Meta-Analysis
- Exploring COVID-19 Pandemic Disparities with Transcriptomic Meta-analysis from the Perspective of Personalized Medicine
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Medi Kori, Ceyda Kasavi, Kazim Yalcin Arga
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J. Microbiol. 2024;62(9):785-798. Published online July 9, 2024
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DOI: https://doi.org/10.1007/s12275-024-00154-9
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Abstract
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Infection with SARS-CoV2, which is responsible for COVID-19, can lead to differences in disease development, severity and mortality rates depending on gender, age or the presence of certain diseases. Considering that existing studies ignore these differences, this study aims to uncover potential differences attributable to gender, age and source of sampling as well as viral load using bioinformatics and multi-omics approaches. Differential gene expression analyses were used to analyse the phenotypic differences between SARS-CoV-2 patients and controls at the mRNA level. Pathway enrichment analyses were performed at the gene set level to identify the activated pathways corresponding to the differences in the samples. Drug repurposing analysis was performed at the protein level, focusing on host-mediated drug candidates to uncover potential therapeutic differences. Significant differences (i.e. the number of differentially expressed genes and their characteristics) were observed for COVID-19 at the mRNA level depending on the sample source, gender and age of the samples. The results of the pathway enrichment show that SARS-CoV-2 can be combated more effectively in the respiratory tract than in the blood samples.
Taking into account the different sample sources and their characteristics, different drug candidates were identified. Evaluating disease prediction, prevention and/or treatment strategies from a personalised perspective is crucial. In this study, we not only evaluated the differences in COVID-19 from a personalised perspective, but also provided valuable data for further experimental and clinical efforts. Our findings could shed light on potential pandemics.
Journal Articles
- Effects of Light and Dark Conditions on the Transcriptome of Aging Cultures of Candidatus Puniceispirillum marinum IMCC1322
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Ji Hyen Lee, Hyun-Myung Oh
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J. Microbiol. 2024;62(4):297-314. Published online April 25, 2024
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DOI: https://doi.org/10.1007/s12275-024-00125-0
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Abstract
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To elucidate the function of proteorhodopsin in Candidatus Puniceispirillum marinum strain IMCC1322, a cultivated representative of SAR116, we produced RNA-seq data under laboratory conditions. We examined the transcriptomes of six different cultures, including sets of expression changes under constant dark (DD), constant light (LL), and diel-cycled (LD; 14 h light: 10 h dark) conditions at the exponential and stationary/death phases. Prepared mRNA extracted from the six samples was analyzed on the Solexa Genome Analyzer with 36 cycles.
Differentially expressed genes on the IMCC1322 genome were distinguished as four clusters by K-mean clustering and each CDS (n = 2546) was annotated based on the KEGG BRITE hierarchy. Cluster 0 (n = 1573) covered most constitutive genes including proteorhodopsin, retinoids, and glycolysis/TCA cycle. Cluster 1 genes (n = 754) were upregulated in stationary/death phase under constant dark conditions and included genes associated with bacterial defense, membrane transporters, nitrogen metabolism, and senescence signaling. Cluster 2 genes (n = 197) demonstrated upregulation in exponential phase cultures and included genes involved in genes for oxidative phosphorylation, translation factors, and transcription machinery. Cluster 3 (n = 22) contained light-stimulated upregulated genes expressed under stationary/phases. Stringent response genes belonged to cluster 2, but affected genes spanned various cellular processes such as amino acids, nucleotides, translation, transcription, glycolysis, fatty acids, and cell wall components. The coordinated expression of antagonistic stringent genes, including mazG, ppx/gppA, and spoT/relA may provide insight into the controlled cultural response observed between constant light and constant dark conditions in IMCC1322 cultures, regardless of cell numbers and biomass.
- Regulatory role of cysteines in (2R, 3R)-butanediol dehydrogenase BdhA of Bacillus velezensis strain GH1-13
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Yunhee Choi , Yong-Hak Kim
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J. Microbiol. 2022;60(4):411-418. Published online March 14, 2022
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DOI: https://doi.org/10.1007/s12275-022-2018-y
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Abstract
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Bacillus velezensis strain GH1-13 contains a (2R,3R)-butanediol
dehydrogenase (R-BDH) BdhA which converts acetoin
to R-BD reversibly, however, little is known about its regulatory
cysteine and biological significance. We performed sitedirected
mutation of three cysteines in BdhA. The C37S mutant
had no enzyme activity and the C34S and C177S mutants
differed from each other and wild type (WT). After zinc affinity
chromatography, 1 mM ZnCl2 treatment resulted in a
3-fold enhancement of the WT activity, but reduced activity
of the C34S mutant by more than 2 folds compared to the untreated
ones. However, ZnCl2 treatment did not affect the activity
of the C177S mutant. Most of the double and triple mutant
proteins (C34S/C37S, C34S/C177S, C37S/C177S, and
C34S/C37S/C177S) were aggregated in zinc resins, likely due
to the decreased protein stability. All of the purified WT and
single mutant proteins increased multiple intermolecular disulfide
bonds in the presence of H2O2 as the buffer pH decreased
from 7.5 to 5.5, whereas an intramolecular disulfide
bond of cysteine 177 and another cysteine in the CGIC motif
region was likely formed at pH higher than pKa of 7.5. When
pH varied, WT and its C34S or C177S mutants reduced acetoin
to R-BD at the optimum pH 5.5 and oxidized R-BD to
acetoin at the optimum pH 10. This study demonstrated that
cysteine residues in BdhA play a regulatory role for the production
of acetoin and R-BD depending on pH as well as
metal binding and oxidative stress.
-
Citations
Citations to this article as recorded by

- Significantly enhanced specific activity of Bacillus subtilis (2,3)-butanediol dehydrogenase through computer-aided refinement of its substrate-binding pocket
Bochun Hu, Xiaoqi Xi, Fugang Xiao, Xiaomeng Bai, Yuanyuan Gong, Yifan Li, Xueqin Qiao, Cunduo Tang, Jihong Huang
International Journal of Biological Macromolecules.2024; 281: 136443. CrossRef - Structural and enzymatic characterization of Bacillus subtilis R,R-2,3-butanediol dehydrogenase
Xiaofei Wang, Lingyun Jia, Fangling Ji
Biochimica et Biophysica Acta (BBA) - General Subjects.2023; 1867(4): 130326. CrossRef - Engineering a BsBDHA substrate-binding pocket entrance for the improvement in catalytic performance toward (R)-phenyl-1,2-ethanediol based on the computer-aided design
Bo-Chun Hu, Meng-Ran Li, Ying-Ying Li, Xin-Shuang Yuan, Yu-Ye Hu, Fu-Gang Xiao
Biochemical Engineering Journal.2023; 194: 108907. CrossRef
- Antibacterial pathway of cefquinome against Staphylococcus aureus based on label-free quantitative proteomics analysis
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Linglin Gao , Hao Zhu , Yun Chen , Yuhui Yang
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J. Microbiol. 2021;59(12):1112-1124. Published online November 9, 2021
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DOI: https://doi.org/10.1007/s12275-021-1201-x
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50
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1
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Abstract
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Cefquinome (CEQ) is a novel β-lactam antibiotic that exhibits
excellent antibacterial activity against Staphylococcus aureus.
However, the bacterial protein targets of CEQ are unclear.
To evaluate the relationship between the pharmacokinetic/
pharmacodynamic (PK/PD) parameters of CEQ and strains
with varying degrees of resistance and to elucidate bacterial
protein responses to CEQ treatment, label-free quantitative
proteomics analysis was conducted. The sensitive S. aureus
ATCC6538 and the resistant 2MIC and 8MIC were tested for
differentially expressed proteins. An in vitro model was treated
with different concentrations of CEQ (3, 5, or 10 μg/ml) with
different terminal half-lives (2.5 or 5 h) at different intervals
(12 or 24 h). Differentially expressed proteins were evaluated
using Gene Ontology analysis followed by KEGG pathway enrichment
analysis and STRING network analysis. RT-qPCR
was performed to validate the differentially expressed proteins
at the molecular level. The results showed that the degree of
resistance increased in a cumulative manner and increased
gradually with the extension of administration time. The resistant
strain would not have appeared in the model only if
%T > mutant prevention concentration ≥ 50%. The expression
of 45 proteins significantly changed following CEQ treatment,
among which 42 proteins were obviously upregulated
and 3 were downregulated. GO analysis revealed that the differentially
expressed proteins were mainly present on cells and
the cell membrane, participated in metabolic and intracellular
processes, and had catalytic and binding activities. The RPSO,
SDHB, CITZ, ADK, and SAOUHSC 00113 genes in S. aureus
may play important roles in the development of resistance
to CEQ. These results provided important reference candidate
proteins as targets for overcoming S. aureus resistance
to CEQ.
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Citations
Citations to this article as recorded by

- Detection of Antibiotic Resistance in Feline-Origin ESBL Escherichia coli from Different Areas of China and the Resistance Elimination of Garlic Oil to Cefquinome on ESBL E. coli
Yin-Chao Tong, Peng-Cheng Li, Yang Yang, Qing-Yi Lin, Jin-Tong Liu, Yi-Nuo Gao, Yi-Ning Zhang, Shuo Jin, Su-Zhu Qing, Fu-Shan Xing, Yun-Peng Fan, Ying-Qiu Liu, Wei-Ling Wang, Wei-Min Zhang, Wu-Ren Ma
International Journal of Molecular Sciences.2023; 24(11): 9627. CrossRef
- Role of melatonin in murine “restraint stress”-induced dysfunction of colonic microbiota
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Rutao Lin , Zixu Wang , Jing Cao , Ting Gao , Yulan Dong , Yaoxing Chen
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J. Microbiol. 2021;59(5):500-512. Published online February 25, 2021
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DOI: https://doi.org/10.1007/s12275-021-0305-7
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13
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15
Crossref
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Abstract
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Intestinal diseases caused by physiological stress have become
a severe public health threat worldwide. Disturbances in the
gut microbiota-host relationship have been associated with
irritable bowel disease (IBD), while melatonin (MT) has antiinflammatory
and antioxidant effects. The objective of this
study was to investigate the mechanisms by which MT-mediated
protection mitigated stress-induced intestinal microbiota
dysbiosis and inflammation. We successfully established a
murine restraint stress model with and without MT supplementation.
Mice subjected to restraint stress had significantly
elevated corticosterone (CORT) levels, decreased MT levels
in their plasma, elevated colonic ROS levels and increased bacterial
abundance, including Bacteroides and Tyzzerella, in
their colon tract, which led to elevated expression of Toll-like
receptor (TLR) 2/4, p-P65 and p-IκB. In contrast, supplementation
with 20 mg/kg MT reversed the elevation of the plasma
CORT levels, downregulated the colon ROS levels and inhibited
the changes in the intestinal microbiota induced by
restraint stress. These effects, in turn, inhibited the activities
of TLR2 and TLR4, p-P65 and p-IκB, and decreased the inflammatory
reaction induced by restraint stress. Our results
suggested that MT may mitigate “restraint stress”-induced
colonic microbiota dysbiosis and intestinal inflammation by
inhibiting the activation of the NF-κB pathway.
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Citations
Citations to this article as recorded by

- Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders
Petra Zimmermann, Salome Kurth, Benoit Pugin, Nicholas A. Bokulich
npj Biofilms and Microbiomes.2024;[Epub] CrossRef - Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review
Xuemeng Wan, Liyuan Wang, Zhiling Wang, Chaomin Wan
Frontiers in Immunology.2024;[Epub] CrossRef - Christensenella minuta mitigates behavioral and cardiometabolic hallmarks of social defeat stress
A. Agusti, GV. Molina-Mendoza, M. Tamayo, V. Rossini, MC. Cenit, C. Frances-Cuesta, V. Tolosa-Enguis, EM. Gómez Del Pulgar, A. Flor-Duro, Y. Sanz
Biomedicine & Pharmacotherapy.2024; 180: 117377. CrossRef - The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes, Paula Sanchez‐Diaz, Cassandra E. Gheorghe, Michael S. Goodson, Nancy Kelley‐Loughnane, Niall P. Hyland, John F. Cryan, Gerard Clarke
The Journal of Physiology.2023; 601(20): 4491. CrossRef - Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease
María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
Antioxidants.2023; 13(1): 34. CrossRef - INVESTIGATION OF THE ROLE OF STRESS IN MALE INFERTILITY AND THE EFFECT OF CURRENT MELATONIN HORMONE TREATMENTS
İshak GÖKÇEK, Leyla AYDIN
Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni.2023; 14(1): 36. CrossRef - The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments
Alane N. Bezerra, Caroline L. Peixoto, Synara C. Lopes, Veralice M. S. Bruin, Pedro Felipe C. Bruin, Reinaldo B. Oriá
Frontiers in Nutrition.2023;[Epub] CrossRef - Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light
Dun-Xian Tan, Russel J. Reiter, Scott Zimmerman, Ruediger Hardeland
Biology.2023; 12(1): 89. CrossRef - Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice
Ichiro Chihara, Hiromitsu Negoro, Jin Kono, Yoshiyuki Nagumo, Haruki Tsuchiya, Kosuke Kojo, Masanobu Shiga, Ken Tanaka, Shuya Kandori, Bryan J. Mathis, Hiroyuki Nishiyama
Communications Biology.2023;[Epub] CrossRef - The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation
Jefferson Luiz da Silva, Lia Vezenfard Barbosa, Camila Figueiredo Pinzan, Viviani Nardini, Irislene Simões Brigo, Cássia Aparecida Sebastião, Jefferson Elias-Oliveira, Vânia Brazão, José Clóvis do Prado Júnior, Daniela Carlos, Cristina Ribeiro de Barros C
Microorganisms.2023; 11(2): 460. CrossRef - The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression
Mauritz F. Herselman, Sheree Bailey, Larisa Bobrovskaya
International Journal of Molecular Sciences.2022; 23(4): 2013. CrossRef - Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
Yiwen Zhang, Rui Lang, Shunyu Guo, Xiaoqin Luo, Huiting Li, Cencen Liu, Wei Dong, Changshun Bao, Yang Yu
Frontiers in Neuroscience.2022;[Epub] CrossRef - Protective Effects and Mechanisms of Melatonin on Stress Myocardial Injury in Rats
Jia-yao Chen, Ting Li, Jiao-ling Wang, Zhan-le Wang, Yun Zhang, Lin-quan Zang
Journal of Cardiovascular Pharmacology.2022; 80(3): 417. CrossRef - Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism
Xia Liu, Yi Cui, Yuhan Zhang, Guo Xiang, Meng Yu, Xianshu Wang, Bin Qiu, Xin-gang Li, Wei Liu, Di Zhang
Biomedicine & Pharmacotherapy.2022; 156: 113949. CrossRef - Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases
Pengwei Li, Mingxian Chang
International Journal of Molecular Sciences.2021; 22(14): 7688. CrossRef
- The cytoplasmic loops of AgrC contribute to the quorum-sensing activity of Staphylococcus aureus
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Qian Huang , Yihui Xie , Ziyu Yang , Danhong Cheng , Lei He , Hua Wang , Qian Liu , Min Li
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J. Microbiol. 2021;59(1):92-100. Published online November 17, 2020
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DOI: https://doi.org/10.1007/s12275-021-0274-x
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45
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4
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Abstract
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In Staphylococcus aureus, the accessory gene regulator (agr)
quorum-sensing system is thought to play an important role
in biofilm formation. The histidine kinase AgrC is one of the
agr system components and activated by the self-generated
auto-inducing peptide (AIP), which is released continuously
into the extracellular environment during bacterial growth.
The extracellular loops (Extra-loops) of AgrC are crucial for
AIP binding. Here, we reported that the cytoplasmic loops
(Cyto-loops) of AgrC are also involved in Agr activity. We
identified S. aureus ST398 clinical isolates containing a naturally
occurring single amino acid substitution (lysine to isoleucine)
at position 73 of an AgrC Cyto-loop that exhibited
significantly stronger biofilm formation and decreased Agr
activity compared to the wild-type strain. A constructed strain
containing the K73I point mutation in AgrC Cyto-loop continued
to show a growth dependent induction of the agr system,
although the growth dependent induction was delayed
by about 6 h compared to the wild-type. In addition, a series
of strains containing deletion mutants of the AgrC Cyto- and
Extra-loops were constructed and revealed that the removal
of the two Cyto-loops and Extra-loops 2 and 3 totally abolished
the Agr activity and the growth-dependence on the agr
system induction. Remarkably, the Extra-loop 1 deletion did
not affect the Agr activity. In conclusion, the AgrC Cyto-loops
play a crucial role in the S. aureus quorum-sensing activity.
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Citations
Citations to this article as recorded by

- Emerging trends in the inhibition of bacterial molecular communication: An overview
B.R. Maha Swetha, M. Saravanan, Prakash Piruthivraj
Microbial Pathogenesis.2024; 186: 106495. CrossRef - In vitro and in silico evaluation of anti-quorum sensing activity of marine red seaweeds-Portieria hornemannii and Halymenia dilatata
Prakash Piruthivraj, B.R. Maha Swetha, A. Anita Margret, A. Sherlin Rosita, Parthasarathi Rengasamy, Rajapandiyan Krishnamoorthy, Mansour K. Gatasheh, Khalid Elfaki Ibrahim, Sekhu Ansari, Natesan Vijayakumar
Journal of King Saud University - Science.2024; 36(6): 103188. CrossRef - Commensal Staphylococcus epidermidis Defends against Staphylococcus aureus through SaeRS Two-Component System
Nadira Nurxat, Lili Wang, Qichen Wang, Shujing Li, Chen Jin, Yaran Shi, Ayjiamali Wulamu, Na Zhao, Yanan Wang, Hua Wang, Min Li, Qian Liu
ACS Omega.2023; 8(20): 17712. CrossRef - Biofilm and Small Colony Variants—An Update on Staphylococcus aureus Strategies toward Drug Resistance
Henan Guo, Yucui Tong, Junhao Cheng, Zaheer Abbas, Zhongxuan Li, Junyong Wang, Yichen Zhou, Dayong Si, Rijun Zhang
International Journal of Molecular Sciences.2022; 23(3): 1241. CrossRef
Review
- [MINIREVIEW]Bacterial bug-out bags: outer membrane vesicles and their proteins and functions
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Kesavan Dineshkumar , Vasudevan Aparna , Liang Wu , Jie Wan , Mohamod Hamed Abdelaziz , Zhaoliang Su , Shengjun Wang , Huaxi Xu
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J. Microbiol. 2020;58(7):531-542. Published online June 10, 2020
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DOI: https://doi.org/10.1007/s12275-020-0026-3
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49
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Abstract
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Among the major bacterial secretions, outer membrane vesicles
(OMVs) are significant and highly functional. The proteins
and other biomolecules identified within OMVs provide
new insights into the possible functions of OMVs in bacteria.
OMVs are rich in proteins, nucleic acids, toxins and
virulence factors that play a critical role in bacteria-host interactions.
In this review, we discuss some proteins with multifunctional
features from bacterial OMVs and their role
involving the mechanisms of bacterial survival and defence.
Proteins with moonlighting activities in OMVs are discussed
based on their functions in bacteria. OMVs harbour many
other proteins that are important, such as proteins involved
in virulence, defence, and competition. Overall, OMVs are a
power-packed aid for bacteria, harbouring many defensive
and moonlighting proteins and acting as a survival kit in
case
of an emergency or as a defence weapon. In summary,
OMVs can be defined as bug-out bags for bacterial defence
and, therefore, survival.
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Citations
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- Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease
Chinasa Valerie Olovo, Dickson Kofi Wiredu Ocansey, Ying Ji, Xinxiang Huang, Min Xu
Gut Microbes.2024;[Epub] CrossRef - Glycosylphosphatidylinositol-anchored proteins as non- DNA matter of inheritance: from molecular to cell to philosophical biology
Günter Müller
Academia Molecular Biology and Genomics.2024;[Epub] CrossRef - Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles
Min Xiao, Guiding Li, Hefeng Yang
Frontiers in Microbiology.2023;[Epub] CrossRef - Wild Wheat Rhizosphere-Associated Plant Growth-Promoting Bacteria Exudates: Effect on Root Development in Modern Wheat and Composition
Houssein Zhour, Fabrice Bray, Israa Dandache, Guillaume Marti, Stéphanie Flament, Amélie Perez, Maëlle Lis, Llorenç Cabrera-Bosquet, Thibaut Perez, Cécile Fizames, Ezekiel Baudoin, Ikram Madani, Loubna El Zein, Anne-Aliénor Véry, Christian Rolando, Hervé
International Journal of Molecular Sciences.2022; 23(23): 15248. CrossRef - Tiny but mighty: Possible roles of bacterial extracellular vesicles in gut‐liver crosstalk for non‐alcoholic fatty liver disease
Li Shao, Junping Shi, Xiaohui Fan
Clinical and Translational Discovery.2022;[Epub] CrossRef - Extracellular membrane vesicles from Limosilactobacillus reuteri strengthen the intestinal epithelial integrity, modulate cytokine responses and antagonize activation of TRPV1
Yanhong Pang, Ludwig Ermann Lundberg, Manuel Mata Forsberg, David Ahl, Helena Bysell, Anton Pallin, Eva Sverremark-Ekström, Roger Karlsson, Hans Jonsson, Stefan Roos
Frontiers in Microbiology.2022;[Epub] CrossRef - Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered
Teresa Faddetta, Giovanni Renzone, Alberto Vassallo, Emilio Rimini, Giorgio Nasillo, Gianpiero Buscarino, Simonpietro Agnello, Mariano Licciardi, Luigi Botta, Andrea Scaloni, Antonio Palumbo Piccionello, Anna Maria Puglia, Giuseppe Gallo, Gladys Alexandre
Applied and Environmental Microbiology.2022;[Epub] CrossRef - Novel devices for isolation and detection of bacterial and mammalian extracellular vesicles
Shiana Malhotra, Zarinah M. Amin, Garima Dobhal, Sophie Cottam, Thomas Nann, Renee V. Goreham
Microchimica Acta.2021;[Epub] CrossRef - Tracing the origins of extracellular DNA in bacterial biofilms: story of death and predation to community benefit
Davide Campoccia, Lucio Montanaro, Carla Renata Arciola
Biofouling.2021; 37(9-10): 1022. CrossRef - The Rcs stress response inversely controls surface and CRISPR–Cas adaptive immunity to discriminate plasmids and phages
Leah M. Smith, Simon A. Jackson, Lucia M. Malone, James E. Ussher, Paul P. Gardner, Peter C. Fineran
Nature Microbiology.2021; 6(2): 162. CrossRef - Role of extracellular vesicles in liver diseases and their therapeutic potential
Enis Kostallari, Shantha Valainathan, Louise Biquard, Vijay H. Shah, Pierre-Emmanuel Rautou
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Journal Articles
- Ciceribacter ferrooxidans sp. nov., a nitrate-reducing Fe(II)-oxidizing bacterium isolated from ferrous ion-rich sediment
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Tongchu Deng , Youfen Qian , Xingjuan Chen , Xunan Yang , Jun Guo , Guoping Sun , Meiying Xu
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J. Microbiol. 2020;58(5):350-356. Published online April 27, 2020
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DOI: https://doi.org/10.1007/s12275-020-9471-2
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49
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Abstract
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A nitrate-reducing Fe(II)-oxidizing bacterial strain, F8825T,
was isolated from the Fe(II)-rich sediment of an urban creek
in Pearl River Delta, China. The strain was Gram-negative,
facultative chemolithotrophic, facultative anaerobic, nonspore-
forming, and rod-shaped with a single flagellum. Phylogenetic
analysis based on 16S rRNA gene sequencing indicated
that it belongs to the genus Ciceribacter and is most
closely related to C. lividus MSSRFBL1T (99.4%), followed
by C. thiooxidans F43bT (98.8%) and C. azotifigens A.slu09T
(98.0%). Fatty acid, polar lipid, respiratory quinone, and
DNA G + C content analyses supported its classification in
the genus Ciceribacter. Multilocus sequence analysis of concatenated
16S rRNA, atpD, glnII, gyrB, recA, and thrC suggested
that the isolate was a novel species. DNA–DNA hybridization
and genome sequence comparisons (90.88 and
89.86%, for values of ANIm and ANIb between strains F8825T
with MSSRFBL1T, respectively) confirmed that strain F8825T
was a novel species, different from C. lividus MSSRFBL1T,
C. thiooxidans F43bT, and C. azotifigens A.slu09T. The physiological
and biochemical properties of the strain, such as
carbon source utilization, nitrate reduction, and ferrous ion
oxidation, further supported that this is a novel species. Based
on the polyphasic taxonomic results, strain F8825T was identified
as a novel species in the genus Ciceribacter, for which
the name Ciceribacter ferrooxidans sp. nov. is proposed.
The type strain is F8825T (= CCTCC AB 2018196T = KCTC
62948T).
-
Citations
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Zhen Peng, Hang Shi, Shengkai Wu, Yao Fan, Xu Ye, Qisong Liu, Bo Liu
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Lifang Hu, Feng Huang, Yating Qian, Tao Ding, Yuzhou Yang, Dongsheng Shen, Yuyang Long
Journal of Hazardous Materials.2024; 473: 134582. CrossRef - Ciceribacter sichuanensis sp. nov., a plant growth promoting rhizobacterium isolated from root nodules of soybean in Sichuan, China
Yanqin Zhang, Yuanxue Chen, Petri Penttinen, Xing Wang, Ying Quan, Licheng Wen, Miao Yang, Xiaoping Zhang, Qiang Chen, Lingzi Zhang, Junjie Zhang, Xiaoxia Zhang, Kaiwei Xu
Antonie van Leeuwenhoek.2024;[Epub] CrossRef - Genomic Insights into the Landfill Microbial Community: Denitrifying Activity Supporting One-Carbon Utilization
Bhagyashri J. Poddar, Anshuman A. Khardenavis
Applied Biochemistry and Biotechnology.2024;[Epub] CrossRef - Sediment-isolated Comamonas terrigena strain HJ-2: a novel nitrate-dependent ferrous-oxidizing bacterium with multifunction on pollutant transformation
Rong Peng, Junhao Shen, Shuang Li, Hui Liu
Letters in Applied Microbiology.2023;[Epub] CrossRef - New Anaerobic Iron-Cycling Bacteria Isolated from the Yessentukskoye Mineral Water Deposit
D. G. Zavarzina, V. A. Pikhtereva, A. A. Klyukina, A. Yu. Merkel, S. N. Gavrilov
Microbiology.2023; 92(S1): S12. CrossRef - Genomic characterization of denitrifying methylotrophic Pseudomonas aeruginosa strain AAK/M5 isolated from municipal solid waste landfill soil
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World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - International Committee on Systematics of Prokaryotes, Subcommittee on the taxonomy of Rhizobia and Agrobacteria, minutes of the annual meeting by videoconference, 5 July 2021, followed by online discussion until 31 December 2021
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- Transcriptome analysis to understand the effects of the toxoflavin and tropolone produced by phytopathogenic Burkholderia on Escherichia coli
-
Jungwook Park , Hyun-Hee Lee , Hyejung Jung , Young-Su Seo
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J. Microbiol. 2019;57(9):781-794. Published online August 27, 2019
-
DOI: https://doi.org/10.1007/s12275-019-9330-1
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48
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8
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Abstract
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The phytopathogenic Burkholderia species B. glumae and
B. plantarii are the causal agents of bacterial wilt, grain rot,
and seedling blight, which threaten the rice industry globally.
Toxoflavin and tropolone are produced by these phytopathogens
and are considered the most hostile biohazards with a
broad spectrum of target organisms. However, despite their
nonspecific toxicity, the effects of toxoflavin and tropolone
on bacteria remain unknown. RNA-seq based transcriptome
analysis was employed to determine the genome-wide expression
patterns under phytotoxin treatment. Expression of 2327
and 830 genes was differentially changed by toxoflavin and
tropolone, respectively. Enriched biological pathways reflected
the down-regulation of oxidative phosphorylation and ribosome
function, beginning with the inhibition of membrane
biosynthesis and nitrogen metabolism under oxidative stress
or iron starvation. Conversely, several systems such as bacterial
chemotaxis, flagellar assembly, biofilm formation, and
sulfur/taurine transporters were highly expressed as countermeasures
against the phytotoxins. In addition, our findings
revealed that three hub genes commonly induced by both phytotoxins
function as the siderophore enterobactin, an ironchelator.
Our study provides new insights into the effects of
phytotoxins on bacteria for better understanding of the interactions
between phytopathogens and other microorganisms.
These data will also be applied as a valuable source in subsequent
applications against phytotoxins, the major virulence
factor.
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Seong Hyuk Lee , Hwan Youn , Sung Gyun Kang , Hyun Sook Lee
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J. Microbiol. 2019;57(2):138-142. Published online January 31, 2019
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DOI: https://doi.org/10.1007/s12275-019-8592-y
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2
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Abstract
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Thermococcus onnurineus NA1, an obligate anaerobic hyperthermophilic
archaeon, showed variable oxygen (O2) sensitivity
depending on the types of substrate employed as an
energy source. Unexpectedly, the culture with yeast extract
as a sole energy source showed enhanced growth by 2-fold
in the presence of O2. Genome-wide transcriptome analysis
revealed the upregulation of several antioxidant-related genes
encoding thioredoxin peroxidase (TON_0862), rubrerythrin
(TON_0864), rubrerythrin-related protein (TON_0873),
NAD(P)H rubredoxin oxidoreductase (TON_0865), or thioredoxin
reductase (TON_1603), which can couple the detoxification
of reactive oxygen species with the regeneration
of NAD(P)+ from NAD(P)H. We present a plausible mechanism
by which O2 serves to maintain the intracellular redox
balance. This study demonstrates an unusual strategy of an
obligate anaerobe underlying O2-mediated growth enhancement
despite not having heme-based or cytochrome-type
proteins.
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Zixuan Zhong , Nannan Li , Binghui He , Yasuo Igarashi , Feng Luo
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J. Microbiol. 2019;57(2):127-137. Published online September 13, 2018
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DOI: https://doi.org/10.1007/s12275-019-8398-y
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Abstract
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Interspecific mycelial interactions between white rot fungi
are always accompanied by an increased production of laccase.
In this study, the potential of the white rot fungus Dichomitus
squalens to enhance laccase production during interactions
with two other white rot fungi, Trametes versicolor or Pleurotus
ostreatus, was assessed. To probe the mechanism of laccase
induction and the role that laccase plays during combative
interaction, we analyzed the differential gene expression profile
of the laccase induction response to stressful conditions
during fungal interaction. We further confirmed the expression
patterns of 16 selected genes by qRT-PCR analysis. We
noted that many differentially expressed genes (DEGs) encoded
proteins that were involved in xenobiotic detoxification
and reactive oxygen species (ROS) generation or reduction,
including aldo/keto reductase, glutathione S-transferases,
cytochrome P450 enzymes, alcohol oxidases and dehydrogenase,
manganese peroxidase and laccase. Furthermore, many
DEG-encoded proteins were involved in antagonistic mechanisms
of nutrient acquisition and antifungal properties, including
glycoside hydrolase, glucanase, chitinase and terpenoid
synthases. DEG analyses effectively revealed that laccase
induction was likely caused by protective responses to
oxidative stress and nutrient competition during interspecific
fungal interactions.
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Research Support, Non-U.S. Gov't
- NOTE] Next-Generation Sequencing-Based Transcriptome Analysis of L-Lysine-Producing Corynebacterium glutamicum ATCC 21300 Strain
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Hong-Il Kim , Jae-Young Nam , Jae-Yong Cho , Chang-Soo Lee , Young-Jin Park
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J. Microbiol. 2013;51(6):877-880. Published online December 19, 2013
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DOI: https://doi.org/10.1007/s12275-013-3236-0
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33
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Abstract
-
In the present study, 151 genes showed a significant change
in their expression levels in Corynebacterium glutamicum
ATCC 21300 compared with those of C. glutamicum ATCC
13032. Of these 151 genes, 56 genes (2%) were up-regulated
and 95 genes (3%) were down-regulated. RNA sequencing
analysis also revealed that 11 genes, involved in the L-lysine
biosynthetic pathway of C. glutamicum, were up- or downregulated
compared with those of C. glutamicum ATCC
13032. Of the 151 genes, 10 genes were identified to have
mutations including SNP (9 genes) and InDel (1 gene). This
information will be useful for genome breeding of C. glutamicum
to develop an industrial amino acid-producing strain
with minimal mutation.
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- Review of the Proteomics and Metabolic Properties of Corynebacterium glutamicum
Juhwan Park, Sooa Lim
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Jian Wang, Xuesong Wang, Qing Liang, Deheng Li, Dawei Li, Qunqun Guo
Amino Acids.2022; 54(2): 229. CrossRef - RETRACTED ARTICLE: Comparative analysis of the Corynebacterium glutamicum transcriptome in response to changes in dissolved oxygen levels
Xiuxia Liu, Sun Yang, Fen Wang, Xiaofeng Dai, Yankun Yang, Zhonghu Bai
Journal of Industrial Microbiology and Biotechnology.2017; 44(2): 181. CrossRef - Transcriptome and Gene Ontology (GO) Enrichment Analysis Reveals Genes Involved in Biotin Metabolism That Affect l-Lysine Production in Corynebacterium glutamicum
Hong-Il Kim, Jong-Hyeon Kim, Young-Jin Park
International Journal of Molecular Sciences.2016; 17(3): 353. CrossRef