Bacterial Crosstalk via Antimicrobial Peptides on the Human Skin: Therapeutics from a Sustainable Perspective

Seon Mi Lee; Hye Lim Keum; Woo Jun Sul

doi:10.1007/s12275-022-00002-8

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Bacterial Crosstalk via Antimicrobial Peptides on the Human Skin: Therapeutics from a Sustainable Perspective: Seon Mi Lee , Hye Lim Keum , Woo Jun Sul; Journal of Microbiology 2023;61(1):1-11.
DOI: https://doi.org/10.1007/s12275-022-00002-8
Published online: January 31, 2023

Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea

Corresponding author: Woo Jun Sul ,

Received: 5 July 2022 • Revised: 18 October 2022 • Accepted: 24 October 2022

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Abstract

The skin’s epidermis is an essential barrier as the first guard against invading pathogens, and physical protector from external injury. The skin microbiome, which consists of numerous bacteria, fungi, viruses, and archaea on the epidermis, play a key role in skin homeostasis. Antibiotics are a fast-acting and effective treatment method, however, antibiotic use is a nuisance that can disrupt skin homeostasis by eradicating beneficial bacteria along with the intended pathogens and cause antibioticresistant bacteria spread. Increased numbers of antimicrobial peptides (AMPs) derived from humans and bacteria have been reported, and their roles have been well defined. Recently, modulation of the skin microbiome with AMPs rather than artificially synthesized antibiotics has attracted the attention of researchers as many antibiotic-resistant strains make treatment mediation difficult in the context of ecological problems. Herein, we discuss the overall insights into the skin microbiome, including its regulation by different AMPs, as well as their composition and role in health and disease.

Keywords: Escherichia coli;ciprofloxacin;fitness cost;soft sweeps;stepwise selection

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Bacterial Crosstalk via Antimicrobial Peptides on the Human Skin: Therapeutics from a Sustainable Perspective

J. Microbiol. 2023;61(1):1-11. Published online January 31, 2023

DOI: https://doi.org/10.1007/s12275-022-00002-8

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