NOTE] Isolation and Characterization of Self-Fertile Suppressors from the Sterile nsdD Deletion Mutant of Aspergillus nidulans

Dong-Beom Lee; Lee Han Kim; Jin-Pyo Kim; Kap-Hoon Han; Dong-Min Han

doi:10.1007/s12275-011-1111-4

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NOTE] Isolation and Characterization of Self-Fertile Suppressors from the Sterile nsdD Deletion Mutant of Aspergillus nidulans: Dong-Beom Lee ¹, Lee Han Kim ¹, Jin-Pyo Kim ², Kap-Hoon Han ², Dong-Min Han ¹; Journal of Microbiology 2011;49(6):1054-1057.
DOI: https://doi.org/10.1007/s12275-011-1111-4
Published online: December 28, 2011

¹Division of Life Science, Wonkwang University, Iksan 570-749, Republic of Korea, ²Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-701, Republic of Korea¹Division of Life Science, Wonkwang University, Iksan 570-749, Republic of Korea, ²Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-701, Republic of Korea

Corresponding author: Kap-Hoon Han , Tel: +82-63-290-1427,
Dong-Min Han , Tel: +82-63-850-6220,

Received: 7 March 2011 • Accepted: 21 July 2011

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Abstract

To identify downstream and/or interactive factors of the nsdD gene, which encodes a positive regulator of sexual development of Aspergillus nidulans, suppressor mutants displaying a self-fertile phenotype were isolated from a sterile nsdD deletion mutant. At least five different loci (sndA-E) were identified and genetically analyzed. In the nsdD+ background, most of the suppressors showed a marked increment of sexual development, even under the stress conditions that normally inhibited sexual development. The common phenotype of the suppressor mutants suggested the involvement of the snd genes in the negative regulation of sexual development in response to the environmental factors.

Keywords: Aspergillus nidulans;nsdD;suppressor;snd;sexual development

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NOTE] Isolation and Characterization of Self-Fertile Suppressors from the Sterile nsdD Deletion Mutant of Aspergillus nidulans

J. Microbiol. 2011;49(6):1054-1057. Published online December 28, 2011

DOI: https://doi.org/10.1007/s12275-011-1111-4

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