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Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007
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HOME > J. Microbiol > Volume 49(2); 2011 > Article
Research Support, Non-U.S. Gov't
Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007
Dieu Linh Tran 1, Kangmo Kim 2,3, Jae Yoo Choi 1, Hyun Dong Paik 1, Si-Woo Choi 4, Jin Yeul Ma 5, Sung-Soon Kim 2, Sung Joon Ahn 3, Young Bong Kim 1
Journal of Microbiology 2011;49(2):274-279
DOI: https://doi.org/10.1007/s12275-011-0311-2
Published online: May 3, 2011
1College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea, 2Center for Immunology and Pathology, Korean National Institute of Health, Seoul 122-701, Republic of Korea, 3School of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea, 4Department of Genetic Engineering, Faculty of Life Science and Technology, Sungkyunkwan University, Suwon 440-746, Republic of Korea, 5Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea1College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea, 2Center for Immunology and Pathology, Korean National Institute of Health, Seoul 122-701, Republic of Korea, 3School of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea, 4Department of Genetic Engineering, Faculty of Life Science and Technology, Sungkyunkwan University, Suwon 440-746, Republic of Korea, 5Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea
Corresponding author:  Sung Joon Ahn , Tel: +82-2-450-4208, 
Young Bong Kim , Tel: +82-2-450-4208, 
Received: 10 August 2010   • Accepted: 6 December 2010
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Abstract

Highly pathogenic H5N1 avian influenza A virus (AIV) crossed the species barrier and caused a number of deaths in humans in Vietnam and 14 other countries. Since the last report of human H5N1 infection in November 2005, the first documented H5N1 human infection was reported in June 2007 in Vietnam and was followed by 7 more cases, including 5 fatalities. In this study, we isolated and analyzed the full length of the H5N1 genome from a sample from the first patient in 2007. Phylogenetic analysis of eight genomic segments of the H5N1 virus strain (A/Vietnam/HN/2007, VNH07) revealed that this strain appears to be of genotype V and contains the HA gene, which is classified into clade 2.3.4. The deduced amino acid sequence of the HA protein has a typical affinity sequence for α2,3 linkage (SAα2,3-Gal) receptors and typical multibasic cleavage sequences. Compared with other H5N1 isolates, VNH07 showed that the possible reassortments for the NA and NP segments occurred between A/goose/Guangxi/3017/2005-like isolates (2.3.2) and A/human/Zhejiang/16/2006-like isolates (2.3.4).

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    Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007
    J. Microbiol. 2011;49(2):274-279.   Published online May 3, 2011
    DOI: https://doi.org/10.1007/s12275-011-0311-2
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