Antiviral Effect of Flavonol Glycosides Isolated from the Leaf of Zanthoxylum piperitum on Influenza Virus

Song-Yi Ha; Hana Youn; Chang-Seon Song; Se Chan Kang; Jong Jin Bae; Hee Tae Kim; Kwang Min Lee; Tae Hoon Eom; In Su Kim; Jong Hwan Kwak

doi:10.1007/s12275-014-4073-5

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Research Support, Non-U.S. Gov't
Antiviral Effect of Flavonol Glycosides Isolated from the Leaf of Zanthoxylum piperitum on Influenza Virus: Song-Yi Ha ¹, Hana Youn ², Chang-Seon Song ², Se Chan Kang ³, Jong Jin Bae ⁴, Hee Tae Kim ¹, Kwang Min Lee ¹, Tae Hoon Eom ¹, In Su Kim ¹, Jong Hwan Kwak ¹; Journal of Microbiology 2014;52(4):340-344.
DOI: https://doi.org/10.1007/s12275-014-4073-5
Published online: March 29, 2014

¹School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ²College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea , ³Department of Life Science, Gachon University, Sungnam 461-701, Republic of Korea , ⁴Department of Oriental Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea¹School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea, ²College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea , ³Department of Life Science, Gachon University, Sungnam 461-701, Republic of Korea , ⁴Department of Oriental Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea

Corresponding author: Jong Hwan Kwak , Tel: +82-31-290-7745,

Received: 4 February 2014 • Revised: 18 February 2014 • Accepted: 26 February 2014

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Abstract

The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-β-D-galactopyranoside (1), quercetin 3-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-rhamnopyranoside (3) by comparing their spectral data with literature values. The anti-influenza viral activity of isolates was evaluated using a plaque reduction assay against influenza A/NWS/33 (H1N1) virus. The compounds also were subjected to neuraminidase inhibition assay in influenza A/NWS/33 virus. Compounds 1-3 exhibited antiviral activity against an influenza A virus in vitro, and inhibited the neuraminidase activity at relatively high concentrations.

Keywords: Zanthoxylum piperitum;Rutaceae;flavonol glycoside;anti-influenza activity;neuraminidase inhibitor

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Antiviral Effect of Flavonol Glycosides Isolated from the Leaf of Zanthoxylum piperitum on Influenza Virus

J. Microbiol. 2014;52(4):340-344. Published online March 29, 2014

DOI: https://doi.org/10.1007/s12275-014-4073-5

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