- Volume 53(2); February 2015
-
Review
- Minireview] The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back
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Xiaolei Wei , Yuanwei Zhang Zhang , Ling Lu
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J. Microbiol. 2015;53(2):91-99. Published online January 28, 2015
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DOI: https://doi.org/10.1007/s12275-015-5014-7
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25
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Abstract
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The growing use of immunosuppressive therapies has resulted
in a dramatic increased incidence of invasive fungal
infections (IFIs) caused by Aspergillus fumigatus, a common
pathogen, and is also associated with a high mortality rate.
Azoles are the primary guideline-recommended therapy agents
for first-line treatment and prevention of IFIs. However,
increased azole usage in medicinal and agricultural settings
has caused azole-resistant isolates to repeatedly emerge in
the environment, resulting in a significant threat to human
health. In this review, we present and summarize current
research on the resistance mechanisms of azoles in A. fumigatus
as well as efficient susceptibility testing methods. Moreover,
we analyze and discuss the putative clinical (bedside)
indication of these findings from bench work.
-
Citations
Citations to this article as recorded by

- Azole resistance in Aspergillus fumigatus- comprehensive review
Mthokozisi Dladla, Marieka Gyzenhout, Gert Marias, Soumya Ghosh
Archives of Microbiology.2024;[Epub] CrossRef -
Unveiling environmental transmission risks: comparative analysis of azole resistance in
Aspergillus fumigatus
clinical and environmental isolates from Yunnan, China
Jianchuan Gong, Jiarui Huang, Yongju Liu, Ying Zhang, Yuhong Gao, Gustavo H. Goldman
Microbiology Spectrum.2024;[Epub] CrossRef -
The mitochondrial protein Bcs1A regulates antifungal drug tolerance by affecting efflux pump expression in the filamentous pathogenic fungus
Aspergillus fumigatus
Guorong Yang, Weiwei Shi, Wenlin He, Jing Wu, Sutao Huang, Li Mo, Junjie Zhang, Huaxue Wang, Xiaogang Zhou, Gustavo H. Goldman
Microbiology Spectrum.2024;[Epub] CrossRef - The expression pattern, subcellular localization and function of three sterol 14α-demethylases in Aspergillus oryzae
Qi Jin, Ganghua Li, Kunhai Qin, Yitong Shang, Huanhuan Yan, Hongliang Liu, Bin Zeng, Zhihong Hu
Frontiers in Genetics.2023;[Epub] CrossRef - Mitochondrial Membrane-Associated Protein Mba1 Confers Antifungal Resistance by Affecting the Production of Reactive Oxygen Species in Aspergillus fumigatus
Guoxing Zhu, Shu Chen, Yuanwei Zhang, Ling Lu
Antimicrobial Agents and Chemotherapy.2023;[Epub] CrossRef - Drug-Resistant Aspergillus spp.: A Literature Review of Its Resistance Mechanisms and Its Prevalence in Europe
Maria Antonia De Francesco
Pathogens.2023; 12(11): 1305. CrossRef -
Deletion of
cox7c
Results in Pan-Azole Resistance in Aspergillus fumigatus
Mingcong Chen, Guowei Zhong, Sha Wang, Peiying Chen, Lei Li
Antimicrobial Agents and Chemotherapy.2022;[Epub] CrossRef - Cannabis and the Cancer Patient
Ilana M Braun, Donald I Abrams, Stacey E Blansky, Steven A Pergam
JNCI Monographs.2021; 2021(58): 68. CrossRef - Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus
Yuying Fan, Yue Wang, Gregory A. Korfanty, Meagan Archer, Jianping Xu
Pathogens.2021; 10(6): 701. CrossRef - Analysis of the prochloraz‐Mn resistance risk and its molecular basis in Mycogone rosea from Agaricus bisporus
Yixin Du, Niuniu Shi, Hongchun Ruan, Jianqiang Miao, He Yan, Chunxi Shi, Furu Chen, Xili Liu
Pest Management Science.2021; 77(10): 4680. CrossRef -
Electron Donor Cytochrome
b
5
Is Required for Hyphal Tip Accumulation of Sterol-Rich Plasma Membrane Domains and Membrane Fluidity in Aspergillus fumigatus
Chi Zhang, Yiran Ren, Lu Gao, Huiyu Gu, Ling Lu, Rebecca E. Parales
Applied and Environmental Microbiology.2021;[Epub] CrossRef - Examining Signatures of Natural Selection in Antifungal Resistance Genes Across Aspergillus Fungi
Renato Augusto Corrêa dos Santos, Matthew E. Mead, Jacob L. Steenwyk, Olga Rivero-Menéndez, Ana Alastruey-Izquierdo, Gustavo Henrique Goldman, Antonis Rokas
Frontiers in Fungal Biology.2021;[Epub] CrossRef - Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene
Peiying Chen, Musang Liu, Qiuqiong Zeng, Zheng Zhang, Weida Liu, Hong Sang, Ling Lu
Frontiers in Microbiology.2020;[Epub] CrossRef - Synergistic Effect of Pyrvinium Pamoate and Azoles Against Aspergillus fumigatus in vitro and in vivo
Yi Sun, Lujuan Gao, Youwen Zhang, Ji Yang, Tongxiang Zeng
Frontiers in Microbiology.2020;[Epub] CrossRef - Recent trends in the epidemiology, diagnosis, treatment, and mechanisms of resistance in clinical Aspergillus species: A general review with a special focus on the Middle Eastern and North African region
Ayate Zakaria, Marwan Osman, Fouad Dabboussi, Rayane Rafei, Hassan Mallat, Nicolas Papon, Jean-Philippe Bouchara, Monzer Hamze
Journal of Infection and Public Health.2020; 13(1): 1. CrossRef - Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human Pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis
Renato A. C. dos Santos, Jacob L. Steenwyk, Olga Rivero-Menendez, Matthew E. Mead, Lilian P. Silva, Rafael W. Bastos, Ana Alastruey-Izquierdo, Gustavo H. Goldman, Antonis Rokas
Frontiers in Genetics.2020;[Epub] CrossRef - Azole resistance mechanisms in Aspergillus: update and recent advances
Alba Pérez-Cantero, Loida López-Fernández, Josep Guarro, Javier Capilla
International Journal of Antimicrobial Agents.2020; 55(1): 105807. CrossRef - Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus
Yeqi Li, Yuanwei Zhang, Ling Lu
Medical Mycology.2019; 57(Supplement): S233. CrossRef - Fungal cytochrome P450 protein Cyp51: What we can learn from its evolution, regulons and Cyp51-based azole resistance
Jinxing Song, Shizhu Zhang, Ling Lu
Fungal Biology Reviews.2018; 32(3): 131. CrossRef - Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus
Zhongyi Lu, Xiaodong Jia, Yong Chen, Xuelin Han, Fangyan Chen, Shuguang Tian, Xueting Su, Zongwei Li, Jingya Zhao, Xi Zhang, Mandong Hu, Liuyu Huang, Li Han
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef -
Aspergillus fumigatus
Afssn3-Afssn8
Pair Reverse Regulates Azole Resistance by Conferring Extracellular Polysaccharide, Sphingolipid Pathway Intermediates, and Efflux Pumps to Biofilm
Nanbiao Long, Liping Zeng, Shanlei Qiao, Lei Li, Guowei Zhong
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef -
Screening and Characterization of a Non-
cyp51A
Mutation in an
Aspergillus fumigatus cox10
Strain Conferring Azole Resistance
Xiaolei Wei, Peiying Chen, Rongsui Gao, Yeqi Li, Anxue Zhang, Feifei Liu, Ling Lu
Antimicrobial Agents and Chemotherapy.2017;[Epub] CrossRef - A Putative Mitochondrial Iron Transporter MrsA in Aspergillus fumigatus Plays Important Roles in Azole-, Oxidative Stress Responses and Virulence
Nanbiao Long, Xiaoling Xu, Hui Qian, Shizhu Zhang, Ling Lu
Frontiers in Microbiology.2016;[Epub] CrossRef - Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus
Chi Zhang, Xiuhua Meng, Xiaolei Wei, Ling Lu
Fungal Genetics and Biology.2016; 86: 47. CrossRef - Triazole Susceptibilities in Thermotolerant Fungal Isolates from Outdoor Air in the Seoul Capital Area in South Korea
Seungeun Lee, Siyu Xu, Chemmeri Padasseri Bivila, Hyeyoung Lee, Myung Soo Park, Young Woon Lim, Naomichi Yamamoto, Kap-Hoon Han
PLOS ONE.2015; 10(9): e0138725. CrossRef
Research Support, Non-U.S. Gov'ts
- Negative regulation of the vacuole-mediated resistance to K+ stress by a novel C2H2 zinc finger transcription factor encoded by aslA in Aspergillus nidulans
-
Dong Soo Park , Yeong Man Yu , Yong Jin Kim , Pil Jae Maeng
-
J. Microbiol. 2015;53(2):100-110. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4701-8
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50
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16
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Abstract
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In fungi and plants, vacuoles function as a storage and sequestration
vessel for a wide variety of ions and are responsible
for cytosolic ion homeostasis and responses to ionic
shock. In the filamentous fungus Aspergillus nidulans, however,
little is known about the molecular genetic mechanisms
of vacuolar biogenesis and function. In the present study,
we analyzed the function of the aslA gene (AN5583) encoding
a novel C2H2-type zinc finger transcription factor (TF)
in relation to K+ stress resistance, vacuolar morphology, and
vacuolar transporters. The mutant lacking aslA showed increased
mycelial growth and decreased branching at high
K+ concentrations. Deletion of aslA also caused elevated K+
stress-inducible expression of the genes, nhxA (AN2288),
vnxA (AN6986), and vcxA (AN0471), encoding putative endosomal
and vacuolar cation/H+ exchangers, as well as cpyA
and vpsA genes encoding the proteins involved in vacuolar
biogenesis. Interestingly, vacuolar fragmentation induced by
K+ stress was alleviated by aslA deletion, resulting in persistence
of unfragmented vacuoles. In the presence of bafilomycin,
an inhibitor of vacuolar H+-ATPase, the mutant phenotype
was suppressed in terms of growth rates and vacuolar
morphology. These results together suggest that the C2H2-
type zinc finger TF AslA attenuates the K+ stress-inducible
expression of the genes encoding the ion pumps involved in
vacuolar sequestration of K+ ions powered by vacuolar H+-
ATPase, as well as the proteins that function in vacuolar
biogenesis.
-
Citations
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- The pleiotropic phenotype of FlbA of Aspergillus niger is explained in part by the activity of seven of its downstream-regulated transcription factors
Xiaoyi Chen, Juan P. Moran Torres, Peter Jan Vonk, J. Mirjam A. Damen, Karli R. Reiding, Jan Dijksterhuis, Luis G. Lugones, Han A.B. Wösten
Fungal Genetics and Biology.2024; 172: 103894. CrossRef - Survival Factor A (SvfA) Contributes to Aspergillus nidulans Pathogenicity
Joo-Yeon Lim, Ye-Eun Jung, Hye-Eun Hwang, Cheol-Hee Kim, Nese Basaran-Akgul, Sri Harshini Goli, Steven P. Templeton, Hee-Moon Park
Journal of Fungi.2023; 9(2): 143. CrossRef - A C2H2 Zinc Finger Protein PlCZF1 Is Necessary for Oospore Development and Virulence in Peronophythora litchii
Honghui Zhu, Junjian Situ, Tianfang Guan, Ziyuan Dou, Guanghui Kong, Zide Jiang, Pinggen Xi
International Journal of Molecular Sciences.2022; 23(5): 2733. CrossRef - The Gβ-like Protein AfCpcB Affects Sexual Development, Response to Oxidative Stress and Phagocytosis by Alveolar Macrophages in Aspergillus fumigatus
Joo-Yeon Lim, Yeon-Ju Kim, Hee-Moon Park
Journal of Fungi.2022; 8(1): 56. CrossRef - Characterization of BbKlf1 as a novel transcription factor vital for asexual and infection cycles of Beauveria bassiana
Rehab Abdelmonem Mohamed, Chong‐Tao Guo, Si‐Yuan Xu, Sheng‐Hua Ying, Ming‐Guang Feng
Environmental Microbiology Reports.2022; 14(5): 719. CrossRef - The LAMMER Kinase, LkhA, Affects Aspergillus fumigatus Pathogenicity by Modulating Reproduction and Biosynthesis of Cell Wall PAMPs
Joo-Yeon Lim, Yeon Ju Kim, Seul Ah Woo, Jae Wan Jeong, Yu-Ri Lee, Cheol-Hee Kim, Hee-Moon Park
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Mannitol-1-phosphate dehydrogenase, MpdA, is required for mannitol production in vegetative cells and involved in hyphal branching, heat resistance of conidia and sexual development in Aspergillus nidulans
Joo-Yeon Lim, Seung-Hyun Jang, Hee-Moon Park
Current Genetics.2021; 67(4): 613. CrossRef - The putative C2H2 transcription factor RocA is a novel regulator of development and secondary metabolism in Aspergillus nidulans
Dong Chan Won, Yong Jin Kim, Da Hye Kim, Hee-Moon Park, Pil Jae Maeng
Journal of Microbiology.2020; 58(7): 574. CrossRef - Survival factor SvfA plays multiple roles in differentiation and is essential for completion of sexual development in Aspergillus nidulans
Joo-Yeon Lim, Eun-Hye Kang, Yun-Hee Park, Jun-Ho Kook, Hee-Moon Park
Scientific Reports.2020;[Epub] CrossRef - Fungal oxylipins direct programmed developmental switches in filamentous fungi
Mengyao Niu, Breanne N. Steffan, Gregory J. Fischer, Nandhitha Venkatesh, Nicholas L. Raffa, Molly A. Wettstein, Jin Woo Bok, Claudio Greco, Can Zhao, Erwin Berthier, Ernst Oliw, David Beebe, Michael Bromley, Nancy P. Keller
Nature Communications.2020;[Epub] CrossRef - The Cys2His2 zinc finger protein Zfp1 regulates sexual reproduction and virulence in Cryptococcus neoformans
Cheng-Li Fan, Lian-Tao Han, Su-Ting Jiang, An-Ni Chang, Ze-Yang Zhou, Tong-Bao Liu
Fungal Genetics and Biology.2019; 124: 59. CrossRef - Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low‐intensity electromagnetic field
Ling Sun, Xinyi Li, Haile Ma, Ronghai He, Prince O. Donkor
Bioelectromagnetics.2019; 40(2): 104. CrossRef - Transcription Factors Controlling Primary and Secondary Metabolism in Filamentous Fungi: The β-Lactam Paradigm
Carlos García-Estrada, Rebeca Domínguez-Santos, Katarina Kosalková, Juan-Francisco Martín
Fermentation.2018; 4(2): 47. CrossRef - Differential Control of Asexual Development and Sterigmatocystin Biosynthesis by a Novel Regulator in Aspergillus nidulans
Yong Jin Kim, Yeong Man Yu, Pil Jae Maeng
Scientific Reports.2017;[Epub] CrossRef - The signal peptide peptidase SppA is involved in sterol regulatory element‐binding protein cleavage and hypoxia adaptation in Aspergillus nidulans
Chinbayar Bat‐Ochir, Jun‐Yong Kwak, Sun‐Ki Koh, Mee‐Hyang Jeon, Dawoon Chung, Yin‐Won Lee, Suhn‐Kee Chae
Molecular Microbiology.2016; 100(4): 635. CrossRef - ZNF1 Encodes a Putative C2H2 Zinc-Finger Protein Essential for Appressorium Differentiation by the Rice Blast Fungus Magnaporthe oryzae
Xiaofeng Yue, Yawei Que, Lin Xu, Shuzhen Deng, Youliang Peng, Nicholas J. Talbot, Zhengyi Wang
Molecular Plant-Microbe Interactions®.2016; 29(1): 22. CrossRef
- Deletion analysis of LSm, FDF, and YjeF domains of Candida albicans Edc3 in hyphal growth and oxidative-stress response
-
Eung-Chul Kim , Jinmi Kim
-
J. Microbiol. 2015;53(2):111-115. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4727-y
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46
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3
Crossref
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Abstract
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Candida albicans is an opportunistic fungal pathogen whose
responses to environmental changes are associated with the
virulence attributes. Edc3 is known to be an enhancer of the
mRNA decapping reactions and a scaffold protein of cytoplasmic
processing bodies (P-bodies). Recent studies of C.
albicans Edc3 suggested its critical roles in filamentous growth
and stress-induced apoptotic cell death. The edc3/edc3 deletion
mutant strain showed increased cell survival and less ROS
accumulation upon treatment with hydrogen peroxide. To
investigate the diverse involvement of Edc3 in the cellular
processes, deletion mutations of LSm, FDF, or YjeF domain
of Edc3 were constructed. The edc3-LSmΔ or edc3-YjeFΔ
mutation showed the filamentation defect, resistance to oxidative
stress, and decreased ROS accumulation. In contrast,
the edc3-FDFΔ mutation exhibited a wild-type level of filamentous
growth and a mild defect in ROS accumulation.
These results suggest that Lsm and YjeF domains of Edc3
are critical in hyphal growth and oxidative stress response.
-
Citations
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- The FomYjeF Protein Influences the Sporulation and Virulence of Fusarium oxysporum f. sp. momordicae
Chenxing Wei, Caiyi Wen, Yuanyuan Zhang, Hongyan Du, Rongrong Zhong, Zhengzhe Guan, Mengjiao Wang, Yanhong Qin, Fei Wang, Luyang Song, Ying Zhao
International Journal of Molecular Sciences.2023; 24(8): 7260. CrossRef - Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence
Ning-Ning Liu, Priya Uppuluri, Achille Broggi, Angelique Besold, Kicki Ryman, Hiroto Kambara, Norma Solis, Viola Lorenz, Wanjun Qi, Maikel Acosta-Zaldívar, S. Noushin Emami, Bin Bao, Dingding An, Francisco A. Bonilla, Martha Sola-Visner, Scott G. Filler,
PLOS Pathogens.2018; 14(7): e1007076. CrossRef - Mutational analysis of metacaspase CaMca1 and decapping activator Edc3 in the pathogenicity of Candida albicans
Jeong-Hoon Jeong, Seok-Eui Lee, Jinmi Kim
Fungal Genetics and Biology.2016; 97: 18. CrossRef
Journal Article
- Anti protein A antibody-gold nanorods conjugate: a targeting agent for selective killing of methicillin resistant Staphylococcus aureus using photothermal therapy method
-
Rasoul Shokri , Mojtaba Salouti , Rahim Sorouri Zanjani
-
J. Microbiol. 2015;53(2):116-121. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4519-4
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48
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20
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Abstract
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The high prevalence of methicillin resistant Staphylococcus
aureus (MRSA) and developing resistance to antibiotics requires
new approaches for treatment of infectious diseases
due to this bacterium. In this study, we developed a targeting
agent for selective killing of MRSA using photothermal
therapy method based on anti protein A antibody and gold
nanorods (GNRs). Polystyrene sulfonate (PSS) coated GNRs
were conjugated with anti protein A antibody. The FT-IR
and UV-vis analyses approved the formation of anti protein
A antibody-gold nanorods conjugate. In vitro study of photothermal
therapy showed 82% reduction in the MRSA cells
viability which was significantly greater than the ablation effect
of free GNRs and laser alone. Significant accumulation
of anti protein A antibody-GNRs in the infected muscle in
comparison with normal muscle approved the targeting ability
of new agent. In vivo study of photothermal therapy resulted
in a significant reduction (73%) in the bacterial cells
viability in the infected mouse model. These results demonstrated
the ability of anti protein A antibody-GNRs conjugate
in combination with NIR laser energy for selective killing of
MRSA in mouse model.
-
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Nano Select.2024;[Epub] CrossRef - Infection Microenvironment‐Sensitive Photothermal Nanotherapeutic Platform to Inhibit Methicillin‐Resistant Staphylococcus aureus Infection
Yu Zhao, Jiaying Yang, Danli Hao, Ran Xie, Lingyu Jia, Miyi Yang, Hai Ma, Pengqian Wang, Weipeng Yang, Feng Sui, Haiyu Zhao, Yanjun Chen, Qinghe Zhao
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Shi Cheng, Qihui Wang, Manlin Qi, Wenyue Sun, Kun Wang, Wen Li, Jinying Lin, Biao Dong, Lin Wang
Materials & Design.2023; 230: 111982. CrossRef - Metallic Nanosystems in the Development of Antimicrobial Strategies with High Antimicrobial Activity and High Biocompatibility
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Yao Ding, Ruichen Ma, Genhua Liu, Xuan Li, Kun Xu, Peng Liu, Kaiyong Cai
ACS Applied Materials & Interfaces.2023; 15(10): 13783. CrossRef - Antimicrobial peptide functionalized gold nanorods combining near-infrared photothermal therapy for effective wound healing
Xinyu Xu, Yujie Ding, Roja Hadianamrei, Songwei Lv, Rongrong You, Fang Pan, Peng Zhang, Nan Wang, Xiubo Zhao
Colloids and Surfaces B: Biointerfaces.2022; 220: 112887. CrossRef - Selective Capture, Separation, and Photothermal Inactivation of Methicillin-Resistant Staphylococcus aureus (MRSA) Using Functional Magnetic Nanoparticles
Chengnan Li, Zongshao Li, Yingying Gan, Fenglin Jiang, Huimin Zhao, Jeremy Tan, Yi Yan Yang, Peiyan Yuan, Xin Ding
ACS Applied Materials & Interfaces.2022; 14(18): 20566. CrossRef - Anti-bacterial monoclonal antibodies: next generation therapy against superbugs
Hui Wang, Daijie Chen, Huili Lu
Applied Microbiology and Biotechnology.2022; 106(11): 3957. CrossRef - Targeted Therapeutic Strategies in the Battle Against Pathogenic Bacteria
Bingqing Yang, Dan Fang, Qingyan Lv, Zhiqiang Wang, Yuan Liu
Frontiers in Pharmacology.2021;[Epub] CrossRef - Harvesting Light To Produce Heat: Photothermal Nanoparticles for Technological Applications and Biomedical Devices
Piersandro Pallavicini, Giuseppe Chirico, Angelo Taglietti
Chemistry – A European Journal.2021; 27(62): 15361. CrossRef - Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment
Yuan Chen, Yujie Gao, Yue Chen, Liu Liu, Anchun Mo, Qiang Peng
Journal of Controlled Release.2020; 328: 251. CrossRef - Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant
Yuan Li, Xiangmei Liu, Bo Li, Yufeng Zheng, Yong Han, Da-fu Chen, Kelvin Wai Kwok Yeung, Zhenduo Cui, Yanqin Liang, Zhaoyang Li, Shengli Zhu, Xianbao Wang, Shuilin Wu
ACS Nano.2020; 14(7): 8157. CrossRef - Aptamer-based selective KB cell killing by the photothermal effect of gold nanorods
Yuseon Noh, Min-Jin Kim, Hyoyoung Mun, Eun-Jung Jo, Hoyeon Lee, Min-Gon Kim
Journal of Nanoparticle Research.2019;[Epub] CrossRef - Nano-Photothermal ablation effect of Hydrophilic and Hydrophobic Functionalized Gold Nanorods on Staphylococcus aureus and Propionibacterium acnes
Nouf N. Mahmoud, Alaaldin M. Alkilany, Enam A. Khalil, Amal G. Al-Bakri
Scientific Reports.2018;[Epub] CrossRef - Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces
Gujie Mi, Di Shi, Mian Wang, Thomas J. Webster
Advanced Healthcare Materials.2018;[Epub] CrossRef - Metal-Based Nanoparticles for the Treatment of Infectious Diseases
Blessing Aderibigbe
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Yash S. Raval, Benjamin D. Fellows, Jamie Murbach, Yves Cordeau, Olin Thompson Mefford, Tzuen‐Rong J. Tzeng
Advanced Functional Materials.2017;[Epub] CrossRef - Engineered gold nanoparticles for photothermal cancer therapy and bacteria killing
Alireza Gharatape, Soodabeh Davaran, Roya Salehi, Hamed Hamishehkar
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Alireza Gharatape, Morteza Milani, Seyed Hossein Rasta, Mohammad Pourhassan-Moghaddam, Sohrab Ahmadi-Kandjani, Soodabeh Davaran, Roya Salehi
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Ki Woo Kim
Journal of Microbiology.2016; 54(11): 703. CrossRef
Research Support, Non-U.S. Gov'ts
- The effects of fluctuating culture temperature on stress tolerance and antioxidase expression in Esteya vermicola
-
Yun-bo Wang , Wen-xing Pang , Xiao-na Yv , Jing-jie Li , Yong-an Zhang , Chang-keun Sung
-
J. Microbiol. 2015;53(2):122-126. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4529-2
-
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51
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5
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Abstract
-
The endoparasitic nematophagous fungus, Esteya vermicola,
has shown great potential as a biological control agent against
the pine wood nematode, Bursaphelenchus xylophilus. Fluctuating
culture temperatures can affect fungal yields and
fungal tolerance to desiccation, UV radiation, H2O2, and
heat stress, as well as antioxidase expression. To explore these
effects, E. vermicola cultured under five temperature ranges,
26oC, 15-26oC, 26-35oC, 20-30oC, and 15-35oC, were compared.
The cultures grown at lower temperatures showed
better growth, stronger tolerance to desiccation, UV, and
H2O2 stresses, and increased catalase expression, However,
these cultures also showed weaker heat stress tolerance and
lower superoxide dismutase expression than the higher-temperature
cultures. In particular, the E. vermicola cultured at
20-30oC, i.e., fluctuating in a narrow range around the optimal
temperature, showed the best performance. Therefore,
for production in practical applications, this narrowly fluctuating,
moderate temperature appears to be optimal for
yield and stress tolerance in E. vermicola.
-
Citations
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- Establishing Gene Expression and Knockout Methods in Esteya vermicola CBS115803
Zhijuan Hu, Chi Chen, Xinyao Zheng, Jingjie Yuan, Run Zou, Chengjian Xie
Molecular Biotechnology.2024; 66(10): 2872. CrossRef - Research Progress on Biocontrol of Pine Wilt Disease by Microorganisms
Guiming Dou, Dong-Hui Yan
Forests.2022; 13(7): 1047. CrossRef -
Effect of culture conditions on conidia production and enhancement of environmental stress resistance of
Esteya vermicola
in solid‐state fermentation
Y. Zhu, Y. Mao, T. Ma, X. Wen
Journal of Applied Microbiology.2021; 131(1): 404. CrossRef - In vivo infection of Bursaphelenchus xylophilus by the fungus Esteya vermicola
Hai‐Hua Wang, Yun‐Bo Wang, Can Yin, Jie Gao, Ran Tao, Yu‐Lou Sun, Chun‐Yan Wang, Zhen Wang, Yong‐Xia Li, Chang‐Keun Sung
Pest Management Science.2020; 76(8): 2854. CrossRef - Research advance on Esteya vermicola, a high potential biocontrol agent of pine wilt disease
Wen Hui Chu, Qing Dou, Hong Long Chu, Hai Hua Wang, Chang Keun Sung, Chun Yan Wang
Mycological Progress.2015;[Epub] CrossRef
- Benzaldehyde as an insecticidal, antimicrobial, and antioxidant compound produced by Photorhabdus temperata M1021
-
Ihsan Ullah , Abdul Latif Khan , Liaqat Ali , Abdur Rahim Khan , Muhammad Waqas , Javid Hussain , In-Jung Lee , Jae-Ho Shin
-
J. Microbiol. 2015;53(2):127-133. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4632-4
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49
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99
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Abstract
-
The Photorhabdus temperata M1021 secretes toxic compounds
that kill their insect hosts by arresting immune
responses. Present study was aimed to purify the insecticidal
and antimicrobial compound(s) from the culture extract of
P. temperata M1021 through bioassay guided fractionation.
An ethyl acetate (EtOAc) extract of the P. temperata M1021
exhibited 100% mortality in Galleria mellonella larvae within
72 h. In addition, EtOAc extract and bioactive compound 1
purified form the extract through to column chromatography,
showed phenol oxidase inhibition up to 60% and
80% respectively. The analysis of 1H and 13C NMR spectra
revealed the identity of pure compound as "benzaldehyde".
The benzaldehyde showed insecticidal activity against G.
mellonella in a dose-dependent manner and 100% insect
mortality was observed at 108 h after injection of 8 mM
benzaldehyde. In a PO inhibition assay, 4, 6, and 8 mM concentrations
of benzaldehyde were found to inhibit PO activity
about 15%, 42%, and 80% respectively. In addition,
nodule formation was significantly (P < 0.05) inhibited by 4,
6, and 8 mM of benzaldehyde as compare to control. Moreover,
benzaldehyde was found to have great antioxidant activity
and maximum antioxidant activity was 52.9% at 8 mM
benzaldehyde as compare to control. Antimicrobial activity
was assessed by MIC values ranged from 6 mM 10 mM for
bacterial strains and 8 mM to 10 mM for fungal strains. The
results
suggest that benzaldehyde could be applicable for
developing novel insecticide for agriculture use.
-
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Daniele Palmieri, Edgar Portillo, Yoelvis Sulbarán, Mayamarú Guerra, Ernesto San-Blas
BioControl.2019; 64(5): 595. CrossRef - Effects of the Botanical Compound p-Anisaldehyde on Horn Fly (Diptera: Muscidae) Repellency, Mortality, and Reproduction
Allan T Showler, Jessica L Harlien
Journal of Medical Entomology.2018; 55(1): 183. CrossRef - Bacterial compounds, as biocontrol agent against early blight (Alternaria solani) and tobacco cut worm (Spodoptera lituraFab.) of tomato (Lycopersicon esculentumMill.)
Kanagaraj Muthu-Pandian Chanthini, Sengottayan Senthil-Nathan, Ramaiah Soranam, Annamalai Thanigaivel, Sengodan Karthi, Chinnadurai Sreenath Kumar, Samuel Jayasurya Kingsley, Ramasamy Kanagaraj Murali-Baskaran
Archives of Phytopathology and Plant Protection.2018; 51(13-14): 729. CrossRef - Valorisation of olive agro-industrial by-products as a source of bioactive compounds
Beatriz Gullón, Patricia Gullón, Gemma Eibes, Cristóbal Cara, Antonia De Torres, Juan Carlos López-Linares, Encarnación Ruiz, Eulogio Castro
Science of The Total Environment.2018; 645: 533. CrossRef - Secondary Metabolites Produced by Heterorhabditis Symbionts and Their Application in Agriculture: What We Know and What to Do Next
S. PATRICIA STOCK, AYAKO KUSAKABE, ROUSEL A. OROZCO
Journal of Nematology.2017; 49(4): 373. CrossRef - Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
J. Masschelein, M. Jenner, G. L. Challis
Natural Product Reports.2017; 34(7): 712. CrossRef - Changes in antioxidant activities and volatile compounds of mixed berry juice through fermentation by lactic acid bacteria
Jae-Bum Park, Seung-Hee Lim, Hyun-Su Sim, Joong-Hee Park, Hun-Joo Kwon, Hee Sop Nam, Myoung-Dong Kim, Hyung-Hee Baek, Suk-Jin Ha
Food Science and Biotechnology.2017; 26(2): 441. CrossRef - Antimicrobial efficacy of Cinnamomum javanicum plant extract against Listeria monocytogenes and its application potential with smoked salmon
Wenqian Yuan, Hui Wen Lee, Hyun-Gyun Yuk
International Journal of Food Microbiology.2017; 260: 42. CrossRef - Screening of the Antimicrobial Activity against Drug Resistant Bacteria of Photorhabdus and Xenorhabdus Associated with Entomopathogenic Nematodes from Mae Wong National Park, Thailand
Paramaporn Muangpat, Temsiri Yooyangket, Chamaiporn Fukruksa, Manawat Suwannaroj, Thatcha Yimthin, Sutthirat Sitthisak, Narisara Chantratita, Apichat Vitta, Nicholas J. Tobias, Helge B. Bode, Aunchalee Thanwisai
Frontiers in Microbiology.2017;[Epub] CrossRef - Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens
Sameh Soliman, Abrar Alsaadi, Eman Youssef, Gregory Khitrov, Ayman Noreddin, Mohamed Husseiny, Ashraf Ibrahim
Molecules.2017; 22(12): 2223. CrossRef - Metabolites profiling reveals for antimicrobial compositional differences and action mechanism in the toothbrushing stick “miswak” Salvadora persica
Mohamed A. Farag, Sherifa Fahmy, Mouchira A. Choucry, Mariam O. Wahdan, Mahmoud Fahmi Elsebai
Journal of Pharmaceutical and Biomedical Analysis.2017; 133: 32. CrossRef - Update: biological and chemical aspects of Nectandra genus (Lauraceae)
Simone S. Grecco, Harry Lorenzi, Andre G. Tempone, João Henrique G. Lago
Tetrahedron: Asymmetry.2016; 27(17-18): 793. CrossRef - Stabilization and Antifungal Activity of Isolated Symbiotic Bacteria from Entomopathogenic Nematodes
Dong-Hee Kang, Hyo-Hyun Kim, Uk-Ho Nam, Hyun-Soo Kim
KSBB Journal.2015; 30(3): 132. CrossRef
- Transcription level analysis of intracellular Burkholderia pseudomallei illustrates the role of BPSL1502 during bacterial interaction with human lung epithelial cells
-
Teerasit Techawiwattanaboon , Tanachaporn Bartpho , Rasana Wongratanacheewin Sermswan , Sorujsiri Chareonsudjai
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J. Microbiol. 2015;53(2):134-140. Published online January 28, 2015
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DOI: https://doi.org/10.1007/s12275-015-4522-9
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51
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6
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Abstract
-
Melioidosis caused by Burkholderia pseudomallei is a globally
important disease of increasing concern according to high
case
-fatality rate and epidemic spreading. The ability of B.
pseudomallei to attach and invade host cells and subsequently
survive intracellularly has stimulated many questions concerning
the comprehension of bacterial pathogenesis progression.
Transcription levels of intracellular B. pseudomallei
genes in human lung epithelial cells were therefore analyzed
using bioinformatic tools, RT-PCR and real time RT-PCR.
Here, it is reported that the identification of bpsl1502, encoding
B. pseudomallei SurE (stationary phase survival protein
E) located in a global transcriptional regulation operon was
accomplished. The up-regulation of B. pseudomallei SurE was
demonstrated during intracellular survival of A549 cells at
12, 18, and 24 h post-infection. To investigate the role of
this protein, a B. pseudomallei SurE defective mutant was
constructed. The invasion and initial survival of the SurE
mutants within the A549 cells were impaired. There was no
difference, however, between the growth of B. pseudomallei
SurE mutant as compared to the wild type in Luria-Bertani
culture. These data suggest that SurE may assist B. pseudomallei
host cells invade and facilitate early intracellular infection
but is not crucial during the stationary growth phase.
The identification of B. pseudomallei SurE provides more
information of bacterial strategy during an early step of the
pathogenesis process of melioidosis.
-
Citations
Citations to this article as recorded by

- Metabolomics Analysis of Bacterial PathogenBurkholderia thailandensisand Mammalian Host Cells in Co-culture
Nicole Aiosa, Anupama Sinha, Olakunle A. Jaiyesimi, Ricardo R. da Silva, Steven S. Branda, Neha Garg
ACS Infectious Diseases.2022; 8(8): 1646. CrossRef - In vitro passage alters virulence, immune activation and proteomic profiles of Burkholderia pseudomallei
Taksaon Duangurai, Onrapak Reamtong, Amporn Rungruengkitkun, Varintip Srinon, Usa Boonyuen, Direk Limmathurotsakul, Narisara Chantratita, Pornpan Pumirat
Scientific Reports.2020;[Epub] CrossRef - Burkholderia pseudomallei Biofilm Promotes Adhesion, Internalization and Stimulates Proinflammatory Cytokines in Human Epithelial A549 Cells
Chanikarn Kunyanee, Watcharaporn Kamjumphol, Suwimol Taweechaisupapong, Sakawrat Kanthawong, Suwin Wongwajana, Surasak Wongratanacheewin, Chariya Hahnvajanawong, Sorujsiri Chareonsudjai, R. Mark Wooten
PLOS ONE.2016; 11(8): e0160741. CrossRef - A predicted cation transporter protein, BPSS1228, is involved in intracellular behaviour ofBurkholderia pseudomalleiin a human lung epithelial cell line (A549)
Teerasit Techawiwattanaboon, Sorujsiri Chareonsudjai, Craig Winstanley
FEMS Microbiology Letters.2016; 363(23): fnw259. CrossRef - Environmental Free-Living Amoebae Isolated from Soil in Khon Kaen, Thailand, Antagonize Burkholderia pseudomallei
Parumon Noinarin, Pisit Chareonsudjai, Pinich Wangsomnuk, Surasak Wongratanacheewin, Sorujsiri Chareonsudjai, William C. Nierman
PLOS ONE.2016; 11(11): e0167355. CrossRef - Mechanisms of Disease: Host-Pathogen Interactions between Burkholderia Species and Lung Epithelial Cells
Jonathan David, Rachel E. Bell, Graeme C. Clark
Frontiers in Cellular and Infection Microbiology.2015;[Epub] CrossRef
- Identification of tyrosine 71 as a critical residue for the cytotoxic activity of Clostridium perfringens epsilon toxin towards MDCK cells
-
Zhigang Jiang , Jitao Chang , Fang Wang , Li Yu
-
J. Microbiol. 2015;53(2):141-146. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4523-8
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50
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6
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Abstract
-
Clostridium perfringens epsilon toxin (Etx) is an extremely
potent toxin, causing fatal enterotoxaemia in many animals.
Several amino acids in domains I and II have been proposed
to be critical for Etx to interact with MDCK cells. However,
the critical amino acids in domain III remain undefined.
Therefore, we assessed the effects of aromatic amino acids
in domain III on Etx activity in this study. All of the results
indicated that Y71 was critical for the cytotoxic activity of
Etx towards MDCK cells, and this activity was dependent
on the existence of an aromatic ring residue in position 71.
Additionally, mutations in Y71 did not affect the binding of
Etx to MDCK cells, indicating that Y71 is not a receptor binding
site for Etx. In summary, we identified an amino acid
in domain III that is important for the cytotoxic activity of
Etx, thereby providing information on the structure-function
relationship of Etx.
-
Citations
Citations to this article as recorded by

- Clostridium perfringens epsilon prototoxin mutant rpETXY30A/Y71A/H106P/Y196A as a vaccine candidate against enterotoxemia
Jige Du, Tuanjie Wang, Lei Xu, Cong Wang, Ying Liu, Chenfan Pan, Xiaoyun Chen, Zhen Zhu, Yufeng Luo, Chunsheng Yin
Vaccine.2023; 41(32): 4762. CrossRef - Etx-Y71A as a non-toxic mutant of Clostridium perfringens epsilon toxin induces protective immunity in mice and sheep
Zhigang Jiang, Jitao Chang, Fang Wang, Yinglin Qi, Yixin Li, Debin Yu, Li Yu
Vaccine.2020; 38(42): 6553. CrossRef - Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells
Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang, Qingwei Li
Cell Communication and Signaling.2019;[Epub] CrossRef - The pore structure of Clostridium perfringens epsilon toxin
Christos G. Savva, Alice R. Clark, Claire E. Naylor, Michel R. Popoff, David S. Moss, Ajit K. Basak, Richard W. Titball, Monika Bokori-Brown
Nature Communications.2019;[Epub] CrossRef - A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization
Jennifer R. Linden, Kiel Telesford, Samantha Shetty, Paige Winokour, Sylvia Haigh, Ellen Cahir-McFarland, Giovanna Antognetti, Abhishek Datta, Tao Wang, Werner Meier, Timothy Vartanian
Antibodies.2018; 7(4): 37. CrossRef - Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines
Marcos Ferreira, Gustavo Moreira, Carlos Cunha, Marcelo Mendonça, Felipe Salvarani, Ângela Moreira, Fabricio Conceição
Toxins.2016; 8(11): 340. CrossRef
- Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models
-
Hongmei Xu , Libin Wang , Jian Huang , Yanqing Zhang , Feng Ma , Jianmin Wang , Wenchun Xu , Xuemei Zhang , Yibing Yin , Kaifeng Wu
-
J. Microbiol. 2015;53(2):147-154. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4616-4
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48
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4
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Abstract
-
Pneumococcal asymptomatic colonization of the respiratory
tracts is a major risk for invasive pneumococcal disease.
We have previously shown that pneumococcal wall teichoic
acid (WTA) was involved in pneumococcal infection of sepsis
and adherence to epithelial and endothelial cells. In this
study, we investigated the contribution of pneumococcal
WTA to bacterial colonization and dissemination in murine
models. The result showed that nasopharynx colonizing D39
bacterial cells have a distinct phenotype showing an increased
exposure of teichoic acids relative to medium-grown bacteria.
The WTA-deficient mutants were impaired in their colonization
to the nasopharynx and lungs, and led to a mild inflammation
in the lungs at 36 h post-inoculation. Pretreatment
of the murine nares with WTA reduced the ability of
wild type D39 bacteria to colonize the nasopharynx. In addition,
the WTA-deficient strain was impaired in its ability
to invade the blood and brain following intranasal administration.
WTA-deficient D39 strain was reduced in C3 deposition
but was more susceptible to the killing by the neutrophils
as compared with its parent strain. Our results also
demonstrated that the WTA enhanced pneumococcal colonization
and dissemination independently of the host strains.
These results indicate that WTA plays an important role in
pneumococcal pathogenesis, both in colonization and dissemination
processes.
-
Citations
Citations to this article as recorded by

- Insight into the structure, biosynthesis, isolation method and biological function of teichoic acid in different gram-positive microorganisms: A review
Jiarun Han, Xin Zhao, Xilian Zhao, Ping Li, Qing Gu
International Journal of Biological Macromolecules.2023; 253: 126825. CrossRef - spd1672, a novel in vivo-induced gene, affects inflammatory response in a murine model of Streptococcus pneumoniae infection
Lingling Gan, Xuemei Zhang, Xiuyu Xu, Wenchun Xu, Chang Lu, Jin Cui, Hong Wang
Canadian Journal of Microbiology.2018; 64(6): 401. CrossRef - Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
Nathalie Heß, Franziska Waldow, Thomas P. Kohler, Manfred Rohde, Bernd Kreikemeyer, Alejandro Gómez-Mejia, Torsten Hain, Dominik Schwudke, Waldemar Vollmer, Sven Hammerschmidt, Nicolas Gisch
Nature Communications.2017;[Epub] CrossRef - New chemical tools to probe cell wall biosynthesis in bacteria
Robert T Gale, Eric D Brown
Current Opinion in Microbiology.2015; 27: 69. CrossRef
- Genipin as a novel chemical activator of EBV lytic cycle
-
Myoungki Son , Minjung Lee , Eunhyun Ryu , Aree Moon , Choon-Sik Jeong , Yong Woo Jung , Gyu Hwan Park , Gi-Ho Sung , Hyosun Cho , Hyojeung Kang
-
J. Microbiol. 2015;53(2):155-165. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4672-9
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53
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29
Crossref
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Abstract
-
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus
that causes acute infection and establishes life-long latency.
EBV causes several human cancers, including Burkitt's lymphoma,
nasopharyngeal and gastric carcinoma. Antiviral
agents can be categorized as virucides, antiviral chemotherapeutic
agents, and immunomodulators. Most antiviral agents
affect actively replicating viruses, but not their latent forms.
Novel antiviral agents must be active on both the replicating
and the latent forms of the virus. Gardenia jasminoides is an
evergreen flowering plant belonging to the Rubiaceae family
and is most commonly found growing wild in Vietnam,
Southern China, Taiwan, Japan, Myanmar, and India. Genipin
is an aglycone derived from an iridoid glycoside called geniposide,
which is present in large quantities in the fruit of
G. jasminoides. In this study, genipin was evaluated for its
role as an antitumor and antiviral agent that produces inhibitory
effects against EBV and EBV associated gastric carcinoma
(EBVaGC). In SNU719 cells, one of EBVaGCs, genipin
caused significant cytotoxicity (70 μM), induced methylation
on EBV C promoter and tumor suppressor gene
BCL7A, arrested cell-cycle progress (S phases), upregulated
EBV latent/lytic genes in a dose-dependent manner, stimulated
EBV progeny production, activated EBV F promoter
for EBV lytic activation, and suppressed EBV infection. These
results
indicated that genipin could be a promising candidate
for antiviral and antitumor agents against EBV and
EBVaGC.
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Citations
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- Research Progress of EB Virus-Associated Gastric Cancer
婷婷 宋
Advances in Clinical Medicine.2024; 14(08): 862. CrossRef - Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
Lapava Natallia, Aida Dama, Era Gorica, Karaliova Darya, Sheila I. Peña-Corona, Hernán Cortés, Antonello Santini, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad
Medical Oncology.2024;[Epub] CrossRef - Update of Natural Products and Their Derivatives Targeting Epstein–Barr Infection
Rosamaria Pennisi, Paola Trischitta, Marianna Costa, Assunta Venuti, Maria Pia Tamburello, Maria Teresa Sciortino
Viruses.2024; 16(1): 124. CrossRef - Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review
Dewi Utami Nike, Nur Izzah Md Fadilah, Nusaibah Sallehuddin, Ahmad Yasser Hamdi Nor Azlan, Farrah Hani Imran, Manira Maarof, Mh Busra Fauzi
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef - Genipin, an Inhibitor of UCP2 as a Promising New Anticancer Agent: A Review of the Literature
Young Seok Cho
International Journal of Molecular Sciences.2022; 23(10): 5637. CrossRef - Preparation, characterization, and in vitro release kinetics of doxorubicin-loaded magnetosomes
Shuang Zhang, Xinxin Fan, Guojing Zhang, Weidong Wang, Lei Yan
Journal of Biomaterials Applications.2022; 36(8): 1469. CrossRef - An Integrated Analysis Reveals Geniposide Extracted From Gardenia jasminoides J.Ellis Regulates Calcium Signaling Pathway Essential for Influenza A Virus Replication
Lirun Zhou, Lei Bao, Yaxin Wang, Mengping Chen, Yingying Zhang, Zihan Geng, Ronghua Zhao, Jing Sun, Yanyan Bao, Yujing Shi, Rongmei Yao, Shanshan Guo, Xiaolan Cui
Frontiers in Pharmacology.2021;[Epub] CrossRef - Synthesis of [3H] and [14C]genipin
Adele.E. Queen, David Hesk, David.M. Lindsay, William.J. Kerr, Kenneth Rehder, Tim Fennell, Wayne Mascarella, Desong Zhong, Scott Runyon
Journal of Labelled Compounds and Radiopharmaceuticals.2020; 63(4): 196. CrossRef - Genipin inhibits rotavirus-induced diarrhea by suppressing viral replication and regulating inflammatory responses
Jong-Hwa Kim, Kiyoung Kim, Wonyong Kim
Scientific Reports.2020;[Epub] CrossRef - Genipap (Genipa americana L.) juice intake biomarkers after medium-term consumption
Livia Dickson, Mathieu Tenon, Ljubica Svilar, Pascale Fança-Berthon, Jean-Charles Martin, Hervé Rogez, Fabrice Vaillant
Food Research International.2020; 137: 109375. CrossRef - Evaluation on the antiviral activity of genipin against white spot syndrome virus in crayfish
Ai-Guo Huang, Xiao-Ping Tan, Shen-Ye Qu, Gao-Xue Wang, Bin Zhu
Fish & Shellfish Immunology.2019; 93: 380. CrossRef - Comparative investigation on metabolite changes in ‘wu mi’ production by Vaccinium bracteatum Thunb. leaves based on multivariate data analysis using UPLC–QToF–MS
Mingcong Fan, Yihui Fan, Zhiming Rao, Yan Li, Haifeng Qian, Hui Zhang, Gangcheng Wu, Xiguang Qi, Li Wang
Food Chemistry.2019; 286: 146. CrossRef - Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts
Dong-eun Kim, Sunhee Jung, Hyung Won Ryu, Miri Choi, Mingu Kang, Hyunju Kang, Heung Joo Yuk, Hyejeong Jeong, Jiyeon Baek, Jae-Hyoung Song, Janghwan Kim, Hyojeung Kang, Sang-Bae Han, Sei-Ryang Oh, Sungchan Cho
Journal of Functional Foods.2018; 42: 146. CrossRef - Curcuminoids as EBV Lytic Activators for Adjuvant Treatment in EBV-Positive Carcinomas
Octavia Ramayanti, Mitch Brinkkemper, Sandra Verkuijlen, Leni Ritmaleni, Mei Go, Jaap Middeldorp
Cancers.2018; 10(4): 89. CrossRef - EBV transformation induces overexpression of hMSH2/3/6 on B lymphocytes and enhances γδT‐cell‐mediated cytotoxicity via TCR and NKG2D
Yu‐mei Dai, Hai‐ying Liu, Yun‐feng Liu, Yuan Zhang, Wei He
Immunology.2018; 154(4): 673. CrossRef - Infection‐associated epigenetic alterations in gastric cancer: New insight in cancer therapy
Sadegh Fattahi, Mohadeseh Kosari‐Monfared, Elham Ghadami, Monireh Golpour, Parastoo Khodadadi, Mohammad Ghasemiyan, Haleh Akhavan‐Niaki
Journal of Cellular Physiology.2018; 233(12): 9261. CrossRef - Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin
Solomon Habtemariam, Giovanni Lentini
Biomedicines.2018; 6(2): 39. CrossRef - Main Human Urinary Metabolites after Genipap (Genipa americana L.) Juice Intake
Livia Dickson, Mathieu Tenon, Ljubica Svilar, Pascale Fança-Berthon, Raphael Lugan, Jean-Charles Martin, Fabrice Vaillant, Hervé Rogez
Nutrients.2018; 10(9): 1155. CrossRef - Genipin: A natural blue pigment for food and health purposes
Iramaia Angélica Neri-Numa, Marina Gabriel Pessoa, Bruno Nicolau Paulino, Glaucia Maria Pastore
Trends in Food Science & Technology.2017; 67: 271. CrossRef - Geniposide and geniposidic acid, modified forms of genipin, attenuate genipin-induced mitochondrial apoptosis without altering the anti-inflammatory ability in KGN cell line
Tao Zuo, Wenming Xu, Henli Li, Hang Song, Minghui Zhu
Medicinal Chemistry Research.2017; 26(2): 499. CrossRef - Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef - Expression of toll‐like receptors in T lymphocytes stimulated with N‐(3‐oxododecanoyl)‐L‐homoserine lactone from Pseudomonas aeruginosa
Lei Bao, Jialin Yu, Haiying Zhong, Daochao Huang, Qi Lu
APMIS.2017; 125(6): 553. CrossRef - Chemical Constituents from the Flowers of Wild Gardenia jasminoides J.Ellis
Hu Zhang, Ning Feng, Yan‐Tong Xu, Tian‐Xiang Li, Xiu‐Mei Gao, Yan Zhu, Yun Seon Song, Ya‐Nan Wang, Hong‐Hua Wu
Chemistry & Biodiversity.2017;[Epub] CrossRef - The Suppressive Effects of Geniposide and Genipin on Helicobacter pylori Infections In Vitro and In Vivo
Chiung‐Hung Chang, Jin‐Bin Wu, Jai‐Sing Yang, Yen‐Ju Lai, Chiu‐Hsian Su, Chi‐Cheng Lu, Yuan‐Man Hsu
Journal of Food Science.2017; 82(12): 3021. CrossRef - Antitumor Effects of Genipin: New and Emerging Insights from Recent Studies
Yu Su Shin, Miyeon Cho, Gyu Hwan Park, Hyosun Cho, Hyojeung Kang
Journal of Bacteriology and Virology.2016; 46(2): 108. CrossRef - Iridoids are natural glycation inhibitors
Brett J. West, Shixin Deng, Akemi Uwaya, Fumiyuki Isami, Yumi Abe, Sho-ichi Yamagishi, C. Jarakae Jensen
Glycoconjugate Journal.2016; 33(4): 671. CrossRef - Genipin Enhances Kaposi’s Sarcoma-Associated Herpesvirus Genome Maintenance
Miyeon Cho, Seok Won Jung, Soomin Lee, Kuwon Son, Gyu Hwan Park, Jong-Wha Jung, Yu Su Shin, Taegun Seo, Hyosun Cho, Hyojeung Kang, Shou-Jiang Gao
PLOS ONE.2016; 11(10): e0163693. CrossRef - Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis
Hwan Hee Lee, Seulki Lee, Kanghyo Lee, Yu Su Shin, Hyojeung Kang, Hyosun Cho
DARU Journal of Pharmaceutical Sciences.2015;[Epub] CrossRef - Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Cho
Journal of Microbiology.2015; 53(7): 468. CrossRef
- Immunological charaterization of monoclonal antibodies used in rapid influenza diagnostic test for detection of the 2009 pandemic influenza A(H1N1)pdm09 infection
-
Hwajung Yi , Mi-Seon Lee , Joo-Yeon Lee , Hae Kyung Lee , Chun Kang
-
J. Microbiol. 2015;53(2):166-175. Published online January 28, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4642-2
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48
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1
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Abstract
-
Since the 2009 pandemic, monoclonal antibodies (mAbs)
for rapid influenza diagnostic tests (RIDT) have been developed
for specific diagnostics of pandemic viral infection.
Most of the mAbs were poorly characterized because of urgency
during the pandemic. Further characterization of the
mAbs for RIDTs would be beneficial for understanding the
immunological properties of the pandemic virus and utilizing
the mAbs for other research purposes. In this study, it
was confirmed that two mAbs (I38 and D383) in an RIDT for
H1N1pdm09 diagnostics were able to detect H1N1pdm09
virus through enzyme-linked immunosorbent assay (ELISA)
and immunofluorescence assay (IFA). Also, the two mAbs
exhibited reactivity to hemagglutinins (HAs) of both the
H1N1pdm09 and 1918 H1N1 viruses; therefore, the RIDT
using the mAbs could detect HAs of H1N1pdm09 and also
HAs of 1918 H1N1-like strains. In an extension to our previous
study, the epitopes (Sa antigenic site and the interface
area of F?and vestigial esterase subdomains on the HA1 domain
of HA of H1N1pdm09) recognized by the mAbs were
corroborated in depth by IFA with escape-mutants from
the mAbs and mapping of the epitopes on the crystal structure
of human H1N1 viral HAs. Collectively, these results
imply that the mAbs for the RIDT may be suitable for use
in studying the immunological properties of H1N1pdm09
viruses and that the Sa antigenic site and the interface area
between F?and vestigial esterase subdomains on influenza
viral HA recognized by the mAbs are immunologically
conserved regions between H1N1pdm09 and 1918 H1N1.
-
Citations
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- Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia
Ayako Ohkawara, Masatoshi Okamatsu, Makoto Ozawa, Duc‐Huy Chu, Lam Thanh Nguyen, Takahiro Hiono, Keita Matsuno, Hiroshi Kida, Yoshihiro Sakoda
Microbiology and Immunology.2017; 61(5): 149. CrossRef
- Note] Inhibition of quorum sensing in Pseudomonas aeruginosa by two herbal essential oils from Apiaceae family
-
Ehsan Sepahi , Saeed Tarighi , Farajollah Shahriari Ahmadi , Abdolreza Bagheri
-
J. Microbiol. 2015;53(2):176-180. Published online January 5, 2015
-
DOI: https://doi.org/10.1007/s12275-015-4203-8
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56
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35
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Abstract
-
Ferula (Ferula asafoetida L.) and Dorema (Dorema aucheri
Bioss.) both from Apiaceae family were tested for their antiquorum
sensing (QS) activity against Pseudomonas aeruginosa.
Both essential oils exhibited anti-QS activity at 25 μg/ml
of concenteration. At this concenteration Ferula fully abolished
and Dorema reduced the violacein production by C.
violaceum. Pyocyanin, pyoverdine, elastase and biofilm production
were decreased in Ferula oil treatments. Dorema
oil reduced pyoverdine and elastase production, while pyocyanin
and biofilm production were not affacted. Expresion
analysis of QS-dependent genes confirmed our phenotypic
data. Our data introduced native Dorema and Ferula plants
as novel QS and virulence inhibitors.
-
Citations
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- Effects of AI-2 quorum sensing inhibitors on mitigating bacterial contamination in bioethanol production
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