Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007

Dieu Linh Tran; Kangmo Kim; Jae Yoo Choi; Hyun Dong Paik; Si-Woo Choi; Jin Yeul Ma; Sung-Soon Kim; Sung Joon Ahn; Young Bong Kim

doi:10.1007/s12275-011-0311-2

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Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007: Dieu Linh Tran ¹, Kangmo Kim ^2,3, Jae Yoo Choi ¹, Hyun Dong Paik ¹, Si-Woo Choi ⁴, Jin Yeul Ma ⁵, Sung-Soon Kim ², Sung Joon Ahn ³, Young Bong Kim ¹; Journal of Microbiology 2011;49(2):274-279.
DOI: https://doi.org/10.1007/s12275-011-0311-2
Published online: May 3, 2011

¹College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea, ²Center for Immunology and Pathology, Korean National Institute of Health, Seoul 122-701, Republic of Korea, ³School of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ⁴Department of Genetic Engineering, Faculty of Life Science and Technology, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ⁵Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea

Corresponding author: Sung Joon Ahn , Tel: +82-2-450-4208,
Young Bong Kim , Tel: +82-2-450-4208,

Received: 10 August 2010 • Accepted: 6 December 2010

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Abstract

Highly pathogenic H5N1 avian influenza A virus (AIV) crossed the species barrier and caused a number of deaths in humans in Vietnam and 14 other countries. Since the last report of human H5N1 infection in November 2005, the first documented H5N1 human infection was reported in June 2007 in Vietnam and was followed by 7 more cases, including 5 fatalities. In this study, we isolated and analyzed the full length of the H5N1 genome from a sample from the first patient in 2007. Phylogenetic analysis of eight genomic segments of the H5N1 virus strain (A/Vietnam/HN/2007, VNH07) revealed that this strain appears to be of genotype V and contains the HA gene, which is classified into clade 2.3.4. The deduced amino acid sequence of the HA protein has a typical affinity sequence for α2,3 linkage (SAα2,3-Gal) receptors and typical multibasic cleavage sequences. Compared with other H5N1 isolates, VNH07 showed that the possible reassortments for the NA and NP segments occurred between A/goose/Guangxi/3017/2005-like isolates (2.3.2) and A/human/Zhejiang/16/2006-like isolates (2.3.4).

Keywords: avian influenza;H5N1;human infection;phylogenetic analysis;reassortment

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Rethinking Approaches to Improve the Utilization of Nucleic Acid Amplification Tests for Detection and Characterization of Influenza A in Diagnostic and Reference Laboratories
Kanti Pabbaraju, Sallene Wong, Steven J Drews
Future Microbiology.2011; 6(12): 1443. CrossRef

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Genome Sequence Analysis of H5N1 Influenza A Virus Isolated from a Vietnamese in 2007

J. Microbiol. 2011;49(2):274-279. Published online May 3, 2011

DOI: https://doi.org/10.1007/s12275-011-0311-2

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