Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007

Dieu Linh Tran; Kangmo Kim; Jae Yoo Choi; Hyun Dong Paik; Si-Woo Choi; Jin Yeul Ma; Sung-Soon Kim; Sung Joon Ahn; Young Bong Kim

doi:10.1007/s12275-011-0311-2

Articles

Page Path: HOME > J. Microbiol > Volume 49(2); 2011 > Article

Research Support, Non-U.S. Gov't
Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007: Dieu Linh Tran ¹, Kangmo Kim ^2,3, Jae Yoo Choi ¹, Hyun Dong Paik ¹, Si-Woo Choi ⁴, Jin Yeul Ma ⁵, Sung-Soon Kim ², Sung Joon Ahn ³, Young Bong Kim ¹; Journal of Microbiology 2011;49(2):274-279
DOI: https://doi.org/10.1007/s12275-011-0311-2
Published online: May 3, 2011

¹College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea, ²Center for Immunology and Pathology, Korean National Institute of Health, Seoul 122-701, Republic of Korea, ³School of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ⁴Department of Genetic Engineering, Faculty of Life Science and Technology, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ⁵Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea¹College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea, ²Center for Immunology and Pathology, Korean National Institute of Health, Seoul 122-701, Republic of Korea, ³School of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ⁴Department of Genetic Engineering, Faculty of Life Science and Technology, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ⁵Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea

Corresponding author: Sung Joon Ahn , Tel: +82-2-450-4208,
Young Bong Kim , Tel: +82-2-450-4208,

Received: 10 August 2010 • Accepted: 6 December 2010

prev next

3 Views
0 Download
0 Crossref
1 Scopus

Full Article

Abstract

Highly pathogenic H5N1 avian influenza A virus (AIV) crossed the species barrier and caused a number of deaths in humans in Vietnam and 14 other countries. Since the last report of human H5N1 infection in November 2005, the first documented H5N1 human infection was reported in June 2007 in Vietnam and was followed by 7 more cases, including 5 fatalities. In this study, we isolated and analyzed the full length of the H5N1 genome from a sample from the first patient in 2007. Phylogenetic analysis of eight genomic segments of the H5N1 virus strain (A/Vietnam/HN/2007, VNH07) revealed that this strain appears to be of genotype V and contains the HA gene, which is classified into clade 2.3.4. The deduced amino acid sequence of the HA protein has a typical affinity sequence for α2,3 linkage (SAα2,3-Gal) receptors and typical multibasic cleavage sequences. Compared with other H5N1 isolates, VNH07 showed that the possible reassortments for the NA and NP segments occurred between A/goose/Guangxi/3017/2005-like isolates (2.3.2) and A/human/Zhejiang/16/2006-like isolates (2.3.4).

Keywords: avian influenza; H5N1; human infection; phylogenetic analysis; reassortment

Figure & Data

References

Citations

Citations to this article as recorded by

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007

J. Microbiol. 2011;49(2):274-279. Published online May 3, 2011

DOI: https://doi.org/10.1007/s12275-011-0311-2

Related articles