Journal of Microbiology

Research Article

Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus: Jueun Oh, Hayeon Kim, Jihye Lee, Suhyun Kim, Seyun Shin, Young-Eui Kim, Sehee Park, SangJoon Lee; J. Microbiol. 2025;63(1):e.2409007. Published online January 24, 2025; DOI: https://doi.org/10.71150/jm.2409007

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Abstract PDF Supplementary Material: Korean Red ginseng has emerged as a potent candidate in the fight against various viral infections, demonstrating significant efficacy both in vitro and in vivo, particularly against influenza A viruses. Despite substantial evidence of its antiviral properties, the detailed molecular mechanisms through which it reduces viral lethality remain insufficiently understood. Our investigations have highlighted the superior effectiveness of Korean Red ginseng against influenza viruses, outperforming its effects on numerous other viral strains. We aim to uncover the specific mechanisms by which Korean Red ginseng exerts its antiviral effects, focusing on influenza A viruses. Our prior studies have identified the role of Z-DNA-binding protein 1 (ZBP1), a signaling complex involved in inducing programmed cell death in response to influenza virus infection. Given the critical role of ZBP1 as a sensor for viral nucleic acid, we hypothesize that Korean Red ginseng may modulate the ZBP1-derived cell death pathway. This interaction is anticipated to enhance cell death while concurrently suppressing viral protein expression, offering novel insights into the antiviral mechanism of Korean Red ginseng against influenza A viruses.

Journal Article

Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice: Sehee Park , Jin Il Kim , Joon-Yong Bae , Kirim Yoo , Hyunung Kim , In-Ho Kim , Man-Seong Park , Ilseob Lee; J. Microbiol. 2018;56(2):145-149. Published online February 2, 2018; DOI: https://doi.org/10.1007/s12275-018-7411-1

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The potential use of dietary measures to treat influenza can be an important alternative for those who lack access to influenza vaccines or antiviral drugs. Lactobacillus plantarum (Lp) is one of many lactic acid bacteria that grow in ‘kimchi’, an essential part of Korean meal, and several strains of Lp reportedly show protective effects against influenza. Using heat-killed Lp (nF1) isolated from kimchi, which is known for its immunomodulatory effects, we investigated whether regular oral intake of nF1 could influence the outcome of influenza virus infection in a mouse model. In a lethal challenge with influenza A (H1N1 and H3N2 subtypes) and influenza B (Yamagata lineage) viruses, daily oral administration of nF1 delayed the mean number of days to death of the infected mice and resulted in increased survival rates compared with those of the non-treated mice. Consistent with these observations, nF1 treatment also significantly reduced viral replication in the lungs of the infected mice. Taken together, our results might suggest the remedial potential of heatkilled Lactobacillus probiotics against influenza.

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Research Support, Non-U.S. Gov'ts

DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation: Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park; J. Microbiol. 2013;51(6):866-871. Published online December 19, 2013; DOI: https://doi.org/10.1007/s12275-013-3428-7

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Abstract

Influenza viruses are seasonally recurring human pathogens. Vaccines and antiviral drugs are available for influenza. However, the viruses, which often change themselves via antigenic drift and shift, demand constant efforts to update vaccine antigens every year and develop new agents with broad-spectrum antiviral efficacy. An animal model is critical for such efforts. While most human influenza viruses are unable to kill BALB/c mice, some strains have been shown to kill DBA/2 mice without prior adaptation. Therefore, in this study, we explored the feasibility of employing DBA/2 mice as a model in the development of anti-influenza drugs. Unlike the BALB/c strain, DBA/2 mice were highly susceptible and could be killed with a relatively low titer (50% DBA/2 lethal dose = 102.83 plaque-forming units) of the A/ Korea/01/2009 virus (2009 pandemic H1N1 virus). When treated with a neuraminidase inhibitor, oseltamivir phosphate, infected DBA/2 mice survived until 14 days postinfection. The reduced morbidity of the infected DBA/2 mice was also consistent with the oseltamivir treatment. Taking these data into consideration, we propose that the DBA/2 mouse is an excellent animal model to evaluate antiviral efficacy against influenza infection and can be further utilized for combination therapies or bioactivity models of existing and newly developed anti-influenza drugs.

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Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice
Sehee Park, Jin Il Kim, Joon-Yong Bae, Kirim Yoo, Hyunung Kim, In-Ho Kim, Man-Seong Park, Ilseob Lee
Journal of Microbiology.2018; 56(2): 145. CrossRef
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The Anti-influenza Virus Effect of Phellinus igniarius Extract: Sangmoo Lee , Jin Il Kim , Jun Heo , Ilseob Lee , Sehee Park , Min-Woong Hwang , Joon-Yong Bae , Mee Sook Park , Hyoung Jin Park , Man-Seong Park; J. Microbiol. 2013;51(5):676-681. Published online October 31, 2013; DOI: https://doi.org/10.1007/s12275-013-3384-2

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Abstract

Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multicomponent nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

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NOTE] Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011: Sehee Park , Jin Il Kim , Ilseob Lee , Sangmoo Lee , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Eun-Joo Lim , Won-Seok Seok , Hee Jin Cheong , Joon Young Song , Woo Joo Kim , Man-Seong Park; J. Microbiol. 2012;50(6):1067-1070. Published online December 30, 2012; DOI: https://doi.org/10.1007/s12275-012-2541-3

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Abstract: During the 2009–2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

NOTE] GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents: Jin Il Kim , Sehee Park , Ilseob Lee , Sangmoo Lee , Saem Shin , Yongkwan Won , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Hye-Eun Hyun , Hyejin Jun , Soon Sung Lim , Man-Seong Park; J. Microbiol. 2012;50(2):359-362. Published online April 27, 2012; DOI: https://doi.org/10.1007/s12275-012-2163-9

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15 Scopus

Abstract: To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.

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