unlike the BALB/c strain, DBA/2 mice were highly susceptible and could be killed with a relatively low titer (50% DBA/2 lethal dose = 102.83 plaque-forming units) of the A/ Korea/01/2009 virus (2009 pandemic H1N1 virus). When treated with a neuraminidase inhibitor, oseltamivir phosphate, infected DBA/2 mice survived until 14 days postinfection. The reduced morbidity of the infected DBA/2 mice was also consistent with the oseltamivir treatment. Taking these data into consideration, we propose that the DBA/2 mouse is an excellent animal model to evaluate antiviral efficacy against influenza infection and can be further utilized for combination therapies or bioactivity models of existing and newly developed anti-influenza drugs.
-
Citations
Citations to this article as recorded by- DNA co-delivery of seasonal H1 influenza hemagglutinin nanoparticle vaccines with chemokine adjuvant CTACK induces potent immunogenicity for heterologous protection in vivo
Kevin Liaw, Kylie M. Konrath, Abigail R. Trachtman, Nicholas J. Tursi, Ebony N. Gary, Cory Livingston, Kaitlyn Flowers, Jacqueline D. Chu, Casey E. Hojecki, Niklas Laenger, Madison E. McCanna, Colby J. Agostino, Neethu Chokkalingam, Kelly Bayruns, Sinja K
Vaccine.2025; 59: 127231. CrossRef - Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model
Shelly J. Curran, Emily F. Griffin, Lucas M. Ferreri, Constantinos S. Kyriakis, Elizabeth W. Howerth, Daniel R. Perez, S. Mark Tompkins, Robert Paul de Vries
Microbiology Spectrum.2024;[Epub] CrossRef - Kinetic of the Antibody Response Following AddaVax-Adjuvanted Immunization with Recombinant Influenza Antigens
Ted. M. Ross, Naveen Gokanapudi, Pan Ge, Hua Shi, Robert A. Richardson, Spencer R. Pierce, Pedro Sanchez, Subhan Ullah, Eliana De Luca, Giuseppe A. Sautto
Vaccines.2022; 10(8): 1315. CrossRef - Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses
Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef, Baohui Xu
Journal of Immunology Research.2022; 2022: 1. CrossRef - The morphine/heroin vaccine decreased the heroin-induced antinociceptive and reinforcing effects in three inbred strains mouse
Susana Barbosa-Méndez, Maura Matus-Ortega, Ricardo Hernández-Miramontes, Alberto Salazar-Juárez
International Immunopharmacology.2021; 98: 107887. CrossRef - Animal models for the risk assessment of viral pandemic potential
Mee Sook Park, Jin Il Kim, Joon-Yong Bae, Man-Seong Park
Laboratory Animal Research.2020;[Epub] CrossRef - In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection
Gautham K Rao, Rodney A Prell, Steven T Laing, Stefanie C M Burleson, Allen Nguyen, Jacqueline M McBride, Crystal Zhang, Daniel Sheinson, Wendy G Halpern
Toxicological Sciences.2019; 169(2): 409. CrossRef - Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses
Silke Bergmann, Husni Elbahesh
Virology.2019; 534: 54. CrossRef - Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice
Sehee Park, Jin Il Kim, Joon-Yong Bae, Kirim Yoo, Hyunung Kim, In-Ho Kim, Man-Seong Park, Ilseob Lee
Journal of Microbiology.2018; 56(2): 145. CrossRef - Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
Zhimin Wan, Stivalis Cardenas Garcia, Jing Liu, Jefferson Santos, Silvia Carnaccini, Ginger Geiger, Lucas Ferreri, Daniela Rajao, Daniel R. Perez, Adolfo García-Sastre
Journal of Virology.2018;[Epub] CrossRef - PPARgamma Deficiency Counteracts Thymic Senescence
David Ernszt, Krisztina Banfai, Zoltan Kellermayer, Attila Pap, Janet M. Lord, Judit E. Pongracz, Krisztian Kvell
Frontiers in Immunology.2017;[Epub] CrossRef - Repeated Low-Dose Influenza Virus Infection Causes Severe Disease in Mice: a Model for Vaccine Evaluation
Yufeng Song, Xiang Wang, Hongbo Zhang, Xinying Tang, Min Li, Jufang Yao, Xia Jin, Hildegund C. J. Ertl, Dongming Zhou, D. S. Lyles
Journal of Virology.2015; 89(15): 7841. CrossRef - A broadly neutralizing human monoclonal antibody is effective against H7N9
Kannan Tharakaraman, Vidya Subramanian, Karthik Viswanathan, Susan Sloan, Hui-Ling Yen, Dale L. Barnard, Y. H. Connie Leung, Kristy J. Szretter, Tyree J. Koch, James C. Delaney, Gregory J. Babcock, Gerald N. Wogan, Ram Sasisekharan, Zachary Shriver
Proceedings of the National Academy of Sciences.2015; 112(35): 10890. CrossRef - Anti-influenza effect of Cordyceps militaris through immunomodulation in a DBA/2 mouse model
Hwan Hee Lee, Heejin Park, Gi-Ho Sung, Kanghyo Lee, Taeho Lee, Ilseob Lee, Man-seong Park, Yong Woo Jung, Yu Su Shin, Hyojeung Kang, Hyosun Cho
Journal of Microbiology.2014; 52(8): 696. CrossRef - Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Hee Jin Cheong, Jin-Won Song, Ki-Joon Song, Luck Ju Baek, Man-Seong Park, Balaji Manicassamy
PLoS ONE.2014; 9(7): e101325. CrossRef
- DNA co-delivery of seasonal H1 influenza hemagglutinin nanoparticle vaccines with chemokine adjuvant CTACK induces potent immunogenicity for heterologous protection in vivo
- Experimental Phasing Using Zinc and Sulfur Anomalous Signals Measured at the Zinc Absorption Peak
- Sangmin Lee , Min-Kyu Kim , Chang-Jun Ji , Jin-Won Lee , Sun-Shin Cha
- J. Microbiol. 2013;51(5):639-643. Published online October 31, 2013
- DOI: https://doi.org/10.1007/s12275-013-3412-2
- 229 View
- 0 Download
-
Abstract
PDF
- Iron is an essential transition metal required for bacterial growth and survival. Excess free iron can lead to the generation of reactive oxygen species that can cause severe damage to cellular functions. Cells have developed iron-sensing regulators to maintain iron homeostasis at the transcription level. The ferric uptake regulator (Fur) is an iron-responsive regulator that controls the expression of genes involved in iron homeostasis, bacterial virulence, stress resistance, and redox metabolism. Here, we report the expression, purification, crystallization, and phasing of the apo-form of Bacillus subtilis Fur (BsFur) in the absence of regulatory metal ions. Crystals were obtained by microbatch crystallization method at 295 K and diffraction data at a resolution of 2.6 Å was collected at the zinc peak wavelength (λ=1.2823 Å). Experimental phasing identified the positions of one zinc atom and four sulfur atoms of cysteine residues coordinating the zinc atom, indicating that the data contained a meaningful anomalous scattering originating from the ordered zinc-coordinating sulfur atoms, in spite of the small anomalous signals of sulfur atoms at the examined wavelength.
- A Novel Retron of Vibrio parahaemolyticus Is Closely Related to Retron-Vc95 of Vibrio cholerae
- Toshi Shimamoto , Ashraf M. Ahmed , Tadashi Shimamoto
- J. Microbiol. 2013;51(3):323-328. Published online June 28, 2013
- DOI: https://doi.org/10.1007/s12275-013-2715-7
- 356 View
- 0 Download
- 2 Crossref
-
Abstract
PDF
- Some bacteria produce a satellite RNA-DNA complex termed msDNA, multicopy single-stranded DNA. In this report, msDNA from Vibrio parahaemolyticus, a cause of acute gastroenteritis, was identified and named msDNA-Vp96. The retron element containing the ret gene, encoding the reverse transcriptase (RT) that is responsible for msDNA production, was cloned and characterized. Comparison of msDNAVp96 and msDNA-Vc95, from Vibrio cholerae, showed a high level of sequence similarity. We exchanged the two ret genes to examine whether msDNA was produced by the RT from different sources. We found that RT-Vp96 of V. parahaemolyticus was able to synthesize msDNA-Vc95 of V. cholerae and vice versa. To the best of our knowledge, this is the first report that RT from different bacterial species can synthesize msDNA.
-
Citations
Citations to this article as recorded by- Retrons and their applications in genome engineering
Anna J Simon, Andrew D Ellington, Ilya J Finkelstein
Nucleic Acids Research.2019; 47(21): 11007. CrossRef - An Unexplored Diversity of Reverse Transcriptases in Bacteria
Steven Zimmerly, Li Wu, Alan Lambowitz, Nancy Craig
Microbiology Spectrum.2015;[Epub] CrossRef
- Retrons and their applications in genome engineering
- The Role of a Dark Septate Endophytic Fungus, Veronaeopsis simplex Y34, in Fusarium Disease Suppression in Chinese Cabbage
- Rida O. Khastini , Hiroyuki Ohta , Kazuhiko Narisawa
- J. Microbiol. 2012;50(4):618-624. Published online August 25, 2012
- DOI: https://doi.org/10.1007/s12275-012-2105-6
- 259 View
- 0 Download
- 38 Crossref
-
Abstract
PDF
- The soil-inhabiting fungal pathogen Fusarium oxysporum has been an increasing threat to Chinese cabbage (Brassica campestris L.). A dark septate endophytic fungus, Veronaeopsis simplex Y34, isolated from Yaku Island, Japan, was evaluated in vitro for the ability to suppress Fusarium disease. Seedlings grown in the presence of the endophyte showed a 71% reduction in Fusarium wilt disease and still had good growth. The disease control was achieved through a synergetic effect involving a mechanical resistance created by a dense network of V. simplex Y34 hyphae, which colonized the host root, and siderophore production acting indirectly to induce a resistance mechanism in the plant. Changes in the relative abundance of the fungal communities in the soil as determined by fluorescently labelled T-RFs (terminal restriction fragments), appeared 3 weeks after application of the fungus. Results showed the dominance of V. simplex Y34, which became established in the rhizosphere and out-competed F. oxysporum.
-
Citations
Citations to this article as recorded by- Acidomelania saccharicola sp. nov., a new species of dark septate endophytes in Helotiales, with potential of controlling Fusarium wilt of banana
Qian Nong, Yan Zhang, Yanyan Long, Yanlu Chen, Liping Qin, Shanyu Lin, Fenghua Zeng, Ling Xie
Biological Control.2025; 206: 105781. CrossRef -
Inhibitory activities of six local endophytic fungi as potential biocontrol agents of cabbage
Fusarium
wilt
Rosmalinda Lobitaña, Junel Fuentes, Donn Jericho Jake Densing, Djamae Manzanares, Neil Pep Dave Sumaya, Nanette Hope Sumaya
Archives of Phytopathology and Plant Protection.2025; 58(6): 365. CrossRef - Effects of dark septate endophytic fungi on the performance of non-mycorrhizal cabbage plants under normal and low water conditions
Alena F. Lukács, Gábor Herczeg, Gábor M. Kovács
Frontiers in Microbiology.2025;[Epub] CrossRef - Enhancing Astragalus mongholicus performance through endophytic fungi Improvement for Fusarium wilt resistance
Li Yao, Changhao Ji, Zhenzhou Wang, Yunfeng Liu, Wanyun Li, Menghui Wang, Xiaotong Yang, Chao He, Xueli He
Physiological and Molecular Plant Pathology.2025; 136: 102532. CrossRef - Pervasive associations between dark septate endophytic fungi with tree root and soil microbiomes across Europe
Tarquin Netherway, Jan Bengtsson, Franz Buegger, Joachim Fritscher, Jane Oja, Karin Pritsch, Falk Hildebrand, Eveline J. Krab, Mohammad Bahram
Nature Communications.2024;[Epub] CrossRef - Utilization of dark septate endophytes (DSE) to control pathogens causing diseases in various cultivated plants: a review
Mariani Mariani, Surono Surono, Marhani Marhani, Muhammad Mirsodi, Henti Rosdayanti, Mirta Ardi Lestari, Dalia Sukmawati, Catur Sriherwanto
Egyptian Journal of Biological Pest Control.2024;[Epub] CrossRef - Cladophialophora guangxiense sp. nov., a New Species of Dark Septate Endophyte, Mitigates Tomato Bacterial Wilt and Growth Promotion Activities
Xihong Wei, Yanyan Long, Yanlu Chen, Stanley Nyenje Mataka, Xue Jiang, Yi Zhou, Zhengxiang Sun, Ling Xie
Agronomy.2024; 14(12): 2771. CrossRef - First Report of Tripartite Symbiosis Potential among Soybean, Bradyrhizobium japonicum, and Dark Septate Endophytes
Ni Luh Putu Citra Innosensia, I Putu Wirya Suputra, Gusti Ngurah Alit Susanta Wirya, Kazuhiko Narisawa
Agronomy.2023; 13(7): 1788. CrossRef - Allelopathy‐selected microbiomes mitigate chemical inhibition of plant performance
Daniel Revillini, Aaron S. David, Alma L. Reyes, Leslie D. Knecht, Carolina Vigo, Preston Allen, Christopher A. Searcy, Michelle E. Afkhami
New Phytologist.2023; 240(5): 2007. CrossRef - Small RNA profiling reveals the involvement of microRNA-mediated gene regulation in response to symbiosis in raspberry
Zhiyu Yang, Lianmei Yuan, Haifeng Zhu, Jing Jiang, Hongyi Yang, Lili Li
Frontiers in Microbiology.2022;[Epub] CrossRef - Fungal endophytes of Brassicaceae: Molecular interactions and crop benefits
Jorge Poveda, Sandra Díaz-González, María Díaz-Urbano, Pablo Velasco, Soledad Sacristán
Frontiers in Plant Science.2022;[Epub] CrossRef - Effects of nitrogen addition and root fungal inoculation on the seedling growth and rhizosphere soil microbial community of Pinus tabulaeformis
Lingjie Xu, Xiaoyun Niu, Xia Li, Yanyan Zheng, Hualei Feng, Qiang Fu, Yong Zhou
Frontiers in Microbiology.2022;[Epub] CrossRef - Plant-soil-microbes: A tripartite interaction for nutrient acquisition and better plant growth for sustainable agricultural practices
Prajna Priyadarshini Das, Kshitij RB Singh, Gunjan Nagpure, Aadil Mansoori, Ravindra Pratap Singh, Irfan Ahmad Ghazi, Anirudh Kumar, Jay Singh
Environmental Research.2022; 214: 113821. CrossRef - Insights into the beneficial roles of dark septate endophytes in plants under challenging environment: resilience to biotic and abiotic stresses
Nahid Akhtar, Atif Khurshid Wani, Daljeet Singh Dhanjal, Soumya Mukherjee
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - Cover crop selection affects maize susceptibility to the fungal pathogen Fusarium verticillioides
Swayamjit Ray, Nancy G. Wenner, Obenewa Ankoma-Darko, Jason P. Kaye, Gretchen A. Kuldau, Jared G. Ali
Pedobiologia.2022; 91-92: 150806. CrossRef - Isolasi dan Respons Tumbuh Cendawan Mutualistik Akar pada Beberapa Tanaman Pangan dan Kehutanan
Rida Oktorida Khastini, Nampiah Sukarno, Utut Widyastuti Suharsono†, Yasuyuki Hashidoko†
Jurnal Ilmu Pertanian Indonesia.2022; 27(1): 85. CrossRef - The Dark Septate Endophyte, Phialocephala fortinii J2PC4, Mitigates Southern Rice Black-Streaked Dwarf Disease and Impacts the Mortality of White Back Planthopper
Yan Zhang, Bixia Qin, Kazuhiko Narisawa, Qian Nong, Liping Qin, Ling Xie
Biological Control.2022; 170: 104911. CrossRef - Antagonistic capacity of dark septate endophytes (DSE) against Ganoderma boninense from oil palm (Elaeis guinensis Jacq.)
G Rahayu, Surono, D A Octaviani
IOP Conference Series: Earth and Environmental Science.2021; 948(1): 012074. CrossRef - Microbial Communities and Functions in the Rhizosphere of Disease-Resistant and Susceptible Camellia spp.
Jun Li, Chenhui Zhang, Xinjing Qu, Ziqiong Luo, Sheng Lu, Yakov Kuzyakov, Hattan A. Alharbi, Jun Yuan, Genhua Niu
Frontiers in Microbiology.2021;[Epub] CrossRef - Synergistic and Offset Effects of Fungal Species Combinations on Plant Performance
Yoshie Hori, Hiroaki Fujita, Kei Hiruma, Kazuhiko Narisawa, Hirokazu Toju
Frontiers in Microbiology.2021;[Epub] CrossRef - Advances in the Role of Dark Septate Endophytes in the Plant Resistance to Abiotic and Biotic Stresses
Mila Santos, Ignacio Cesanelli, Fernando Diánez, Brenda Sánchez-Montesinos, Alejandro Moreno-Gavíra
Journal of Fungi.2021; 7(11): 939. CrossRef - The cellulolytic activity and symbiotic potential of dark septate endophytic fungus Phialocephala fortinii to promote non-mycorrhizal plants growth
Surono, K Narisawa
IOP Conference Series: Earth and Environmental Science.2021; 648(1): 012165. CrossRef - Potential of endophytic fungi collected from Cucurbita pepo roots grown under three different agricultural mulches as antagonistic endophytes to Verticillium dahliae in western Washington
Lydia S. Tymon, Paul Morgan, Babette Gundersen, Debra Ann Inglis
Microbiological Research.2020; 240: 126535. CrossRef - Colonization by dark septate endophytes improves the growth of Hedysarum scoparium under multiple inoculum levels
Yiling Zuo, Fang Su, Xueli He, Min Li
Symbiosis.2020; 82(3): 201. CrossRef - Effects of Dark Septate Endophytes on the Performance of Hedysarum scoparium Under Water Deficit Stress
Xia Li, Xue-Li He, Yong Zhou, Yi-Ting Hou, Yi-Ling Zuo
Frontiers in Plant Science.2019;[Epub] CrossRef - Dark septate endophytes improve the growth of host and non-host plants under drought stress through altered root development
Xia Li, Chao He, Xueli He, Fang Su, Lifeng Hou, Ying Ren, Yiting Hou
Plant and Soil.2019; 439(1-2): 259. CrossRef - The Dark Septate Endophytes and Ectomycorrhizal Fungi Effect on Pinus tabulaeformis Carr. Seedling Growth and their Potential Effects to Pine Wilt Disease Resistance
Honglong Chu, Chunyan Wang, Zhumei Li, Haihua Wang, Yuguo Xiao, Jie Chen, Ming Tang
Forests.2019; 10(2): 140. CrossRef - The inhibitory role of dark septate endophytic fungus Phialocephala fortinii against Fusarium disease on the Asparagus officinalis growth in organic source conditions
Surono, Kazuhiko Narisawa
Biological Control.2018; 121: 159. CrossRef - Isolation of endophytic fungi from tropical forest in Indonesia
Ahdiar Fikri Maulana, Maman Turjaman, Takumi Sato, Yasushi Hashimoto, Weiguo Cheng, Keitaro Tawaraya
Symbiosis.2018; 76(2): 151. CrossRef - Effects of Rhizobium Species Living with the Dark Septate Endophytic Fungus Veronaeopsis simplex on Organic Substrate Utilization by the Host
Yong Guo, Yuuto Matsuoka, Tomoyasu Nishizawa, Hiroyuki Ohta, Kazuhiko Narisawa
Microbes and Environments.2018; 33(1): 102. CrossRef - Complete genome sequence of Agrobacterium pusense VsBac-Y9, a bacterial symbiont of the dark septate endophytic fungus Veronaeopsis simplex Y34 with potential for improving fungal colonization in roots
Yong Guo, Yuuto Matsuoka, Takamasa Miura, Tomoyasu Nishizawa, Hiroyuki Ohta, Kazuhiko Narisawa
Journal of Biotechnology.2018; 284: 31. CrossRef - Development of PCR-based molecular marker for screening of disease-suppressive composts against Fusarium wilt of tomato (Solanum lycopersicum L.)
C. M. Mehta, Ramesh N. Pudake, Rashmi Srivastava, Uma Palni, Anil K. Sharma
3 Biotech.2018;[Epub] CrossRef - Pine wilt disease alters soil properties and root-associated fungal communities in Pinus tabulaeformis forest
Honglong Chu, Chunyan Wang, Haihua Wang, Hui Chen, Ming Tang
Plant and Soil.2016; 404(1-2): 237. CrossRef - A endophytic fungus, Ramichloridium cerophilum, promotes growth of a non-mycorrhizal plant, Chinese cabbage
Xie Ling, Usui Erika, Narisawa Kazuhiko
African Journal of Biotechnology.2016; 15(25): 1299. CrossRef - Fungal endophytes: modifiers of plant disease
Posy E. Busby, Mary Ridout, George Newcombe
Plant Molecular Biology.2016; 90(6): 645. CrossRef - Diversity of indigenous endophytic bacteria associated with the roots of Chinese cabbage (Brassica campestris L.) cultivars and their antagonism towards pathogens
Md. Azizul Haque, Han Dae Yun, Kye Man Cho
Journal of Microbiology.2016; 54(5): 353. CrossRef - The Role of Dark Septate Endophytic Fungal Isolates in the Accumulation of Cesium by Chinese Cabbage and Tomato Plants under Contaminated Environments
Ousmane Diene, Nobuo Sakagami, Kazuhiko Narisawa, Andrew C. Singer
PLoS ONE.2014; 9(10): e109233. CrossRef - Isolates of dark septate endophytes reduce metal uptake and improve physiology of Salix caprea L.
M. Likar, M. Regvar
Plant and Soil.2013; 370(1-2): 593. CrossRef
- Acidomelania saccharicola sp. nov., a new species of dark septate endophytes in Helotiales, with potential of controlling Fusarium wilt of banana
- Effects of a Dark-Septate Endophytic Isolate LBF-2 on the Medicinal Plant Lycium barbarum L.
- Hai-han Zhang , Ming Tang , Hui Chen , Ya-jun Wang
- J. Microbiol. 2012;50(1):91-96. Published online February 27, 2012
- DOI: https://doi.org/10.1007/s12275-012-1159-9
- 298 View
- 0 Download
- 33 Crossref
-
Abstract
PDF
- Dark septate endophytes (DSE) are ubiquitous root associated fungi; however, our understanding of their ecological function remains unclear. Here, we investigated the positive effect of a DSE fungus on its host plant Lycium barbarum L. A DSE isolate, LBF-2, isolated from the roots of L. barbarum, was inoculated onto the roots of plants, which were grown under greenhouse conditions for five weeks. The result of molecular analyses of internal transcribed spacer regions indicated that LBF-2 was 96% similar to Paraphoma chrysanthemicola. Melanized septate hyphae were observed in the root cortical cells of L. barbarum using a light microscope. Inoculation with LBF-2 increased the total biomass by 39.2% and also enhanced chlorophyll fluorescence. Inoculation increased the concentration of total chlorophyll by 22.8% and of chlorophyll a by 21.3%, relative to uninoculated controls. These data indicate that the LBF-2 isolate might be used to facilitate the cultivation of L. barbarum, which has medicinal applications.
-
Citations
Citations to this article as recorded by- Symbiotic fungal inoculation promotes the growth of Pinus tabuliformis seedlings in relation to the applied nitrogen form
Lingjie Xu, Yanhui Li, Xiaoyu Dai, Xueyu Jin, Qiannai Zhao, Boyu Tian, Yong Zhou
BMC Plant Biology.2025;[Epub] CrossRef - Effects of Dark Septate Endophytes on the Growth of Wheat Seedlings Under Different Fertilizer Conditions
Wenyi Shi, Zhenzhou Wang, Qing Wang, Xin Zheng, Wenjing Chen, Xia Li, Xueli He
Journal of Plant Growth Regulation.2025; 44(9): 5340. CrossRef - Effect of UV-A on endophyte colonisation of Arabidopsis thaliana
Aleksandra Giza, Paweł Hermanowicz, Rafał Ważny, Agnieszka Domka, Piotr Rozpądek, Justyna Łabuz, Eugenio Llorens
PLOS One.2025; 20(5): e0323576. CrossRef - Effects of dark septate endophytic fungi on the performance of non-mycorrhizal cabbage plants under normal and low water conditions
Alena F. Lukács, Gábor Herczeg, Gábor M. Kovács
Frontiers in Microbiology.2025;[Epub] CrossRef - The Promotion of Dark Septate Endophytes on the Performance and Active Ingredients Accumulation of Astragalus mongholicus under Cadmium Stress
Min Li, Li Han, Chao He, Xia Li, Xueli He
Agronomy.2024; 14(8): 1801. CrossRef - Insight of endophytic fungi promoting the growth and development of woody plants
Xiangyu Qin, Jian Xu, Xiaoli An, Jie Yang, Yao Wang, Meijia Dou, Minggang Wang, Jin Huang, Yujie Fu
Critical Reviews in Biotechnology.2024; 44(1): 78. CrossRef - Biochar aging, soil microbiota and chemistry of charcoal kilns in Mediterranean forests
Giuseppina Iacomino, Mohamed Idbella, Luigi di Costanzo, Giandomenico Amoroso, Emilia Allevato, Ahmed M. Abd-ElGawad, Giuliano Bonanomi
Biochar.2024;[Epub] CrossRef - Genomic Characteristics and Comparative Genomics Analysis of the Endophytic Fungus Paraphoma chrysanthemicola DS-84 Isolated from Codonopsis pilosula Root
Wenbin Sun, Min Feng, Ning Zhu, Feifan Leng, Mingjun Yang, Yonggang Wang
Journal of Fungi.2023; 9(10): 1022. CrossRef - Complementary Effects of Dark Septate Endophytes and Trichoderma Strains on Growth and Active Ingredient Accumulation of Astragalus mongholicus under Drought Stress
Min Li, Yanfang Ren, Chao He, Jiaojie Yao, Miao Wei, Xueli He
Journal of Fungi.2022; 8(9): 920. CrossRef - Insights into the beneficial roles of dark septate endophytes in plants under challenging environment: resilience to biotic and abiotic stresses
Nahid Akhtar, Atif Khurshid Wani, Daljeet Singh Dhanjal, Soumya Mukherjee
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - Effects of Dark Septate Endophytes on the Performance and Soil Microbia of Lycium ruthenicum Under Drought Stress
Chao He, Tingting Han, Ling Tan, Xianen Li
Frontiers in Plant Science.2022;[Epub] CrossRef - Network analysis reveals the root endophytic fungi associated with Fusarium root rot invasion
Lin Tan, Yansong Xiao, Wei-ai Zeng, Songsong Gu, Zhengguang Zhai, Shaolong Wu, Pengfei Li, Kai Feng, Ye Deng, Qiulong Hu
Applied Soil Ecology.2022; 178: 104567. CrossRef - Growth-promoting effects of dark septate endophytes on the non-mycorrhizal plant Isatis indigotica under different water conditions
Min Li, Lifeng Hou, Jiaqiang Liu, Jingya Yang, Yiling Zuo, Lili Zhao, Xueli He
Symbiosis.2021; 85(3): 291. CrossRef - The Effect of Dark Septate Endophytic Fungi on Mahonia oiwakensis
Lei-Chen Lin, Yin-Ling Tan, Wan-Rou Lin, Kuo-Lung Ku, Shang-Tse Ho
Plants.2021; 10(8): 1723. CrossRef - Plant identity and soil variables shift the colonisation and species composition of dark septate endophytes associated with medicinal plants in a northern farmland in China
Li Han, Yiling Zuo, Xueli He, Yiting Hou, Min Li, Baoku Li
Applied Soil Ecology.2021; 167: 104042. CrossRef - Temporal and Spatial Dynamics of Dark Septate Endophytes in the Roots of Lycium ruthenicum in the Desert Region of Northwest China
Li Han, Jingxin Shi, Chao He, Xueli He
Agronomy.2021; 11(4): 648. CrossRef - Effects of enhancement of liquorice plants with dark septate endophytes on the root growth, glycyrrhizic acid and glycyrrhizin accumulation amended with organic residues
Chao He, Jie Cui, Xiaoyu Chen, Wenquan Wang, Junling Hou
Current Plant Biology.2020; 23: 100154. CrossRef - Colonization by dark septate endophytes improves the growth of Hedysarum scoparium under multiple inoculum levels
Yiling Zuo, Fang Su, Xueli He, Min Li
Symbiosis.2020; 82(3): 201. CrossRef - Functional roles of fungal endophytes in host fitness during stress conditions
B. Shankar Naik
Symbiosis.2019; 79(2): 99. CrossRef - Plant-mycorrhizal fungi interaction and response to inoculation with different growth-promoting fungi
Carlos Vergara, Karla Emanuelle Campos Araujo, Sônia Regina de Souza, Nivaldo Schultz, Orivaldo José Saggin Júnior, Marcus Vinícius Loss Sperandio, Jerri Édson Zilli
Pesquisa Agropecuária Brasileira.2019;[Epub] CrossRef - Dark septate endophytes improve the growth of host and non-host plants under drought stress through altered root development
Xia Li, Chao He, Xueli He, Fang Su, Lifeng Hou, Ying Ren, Yiting Hou
Plant and Soil.2019; 439(1-2): 259. CrossRef - Plant performance response to eight different types of symbiosis
Anais Gibert, Wade Tozer, Mark Westoby
New Phytologist.2019; 222(1): 526. CrossRef - Characterization of Dark Septate Endophytic Fungi and Improve the Performance of Liquorice Under Organic Residue Treatment
Chao He, Wenquan Wang, Junling Hou
Frontiers in Microbiology.2019;[Epub] CrossRef - Contribution of dark septate fungi to the nutrient uptake and growth of rice plants
Carlos Vergara, Karla Emanuelle Campos Araujo, Luiziene Soares Alves, Sônia Regina de Souza, Leandro Azevedo Santos, Claudete Santa-Catarina, Krisle da Silva, Gilmara Maria Duarte Pereira, Gustavo Ribeiro Xavier, Jerri Édson Zilli
Brazilian Journal of Microbiology.2018; 49(1): 67. CrossRef - Endophytic fungal diversity ofFragaria vesca, a crop wild relative of strawberry, along environmental gradients within a small geographical area
Kazutomo Yokoya, Sarah Postel, Rui Fang, Viswambharan Sarasan
PeerJ.2017; 5: e2860. CrossRef - Dark Septate Endophytic Fungi Help Tomato to Acquire Nutrients from Ground Plant Material
Carlos Vergara, Karla E. C. Araujo, Segundo Urquiaga, Nivaldo Schultz, Fabiano de Carvalho Balieiro, Peter S. Medeiros, Leandro A. Santos, Gustavo R. Xavier, Jerri E. Zilli
Frontiers in Microbiology.2017;[Epub] CrossRef - Effect of Dark Septate Endophytic Fungus Gaeumannomyces cylindrosporus on Plant Growth, Photosynthesis and Pb Tolerance of Maize ( Zea mays L.)
Yihui BAN, Zhouying XU, Yurong YANG, Haihan ZHANG, Hui CHEN, Ming TANG
Pedosphere.2017; 27(2): 283. CrossRef - Application of Locked Nucleic Acid (LNA) Primer and PCR Clamping by LNA Oligonucleotide to Enhance the Amplification of Internal Transcribed Spacer (ITS) Regions in Investigating the Community Structures of Plant–Associated Fungi
Makoto Ikenaga, Masakazu Tabuchi, Tomohiro Kawauchi, Masao Sakai
Microbes and environments.2016; 31(3): 339. CrossRef - Growth Effect of Cinnamomum kanehirae Cuttings Associated with its Dark Septate Endophytes
Lei-Chen Lin
Pakistan Journal of Biological Sciences.2016; 19(7): 299. CrossRef - The growth and medicinal quality ofEpimedium wushanenseare improved by an isolate of dark septate fungus
Zai-Biao Zhu, Jia-Yi Fan, Qiao-Sheng Guo, Zuo-Yi Liu, Guo-Sheng Zhu
Pharmaceutical Biology.2015; 53(9): 1344. CrossRef - The effects of fungal root endophytes on plant growth: a meta-analysis
Michael S. Mayerhofer, Gavin Kernaghan, Karen A. Harper
Mycorrhiza.2013; 23(2): 119. CrossRef - The Response of Dark Septate Endophytes (DSE) to Heavy Metals in Pure Culture
Yihui Ban, Ming Tang, Hui Chen, Zhouying Xu, Haihan Zhang, Yurong Yang, Vishal Shah
PLoS ONE.2012; 7(10): e47968. CrossRef - Exploring the potential of symbiotic fungal endophytes in cereal disease suppression
Karen A. O’Hanlon, Kamilla Knorr, Lise Nistrup Jørgensen, Mogens Nicolaisen, Birte Boelt
Biological Control.2012; 63(2): 69. CrossRef
- Symbiotic fungal inoculation promotes the growth of Pinus tabuliformis seedlings in relation to the applied nitrogen form
- Complete Genome of Leptospirillum ferriphilum ML-04 Provides Insight into Its Physiology and Environmental Adaptation
- Shuang Mi , Jian Song , Jianqun Lin , Yuanyuan Che , Huajun Zheng , Jianqiang Lin
- J. Microbiol. 2011;49(6):890-901. Published online December 28, 2011
- DOI: https://doi.org/10.1007/s12275-011-1099-9
- 257 View
- 0 Download
- 42 Crossref
-
Abstract
PDF
- Leptospirillum ferriphilum has been identified as the dominant, moderately thermophilic, bioleaching microorganism in bioleaching processes. It is an acidic and chemolithoautrophic bacterium that gains electrons from ferrous iron oxidation for energy production and cell growth. Genetic information about this microorganism has been limited until now, which has hindered its further exploration. In this study, the complete genome of L. ferripilum ML-04 is sequenced and annotated. The bacterium has a single circular chromosome of 2,406,157 bp containing 2,471 coding sequences (CDS), 2 rRNA operons, 48 tRNA genes, a large number of mobile genetic elements and 2 genomic islands. In silico analysis shows L. ferriphilum ML-04 fixes carbon through a reductive citric acid (rTCA) cycle, and obtains nitrogen through ammonium assimilation. The genes related to “cell envelope biogenesis, outer membrane” (6.9%) and “DNA replication, recombination and repair” (5.6%) are abundant, and a large number of genes related to heavy metal detoxification, oxidative and acidic stress defense, and signal transduction pathways were detected. The genomic plasticity, plentiful cell envelope components, inorganic element metabolic abilities and stress response mechanisms found the base for this organism’s survival in the bioleaching niche.
-
Citations
Citations to this article as recorded by- Investigating the impact of inoculation on bioleaching of copper flotation concentrate using a continuous reactor at pilot scale - study case: Tizert deposit
Laila Barfoud, Issam Meftah Kadmiri, Salah Eddine Azaroual, Kaoutar Dachri, Hakim Faqir, Intissar Benzakour, Abderrahmane Kaddami, Khalid Naji, Samira Ait Mbarek
Minerals Engineering.2024; 205: 108455. CrossRef - Multi-stress adaptive lifestyle of acidophiles enhances their robustness for biotechnological and environmental applications
Godwin O. Aliyu, Flora N. Ezugworie, Chukwudi O. Onwosi, Chukwudi I. Nnamchi, Chito C. Ekwealor, Victor C. Igbokwe, Rajesh K. Sani
Science of The Total Environment.2024; 954: 176190. CrossRef - Bioleaching of Chalcopyrite by a New Strain Leptospirillum ferrodiazotrophum Ksh-L Isolated from a Dump-Bioleaching System of Kashen Copper-Molybdenum Mine
Anna Khachatryan, Narine Vardanyan, Sabine Willscher, Garegin Sevoyan, Ruiyong Zhang, Arevik Vardanyan
Minerals.2023; 14(1): 26. CrossRef - Carbon fixation by chemoautotrophic microbes and strategies for their artificial regulation
Qing Chang, Zhanhua Zhang, Yaqi Liu, Tong Zhang
Chinese Science Bulletin.2023; 68(28-29): 3792. CrossRef - A Critical Review on the Recovery of Base and Critical Elements from Electronic Waste-Contaminated Streams Using Microbial Biotechnology
Sunanda Mishra, Shreya Ghosh, Eric D. van Hullebusch, Shikha Singh, Alok Prasad Das
Applied Biochemistry and Biotechnology.2023; 195(12): 7859. CrossRef - Bioleaching of E-Waste: Influence of Printed Circuit Boards on the Activity of Acidophilic Iron-Oxidizing Bacteria
Juan Anaya-Garzon, Agathe Hubau, Catherine Joulian, Anne-Gwénaëlle Guezennec
Frontiers in Microbiology.2021;[Epub] CrossRef - Genomic Analysis of a Newly Isolated Acidithiobacillus ferridurans JAGS Strain Reveals Its Adaptation to Acid Mine Drainage
Jinjin Chen, Yilan Liu, Patrick Diep, Radhakrishnan Mahadevan
Minerals.2021; 11(1): 74. CrossRef - Industrial wastewater purification through metal pollution reduction employing microbes and magnetic nanocomposites
Pooja Sharma, Deblina Dutta, Aswathy Udayan, Sunil Kumar
Journal of Environmental Chemical Engineering.2021; 9(6): 106673. CrossRef - Recent progress in the application of omics technologies in the study of bio-mining microorganisms from extreme environments
Min Li, Jianping Wen
Microbial Cell Factories.2021;[Epub] CrossRef - Homogeneous Cytochrome 579 Is an Octamer That Reacts Too Slowly With Soluble Iron to Be the Initial Iron Oxidase in the Respiratory Chain of Leptospirillum ferriphilum
Robert C. Blake, John E. Shively, Russell Timkovich, Richard Allen White
Frontiers in Microbiology.2021;[Epub] CrossRef - Comparative genome analysis on intraspecific evolution and nitrogen fixation of Leptospirillum ferriphilum isolates
Hong-wei LIU, Liang-feng XU, Xue GUO, Hui-dan JIANG, Xue-duan LIU, Yi-li LIANG, Hua-qun YIN, Ya-zi LIU
Transactions of Nonferrous Metals Society of China.2020; 30(6): 1635. CrossRef - Metal and organic pollutants bioremediation by extremophile microorganisms
Patricia Giovanella, Gabriela A.L. Vieira, Igor V. Ramos Otero, Elisa Pais Pellizzer, Bruno de Jesus Fontes, Lara D. Sette
Journal of Hazardous Materials.2020; 382: 121024. CrossRef - Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus
Eva Vergara, Gonzalo Neira, Carolina González, Diego Cortez, Mark Dopson, David S. Holmes
Genes.2020; 11(4): 389. CrossRef - Microorganisms and Their Metabolic Capabilities in the Context of the Biogeochemical Nitrogen Cycle at Extreme Environments
Rosa María Martínez-Espinosa
International Journal of Molecular Sciences.2020; 21(12): 4228. CrossRef - Reconstruction of the Functional Ecosystem in the High Light, Low Temperature Union Glacier Region, Antarctica
Yi Li, Qian-Qian Cha, Yan-Ru Dang, Xiu-Lan Chen, Min Wang, Andrew McMinn, Giannina Espina, Yu-Zhong Zhang, Jenny M. Blamey, Qi-Long Qin
Frontiers in Microbiology.2019;[Epub] CrossRef - Enhancing microbial community performance on acid resistance by modified adaptive laboratory evolution
Ronghui Liu, Yanzhi Chen, Zhuang Tian, Zhenghua Mao, Haina Cheng, Hongbo Zhou, Wei Wang
Bioresource Technology.2019; 287: 121416. CrossRef - Insight to the early-stage adsorption mechanism of moderately thermophilic consortia and intensified bioleaching of chalcopyrite
Ronghui Liu, Jing Chen, Wenbo Zhou, Haina Cheng, Hongbo Zhou
Biochemical Engineering Journal.2019; 144: 40. CrossRef -
Multi-omics Reveals the Lifestyle of the Acidophilic, Mineral-Oxidizing Model Species Leptospirillum ferriphilum
T
Stephan Christel, Malte Herold, Sören Bellenberg, Mohamed El Hajjami, Antoine Buetti-Dinh, Igor V. Pivkin, Wolfgang Sand, Paul Wilmes, Ansgar Poetsch, Mark Dopson, M. Julia Pettinari
Applied and Environmental Microbiology.2018;[Epub] CrossRef - Pan-Genome Analysis Links the Hereditary Variation of Leptospirillum ferriphilum With Its Evolutionary Adaptation
Xian Zhang, Xueduan Liu, Fei Yang, Lv Chen
Frontiers in Microbiology.2018;[Epub] CrossRef - THE STRUCTURE AND PROPERTIES OF MICROBIOCENOSIS IN DUMPS OF THE FUEL AND ENERGY COMPLEX OF UKRAINE
I. A. Blayda
Biotechnologia Acta.2018; 11(5): 54. CrossRef - Codon usage bias reveals genomic adaptations to environmental conditions in an acidophilic consortium
Andrew Hart, María Paz Cortés, Mauricio Latorre, Servet Martinez, Ulrich Melcher
PLOS ONE.2018; 13(5): e0195869. CrossRef - In a quest for engineering acidophiles for biomining applications: challenges and opportunities
Yosephine Gumulya, Naomi Boxall, Himel Khaleque, Ville Santala, Ross Carlson, Anna Kaksonen
Genes.2018; 9(2): 116. CrossRef - Continuous production of a biogenic ferric iron lixiviant for the bioleaching of printed circuit boards (PCBs)
Agathe Hubau, Michel Minier, Alexandre Chagnes, Catherine Joulian, Cédric Perez, Anne-Gwenaëlle Guezennec
Hydrometallurgy.2018; 180: 180. CrossRef - Comparative Genomics Unravels the Functional Roles of Co-occurring Acidophilic Bacteria in Bioleaching Heaps
Xian Zhang, Xueduan Liu, Yili Liang, Yunhua Xiao, Liyuan Ma, Xue Guo, Bo Miao, Hongwei Liu, Deliang Peng, Wenkun Huang, Huaqun Yin
Frontiers in Microbiology.2017;[Epub] CrossRef - Draft genome sequence of chloride-tolerant Leptospirillum ferriphilum Sp-Cl from industrial bioleaching operations in northern Chile
Francisco Issotta, Pedro A. Galleguillos, Ana Moya-Beltrán, Carol S. Davis-Belmar, George Rautenbach, Paulo C. Covarrubias, Mauricio Acosta, Francisco J. Ossandon, Yasna Contador, David S. Holmes, Sabrina Marín-Eliantonio, Raquel Quatrini, Cecilia Demerga
Standards in Genomic Sciences.2016;[Epub] CrossRef - Putative bacterial interactions from metagenomic knowledge with an integrative systems ecology approach
Philippe Bordron, Mauricio Latorre, Maria‐Paz Cortés, Mauricio González, Sven Thiele, Anne Siegel, Alejandro Maass, Damien Eveillard
MicrobiologyOpen.2016; 5(1): 106. CrossRef - Post-translational modifications are enriched within protein functional groups important to bacterial adaptation within a deep-sea hydrothermal vent environment
Weipeng Zhang, Jin Sun, Huiluo Cao, Renmao Tian, Lin Cai, Wei Ding, Pei-Yuan Qian
Microbiome.2016;[Epub] CrossRef - Cobalamin Protection against Oxidative Stress in the Acidophilic Iron-oxidizing Bacterium Leptospirillum Group II CF-1
Alonso Ferrer, Javier Rivera, Claudia Zapata, Javiera Norambuena, Álvaro Sandoval, Renato Chávez, Omar Orellana, Gloria Levicán
Frontiers in Microbiology.2016;[Epub] CrossRef - Experiences and Future Challenges of Bioleaching Research in South Korea
Danilo Borja, Kim Nguyen, Rene Silva, Jay Park, Vishal Gupta, Yosep Han, Youngsoo Lee, Hyunjung Kim
Minerals.2016; 6(4): 128. CrossRef - The bioleaching potential of a bacterial consortium
Mauricio Latorre, María Paz Cortés, Dante Travisany, Alex Di Genova, Marko Budinich, Angélica Reyes-Jara, Christian Hödar, Mauricio González, Pilar Parada, Roberto A. Bobadilla-Fazzini, Verónica Cambiazo, Alejandro Maass
Bioresource Technology.2016; 218: 659. CrossRef - Metabolic diversity and adaptive mechanisms of iron‐ and/or sulfur‐oxidizing autotrophic acidophiles in extremely acidic environments
Xian Zhang, Xueduan Liu, Yili Liang, Fenliang Fan, Xiaoxia Zhang, Huaqun Yin
Environmental Microbiology Reports.2016; 8(5): 738. CrossRef - Stoichiometric model and flux balance analysis for a mixed culture of Leptospirillum ferriphilum and Ferroplasma acidiphilum
M. P. Merino, B. A. Andrews, J. A. Asenjo
Biotechnology Progress.2015; 31(2): 307. CrossRef - Draft genome of iron-oxidizing bacterium Leptospirillum sp. YQP-1 isolated from a volcanic lake in the Wudalianchi volcano, China
Lei Yan, Shuang Zhang, Gaobo Yu, Yongqing Ni, Weidong Wang, Huixin Hu, Peng Chen
Genomics Data.2015; 6: 164. CrossRef - Microbial diversity and metabolic networks in acid mine drainage habitats
Celia Méndez-GarcÃa, Ana I. Peláez, Victoria Mesa, Jesús Sánchez, Olga V. Golyshina, Manuel Ferrer
Frontiers in Microbiology.2015;[Epub] CrossRef - Microbial leaching of metals from solid industrial wastes
Debaraj Mishra, Young Ha Rhee
Journal of Microbiology.2014; 52(1): 1. CrossRef - Variation in microbial community from predominantly mesophilic to thermotolerant and moderately thermophilic species in an industrial copper heap bioleaching operation
Mauricio Acosta, Pedro Galleguillos, Yousef Ghorbani, Pierina Tapia, Yasna Contador, Antonio Velásquez, Cristian Espoz, Carlos Pinilla, Cecilia Demergasso
Hydrometallurgy.2014; 150: 281. CrossRef - Metal resistance in acidophilic microorganisms and its significance for biotechnologies
Mark Dopson, David S. Holmes
Applied Microbiology and Biotechnology.2014; 98(19): 8133. CrossRef - Insight into the evolution of the iron oxidation pathways
Marianne Ilbert, Violaine Bonnefoy
Biochimica et Biophysica Acta (BBA) - Bioenergetics.2013; 1827(2): 161. CrossRef - New Group in the Leptospirillum Clade: Cultivation-Independent Community Genomics, Proteomics, and Transcriptomics of the New Species “Leptospirillum Group IV UBA BS”
Daniela S. Aliaga Goltsman, Mauna Dasari, Brian C. Thomas, Manesh B. Shah, Nathan C. VerBerkmoes, Robert L. Hettich, Jillian F. Banfield
Applied and Environmental Microbiology.2013; 79(17): 5384. CrossRef - ContigScape: a Cytoscape plugin facilitating microbial genome gap closing
Biao Tang, Qi Wang, Minjun Yang, Feng Xie, Yongqiang Zhu, Ying Zhuo, Shengyue Wang, Hong Gao, Xiaoming Ding, Lixin Zhang, Guoping Zhao, Huajun Zheng
BMC Genomics.2013;[Epub] CrossRef - Shifts in microbial community composition and function in the acidification of a lead/zinc mine tailings
Lin‐xing Chen, Jin‐tian Li, Ya‐ting Chen, Li‐nan Huang, Zheng‐shuang Hua, Min Hu, Wen‐sheng Shu
Environmental Microbiology.2013; 15(9): 2431. CrossRef - Multiple Rieske/cytb complexes in a single organism
F. ten Brink, B. Schoepp-Cothenet, R. van Lis, W. Nitschke, F. Baymann
Biochimica et Biophysica Acta (BBA) - Bioenergetics.2013; 1827(11-12): 1392. CrossRef
- Investigating the impact of inoculation on bioleaching of copper flotation concentrate using a continuous reactor at pilot scale - study case: Tizert deposit
Research Support, N.I.H., Extramural
- Helicobacter pylori apo-Fur Regulation Appears Unconserved Across Species
- Shana Miles , Beth M. Carpenter , Hanan Gancz , D. Scott Merrell
- J. Microbiol. 2010;48(3):378-386. Published online June 23, 2010
- DOI: https://doi.org/10.1007/s12275-010-0022-0
- 194 View
- 0 Download
- 25 Scopus
-
Abstract
PDF
- The Ferric Uptake Regulator (Fur) is a transcriptional regulator that is conserved across a broad number of bacterial species and has been shown to regulate expression of iron uptake and storage genes. Additionally, Fur has been shown to be an important colonization factor of the gastric pathogen Helicobacter pylori. In H. pylori, Fur-dependent regulation appears to be unique in that Fur is able to act as a transcriptional repressor when bound to iron as well as in its iron free (apo) form. To date, apo-regulation has not been identified in any other bacterium. To determine whether Fur from other species has the capacity for aporegulation, we investigated the ability of Fur from Escherichia coli, Campylobacter jejuni, Desulfovibrio vulgaris Hildenborough, Pseudomonas aeruginosa, and Vibrio cholerae to complement both iron-bound and apo-Fur regulation within the context of a H. pylori fur mutant. We found that while some Fur species (E. coli, C. jejuni, and V. cholerae) complemented iron-bound regulation, apo-regulation was unable to be complemented by any of the examined species. These data suggest that despite the conservation among bacterial Fur proteins, H. pylori Fur contains unique structure/function features that make it novel in comparison to Fur from other species.
Research Support, Non-U.S. Gov'ts
- Experimental and Computational Characterization of the Ferric Uptake Regulator from Aliivibrio salmonicida (Vibrio salmonicida)
- Hege Lynum Pedersen , Rafi Ahmad , Ellen Kristin Riise , Hanna-Kirsti Schrøder Leiros , Stefan Hauglid , Sigrun Espelid , Bjørn Olav Brandsdal , Ingar Leiros , Nils-Peder Willassen , Peik Haugen
- J. Microbiol. 2010;48(2):174-183. Published online May 1, 2010
- DOI: https://doi.org/10.1007/s12275-010-9199-5
- 198 View
- 0 Download
- 5 Scopus
-
Abstract
PDF
- The Ferric uptake regulator (Fur) is a global transcription factor that affects expression of bacterial genes in an iron-dependent fashion. Although the Fur protein and its iron-responsive regulon are well studied, there are still important questions that remain to be answered. For example, the consensus Fur binding site also known as the “Fur box” is under debate, and it is still unclear which Fur residues directly interact with the DNA. Our long-term goal is to dissect the biological roles of Fur in the development of the disease cold-water vibriosis, which is caused by the psychrophilic bacteria Aliivibrio salmonicida (also known as Vibrio salmonicida). Here, we have used experimental and computational methods to characterise the Fur protein from A. salmonicida (AS-Fur). Electrophoretic mobility shift assays show that AS-Fur binds to the recently proposed vibrio Fur box consensus in addition to nine promoter regions that contain Fur boxes. Binding appears to be dependent on the number of Fur boxes, and the predicted “strength” of Fur boxes. Finally, structure modeling and molecular dynamics simulations provide new insights into potential AS-Fur–DNA interactions.
- Adaptation and Cross-Adaptation of Listeria monocytogenes and Salmonella enterica to Poultry Decontaminants
- Alicia Alonso-Hernando , Rosa Capita , Miguel Prieto , Carlos Alonso-Calleja
- J. Microbiol. 2009;47(2):142-146. Published online May 2, 2009
- DOI: https://doi.org/10.1007/s12275-008-0237-5
- 255 View
- 0 Download
- 22 Crossref
-
Abstract
PDF
- Information on the potential for acquired reduced susceptibility of bacteria to poultry decontaminants occurring is lacking. Minimal Inhibitory Concentrations (MICs) were established for assessing the initial susceptibility and the adaptative and cross-adaptative responses of four bacterial strains (Listeria monocytogenes serovar 1/2a, L. monocytogenes serovar 4b, Salmonella enterica serotype Typhimurium, and S. enterica serotype Enteritidis) to four poultry decontaminants (trisodium phosphate, acidified sodium chlorite -ASC-, citric acid, and peroxyacetic acid). The initial susceptibility was observed to differ among species (all decontaminants) and between Salmonella strains (ASC). These inter- and intra-specific variations highlight (1) the need for strict monitoring of decontaminant concentrations to inactivate all target pathogens of concern, and (2) the importance of selecting adequate test strains in decontamination studies. MICs of ASC (0.17±0.02 to 0.21±0.02 mg/ml) were higher than the U.S. authorized concentration when applied as a pre-chiller or chiller solution (0.05 to 0.15 mg/ml). Progressively increasing decontaminant concentrations resulted in reduced susceptibility of strains. The highest increase in MIC was 1.88 to 2.71-fold (ASC). All decontaminants were shown to cause cross-adaptation of strains between both related and unrelated compounds, the highest increase in MIC being 1.82-fold (ASC). Our results suggest that the in-use concentrations of ASC could, in certain conditions, be ineffective against Listeria and Salmonella strains. The adaptative and cross-adaptative responses of strains tested to poultry decontaminants are of minor concern. However, the observations being presented here are based on in vitro studies, and further research into practical applications are needed in order to confirm these findings.
-
Citations
Citations to this article as recorded by- Exposure to Low Doses of Biocides Increases Resistance to Other Biocides and to Antibiotics in Strains of Listeria monocytogenes
Cristina Rodríguez-Melcón, Rosa Capita, Carlos Alonso-Calleja
Biology.2025; 14(5): 495. CrossRef - Pseudomonadaceae increased the tolerance of Listeria monocytogenes to sanitizers in multi-species biofilms
Olena Voloshchuk, M. Laura Rolon, Katelyn V. Bartlett, Marysabel Mendez Acevedo, Luke F. LaBorde, Jasna Kovac
Food Microbiology.2025; 128: 104687. CrossRef - Overuse of food-grade disinfectants threatens a global spread of antimicrobial-resistant bacteria
Ricardo A. Wu, Jinsong Feng, Min Yue, Donghong Liu, Tian Ding
Critical Reviews in Food Science and Nutrition.2024; 64(19): 6870. CrossRef - Estimation by flow cytometry of percentages of survival of Listeria monocytogenes cells treated with tetracycline, with or without prior exposure to several biocides
Cristina Rodríguez-Melcón, Víctor Serrano-Galán, Rosa Capita, Carlos Alonso-Calleja
Food Microbiology.2023; 112: 104210. CrossRef - Effect of low doses of biocides on the susceptibility of Listeria monocytogenes and Salmonella enterica to various antibiotics of clinical importance
Cristina Rodríguez-Melcón, Carlos Alonso-Calleja, Rosa Capita
Food Control.2023; 149: 109602. CrossRef - Exploring Peracetic Acid and Acidic pH Tolerance of Antibiotic-Resistant Non-Typhoidal Salmonella and Enterococcus faecium from Diverse Epidemiological and Genetic Backgrounds
Andreia Rebelo, Bárbara Duarte, Ana R. Freitas, Luísa Peixe, Patrícia Antunes, Carla Novais
Microorganisms.2023; 11(9): 2330. CrossRef - Unraveling the Role of Metals and Organic Acids in Bacterial Antimicrobial Resistance in the Food Chain
Andreia Rebelo, Agostinho Almeida, Luísa Peixe, Patrícia Antunes, Carla Novais
Antibiotics.2023; 12(9): 1474. CrossRef - In Vitro Investigation of the Antibacterial Activity of Nine Commercial Water Disinfectants, Acidifiers, and Glyceride Blends against the Most Important Poultry Zoonotic Bacteria
Tilemachos Mantzios, Vasilios Tsiouris, Konstantinos Kiskinis, Vangelis Economou, Evanthia Petridou, Anestis Tsitsos, Apostolos Patsias, Ioanna Apostolou, Georgios A. Papadopoulos, Ilias Giannenas, Paschalis Fortomaris
Pathogens.2023; 12(3): 381. CrossRef - Probing antimicrobial resistance and sanitizer tolerance themes and their implications for the food industry through the Listeria monocytogenes lens
Rebecca Bland, Stephanie R. B. Brown, Joy Waite‐Cusic, Jovana Kovacevic
Comprehensive Reviews in Food Science and Food Safety.2022; 21(2): 1777. CrossRef - Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for Twelve Antimicrobials (Biocides and Antibiotics) in Eight Strains of Listeria monocytogenes
Cristina Rodríguez-Melcón, Carlos Alonso-Calleja, Camino García-Fernández, Javier Carballo, Rosa Capita
Biology.2021; 11(1): 46. CrossRef - Adaptive Response of Listeria monocytogenes to the Stress Factors in the Food Processing Environment
Natalia Wiktorczyk-Kapischke, Krzysztof Skowron, Katarzyna Grudlewska-Buda, Ewa Wałecka-Zacharska, Jakub Korkus, Eugenia Gospodarek-Komkowska
Frontiers in Microbiology.2021;[Epub] CrossRef - Antimicrobial resistance associated with the use of antimicrobial processing aids during poultry processing operations: cause for concern?
Mohamed Rhouma, Pablo Romero-Barrios, Marie-Lou Gaucher, Sujinder Bhachoo
Critical Reviews in Food Science and Nutrition.2021; 61(19): 3279. CrossRef - Screening of antimicrobial synergism between phenolic acids derivatives and UV-A light radiation
Erick F. de Oliveira, Xu Yang, Nikeshala Basnayake, Cuong Nguyen Huu, Luxin Wang, Rohan Tikekar, Nitin Nitin
Journal of Photochemistry and Photobiology B: Biology.2021; 214: 112081. CrossRef - Exposure of ciprofloxacin-resistant Escherichia coli broiler isolates to subinhibitory concentrations of a quaternary ammonium compound does not increase antibiotic resistance gene transfer
H. Maertens, K. De Reu, E. Meyer, S. Van Weyenberg, J. Dewulf, E. Van Coillie
Poultry Science.2019; 98(7): 2972. CrossRef - Thermal inactivation of Salmonella Enteritidis on chicken skin previously exposed to acidified Sodium chlorite or tri-sodium phosphate
K. Karuppasamy, Ajit S. Yadav, Gaurav K. Saxena
Journal of Food Science and Technology.2015; 52(12): 8236. CrossRef - Scientific Opinion on the evaluation of the safety and efficacy of peroxyacetic acid solutions for reduction of pathogens on poultry carcasses and meat
EFSA Journal.2014;[Epub] CrossRef - Growth kinetic parameters of Gram-positive and Gram-negative bacteria on poultry treated with various chemical decontaminants
Alicia Alonso-Hernando, Carlos Alonso-Calleja, Rosa Capita
Food Control.2013; 33(2): 429. CrossRef - Decontamination treatments can increase the prevalence of resistance to antibiotics of Escherichia coli naturally present on poultry
Rosa Capita, Elena Álvarez-Fernández, Esther Fernández-Buelta, Jennifer Manteca, Carlos Alonso-Calleja
Food Microbiology.2013; 34(1): 112. CrossRef - Antibiotic-Resistant Bacteria: A Challenge for the Food Industry
Rosa Capita, Carlos Alonso-Calleja
Critical Reviews in Food Science and Nutrition.2013; 53(1): 11. CrossRef - Effects of exposure to poultry chemical decontaminants on the membrane fluidity of Listeria monocytogenes and Salmonella enterica strains
Alicia Alonso-Hernando, Carlos Alonso-Calleja, Rosa Capita
International Journal of Food Microbiology.2010; 137(2-3): 130. CrossRef - Comparison of antibiotic resistance patterns in Listeria monocytogenes and Salmonella enterica strains pre-exposed and exposed to poultry decontaminants
Alicia Alonso-Hernando, Rosa Capita, Miguel Prieto, Carlos Alonso-Calleja
Food Control.2009; 20(12): 1108. CrossRef - Comparative analysis of acid resistance in Listeria monocytogenes and Salmonella enterica strains before and after exposure to poultry decontaminants. Role of the glutamate decarboxylase (GAD) system
Alicia Alonso-Hernando, Carlos Alonso-Calleja, Rosa Capita
Food Microbiology.2009; 26(8): 905. CrossRef
- Exposure to Low Doses of Biocides Increases Resistance to Other Biocides and to Antibiotics in Strains of Listeria monocytogenes
- Dark Septate Endophyte (DSE) Fungi Isolated from Metal Polluted Soils: Their Taxonomic Position, Tolerance, and Accumulation of Heavy Metals In Vitro
- Yujie Zhang , Yan Zhang , Maojun Liu , Xiaodong Shi , Zhiwei Zhao
- J. Microbiol. 2008;46(6):624-632. Published online December 24, 2008
- DOI: https://doi.org/10.1007/s12275-008-0163-6
- 275 View
- 0 Download
- 72 Crossref
-
Abstract
PDF
- To understand the possible role of the plant root associated fungi on metal tolerance, their role in the uptake of heavy metals and the potential transfer of these metal ions to the plant, three strains of dark septate endophytic (DSE) fungi were isolated from a waste smelter site in southwest China, and one strain was isolated from a non-contaminated site. According to molecular phylogenetic analysis of the ITS 1-5.8S rDNA-ITS 2 gene regions and morphological characteristics, one is identified as Exophiala pisciphila, and the other three are non-sporulating fungi under the experiment condition with the nearest phylogenetic affinities to the Thysanorea papuana strain EU041814. Tolerance and accumulation abilities of the three DSE strains for metals were investigated in liquid culture. Minimum inhibitory concentrations (MIC) of Pb, Zn, and Cd were determined. It was demonstrated that the tolerance of the DSE strains varied between metal species and strains. The E. pisciphila strain is able to accumulate lead and cadmium over 20% and 5% of dry weight of biomass, respectively. Partial of the sequestrated metals can be washed with CaCl2. Morphological and enzyme activity changes taking place in the presence of excessive Pb, Cd, and/or Zn also indicate that the mechanism of heavy metal tolerance and accumulation of the DSE strains would be a complex process. The findings indicated promising tolerance and accumulation of the DSE strains with potential values in metal cycling and restoration of soil and water system.
-
Citations
Citations to this article as recorded by- Characterization of Fusarium crown rot pathogens and trichothecene genotypes in wheat crops of Hebei province, China
Kahsay Tadesse Mawcha, Mewael Kiros Assefa, Yiying Xu, Na Zhang, Wenxiang Yang, Dennis Ndolo
NFS Journal.2025; 39: 100230. CrossRef - Growth-Promoting Effects of Dark Septate Endophytes Fungus Acrocalymma on Tomato (Solanum lycopersicum)
Xiaoxiao Feng, Ying Jin, Zhupeiqi Zhong, Yongli Zheng, Huiming Wu
Journal of Fungi.2025; 11(7): 510. CrossRef - Dark septate endophytes : A review potential of fungi from mangrove roots (Rhizophora sp) in microplastic biodegradation
Syafrina Sari Lubis, Rina Sriwati, Surono, Suhartono
IOP Conference Series: Earth and Environmental Science.2025; 1510(1): 012010. CrossRef - Composition and Biodiversity of Culturable Endophytic Fungi in the Roots of Alpine Medicinal Plants in Xinjiang, China
Mengyan Hou, Jun Zhu, Chunyan Leng, Xinjie Huang, Mingshu Yang, Yifei Yin, Yongmei Xing, Juan Chen
Journal of Fungi.2025; 11(2): 113. CrossRef - Application prospects of dark septate endophytes and humic acid in the remediation of heavy metal contaminated soil
Zike Xue, Guohuan Xiong, Chao He, Haoyu Yue, Huajun Chen, Hongxu Zhu, Weiwei Liu
Bioresource Technology Reports.2025; 32: 102302. CrossRef - Temporal and spatial dynamics and functional metabolism of dark septate endophytes of Gymnocarpos przewalskii Maxim. in Northwest Desert, China
Min Li, Chao He, Miao Wei, Junmeng Long, Jingru Wang, Xinrong Yang, Kehan Wang, Xueli He
Applied Soil Ecology.2024; 194: 105194. CrossRef - Occurrence of dark septate endophytes in Phragmites australis in the Baiyang Lake and their resistance to Cd stress
Minghui XU, Xia LI, Qiannan YE, Feng GONG, Xueli HE
Pedosphere.2024; 34(2): 484. CrossRef - WITHDRAWN: Deciphering the mechanisms, signaling, and applications of newly isolated Cladosporium crousii SHF to alleviate the negative effects of Pb stress in tomato plants
Shifa Shaffique, Raheem Shahzad, Md Injamum Ul-Hoque, Anis Ali Shah, Sang-Mo kang, Tiba Nazar Ibrahim Al Azzawi, Byung-Wook Yun, In-Jung Lee
Plant Stress.2024; : 100666. CrossRef - The Metallotolerance and Biosorption of As(V) and Cr(VI) by Black Fungi
Cristy Medina-Armijo, Daniela Isola, Josep Illa, Anna Puerta, Marc Viñas, Francesc X. Prenafeta-Boldú
Journal of Fungi.2024; 10(1): 47. CrossRef - Characterization of dark septate endophytic fungi Periconia macrospinosa isolated from roots of sugarcane in São Paulo, Brazil
LUANA C. SILVA, ORIVALDO JOSÉ SAGGIN-JÚNIOR, MARCO AURÉLIO C. CARNEIRO, ELIANE MARIA R. DA SILVA, JERRI ÉDSON ZILLI, RICARDO LUIS L. BERBARA
Anais da Academia Brasileira de Ciências.2024;[Epub] CrossRef - Microbe-Plant Combined Remediation Technology for Heavy Metals in Soil: A Comprehensive Review
Yingbo Dong, Jing Guo, Hai Lin
Water, Air, & Soil Pollution.2024;[Epub] CrossRef - The origin of human pathogenicity and biological interactions in Chaetothyriales
Yu Quan, Shuwen Deng, Francesc X. Prenafeta-Boldủ, Veronika E. Mayer, Lucia Muggia, Agnese Cometto, Vania A. Vicente, Nickolas Menezes da Silva, Maria Eduarda Grisolia, Yinggai Song, Sarah A. Ahmed, Xueke Niu, Bruna Jacomel Favoreto de Souza Lima, Peiying
Fungal Diversity.2023; 125(1): 99. CrossRef - Regulation mechanism of plant response to heavy metal stress mediated by endophytic fungi
Jiadong Zheng, Xingguang Xie, Chunyan Li, Hongxia Wang, Yaru Yu, Baokang Huang
International Journal of Phytoremediation.2023; 25(12): 1596. CrossRef - An Endophytic Fungal Isolate Paecilomyces lilacinus Produces Bioactive Secondary Metabolites and Promotes Growth of Solanum lycopersicum under Heavy Metal Stress
Muhammad Musa, Farzana Gul Jan, Muhammad Hamayun, Gul Jan, Sumera Afzal Khan, Gauhar Rehman, Sajid Ali, In-Jung Lee
Agronomy.2023; 13(3): 883. CrossRef - Characterization of root-associated fungi and reduced plant growth in soils from a New Mexico uranium mine
Taylor A. Portman, Abigail Granath, Michael A. Mann, Eliane El Hayek, Kelsie Herzer, José M. Cerrato, Jennifer A. Rudgers
Mycologia.2023; 115(2): 165. CrossRef - Arbuscular Mycorrhizal Fungi as an Important Factor Enabling the Adaptation of Anthyllis vulneraria L. to Zn-Pb-Polluted Tailings
Marzena Sujkowska-Rybkowska, Anna Lisek, Beata Sumorok, Edyta Derkowska, Magdalena Szymańska, Lidia Sas-Paszt
Plants.2023; 12(11): 2092. CrossRef - Coronilla juncea, a native candidate for phytostabilization of potentially toxic elements and restoration of Mediterranean soils
Alma Heckenroth, Pascale Prudent, Hélène Folzer, Jacques Rabier, Stéven Criquet, Arne Saatkamp, Marie-Dominique Salducci, Laurent Vassalo, Isabelle Laffont-Schwob
Scientific Reports.2022;[Epub] CrossRef - Insights into the beneficial roles of dark septate endophytes in plants under challenging environment: resilience to biotic and abiotic stresses
Nahid Akhtar, Atif Khurshid Wani, Daljeet Singh Dhanjal, Soumya Mukherjee
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - Tannin tolerance and resistance in dark septate endophytes
G. Kernaghan, A. Griffin, J. Gailey, A. Hussain
Rhizosphere.2022; 23: 100574. CrossRef - A bZIP transcription factor VabZIP12 from blueberry induced by dark septate endocyte improving the salt tolerance of transgenic Arabidopsis
Dehui Qu, Fanlin Wu, Xiaohui Zhao, Dongzi Zhu, Liang Gu, Lina Yang, Weiwei Zhao, Yadong Sun, Jingjing Yang, Wei Tian, Hongyan Su, Lei Wang
Plant Science.2022; 315: 111135. CrossRef - The responses and detoxification mechanisms of dark septate endophytes (DSE), Exophiala salmonis, to CuO nanoparticles
Yihui Ban, Jiayuan Tan, Yang Xiong, Xiantong Mo, Wenxuan Li, Chenyue Jia, Yiwen Ding, Zhouying Xu
Environmental Science and Pollution Research.2022; 30(5): 13773. CrossRef - Comparison of response mechanism of ordinary Cordyceps militaris and domesticated Cordyceps militaris to Pb2+ stress
Qiaoying Song, Yaqi Li, Yunqin Jia, Lichao Pan, Zhen-yuan Zhu
Process Biochemistry.2021; 107: 112. CrossRef - Isolation, identification, and characterization of cadmium-tolerant endophytic fungi isolated from barley (Hordeum vulgare L.) roots and their role in enhancing phytoremediation
Leila Shadmani, Samad Jamali, Akram Fatemi
Brazilian Journal of Microbiology.2021; 52(3): 1097. CrossRef - Advances in fungal-assisted phytoremediation of heavy metals: A review
Muhammad KHALID, Saeed UR-RAHMAN, Danial HASSANI, Kashif HAYAT, Pei ZHOU, Nan HUI
Pedosphere.2021; 31(3): 475. CrossRef - Mutualism between Dark Septate Endophytes (DSEs) and their host plants under metal stress: a case study
Di Liu, Lingling Zhu, Tao Li, Zhiwei Zhao
All Life.2021; 14(1): 667. CrossRef - Full Issue PDF
Phytobiomes Journal.2021; 5(3): 249. CrossRef - Metagenomic Analysis Reveals Reduced Beneficial Microorganism Associations in Roots of Foot-Rot-Affected Citrus Trees
Chuanyu Yang, Veronica Ancona
Phytobiomes Journal.2021; 5(3): 305. CrossRef - Dark septate endophyte Falciphora oryzae-assisted alleviation of cadmium in rice
Zhen-Zhu Su, Meng-Di Dai, Jia-Nan Zhu, Xiao-Hong Liu, Lin Li, Xue-Ming Zhu, Jiao-Yu Wang, Zhi-Lin Yuan, Fu-Cheng Lin
Journal of Hazardous Materials.2021; 419: 126435. CrossRef - Transcriptome analysis for understanding the mechanism of dark septate endophyte S16 in promoting the growth and nitrate uptake of sweet cherry
Fan-lin WU, De-hui QU, Wei TIAN, Meng-yun WANG, Fei-yan CHEN, Ke-ke LI, Ya-dong SUN, Ying-hua SU, Li-na YANG, Hong-yan SU, Lei WANG
Journal of Integrative Agriculture.2021; 20(7): 1819. CrossRef - Effects of root endophytic fungus, Microdochium bolleyi on cadmium uptake, translocation and tolerance by Hordeum vulgare L.
Leila Shadmani, Samad Jamali, Akram Fatemi
Biologia.2021; 76(2): 711. CrossRef - Fungal Endophytes for Grass Based Bioremediation: An Endophytic Consortium Isolated from Agrostis stolonifera Stimulates the Growth of Festuca arundinacea in Lead Contaminated Soil
Erika Soldi, Catelyn Casey, Brian R. Murphy, Trevor R. Hodkinson
Journal of Fungi.2020; 6(4): 254. CrossRef - Effects of arbuscular mycorrhizal fungi and dark septate endophytes on maize performance and root traits under a high cadmium stress
Y.M. He, X.M. Fan, G.Q. Zhang, B. Li, T.G. Li, Y.Q. Zu, F.D. Zhan
South African Journal of Botany.2020; 134: 415. CrossRef - Vegetation drives the structure of active microbial communities on an acidogenic mine tailings deposit
Vanessa Gagnon, Michaël Rodrigue-Morin, Julien Tremblay, Jessica Wasserscheid, Julie Champagne, Jean-Philippe Bellenger, Charles W. Greer, Sébastien Roy
PeerJ.2020; 8: e10109. CrossRef - Evidence for a Dark Septate Endophyte (Exophiala Pisciphila, H93) Enhancing Phosphorus Absorption by Maize Seedlings
Runbing Xu, Tao Li, Mi Shen, Zhu L. Yang, Zhi-Wei Zhao
Plant and Soil.2020; 452(1-2): 249. CrossRef - The ameliorative effects of exogenous inoculation of Piriformospora indica on molecular, biochemical and physiological parameters of Artemisia annua L. under arsenic stress condition
Saeed-ur- Rahman, Muhammad Khalid, Sadaf-Ilyas Kayani, Kexuan Tang
Ecotoxicology and Environmental Safety.2020; 206: 111202. CrossRef - Fungal endophytes: Futuristic tool in recent research area of phytoremediation
Samapika Nandy, Tuyelee Das, Champa Keeya Tudu, Devendra Kumar Pandey, Abhijit Dey, Puja Ray
South African Journal of Botany.2020; 134: 285. CrossRef -
EpABC
Genes in the Adaptive Responses of
Exophiala pisciphila
to Metal Stress: Functional Importance and Relation to Metal Tolerance
Guan-Hua Cao, Sen He, Di Chen, Tao Li, Zhi-Wei Zhao, Emma R. Master
Applied and Environmental Microbiology.2019;[Epub] CrossRef - Dark septate endophytes improve the growth of host and non-host plants under drought stress through altered root development
Xia Li, Chao He, Xueli He, Fang Su, Lifeng Hou, Ying Ren, Yiting Hou
Plant and Soil.2019; 439(1-2): 259. CrossRef - Functional roles of fungal endophytes in host fitness during stress conditions
B. Shankar Naik
Symbiosis.2019; 79(2): 99. CrossRef - The effects of dark septate endophyte (DSE) inoculation on tomato seedlings under Zn and Cd stress
Lingling Zhu, Tao Li, Chaojun Wang, Xiaorong Zhang, Lujuan Xu, Runbing Xu, Zhiwei Zhao
Environmental Science and Pollution Research.2018; 25(35): 35232. CrossRef - Ecological Potential of Plants for Phytoremediation and Ecorestoration of Fly Ash Deposits and Mine Wastes
Gordana Gajić, Lola Djurdjević, Olga Kostić, SneŽana Jarić, Miroslava Mitrović, Pavle Pavlović
Frontiers in Environmental Science.2018;[Epub] CrossRef - Developing Sustainable Agromining Systems in Agricultural Ultramafic Soils for Nickel Recovery
Petra Susan Kidd, Aida Bani, Emile Benizri, Cristina Gonnelli, Claire Hazotte, Johannes Kisser, Maria Konstantinou, Tom Kuppens, Dimitris Kyrkas, Baptiste Laubie, Robert Malina, Jean-Louis Morel, Hakan Olcay, Tania Pardo, Marie-Noëlle Pons, Ángeles Prieto
Frontiers in Environmental Science.2018;[Epub] CrossRef - Chromium tolerance, oxidative stress response, morphological characteristics, and FTIR studies of phytopathogenic fungus Sclerotium rolfsii
Shahid Rafi, Amna Shoaib, Zoia Arshad Awan, Nayab Batool Rizvi, Nafisa, Muhammad Shafiq
Folia Microbiologica.2017; 62(3): 207. CrossRef - Differential growth promotion of poplar and birch inoculated with three dark septate endophytes in two trace element-contaminated soils
Charlotte Berthelot, Damien Blaudez, Corinne Leyval
International Journal of Phytoremediation.2017; 19(12): 1118. CrossRef - Endophytic Fungi Piriformospora indica Mediated Protection of Host from Arsenic Toxicity
Shayan Mohd, Jagriti Shukla, Aparna S. Kushwaha, Kapil Mandrah, Jai Shankar, Nidhi Arjaria, Prem N. Saxena, Ram Narayan, Somendu K. Roy, Manoj Kumar
Frontiers in Microbiology.2017;[Epub] CrossRef - Effects of a dark septate endophyte (DSE) on growth, cadmium content, and physiology in maize under cadmium stress
Yongmei He, Zhixin Yang, Mingrui Li, Ming Jiang, Fangdong Zhan, Yanqun Zu, Tao Li, Zhiwei Zhao
Environmental Science and Pollution Research.2017; 24(22): 18494. CrossRef - Effect of Dark Septate Endophytic Fungus Gaeumannomyces cylindrosporus on Plant Growth, Photosynthesis and Pb Tolerance of Maize ( Zea mays L.)
Yihui BAN, Zhouying XU, Yurong YANG, Haihan ZHANG, Hui CHEN, Ming TANG
Pedosphere.2017; 27(2): 283. CrossRef - Functions of fungal melanin beyond virulence
Radames J.B. Cordero, Arturo Casadevall
Fungal Biology Reviews.2017; 31(2): 99. CrossRef - Culturable endophytic fungal diversity in the cadmium hyperaccumulator Solanum nigrum L. and their role in enhancing phytoremediation
Abdur Rahim Khan, Muhammad Waqas, Ihsan Ullah, Abdul Latif Khan, Muhammad Aaqil Khan, In-Jung Lee, Jae-Ho Shin
Environmental and Experimental Botany.2017; 135: 126. CrossRef - Interactions of arbuscular mycorrhizal and endophytic fungi improve seedling survival and growth in post-mining waste
Katarzyna Wężowicz, Piotr Rozpądek, Katarzyna Turnau
Mycorrhiza.2017; 27(5): 499. CrossRef - Root Fungal Endophytes Enhance Heavy-Metal Stress Tolerance of Clethra barbinervis Growing Naturally at Mining Sites via Growth Enhancement, Promotion of Nutrient Uptake and Decrease of Heavy-Metal Concentration
Keiko Yamaji, Yumiko Watanabe, Hayato Masuya, Arisa Shigeto, Hiroshi Yui, Toshikatsu Haruma, Ricardo Aroca
PLOS ONE.2016; 11(12): e0169089. CrossRef - Effects of Tricyclazole on Cadmium Tolerance and Accumulation Characteristics of a Dark Septate Endophyte (DSE), Exophiala pisciphila
Fangdong Zhan, Yongmei He, Yiyan Yang, Yuan Li, Tao Li, Zhiwei Zhao
Bulletin of Environmental Contamination and Toxicology.2016; 96(2): 235. CrossRef - Plant growth promotion, metabolite production and metal tolerance of dark septate endophytes isolated from metal-polluted poplar phytomanagement sites
Charlotte Berthelot, Corinne Leyval, Julie Foulon, Michel Chalot, Damien Blaudez, Angela Sessitsch
FEMS Microbiology Ecology.2016; 92(10): fiw144. CrossRef - Functional and transcript analysis of a novel metal transporter gene EpNramp from a dark septate endophyte (Exophiala pisciphila)
Yun-Fang Wei, Tao Li, Ling-Fei Li, Jun-Ling Wang, Guan-Hua Cao, Zhi-Wei Zhao
Ecotoxicology and Environmental Safety.2016; 124: 363. CrossRef - Unraveling the role of dark septate endophyte (DSE) colonizing maize (Zea mays) under cadmium stress: physiological, cytological and genic aspects
Jun-ling Wang, Tao Li, Gao-yuan Liu, Joshua M. Smith, Zhi-wei Zhao
Scientific Reports.2016;[Epub] CrossRef - Identification of Glutathione S-Transferase (GST) Genes from a Dark Septate Endophytic Fungus (Exophiala pisciphila) and Their Expression Patterns under Varied Metals Stress
Mi Shen, Da-Ke Zhao, Qin Qiao, Lei Liu, Jun-Ling Wang, Guan-Hua Cao, Tao Li, Zhi-Wei Zhao, Prabodh Kumar Trivedi
PLOS ONE.2015; 10(4): e0123418. CrossRef - Characterization of cadmium-resistant endophytic fungi from Salix variegata Franch. in Three Gorges Reservoir Region, China
Hongmei An, Yan Liu, Xinfei Zhao, Qian Huang, Shenhong Yuan, Xingyong Yang, Jinyan Dong
Microbiological Research.2015; 176: 29. CrossRef - Subcellular distribution and chemical forms of cadmium in a dark septate endophyte (DSE), Exophiala pisciphila
Fangdong Zhan, Yongmei He, Yuan Li, Tao Li, Yun-Ya Yang, Gurpal S. Toor, Zhiwei Zhao
Environmental Science and Pollution Research.2015; 22(22): 17897. CrossRef - Diverse strategies conferring extreme cadmium (Cd) tolerance in the dark septate endophyte (DSE), Exophiala pisciphila: Evidence from RNA-seq data
Dake Zhao, Tao Li, Mi shen, Junling Wang, Zhiwei Zhao
Microbiological Research.2015; 170: 27. CrossRef - Tolerance and Antioxidant Response of a Dark Septate Endophyte (DSE), Exophiala pisciphila, to Cadmium Stress
Fangdong Zhan, Yongmei He, Tao Li, Yun-ya Yang, Gurpal S. Toor, Zhiwei Zhao
Bulletin of Environmental Contamination and Toxicology.2015; 94(1): 96. CrossRef - Diversity and characterization of Cd-tolerant dark septate endophytes (DSEs) associated with the roots of Nepal alder (Alnus nepalensis) in a metal mine tailing of southwest China
Runbing Xu, Tao Li, Hongliang Cui, Junling Wang, Xin Yu, Yanhua Ding, Chaojun Wang, Zhuliang Yang, Zhiwei Zhao
Applied Soil Ecology.2015; 93: 11. CrossRef - Zinc Accumulation Characteristics of Two Exophiala Strains and Their Antioxidant Response to Zn<sup>2+</sup> Stress
Y. H. Diao, T. Li, Z. W. Zhao
Journal of Environmental Protection.2013; 04(04): 12. CrossRef - The effect of endophytic Peyronellaea from heavy metal-contaminated and uncontaminated sites on maize growth, heavy metal absorption and accumulation
Mi Shen, Li Liu, Dong-Wei Li, Wen-Na Zhou, Zuo-Ping Zhou, Chang-Fei Zhang, Yi-Yong Luo, Hong-Bin Wang, Hai-Yan Li
Fungal Ecology.2013; 6(6): 539. CrossRef - Colonization Characteristics and Composition of Dark Septate Endophytes (DSE) in a Lead and Zinc Slag Heap in Southwest China
Yan Zhang, Tao Li, Zhi-Wei Zhao
Soil and Sediment Contamination: An International Journal.2013; 22(5): 532. CrossRef - Prediction of Reservoir Performance Applying Decline Curve Analysis
Khulud M. Rahuma, H. Mohamed, N. Hissein, S. Giuma
International Journal of Chemical Engineering and Applications.2013; : 74. CrossRef - Diversity and heavy metal tolerance of endophytic fungi from six dominant plant species in a Pb–Zn mine wasteland in China
Hai-Yan Li, Dong-Wei Li, Cai-Mei He, Zuo-Ping Zhou, Tao Mei, Hong-Mei Xu
Fungal Ecology.2012; 5(3): 309. CrossRef - The Response of Dark Septate Endophytes (DSE) to Heavy Metals in Pure Culture
Yihui Ban, Ming Tang, Hui Chen, Zhouying Xu, Haihan Zhang, Yurong Yang, Vishal Shah
PLoS ONE.2012; 7(10): e47968. CrossRef - Improved tolerance of maize (Zea mays L.) to heavy metals by colonization of a dark septate endophyte (DSE) Exophiala pisciphila
T. Li, M.J. Liu, X.T. Zhang, H.B. Zhang, T. Sha, Z.W. Zhao
Science of The Total Environment.2011; 409(6): 1069. CrossRef - Symbiotic fungi in roots ofArtemisia annuawith special reference to endophytic colonizers
Z. L. Yuan, Y. C. Chen, X. J. Ma
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology.2011; 145(2): 495. CrossRef - Characterization of melanin isolated from a dark septate endophyte (DSE), Exophiala pisciphila
Fangdong Zhan, Yongmei He, Yanqun Zu, Tao Li, Zhiwei Zhao
World Journal of Microbiology and Biotechnology.2011; 27(10): 2483. CrossRef - A 60-year journey of mycorrhizal research in China: Past, present and future directions
XinHua He, YingHua Duan, YingLong Chen, MingGang Xu
Science China Life Sciences.2010; 53(12): 1374. CrossRef -
Identity, Diversity, and Molecular Phylogeny of the Endophytic Mycobiota in the Roots of Rare Wild Rice (
Oryza granulate
) from a Nature Reserve in Yunnan, China
Zhi-lin Yuan, Chu-long Zhang, Fu-cheng Lin, Christian P. Kubicek
Applied and Environmental Microbiology.2010; 76(5): 1642. CrossRef
- Characterization of Fusarium crown rot pathogens and trichothecene genotypes in wheat crops of Hebei province, China
- Cys-92, Cys-95, and the C-Terminal 12 Residues of the Vibrio harveyi Ferric Uptake Regulator (Fur) are Functionally Inessential
- Kun Sun , Shuang Cheng , Min Zhang , Fang Wang , Li Sun
- J. Microbiol. 2008;46(6):670-680. Published online December 24, 2008
- DOI: https://doi.org/10.1007/s12275-008-0113-3
- 282 View
- 0 Download
- 10 Crossref
-
Abstract
PDF
- Ferric uptake regulator (Fur) is a global regulator involved in multiple aspects of bacterial life. The gene encoding the Vibrio harveyi Fur (FurVh) was cloned from a pathogenic V. harveyi strain isolated from diseased fish. FurVh shares 77% overall sequence identity with the Escherichia coli Fur (FurEc) and could complement a mutant of FurEc. Like FurEc, FurVh possesses two cysteine residues at positions 92 and 95, yet unlike FurEc, in which these cysteine residues constitute part of the metal ion coordination site and hence are vital to the repressor activity, C92 and C95 of FurVh proved to be functionally inessential. Further study identified a Vibrio Fur signature sequence, which is preserved in all the ten Vibrio Fur proteins that have been discovered to date but in none of the non-vibrio Fur proteins. Site-directed and random mutation analyses of the signature residues, the cysteine residues, and seven highly charged amino acid residues indicated that D9, H32, C137, and K138 of FurVh are functionally important but D9, C137, and K138 can be replaced by more than one functional substitutes. Systematic deletion analysis demonstrated that the C-terminal 12 residues of FurVh are functionally inessential. These results (i) indicated that the activation mechanism, or certain aspects of which, of FurVh is possibly different from that of FurEc; and (ii) suggested that it is not very likely that the C-terminal 12 residues play any significant role in the activation or stability of FurVh; and (iii) provided insights into the potential function of the local structure involving C137 and K138.
-
Citations
Citations to this article as recorded by- Comparative analysis of the survival and gene expression of pathogenic strainsVibrio harveyiafter starvation
Jingjing Sun, Xiaojian Gao, Jiang Qun, Xuedi Du, Keran Bi, Xiaojun Zhang, Li Lin, Alejandra Bravo
FEMS Microbiology Letters.2016; 363(22): fnw250. CrossRef - The FUR (ferric uptake regulator) superfamily: Diversity and versatility of key transcriptional regulators
María F. Fillat
Archives of Biochemistry and Biophysics.2014; 546: 41. CrossRef - DNA adenine methylase is involved in the pathogenesis of Edwardsiella tarda
Kun Sun, Xu-dong Jiao, Min Zhang, Li Sun
Veterinary Microbiology.2010; 141(1-2): 149. CrossRef - Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)
Hege Lynum Pedersen, Rafi Ahmad, Ellen Kristin Riise, Hanna-Kirsti Schrøder Leiros, Stefan Hauglid, Sigrun Espelid, Bjøn Olav Brandsdal, Ingar Leiros, Nils-Peder Willassen, Peik Haugen
The Journal of Microbiology.2010; 48(2): 174. CrossRef - Helicobacter pylori apo-Fur regulation appears unconserved across species
Shana Miles, Beth M. Carpenter, Hanan Gancz, D. Scott Merrell
The Journal of Microbiology.2010; 48(3): 378. CrossRef - Construction of an attenuated Pseudomonas fluorescens strain and evaluation of its potential as a cross-protective vaccine
Huan-ran Wang, Yong-hua Hu, Wei-wei Zhang, Li Sun
Vaccine.2009; 27(30): 4047. CrossRef - A ZnS4 Structural Zinc Site in the Helicobacter pylori Ferric Uptake Regulator
Sylvia Vitale, Caroline Fauquant, David Lascoux, Kristine Schauer, Christine Saint-Pierre, Isabelle Michaud-Soret
Biochemistry.2009; 48(24): 5582. CrossRef - Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co‐ordination
Md. Arif Sheikh, Garry L. Taylor
Molecular Microbiology.2009; 72(5): 1208. CrossRef - Attenuation ofEdwardsiella tardaVirulence by Small Peptides That Interfere with LuxS/Autoinducer Type 2 Quorum Sensing
Min Zhang, Xu-dong Jiao, Yong-hua Hu, Li Sun
Applied and Environmental Microbiology.2009; 75(12): 3882. CrossRef - Domain analysis of the Edwardsiella tarda ferric uptake regulator
Kun Sun, Shuang Cheng, Fang Wang, Li Sun
The Journal of General and Applied Microbiology.2009; 55(5): 351. CrossRef
- Comparative analysis of the survival and gene expression of pathogenic strainsVibrio harveyiafter starvation
- Phylogenetic Diversity of Acidophilic Sporoactinobacteria Isolated from Various Soils
- Sung-Heun Cho , Ji-Hye Han , Chi Nam Seong , Seung Bum Kim
- J. Microbiol. 2006;44(6):600-606.
- DOI: https://doi.org/2468 [pii]
- 181 View
- 0 Download
-
Abstract
PDF
- Spore forming actinobacteria (sporoactinobacteria) isolated from soils with an acidic pH in Pinus thunbergii forests and coal mine waste were subjected to taxonomic characterization. For the isolation of acidophilic actinobacteria, acidified starch casein agar (pH adjusted to 4-5) was used. The numbers of actinobacteria growing in acidic media were between 3.2 × 104 and 8.0 × 106 CFU/g soil. Forty three acidophilic actinobacterial strains were isolated and their 16S rDNA sequences were determined. The isolates were divided into eight distinctive phylogenetic clusters within the variation encompassed by the family Streptomycetaceae. Four clusters among them were assigned to the genus Streptacidiphilus, whereas the remaining four were assigned to Streptomyces. The clusters belonging to either Streptomyces or Streptacidiphilus did not form monophyletic clade. The growth pH profiles indicated that the representative isolates grew best between pH 5 and 6. It is evident from this study that acidity has played a critical role in the differentiation of the family Streptomycetaceae, and also that different mechanisms might have resulted in the evolution of two groups, Streptacidiphilus (strict acidophiles) and neutrotolerant acidophilic Streptomyces. The effect of geographic separation was clearly seen among the Streptacidiphilus isolates, which may be a key factor in speciation of the genus.
- Identification and Expression of the cym, cmt, and tod Catabolic Genes from Pseudomonas putida KL47: Expression of the Regulatory todST Genes as a Factor for Catabolic Adaptation
- Kyoung Lee , Eun Kyeong Ryu , Kyung Soon Choi , Min Chul Cho , Jae Jun Jeong , Eun Na Choi , Soo O Lee , Do-Young Yoon , Ingyu Hwang , Chi-Kyung Kim
- J. Microbiol. 2006;44(2):192-199.
- DOI: https://doi.org/2365 [pii]
- 235 View
- 0 Download
-
Abstract
PDF
- Pseudomonas putida KL47 is a natural isolate that assimilates benzene, 1-alkylbenzene (C1-C4), biphenyl, p-cumate, and p-cymene. The genetic background of strain KL47 underlying the broad range of growth substrates was examined. It was found that the cym and cmt operons are constitutively expressed due to a lack of the cymR gene, and the tod operon is still inducible by toluene and biphenyl. The entire array of gene clusters responsible for the catabolism of toluene and p-cymene/p-cumate has been cloned in a cosmid vector, pLAFR3, and were named pEK6 and pEK27, respectively. The two inserts overlap one another and the nucleotide sequence (42,505 bp) comprising the cym, cmt, and tod operons and its flanking genes in KL47 are almost identical (>99%) to those of P. putida F1. In the cloned DNA fragment, two genes with unknown functions, labeled cymZ and cmtR, were newly identified and show high sequence homology to dienelactone hydrolase and CymR proteins, respectively. The cmtR gene was identified in the place of the cmtI gene of previous annotation. Western blot analysis showed that, in strains F1 and KL47, the todT gene is not expressed during growth on Luria Bertani medium. In minimal basal salt medium, expression of the todT gene is inducible by toluene, but not by biphenyl in strain F1; however, it is constantly expressed in strain KL47, indicating that high levels of expression of the todST genes with one amino acid substitution in TodS might provide strain KL47 with a means of adaptation of the tod catabolic operon to various aromatic hydrocarbons.
- A Proteomic Approach to Study msDNA Function in Escherichia coli
- Mi-Ae Jeong , Dongbin Lim
- J. Microbiol. 2004;42(3):200-204.
- DOI: https://doi.org/2089 [pii]
- 217 View
- 0 Download
-
Abstract
PDF
- Retron is a prokaryotic genetic element that produces multicopy single-stranded DNA covalently linked to RNA (msDNA) by a reverse transcriptase. It was found that cells producing a large amount of msDNA, rather than those that did not, showed a higher rate of mutation. In order to understand the molecular mechanism connecting msDNA production to the high mutation rate the protein patterns were compared by two dimensional gel electrophoresis. Ten proteins were found to be differentially expressed at levels more than three fold greater in cells with than without msDNA, nine of which were identified by MALDI TOF MS. Eight of the nine identified proteins were repressed in msDNA-producing cells and, surprisingly, most were proteins functioning in the dissimilation of various carbon sources. One protein was induced four fold greater in the msDNA producing cells and was identified as a 30S ribosomal protein S2 involved in the regulation of translation. The molecular mechanism underlying the elevated mutation in msDNA-producing cell still remains elusive.
Review
- The Use of the Rare UUA Codon to Define "Expression Space" for Genes Involved in Secondary Metabolism, Development and Environmental Adaptation in Streptomyces
- Keith F. Chater , Govind Chandra
- J. Microbiol. 2008;46(1):1-11.
- DOI: https://doi.org/10.1007/s12275-007-0233-1
- 369 View
- 1 Download
- 110 Crossref
-
Abstract
PDF
- In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development, as revealed by the phenotypes of bldA mutants in diverse streptomycetes. This article is a comprehensive review of out understanding of this unusual situation. Based on information from four sequenced genomes it now appears that, typically, about 2~3% of genes in any one streptomycete contain a TTA codon, most having been acquired through species-specific horizontal gene transfer. Among the few widely conserved TTA-containing genes, mutations in just one, the pleiotropic regulatory gene adpA, give an obvious phenotype: such mutants are defective in aerial growth and sporulation, but vary in the extent of their impairment in secondary metabolism in different streptomycetes. The TTA codon in adpA is largely responsible for the morphological phenotype of a bldA mutant of S. coelicolor. AdpA-dependent targets include several genes involved in the integrated action of extracellular proteases that, at least in some species, are involved in the conversion of primary biomass into spores. The effects of bldA mutations on secondary metabolism are mostly attributable to the presence of TTA codons in pathway-specific genes, particularly in transcriptional activator genes. This is not confined to S. coelicolor-it is true for about half of all known antibiotic biosynthetic gene sets from streptomycetes. Combined microarray and proteomic analysis of liquid (and therefore non-sporulating) S. coelicolor bldA mutant cultures revealed effects of the mutation during rapid growth, during transition phase, and in stationary phase. Some of these effects may be secondary consequences of changes in the pattern of ppGpp accumulation. It is argued that the preferential accumulation of the bldA tRNA under conditions in which growth is significantly constrained has evolved to favour the expression of genes that confer adaptive benefits in intermittently encountered sub-optimal environments. The evolution of this system may have been a secondary consequence of the selective pressure exerted by bacteriophage attack. Some biotechnological implications of bldA phenomenology are considered.
-
Citations
Citations to this article as recorded by- Regulatory orchestration of FK506 biosynthesis in Streptomyces tsukubaensis NRRL 18488 revealed through systematic analysis
Namil Lee, Woori Kim, Ji Hun Kim, Yongjae Lee, Soonkyu Hwang, Gahyeon Kim, Hyeseong Kim, Qingyun Dan, Matthias Schmidt, Yeo Joon Yoon, Suhyung Cho, Bernhard Palsson, Jay D. Keasling, Byung-Kwan Cho
iScience.2025; 28(6): 112698. CrossRef - Research progress on AdpA: a pleiotropic regulator for <?A3B2 pi6?><italic>Streptomyces</italic> antibiotic synthesis
QingQing TIAN, JiaHan GANG, LiuXi WANG, ChunMei DU
SCIENTIA SINICA Vitae.2025; 55(11): 2434. CrossRef - CRISPR-aided genome engineering for secondary metabolite biosynthesis in Streptomyces
Yongjae Lee, Soonkyu Hwang, Woori Kim, Ji Hun Kim, Bernhard O Palsson, Byung-Kwan Cho
Journal of Industrial Microbiology and Biotechnology.2024;[Epub] CrossRef - A new peucemycin derivative and impacts of peuR and bldA on peucemycin biosynthesis in Streptomyces peucetius
Rubin Thapa Magar, Van Thuy Thi Pham, Purna Bahadur Poudel, Adzemye Fovennso Bridget, Jae Kyung Sohng
Applied Microbiology and Biotechnology.2024;[Epub] CrossRef - Regulation of virulence mechanisms in plant-pathogenic Streptomyces
Corrie V. Vincent, Dawn R.D. Bignell
Canadian Journal of Microbiology.2024; 70(6): 199. CrossRef - Unraveling the Biosynthetic Logic Behind the Production of Ramoplanin and Related Lipodepsipeptide Antibiotics
Oleksandr Yushchuk, Kseniia Zhukrovska, Elisa Binda, Flavia Marinelli
Fermentation.2024; 10(11): 544. CrossRef - Promoter engineering of natural product biosynthetic gene clusters in actinomycetes: concepts and applications
Chang-Hun Ji, Hyun-Woo Je, Hiyoung Kim, Hahk-Soo Kang
Natural Product Reports.2024; 41(4): 672. CrossRef - Analysis of the cryptic biosynthetic gene cluster encoding the RiPP curacozole reveals a phenylalanine-specific peptide hydroxylase
Samantha Hollands, Julia Tasch, David J. Simon, Dimah Wassouf, Isobel Barber, Arne Gessner, Andreas Bechthold, David L. Zechel
Chemical Science.2024; 15(47): 19858. CrossRef - Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts
Shiwen Qiu, Bowen Yang, Zilong Li, Shanshan Li, Hao Yan, Zhenguo Xin, Jingfang Liu, Xuejin Zhao, Lixin Zhang, Wensheng Xiang, Weishan Wang
Metabolic Engineering.2024; 81: 210. CrossRef - A panoramic view of the genomic landscape of the genus Streptomyces
Marios Nikolaidis, Andrew Hesketh, Nikoletta Frangou, Dimitris Mossialos, Yves Van de Peer, Stephen G. Oliver, Grigorios D. Amoutzias
Microbial Genomics .2023;[Epub] CrossRef - Deciphering host–pathogen interaction during Streptomyces spp. infestation of potato
Ihtisham Ul Haq, Zahid Mukhtar, Muhammad Anwar-ul-Haq, Sana Liaqat
Archives of Microbiology.2023;[Epub] CrossRef -
Comparative genomics of the niche-specific plant pathogen
Streptomyces ipomoeae
reveal novel genome content and organization
Natasha R. Soares, José C. Huguet-Tapia, Dongli Guan, Christopher A. Clark, Kuei-Ting Yang, Olivia R. Kluchka, Raju S. Thombal, Rendy Kartika, Jonathan H. Badger, Gregg S. Pettis, Isaac Cann
Applied and Environmental Microbiology.2023;[Epub] CrossRef - Global Effects of the Developmental Regulator BldB in Streptomyces venezuelae
Marieta M. Avramova, Clare E. M. Stevenson, Govind Chandra, Neil A. Holmes, Matthew J. Bush, Kim C. Findlay, Mark J. Buttner, George O'Toole
Journal of Bacteriology.2023;[Epub] CrossRef -
Streptomyces
rare codon UUA: from features associated with 2
adpA
related locations to candidate phage regulatory translational bypassing
Ivan V. Antonov, Sinéad O’Loughlin, Alessandro N. Gorohovski, Patrick B.F. O’Connor, Pavel V. Baranov, John F. Atkins
RNA Biology.2023; 20(1): 926. CrossRef - Multi-omic characterisation ofStreptomyces hygroscopicusNRRL 30439: detailed assessment of its secondary metabolic potential
Craig P. Barry, Rosemary Gillane, Gert H. Talbo, Manual Plan, Robin Palfreyman, Andrea K Haber-Stuk, John Power, Lars K Nielsen, Esteban Marcellin
Molecular Omics.2022; 18(3): 226. CrossRef - System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact onStreptomycesDevelopment
Chao Du, Joost Willemse, Amanda M. Erkelens, Victor J. Carrion, Remus T. Dame, Gilles P. van Wezel, Jeroen Raes
mSystems.2022;[Epub] CrossRef - AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus
Rui Huang, Honglu Liu, Wanwan Zhao, Siqi Wang, Shufang Wang, Jun Cai, Chao Yang
Microbial Cell Factories.2022;[Epub] CrossRef - WITHDRAWN: Interplay between non-coding RNA transcription, stringent phenotype and antibiotic production in Streptomyces
Eva Pinatel, Matteo Calcagnile, Adelfia Talà, Fabrizio Damiano, Luisa Siculella, Clelia Peano, Giuseppe Egidio De Benedetto, Antonio Pennetta, Gianluca De Bellis, Pietro Alifano
Journal of Biotechnology.2022;[Epub] CrossRef - A new bacterial tRNA enhances antibiotic production in Streptomyces by circumventing inefficient wobble base-pairing
Ximing Chen, Shuyan Li, Binglin Zhang, Haili Sun, Jinxiu Wang, Wei Zhang, Wenbo Meng, Tuo Chen, Paul Dyson, Guangxiu Liu
Nucleic Acids Research.2022; 50(12): 7084. CrossRef - Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue
Yingzi Tan, Miao Wang, Yijun Chen
ACS Synthetic Biology.2022; 11(1): 85. CrossRef - Genetic approaches to improve clorobiocin production in Streptomyces roseochromogenes NRRL 3504
Sofia Melnyk, Anastasia Stepanyshyn, Oleksandr Yushchuk, Michael Mandler, Iryna Ostash, Oksana Koshla, Victor Fedorenko, Daniel Kahne, Bohdan Ostash
Applied Microbiology and Biotechnology.2022; 106(4): 1543. CrossRef - Biological Functions and Applications of Virus-Related Bacterial Nanoparticles: A Review
Toshiki Nagakubo
International Journal of Molecular Sciences.2022; 23(5): 2595. CrossRef -
Cryptic specialized metabolites drive
Streptomyces
exploration and provide a competitive advantage during growth with other microbes
Evan M. F. Shepherdson, Marie A. Elliot
Proceedings of the National Academy of Sciences.2022;[Epub] CrossRef - Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii
Zhong Li, Shuai Li, Lei Du, Xingwang Zhang, Yuanyuan Jiang, Wenhua Liu, Wei Zhang, Shengying Li
Marine Drugs.2021; 19(1): 29. CrossRef - Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes
Namil Lee, Soonkyu Hwang, Woori Kim, Yongjae Lee, Ji Hun Kim, Suhyung Cho, Hyun Uk Kim, Yeo Joon Yoon, Min-Kyu Oh, Bernhard O. Palsson, Byung-Kwan Cho
Natural Product Reports.2021; 38(7): 1330. CrossRef - Interplay between Non-Coding RNA Transcription, Stringent/Relaxed Phenotype and Antibiotic Production in Streptomyces ambofaciens
Eva Pinatel, Matteo Calcagnile, Adelfia Talà, Fabrizio Damiano, Luisa Siculella, Clelia Peano, Giuseppe Egidio De Benedetto, Antonio Pennetta, Gianluca De Bellis, Pietro Alifano
Antibiotics.2021; 10(8): 947. CrossRef - Transcriptional Regulation of Congocidine (Netropsin) Biosynthesis and Resistance
Audrey Vingadassalon, Florence Lorieux, Maud Juguet, Alba Noël, Luisa D. F. Santos, Laura Marin Fernandez, Jean-Luc Pernodet, Stéphanie Bury-Moné, Sylvie Lautru, Maia Kivisaar
Applied and Environmental Microbiology.2021;[Epub] CrossRef - AdpA Positively Regulates Morphological Differentiation and Chloramphenicol Biosynthesis in Streptomyces venezuelae
Małgorzata Płachetka, Michał Krawiec, Jolanta Zakrzewska-Czerwińska, Marcin Wolański, Jeffrey A. Gralnick
Microbiology Spectrum.2021;[Epub] CrossRef - The Use of the Rare TTA Codon in Streptomyces Genes: Significance of the Codon Context?
Serhii Silov, Nestor Zaburannyi, Maria Anisimova, Bohdan Ostash
Indian Journal of Microbiology.2021; 61(1): 24. CrossRef - Activation of cryptic milbemycin A4 production in Streptomyces sp. BB47 by the introduction of a functional bldA gene
Nana Matsui, Shizuka Kawakami, Dai Hamamoto, Sayuri Nohara, Reina Sunada, Watanalai Panbangred, Yasuhiro Igarashi, Takuya Nihira, Shigeru Kitani
The Journal of General and Applied Microbiology.2021; 67(6): 240. CrossRef - The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production in Streptomyces lividans
Noriyasu Shikura, Emmanuelle Darbon, Catherine Esnault, Ariane Deniset-Besseau, Delin Xu, Clara Lejeune, Eric Jacquet, Naima Nhiri, Laila Sago, David Cornu, Sebastiaan Werten, Cécile Martel, Marie-Joelle Virolle
Antibiotics.2021; 10(3): 325. CrossRef - The Streptomyces filipinensis Gamma-Butyrolactone System Reveals Novel Clues for Understanding the Control of Secondary Metabolism
Eva G. Barreales, Tamara D. Payero, Ester Jambrina, Jesús F. Aparicio, Rebecca E. Parales
Applied and Environmental Microbiology.2020;[Epub] CrossRef - Phenazine-1-carboxylic acid-producing Pseudomonas synxantha LBUM223 alters the transcriptome of Streptomyces scabies, the causal agent of potato common scab
Tanya Arseneault, Roxane Roquigny, Amy Novinscak, Claudia Goyer, Martin Filion
Physiological and Molecular Plant Pathology.2020; 110: 101480. CrossRef - The Identification and Conservation of Tunicaminyluracil-Related Biosynthetic Gene Clusters in Several Rathayibacter Species Collected From Australia, Africa, Eurasia, and North America
Matthew A. Tancos, Aaron J. Sechler, Edward W. Davis, Jeff H. Chang, Brenda K. Schroeder, Timothy D. Murray, Elizabeth E. Rogers
Frontiers in Microbiology.2020;[Epub] CrossRef - Gene miaA for post‐transcriptional modification of tRNAXXA is important for morphological and metabolic differentiation in Streptomyces
Oksana Koshla, Oleksandr Yushchuk, Iryna Ostash, Yuriy Dacyuk, Maksym Myronovskyi, Gunilla Jäger, Roderich D. Süssmuth, Andriy Luzhetskyy, Anders Byström, Leif A. Kirsebom, Bohdan Ostash
Molecular Microbiology.2019; 112(1): 249. CrossRef - Gene ssfg_01967 (miaB) for tRNA modification influences morphogenesis and moenomycin biosynthesis in Streptomyces ghanaensis ATCC14672
Yuliia Sehin, Oksana Koshla, Yuriy Dacyuk, Ruoxia Zhao, Robert Ross, Maksym Myronovskyi, Patrick A. Limbach, Andriy Luzhetskyy, Suzanne Walker, Victor Fedorenko, Bohdan Ostash
Microbiology.2019; 165(2): 233. CrossRef - LeuRS can leucylate type I and type II tRNALeus in Streptomyces coelicolor
Jia-Yi Fan, Qian Huang, Quan-Quan Ji, En-Duo Wang
Nucleic Acids Research.2019; 47(12): 6369. CrossRef - Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452
Songya Zhang, Dennis Klementz, Jing Zhu, Roman Makitrynskyy, A.R. Ola Pasternak, Stefan Günther, David L. Zechel, Andreas Bechthold
Journal of Biotechnology.2019; 292: 23. CrossRef - Genomic Insights into Evolution of AdpA Family Master Regulators of Morphological Differentiation and Secondary Metabolism in Streptomyces
Mariia Rabyk, Oleksandr Yushchuk, Ihor Rokytskyy, Maria Anisimova, Bohdan Ostash
Journal of Molecular Evolution.2018; 86(3-4): 204. CrossRef - Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis
Bingbing Hou, Liyuan Tao, Xiaoyu Zhu, Wei Wu, Meijin Guo, Jiang Ye, Haizhen Wu, Huizhan Zhang
Applied Microbiology and Biotechnology.2018; 102(9): 4101. CrossRef - Genome-guided exploration of metabolic features of Streptomyces peucetius ATCC 27952: past, current, and prospect
Nguyen Huy Thuan, Dipesh Dhakal, Anaya Raj Pokhrel, Luan Luong Chu, Thi Thuy Van Pham, Anil Shrestha, Jae Kyung Sohng
Applied Microbiology and Biotechnology.2018; 102(10): 4355. CrossRef - Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters
Dimitris Kallifidas, Guangde Jiang, Yousong Ding, Hendrik Luesch
Microbial Cell Factories.2018;[Epub] CrossRef - In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24
Lan Yan, Qizhong Zhang, Marie-Joelle Virolle, Delin Xu, Dongsheng Zhou
PLOS ONE.2017; 12(3): e0174781. CrossRef -
Tracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen
Streptomyces scabies
Samuel Jourdan, Isolde M. Francis, Benoit Deflandre, Rosemary Loria, Sébastien Rigali, Karen L. Visick
mSphere.2017;[Epub] CrossRef - Properties of Streptomyces albus J1074 mutant deficient in tRNALeu UAA gene bldA
Oksana Koshla, Maria Lopatniuk, Ihor Rokytskyy, Oleksandr Yushchuk, Yuriy Dacyuk, Victor Fedorenko, Andriy Luzhetskyy, Bohdan Ostash
Archives of Microbiology.2017; 199(8): 1175. CrossRef - Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis
Nestor Zaburannyi, Boyke Bunk, Josef Maier, Jörg Overmann, Rolf Müller, C. Vieille
Applied and Environmental Microbiology.2016; 82(6): 1945. CrossRef - Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation
Barbara Gorgoni, Luca Ciandrini, Matthew R. McFarland, M. Carmen Romano, Ian Stansfield
Nucleic Acids Research.2016; : gkw630. CrossRef - Overexpression of a pathway specific negative regulator enhances production of daunorubicin in bldA deficient Streptomyces peucetius ATCC 27952
Anaya Raj Pokhrel, Amit Kumar Chaudhary, Hue Thi Nguyen, Dipesh Dhakal, Tuoi Thi Le, Anil Shrestha, Kwangkyoung Liou, Jae Kyung Sohng
Microbiological Research.2016; 192: 96. CrossRef - Identification and engineering of regulation-related genes toward improved kasugamycin production
Chenchen Zhu, Qianjin Kang, Linquan Bai, Lin Cheng, Zixin Deng
Applied Microbiology and Biotechnology.2016; 100(4): 1811. CrossRef - Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
John F. Atkins, Gary Loughran, Pramod R. Bhatt, Andrew E. Firth, Pavel V. Baranov
Nucleic Acids Research.2016; : gkw530. CrossRef - Development of an Unnatural Amino Acid Incorporation System in the Actinobacterial Natural Product Producer Streptomyces venezuelae ATCC 15439
Jingxuan He, Briana Van Treeck, Han B. Nguyen, Charles E. Melançon
ACS Synthetic Biology.2016; 5(2): 125. CrossRef - The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5
Qing Yan, Benjamin Philmus, Cedar Hesse, Max Kohen, Jeff H. Chang, Joyce E. Loper
Frontiers in Microbiology.2016;[Epub] CrossRef - Recent advances in understanding Streptomyces
Keith F. Chater
F1000Research.2016; 5: 2795. CrossRef - Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains
Arne Gessner, Tanja Heitzler, Songya Zhang, Christine Klaus, Renato Murillo, Hanna Zhao, Stephanie Vanner, David L. Zechel, Andreas Bechthold
ChemBioChem.2015; 16(15): 2244. CrossRef - Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway
Carolina Cano‐Prieto, Raúl García‐Salcedo, Marina Sánchez‐Hidalgo, Alfredo F. Braña, Hans‐Peter Fiedler, Carmen Méndez, José A. Salas, Carlos Olano
ChemBioChem.2015; 16(10): 1461. CrossRef - Identification of BagI as a positive transcriptional regulator of bagremycin biosynthesis in engineered Streptomyces sp. Tü 4128
Feng Liu, Dakui Xu, Yuchen Zhang, Yunxia Zhu, Jiang Ye, Huizhan Zhang
Microbiological Research.2015; 173: 18. CrossRef - Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering
Pietro Alifano, Carla Palumbo, Daniela Pasanisi, Adelfia Talà
Journal of Biotechnology.2015; 202: 60. CrossRef - Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning
Pavel V. Baranov, John F. Atkins, Martina M. Yordanova
Nature Reviews Genetics.2015; 16(9): 517. CrossRef - The Gene bldA, a Regulator of Morphological Differentiation and Antibiotic Production in Streptomyces
Stefanie Hackl, Andreas Bechthold
Archiv der Pharmazie.2015; 348(7): 455. CrossRef - Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor
Corey L. Compton, Michael S. Fernandopulle, Rohith T. Nagari, Jason K. Sello, W. W. Metcalf
Journal of Bacteriology.2015; 197(17): 2747. CrossRef - c-di-GMP signalling and the regulation of developmental transitions in streptomycetes
Matthew J. Bush, Natalia Tschowri, Susan Schlimpert, Klas Flärdh, Mark J. Buttner
Nature Reviews Microbiology.2015; 13(12): 749. CrossRef - Construction and development of a novel expression system of Streptomyces
Chengran Guan, Wenjing Cui, Xiaotian He, Xu Hu, Jun Xu, Guocheng Du, Jian Chen, Zhemin Zhou
Protein Expression and Purification.2015; 113: 17. CrossRef - Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism
Aurélie Guyet, Nadia Benaroudj, Caroline Proux, Myriam Gominet, Jean-Yves Coppée, Philippe Mazodier
BMC Microbiology.2014;[Epub] CrossRef - Thaxtomin A Production and Virulence Are Controlled by Several bld Gene Global Regulators in Streptomyces scabies
Dawn R. D. Bignell, Isolde M. Francis, Joanna K. Fyans, Rosemary Loria
Molecular Plant-Microbe Interactions®.2014; 27(8): 875. CrossRef - Developmental biology ofStreptomycesfrom the perspective of 100 actinobacterial genome sequences
Govind Chandra, Keith F. Chater
FEMS Microbiology Reviews.2014; 38(3): 345. CrossRef - The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control
Zahra Salehi-Najafabadi, Carlos Barreiro, Antonio Rodríguez-García, Anthony Cruz, Gustavo E. López, Juan F. Martín
Applied Microbiology and Biotechnology.2014; 98(11): 4919. CrossRef - Gene networks regulating secondary metabolism in actinomycetes: Pleiotropic regulators
M. V. Rabyk, B. O. Ostash, V. O. Fedorenko
Cytology and Genetics.2014; 48(1): 55. CrossRef - Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei
M. Moutiez, J. Seguin, M. Fonvielle, P. Belin, I. B. Jacques, E. Favry, M. Arthur, M. Gondry
Nucleic Acids Research.2014; 42(11): 7247. CrossRef - Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?
Yuriy Rebets, Elke Brötz, Bogdan Tokovenko, Andriy Luzhetskyy
Journal of Industrial Microbiology and Biotechnology.2014; 41(2): 387. CrossRef - Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA
Barbara Gorgoni, Elizabeth Marshall, Matthew R. McFarland, M. Carmen Romano, Ian Stansfield
Biochemical Society Transactions.2014; 42(1): 160. CrossRef - Collismycin A biosynthesis in Streptomyces sp. CS40 is regulated by iron levels through two pathway-specific regulators
Natalia M. Vior, Carlos Olano, Ignacio García, Carmen Méndez, José A. Salas
Microbiology.2014; 160(3): 467. CrossRef - Genes Required for Aerial Growth, Cell Division, and Chromosome Segregation Are Targets of WhiA before Sporulation in Streptomyces venezuelae
Matthew J. Bush, Maureen J. Bibb, Govind Chandra, Kim C. Findlay, Mark J. Buttner, Yves V. Brun
mBio.2013;[Epub] CrossRef -
Pleiotropic regulatory genes
bldA
,
adpA
and
absB
are implicated in production of phosphoglycolipid antibiotic moenomycin
Roman Makitrynskyy, Bohdan Ostash, Olga Tsypik, Yuriy Rebets, Emma Doud, Timothy Meredith, Andriy Luzhetskyy, Andreas Bechthold, Suzanne Walker, Victor Fedorenko
Open Biology.2013; 3(10): 130121. CrossRef - A Microbial Metagenome (Leucobactersp.) inCaenorhabditisWhole Genome Sequences
Riccardo Percudani
Bioinformatics and Biology Insights.2013; 7: BBI.S11064. CrossRef - Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
Gang Liu, Keith F. Chater, Govind Chandra, Guoqing Niu, Huarong Tan
Microbiology and Molecular Biology Reviews.2013; 77(1): 112. CrossRef - Towards a new science of secondary metabolism
Arryn Craney, Salman Ahmed, Justin Nodwell
The Journal of Antibiotics.2013; 66(7): 387. CrossRef - Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
Gulay Ozcengiz, Arnold L. Demain
Biotechnology Advances.2013; 31(2): 287. CrossRef - 5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus
Thomas Kwong, Nathan J. Zelyas, Hui Cai, Kapil Tahlan, Annie Wong, Susan E. Jensen
Antimicrobial Agents and Chemotherapy.2012; 56(9): 4845. CrossRef - Interspecies modulation of bacterial development through iron competition and siderophore piracy
Matthew F. Traxler, Mohammad R. Seyedsayamdost, Jon Clardy, Roberto Kolter
Molecular Microbiology.2012; 86(3): 628. CrossRef - FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
Dušan Goranovič, Marko Blažič, Vasilka Magdevska, Jaka Horvat, Enej Kuščer, Tomaž Polak, Javier Santos-Aberturas, Miriam Martínez-Castro, Carlos Barreiro, Peter Mrak, Gregor Kopitar, Gregor Kosec, Štefan Fujs, Juan F Martín, Hrvoje Petković
BMC Microbiology.2012;[Epub] CrossRef - Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A
Adam C. Jones, Sabine Ottilie, Alessandra S. Eustáquio, Daniel J. Edwards, Lena Gerwick, Bradley S. Moore, William H. Gerwick
The FEBS Journal.2012; 279(7): 1243. CrossRef - Signals and regulators that governStreptomycesdevelopment
Joseph R. McCormick, Klas Flärdh
FEMS Microbiology Reviews.2012; 36(1): 206. CrossRef - Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus
Cristina Gómez, Carlos Olano, Carmen Méndez, José A. Salas
Microbiology.2012; 158(10): 2504. CrossRef -
Roles of
fkbN
in Positive Regulation and
tcs7
in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP
SangJoon Mo, Young Ji Yoo, Yeon Hee Ban, Sung-Kwon Lee, Eunji Kim, Joo-Won Suh, Yeo Joon Yoon
Applied and Environmental Microbiology.2012; 78(7): 2249. CrossRef - Expression of the chaplin and rodlin hydrophobic sheath proteins in Streptomyces venezuelae is controlled by σBldN and a cognate anti‐sigma factor, RsbN
Maureen J. Bibb, Ágota Domonkos, Govind Chandra, Mark J. Buttner
Molecular Microbiology.2012; 84(6): 1033. CrossRef - tRNA accumulation and suppression of the bldA phenotype during development in Streptomyces coelicolor
B. M. Fredrik Pettersson, Leif A. Kirsebom
Molecular Microbiology.2011; 79(6): 1602. CrossRef - Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor
Ana Yepes, Sergio Rico, Antonio Rodríguez-García, Ramón I. Santamaría, Margarita Díaz, Ching-Hong Yang
PLoS ONE.2011; 6(5): e19980. CrossRef - The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
Gilles P. van Wezel, Kenneth J. McDowall
Natural Product Reports.2011; 28(7): 1311. CrossRef - Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus
Akiyoshi Higo, Sueharu Horinouchi, Yasuo Ohnishi
Molecular Microbiology.2011; 81(6): 1607. CrossRef - The Level of AdpA Directly Affects Expression of Developmental Genes in Streptomyces coelicolor
Marcin Wolański, Rafał Donczew, Agnieszka Kois-Ostrowska, Paweł Masiewicz, Dagmara Jakimowicz, Jolanta Zakrzewska-Czerwińska
Journal of Bacteriology.2011; 193(22): 6358. CrossRef - SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN–sanO intergenic region in Streptomyces ansochromogenes
Xihong He, Rui Li, Yuanyuan Pan, Gang Liu, Huarong Tan
Microbiology .2010; 156(3): 828. CrossRef - Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina
Giuseppe Gallo, Giovanni Renzone, Rosa Alduina, Efthimia Stegmann, Tilmann Weber, Anna Eliasson Lantz, Jette Thykaer, Fabio Sangiorgi, Andrea Scaloni, Anna Maria Puglia
PROTEOMICS.2010; 10(7): 1336. CrossRef -
Adaptation of the Highly Productive T7 Expression System to
Streptomyces lividans
François-Xavier Lussier, François Denis, François Shareck
Applied and Environmental Microbiology.2010; 76(3): 967. CrossRef - Autoregulation of hpdR and its effect on CDA biosynthesis in Streptomyces coelicolor
Haihua Yang, Yang An, Linqi Wang, Shuli Zhang, Yue Zhang, Yuqing Tian, Gang Liu, Huarong Tan
Microbiology .2010; 156(9): 2641. CrossRef -
Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in
Streptomyces ambofaciens
Fatma Karray, Emmanuelle Darbon, Hoang Chuong Nguyen, Josette Gagnat, Jean-Luc Pernodet
Journal of Bacteriology.2010; 192(21): 5813. CrossRef - Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity
Bohdan Ostash, Suzanne Walker
Natural Product Reports.2010; 27(11): 1594. CrossRef - Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant
M. T. Lopez-Garcia, I. Santamarta, P. Liras
Microbiology.2010; 156(8): 2354. CrossRef - Quantitative Proteome Analysis of Streptomyces coelicolor Nonsporulating Liquid Cultures Demonstrates a Complex Differentiation Process Comparable to That Occurring in Sporulating Solid Cultures
Angel Manteca, Hye R. Jung, Veit Schwämmle, Ole N. Jensen, Jesus Sanchez
Journal of Proteome Research.2010; 9(9): 4801. CrossRef - Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties
Kien T. Nguyen, Xiaowei He, Dylan C. Alexander, Chen Li, Jian-Qiao Gu, Carmela Mascio, Andrew Van Praagh, Larry Mortin, Min Chu, Jared A. Silverman, Paul Brian, Richard H. Baltz
Antimicrobial Agents and Chemotherapy.2010; 54(4): 1404. CrossRef - Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth
Chris D. Den Hengst, Ngat T. Tran, Maureen J. Bibb, Govind Chandra, Brenda K. Leskiw, Mark J. Buttner
Molecular Microbiology.2010; 78(2): 361. CrossRef - The complex extracellular biology ofStreptomyces
Keith F. Chater, Sandor Biró, Kye Joon Lee, Tracy Palmer, Hildgund Schrempf
FEMS Microbiology Reviews.2010; 34(2): 171. CrossRef - Streptomyces scabies 87-22 Contains a Coronafacic Acid-Like Biosynthetic Cluster That Contributes to Plant–Microbe Interactions
Dawn R. D. Bignell, Ryan F. Seipke, José C. Huguet-Tapia, Alan H. Chambers, Ronald J. Parry, Rosemary Loria
Molecular Plant-Microbe Interactions®.2010; 23(2): 161. CrossRef - Characterization of γ-Butyrolactone Autoregulatory Signaling Gene Homologs in the Angucyclinone Polyketide WS5995B ProducerStreptomyces acidiscabies
Frank G. Healy, Kevin P. Eaton, Prajit Limsirichai, Joel F. Aldrich, Alaina K. Plowman, Russell R. King
Journal of Bacteriology.2009; 191(15): 4786. CrossRef - The pleiotropic regulator AdpA‐L directly controls the pathway‐specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes
Yuanyuan Pan, Gang Liu, Haihua Yang, Yuqing Tian, Huarong Tan
Molecular Microbiology.2009; 72(3): 710. CrossRef - The SmpB-tmRNA Tagging System Plays Important Roles in Streptomyces coelicolor Growth and Development
Chunzhong Yang, John R. Glover, Christophe Herman
PLoS ONE.2009; 4(2): e4459. CrossRef - Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives
Carlos Olano, Cristina Gómez, María Pérez, Martina Palomino, Antonio Pineda-Lucena, Rodrigo J. Carbajo, Alfredo F. Braña, Carmen Méndez, José A. Salas
Chemistry & Biology.2009; 16(10): 1031. CrossRef - Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor
Sean O'Rourke, Andreas Wietzorrek, Kay Fowler, Christophe Corre, Greg L. Challis, Keith F. Chater
Molecular Microbiology.2009; 71(3): 763. CrossRef - Evolutionary flux of potentially bldA-dependent Streptomyces genes containing the rare leucine codon TTA
Govind Chandra, Keith F. Chater
Antonie van Leeuwenhoek.2008; 94(1): 111. CrossRef - novE and novG act as positive regulators of novobiocin biosynthesis
Volker Dangel, Alessandra S. Eustáquio, Bertolt Gust, Lutz Heide
Archives of Microbiology.2008; 190(5): 509. CrossRef - SarA influences the sporulation and secondary metabolism inStreptomyces coelicolorM145
Xijun Ou, Bo Zhang, Lin Zhang, Kai Dong, Chun Liu, Guoping Zhao, Xiaoming Ding
Acta Biochimica et Biophysica Sinica.2008; 40(10): 877. CrossRef
- Regulatory orchestration of FK506 biosynthesis in Streptomyces tsukubaensis NRRL 18488 revealed through systematic analysis
- Incorpotation and production of glucose in Lake Soyang
- kwag, No Tae , Choi, Seung Ik , Ahn, Tae Young , Ahn, Tae Seok
- J. Microbiol. 1995;33(1):74-79.
- 215 View
- 1 Download
-
Abstract
PDF
- Kinetics of heterotrophic activity (glucose uptake) and extracellular enzyme activity(β-glucosidase, cellobiohydrolase) and cell numbers were measured in Lake Soyang during phytoplankton bloom development and after its breakdown. V_max for glucose was lower during Diatom bloom and that was higher after its breakdown. But the increase ion β-glucosidase activity was detected in late of Diatom bloom. Glucose uptake did not associated with β-glucosidase activity. The tight relationship between β-glucosidase and the incorporation of glucose by bacteria was not shown and the significance of depolymerization on the incorporation of glucose in lake water are discussed.
First
Prev
TOP
