Competition/antagonism associations of biofilm formation among Staphylococcus epidermidis Agr groups I, II, and III

Sergio Martínez-García; César I. Ortiz-García; Marisa Cruz-Aguilar; Juan Carlos Zenteno; José Martin Murrieta-Coxca; Sonia Mayra Pérez-Tapia; Sandra Rodríguez-Martínez; Mario E. Cancino-Diaz; Juan C. Cancino-Diaz

doi:10.1007/s12275-019-8322-5

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Competition/antagonism associations of biofilm formation among Staphylococcus epidermidis Agr groups I, II, and III: Sergio Martínez-García ¹, César I. Ortiz-García ¹, Marisa Cruz-Aguilar ², Juan Carlos Zenteno ², José Martin Murrieta-Coxca ³, Sonia Mayra Pérez-Tapia ⁴, Sandra Rodríguez-Martínez ³, Mario E. Cancino-Diaz ³, Juan C. Cancino-Diaz ¹; Journal of Microbiology 2019;57(2):143-153.
DOI: https://doi.org/10.1007/s12275-019-8322-5
Published online: January 31, 2019

¹Laboratory of Immunomicrobiology, Department of Microbiology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, 11340, Mexico City, Mexico, ²Laboratory of Genetics, Department of Genetics-Research Unit, Instituto de Oftalmología Conde de Valenciana, 06800, Mexico City, Mexico, ³Laboratory of Innate Immunity, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, 11340, Mexico City, Mexico, ⁴“Unidad de Desarrollo e Investigación en Bioprocesos” (UDIBI), Department of Immunology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, 11340, Mexico City, Mexico¹Laboratory of Immunomicrobiology, Department of Microbiology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, 11340, Mexico City, Mexico, ²Laboratory of Genetics, Department of Genetics-Research Unit, Instituto de Oftalmología Conde de Valenciana, 06800, Mexico City, Mexico, ³Laboratory of Innate Immunity, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, 11340, Mexico City, Mexico, ⁴“Unidad de Desarrollo e Investigación en Bioprocesos” (UDIBI), Department of Immunology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, 11340, Mexico City, Mexico

Corresponding author: Juan C. Cancino-Diaz , Tel: +52-57-29-63-00 (Ext: 62464),

Received: 14 June 2018 • Revised: 5 October 2018 • Accepted: 10 October 2018

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Abstract

Staphylococci have quorum-sensing (QS) systems that enable cell-to-cell communication, as well as the regulation of numerous colonization and virulence factors. The accessory gene regulator (Agr) operon is one of the Staphylococcus genus QS systems. Three groups (I, II, and III) are present in Staphylococcus epidermidis Agr operon. To date, it is unknown whether Agr groups can interact symbiotically during biofilm development. This study analyzed a symbiotic association among Agr groups during biofilm formation in clinical and commensal isolates. Different combinations among Agr group isolates was used to study biofilm formation in vitro and in vivo (using a mouse catheter-infection model). The analysis of Agr groups were also performed from samples of human skin (head, armpits, and nostrils). Different predominant coexistence was found within biofilms, suggesting symbiosis type. In vitro, Agr I had a competition with Agr II and Agr III. Agr II had a competition with Agr III, and Agr II was an antagonist to Agr I and III when the three strains were combined. In vivo, Agr II had a competition to Agr I, but Agr I and II were antagonists to Agr III. The associations found in vitro and in vivo were also found in different sites of the skin. Besides, other associations were observed: Agr III antagonized Agr I and II, and Agr III competed with Agr I and Agr II. These results suggest that, in S. epidermidis, a symbiotic association of competition and antagonism occurs among different Agr groups during biofilm formation.

Keywords: symbiosis;Staphylococcus epidermidis;Agr;clinical;commensal

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Competition/antagonism associations of biofilm formation among Staphylococcus epidermidis Agr groups I, II, and III

J. Microbiol. 2019;57(2):143-153. Published online January 31, 2019

DOI: https://doi.org/10.1007/s12275-019-8322-5

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