Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathway

Jinjong Myoung; Jeong Yoon Lee; Kang Sang Min

doi:10.1007/s12275-019-9478-8

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Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathway: Jinjong Myoung , Jeong Yoon Lee , Kang Sang Min; Journal of Microbiology 2019;57(12):1126-1131.
DOI: https://doi.org/10.1007/s12275-019-9478-8
Published online: November 22, 2019

Korea Zoonosis Research Institute, Genetic Engineering Research Institute and Department of Bioactive Material Science, Jeonbuk National University, Jeonju 54896, Republic of KoreaKorea Zoonosis Research Institute, Genetic Engineering Research Institute and Department of Bioactive Material Science, Jeonbuk National University, Jeonju 54896, Republic of Korea

Corresponding author: Jinjong Myoung , Tel: +82-63-,

Received: 11 October 2019 • Revised: 18 October 2019 • Accepted: 21 October 2019

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Abstract

Hepatitis E virus (HEV) is a causative agent of acute hepatitis and jaundice. The number of human infections is approximated to be over 20 million cases per year. The transmission is mainly via the fecal-oral route and contaminated water and food are considered to be a major source of infection. As a mouse model is not available, a recent development of a cell culture-adapted HEV strain (47832c) is considered as a very important tools for molecular analysis of HEV pathogenesis in cells. Previously, we demonstrated that HEV-encoded methyltransferase (MeT) encoded by the 47832c strain inhibits MDA5- and RIG-I-mediated activation of interferon β (IFN-β) promoter. Here, we report that MeT impairs the phosphorylation and activation of interferon regulatory factor 3 and the p65 subunit of NF-κB in a dose-dependent manner. In addition, the MeT encoded by the 47832c, but not that of HEV clinical or field isolates (SAR-55, Mex-14, KC-1, and ZJ-1), displays the inhibitory effect. A deeper understanding of MeTmediated suppression of IFN-β expression would provide basis of the cell culture adaptation of HEV.

Keywords: hepatitis E virus;methyltransferase;interferon

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Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathway

J. Microbiol. 2019;57(12):1126-1131. Published online November 22, 2019

DOI: https://doi.org/10.1007/s12275-019-9478-8

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